Negative / Null Result ReportOpen accessMedicine
Cláudia Saraiva, Daniela Talhada, Akhilesh Rai et al. · 2018 · PLoS ONE
There is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential in an in vitro and in vivo model of stroke. For that, neuroprotective and neurogenic responses were assessed in an in vitro model of stroke. Here, we found that miR-124 NPs decreased cell death and imp
View details →DOI: 10.1371/journal.pone.0193609 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Maria Comas, Alejandra Solis Flores, Nicole Lovato et al. · 2023 · Brain Sciences
Insomnia is a highly prevalent sleep disorder with strong bidirectional associations with depressive symptoms. The circadian preference for eveningness has been shown to be associated with depressive symptoms in insomnia and other mental health conditions. However, there is a lack of studies in insomnia investigating whether objective measures, such as dim light melatonin onset (DLMO) or polysomnographic (PSG) sleep, are associated with depressive symptoms. Therefore, we investigated the associations between subjective measures (questionnaires assessing anxiety, sleep quality and circadian pre
View details →DOI: 10.3390/brainsci13040613 Negative / Null Result ReportOpen accessVeterinary medicine
William Taylor Fair, Jeffrey Bryan Breeden, Thomas Wayne Atchley et al. · 2022 · Animals
Mesquite ( Prosopis L.) is considered an invasive browse species in most of the American Southwest. Mechanical intervention removes yields an excess of organic debris. Anecdotal evidence in the past has supported using such browse as feed for livestock. Thus, our objectives were to (1) determine the nutritive value and fermentation characteristics of silage produced with mesquite biomass, and (2) evaluate solvent treatment of mesquite biomass prior to ensiling. In Experiment 1, we evaluated mesquite inclusion rate (0, 250, 500, 750, or 1000 g kg −1 DM), length of fermentation (28, 56, or 84 d)
View details →DOI: 10.3390/ani12202795 Negative / Null Result ReportOpen accessInternal medicine
Xiangyan Liu, Tian Shen, Zhuoyi Wang et al. · 2014 · Journal of Infection in Developing Countries
Hepatitis E virus (HEV) infection in most individuals is known as a self-limiting, acute, icteric hepatitis, but evidence shows HEV is responsible for choric hepatitis and rapid progressed liver cirrhosis in immuno-compromised patients. We present the case of a patient whose diagnosis of acute graft failure was due to a HEV infection 7 years after his first liver transplantation because of Wilson’s disease. The process showed severe jaundice with fatigue, poor appetite and continually rising serum aminopherase. The blood serum was found positive for the anti-HEV IgG antibody but negative for a
View details →DOI: 10.3855/jidc.3638 Negative / Null Result ReportOpen accessMedicine
Athan P Papailiou, David V Yokum, Christopher T Robertson · 2015 · PLoS ONE
In recent decades, social scientists have shown that the reliability of eyewitness identifications is much worse than laypersons tend to believe. Although courts have only recently begun to react to this evidence, the New Jersey judiciary has reformed its jury instructions to notify jurors about the frailties of human memory, the potential for lineup administrators to nudge witnesses towards suspects that they police have already identified, and the advantages of alternative lineup procedures, including blinding of the administrator. This experiment tested the efficacy of New Jersey's jury ins
View details →DOI: 10.1371/journal.pone.0142695 Methods Dead-EndOpen accessEnvironmental sciences
Ashkan Talebi, Brent E. Sleep, Denis M. O'Carroll · 2023 · Water Resources Research
Abstract Mathematical models in engineering play an important role in understanding and predicting the behavior of a system. A mechanistic coupled liquid water, water vapor and heat transfer model incorporating kinetic phase change accounting for real‐time interfacial area between water and gas phases was developed to predict coupled subsurface processes and evaporation (drying) rates from bare soils. To enhance the model capability to predict evaporation rates, the air resistance associated with the viscous sublayer was implemented in energy and mass exchange across the soil‐air interface (th
View details →DOI: 10.1029/2023wr035573 Negative / Null Result ReportOpen accessEducation
Reza sharifinia, Abdolhussein Shakurnia · 2022 · Journal of Medical Education Development
Background & Objective: Critical thinking (CT) is essential in medical education and improves physicians' clinical ability and competency. The present study aimed to determine the CT level and the trend of its changes in medical education at Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, in 2021. Materials & Methods: In this cross-sectional descriptive study, the CT levels of 165 medical students in three curricular phases, namely basic sciences, externship, and internship courses were examined. The data collection tool was the California Critical Thinking Skills Questionnaire
