A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21216 results · page 46 of 708
Samantha Stevenson, Baylor Fox-Kemper, Markus Jochum et al. · 2012 · Journal of Climate
Abstract The El Niño–Southern Oscillation (ENSO) response to anthropogenic climate change is assessed in the following 1° nominal resolution Community Climate System Model, version 4 (CCSM4) Coupled Model Intercomparison Project phase 5…
Clive S. Lennox · 2015 · The Accounting Review
ABSTRACT In 2005–2006, the PCAOB imposed restrictions on auditors' tax services in order to strengthen auditor independence and improve audit quality. The restrictions resulted in a significant drop in auditor-provided tax services (APTS).…
Min-Sun Kim, Yuan Yuan · 2015 · Episteme
Abstract In “Normativity and Epistemic Intuitions” (NEI), Weinberg, Nichols and Stich famously argue from empirical data that East Asians and Westerners have different intuitions about Gettier-style cases. We attempted to replicate their…
Tobias Wingen, Jana Berkessel, Birte Englich · 2019 · Social Psychological and Personality Science
In the current psychological debate, low replicability of psychological findings is a central topic. While the discussion about the replication crisis has a huge impact on psychological research, we know less about how it impacts public trust in psychology. In this article, we examine whether low replicability damages public trust and how this damage can be repaired. Studies 1–3 provide correlational and experimental evidence that low replicability reduces public trust in psychology. Additionally, Studies 3–5 evaluate the effectiveness of commonly used trust-repair strategies such as informati
Carol Shennan, Timothy J. Krupnik, Graeme Baird et al. · 2017 · Annual Review of Environment and Resources
In this review, we examine the debate surrounding the role for organic agriculture in future food production systems. Typically represented as a binary organic–conventional question, this debate perpetuates an either/or mentality. We…
Ji Min Choi, Jong In Yang, Seung Joo Kang et al. · 2018 · Journal of Neurogastroenterology and Motility
BACKGROUND/AIMS: The different clinical manifestations of gastroesophageal reflux disease (GERD) may be influenced by associated psychological factors. We evaluated the psychological status (anxiety and depression) according to each…
Eze Simpson Osuagwu, Eseoghene Olaifa · 2018 · PLoS ONE
The Niger Delta region is the oil producing area of Nigeria, which consists of highly diverse ecosystems that are supportive of numerous species of terrestrial and aquatic fauna and flora. Crude oil spills endanger fish hatcheries in coastal water and also contaminate valuable fish. This study examines the effects of oil spills on fish production in the Niger Delta of Nigeria from 1981-2015 using an estimable Cobb Douglas production function. The findings suggest that oil production and spills negatively affect fish production, while farm labour has a positive effect on fish production. On the
Theodore Garland, Scott A. Kelly, Jessica L. Malisch et al. · 2010 · Proceedings of the Royal Society B Biological Sciences
The response to uniform selection may occur in alternate ways that result in similar performance. We tested for multiple adaptive solutions during artificial selection for high voluntary wheel running in laboratory mice. At generation 43,…
Laura Evgin, Amanda L. Huff, Phonphimon Wongthida et al. · 2020 · Nature Communications
The application of adoptive T cell therapies, including those using chimeric antigen receptor (CAR)-modified T cells, to solid tumors requires combinatorial strategies to overcome immune suppression associated with the tumor microenvironment. Here we test whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells. Contrary to our hypothesis, VSVmIFNβ infection is associated with attrition of murine EGFRvIII CAR T cells in a B16EGFRvIII model, despite inducing a robust proinflam
Alan L. Gustman, Thomas L. Steinmeier, Nahid Tabatabai · 2012 · American Economic Review
There is evidence of a relation between numeracy and wealth held outside of pensions and Social Security. With pensions and Social Security accounting for half of wealth at retirement, and evidence that those with pensions save more in…
Suejung G. Kim, Mysore S. Veena, Saroj K. Basak et al. · 2011 · Clinical Cancer Research
PURPOSE: To determine whether curcumin would inhibit IκB kinase β (IKKβ) kinase activity and suppress expression of proinflammatory cytokines in head and neck squamous cell carcinoma cancer (HNSCC) patients. EXPERIMENTAL DESIGN: Saliva was…
Lingling Fang, Fangjian Guo, Lihua Zhou et al. · 2015 · Adipocyte
AIMS/HYPOTHESIS: Regional deposition of adipose tissue and adipocyte morphology may contribute to increased risk for insulin resistance. The aim of this study was to compare adipocyte cell size and size distribution from multiple fat…
Dóra Matzke, Sander Nieuwenhuis, Hedderik van Rijn et al. · 2015 · Journal of Experimental Psychology General
A growing body of research has suggested that horizontal saccadic eye movements facilitate the retrieval of episodic memories in free recall and recognition memory tasks. Nevertheless, a minority of studies have failed to replicate this…
Zhenya Zhai, Fan Zhang, Ruihua Cao et al. · 2019 · Frontiers in Microbiology
The present study is undertaken to assess the alleviating effects of antimicrobial peptide cecropin A on inflammatory bowel disease (IBD) in C57BL/6 mice and changes in the gut microbiota, compared to an antibiotic gentamicin. Different doses of cecropin A were intraperitoneally injected into C57BL/6 mice for 5 days to determine the safe doses. The injection doses at ≤ 15 mg/kg showed no negative impact on the liver, heart, spleen and kidney. The severe and moderate IBD mice model was successfully established via supplementation of 4% or 2.5% dextran sulfate sodium (DSS) in drinking water for
Athanassios Argiris, Michalis V. Karamouzis, William E. Gooding et al. · 2011 · Journal of Clinical Oncology
