The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation
Yaping Lin-Moshier; Michael V. Keebler; Robert Hooper; Michael J. Boulware; Xiaolong Liu; Dev Churamani; Mary E. Abood; Timothy F. Walseth · 2014 · Proceedings of the National Academy of Sciences
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Abstract (excerpt)
The two-pore channels (TPC1 and TPC2) belong to an ancient family of intracellular ion channels expressed in the endolysosomal system. Little is known about how regulatory inputs converge to modulate TPC activity, and proposed activation…
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Metadata source: OpenAlex · DOI 10.1073/pnas.1407004111