PURPOSE: We hypothesized that bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), will potentiate the activity of pemetrexed, a multitargeted antifolate, in squamous cell carcinoma of the head and neck…
Jialiu Wei, Jianhui Liu, Shuang Liang et al. · 2020 · International Journal of Nanomedicine
Objective: Silica nanoparticles (SiO 2 NPs) have been extensively employed in biomedical field. SiO 2 NPs are primarily designed to enter the circulatory system; however, little information is available on potential adverse effects of SiO…
Stuart Faulkner, Alan Bainbridge, Takenori Kato et al. · 2011 · Annals of Neurology
OBJECTIVE: Additional treatments for therapeutic hypothermia are required to maximize neuroprotection for perinatal asphyxial encephalopathy. We assessed neuroprotective effects of combining inhaled xenon with therapeutic hypothermia after…
Girmay Tsegay Kiross, Catherine Chojenta, Daniel Barker et al. · 2020 · Health Economics Review
INTRODUCTION: Although health expenditure in sub-Saharan African countries is the lowest compared with other regions in the world, most African countries have improved their budget allocations to health care over the past 15 years. The majority of health care sources in sub-Saharan Africa are private and largely involve out-of-pocket expenditure, which may prevent healthcare access. Access to healthcare is a known predictor of infant mortality. Therefore the objective of this study is to determine the impact of health care expenditure on infant mortality in sub-Saharan Africa. METHODS: The stu
Antarpreet Jutla, A. S. Akanda, Jeffrey K. Griffiths et al. · 2011 · American Journal of Tropical Medicine and Hygiene
Phytoplankton abundance is inversely related to sea surface temperature (SST). However, a positive relationship is observed between SST and phytoplankton abundance in coastal waters of Bay of Bengal. This has led to an assertion that in a…
Yunzhen Ye, Yu Xiong, Qiongjie Zhou et al. · 2020 · Journal of Diabetes Research
BACKGROUND: Gestational diabetes mellitus (GDM) contributes to adverse pregnancy and birth outcomes. In recent decades, extensive research has been devoted to the early prediction of GDM by various methods. Machine learning methods are flexible prediction algorithms with potential advantages over conventional regression. OBJECTIVE: The purpose of this study was to use machine learning methods to predict GDM and compare their performance with that of logistic regressions. METHODS: We performed a retrospective, observational study including women who attended their routine first hospital visits
Erick Cardenas, Wei‐Min Wu, Mary Beth Leigh et al. · 2010 · Applied and Environmental Microbiology
Massively parallel sequencing has provided a more affordable and high-throughput method to study microbial communities, although it has mostly been used in an exploratory fashion. We combined pyrosequencing with a strict indicator species…
Constantin Ahlmann-Eltze, Wolfgang Huber, Simon Anders · 2025 · Nature Methods
Abstract Recent research in deep-learning-based foundation models promises to learn representations of single-cell data that enable prediction of the effects of genetic perturbations. Here we compared five foundation models and two other…
Priya Palta, Elbert S. Huang, Rita R. Kalyani et al. · 2017 · Diabetes Care
OBJECTIVE Hemoglobin A1c (HbA1c) level has been associated with increased mortality in middle-aged populations. The optimal intensity of glucose control in older adults with diabetes remains uncertain. We sought to estimate the risk of…
Harry Sokol, Laurent Beaugerie, Marc Maynadié et al. · 2012 · Inflammatory Bowel Diseases
BACKGROUND: It remains to be shown whether inflammatory bowel disease (IBD) is associated with an increased risk of primary intestinal lymphoproliferative disorders (PILD). We assessed this risk in the CESAME French nationwide prospective…
Gholam Ali Gholami, Babak Najafi, Fatemeh Mashhadiabbas et al. · 2011 · Clinical Oral Implants Research
OBJECTIVES: The aim of this study was to compare a nanocrystalline hydroxyapatite (NCHA), NanoBone(®) and a deproteinized bovine bone mineral (DBBM), Bio-Oss(®) with a collagen membrane on the horizontal ridge width alterations following…
Linda Spiegelberg, Ruud Houben, Raymon Niemans et al. · 2019 · Clinical and Translational Radiation Oncology
Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of treatment resistance to conventional therapies. Despite promising preclinical and clinical phase I and II…
Suzanna M. Zick, Benjamin D. Wright, Ananda Sen et al. · 2011 · BMC Complementary and Alternative Medicine
BACKGROUND: Despite being the most commonly used herbal for sleep disorders, chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia is unknown. We examined the preliminary efficacy and safety of chamomile for improving subjective sleep and daytime symptoms in patients with chronic insomnia. METHODS: We performed a randomized, double-blind, placebo-controlled pilot trial in 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6-months. Patients were randomized to 270 mg of chamomile twice daily or placebo for 28-days. The primary outcomes were sle
Andrea L. Roberts, Susan Malspeis, Laura D. Kubzansky et al. · 2017 · Arthritis & Rheumatology
OBJECTIVE: To conduct the first longitudinal study examining whether trauma exposure and posttraumatic stress disorder (PTSD) are associated with increased risk of incident systemic lupus erythematosus (SLE) in a civilian cohort. METHODS:…
Rifat Latifi, GeorgeJ Hadeed, Judith Smith et al. · 2016 · Journal of Emergencies Trauma and Shock
OBJECTIVES: Early diagnosis and emergent surgical debridement of necrotizing soft tissue infections (NSTIs) remains the cornerstone of care. We aimed to study the effect of early surgery on patients' outcomes and, in particular, on…
James R. Lewis, Jeff Sauro · 2017 · Journal of Usability Studies archive
In 2009, we published a paper in which we showed how three independent sources of data indicated that, rather than being a unidimensional measure of perceived usability, the System Usability Scale apparently had two factors: Usability (all…