View details →DOI: 10.52547/edcj.15.45.26 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Ye Li Lee, Sang Yeoup Lee, Sang Yeoup Lee et al. · 2022 · Frontiers in Nutrition
IntroductionOysters possess an excellent nutritional profile containing γ-aminobutyric acid (GABA). Previous data suggest that GABA is a potent bioactive compound for improving muscle health. Lactic acid fermentation is thought to increase GABA content. However, the effect of oral supplementation of fermented oyster extracts (FO) on human muscle strength and mass is unclear. Therefore, we tested the effects and safety of consumption of FO combined with regular walking for 12 weeks on muscle strength and mass in older adults with relatively low muscle mass.Materials and methodsA randomized cont
View details →DOI: 10.3389/fnut.2022.935395 Negative / Null Result ReportOpen accessVeterinary medicine
Lina Fernanda Pulido-Rodríguez, Alfredo Manuel Franco Pereira, Fábio Luís Henrique et al. · 2025 · Veterinary Sciences
Shearing to improve heat dissipation is common in sheep farming. This study evaluated the influence of shearing on thermoregulatory responses of crossbred sheep from adapted breeds exposed to heat stress. Ten ewes were kept in a climate chamber exposed to heat stress (10–13 h), reaching 37 ± 1.0 °C for nine days, during two consecutive periods, without shearing, and then at 14 days after shearing, evaluating all variables. Rectal temperature, respiration rate, sweating rate, ocular surface temperature, and skin temperature were analyzed at 7, 10, 13, 17, and 20 h, and blood cortisol was analyz
View details →DOI: 10.3390/vetsci12040358 Negative / Null Result ReportOpen accessOphthalmology
Mahmoud F. Abdelaal, Soheir M. Esmat, Mohamed A. Salah Eldein et al. · 2026 · Delta Journal of Ophthalmology
Purpose This study aimed to compare the anatomical and functional outcomes of pars plana vitrectomy (PPV), intravitreal ranibizumab (IVR), and intravitreal triamcinolone acetonide (IVTA) injection in chronic persistent diabetic macular edema (DME) with nontractional epiretinal membrane (NT-ERM). Patients and methods This is a randomized prospective study that included 52 patients having chronic DME with NT-ERM who were divided into three groups: PPV with internal limiting membrane peeling group, IVR group, and IVTA group. The patients were evaluated by optical coherence tomography angiography
View details →DOI: 10.4103/djo.djo_36_25 Negative / Null Result ReportOpen accessMedicine
Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE
Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des
View details →DOI: 10.1371/journal.pone.0294767 Negative / Null Result ReportOpen accessVeterinary medicine
Jesús A. Quezada-Rubio, Alfredo Estrada-Angulo, Beatriz I. Castro-Pérez et al. · 2026 · Animals
Due to their specific properties, the autolyzed yeast Saccharomyces cerevisiae (SC) and bacterial Bacillus subtilis (BS) theoretically can have a synergistic effect when combined and offered in ruminant diets. Thus, the aim of this experiment was to evaluate the effect of their combination as feed additives on growth performance, dietary energy, carcass traits, and visceral organ mass in finishing lambs. For this reason, 48 Pelibuey × Katahdin lambs (98 ± 17 d age; initial weight = 20.25 ± 3.37 kg) were used in a feeding trial lasting 83 d. Lambs were blocked by weight and assigned to 24 pens.
View details →DOI: 10.3390/ani16040610 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Anoek L. I. van Leeuwen, Nicole A. M. Dekker, Paul Van Slyke et al. · 2021 · Intensive Care Medicine Experimental
Abstract Background Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic shock-induced vascular leakage. We hypothesized that as a consequence of vascular leakage, renal perfusion and function is impaired and that activating Tie2 restores renal perfusion and function. Methods Rats underwent 1 h of hemorrhagic shock and were treated with either vasculotide or PBS as control, followed by fluid resuscitation for 4 h. Microcirculatory perfusion w
View details →DOI: 10.1186/s40635-021-00389-5 Negative / Null Result ReportOpen accessBusiness
H. M. Zakaria, Gusganda Suria Manda, Arif Rakhman · 2020
This study is aiming to determine the effect of mudharabah financing on the profitability (ROA) in Sharia Commercial Banks (BUS) for the 2015-2018 period, the effect of musyarakah financing on the profitability (ROA) on Sharia Commercial…
View details →DOI: 10.34308/eqien.v7i2.146 Methods Dead-EndOpen accessAgriculture
Luis Sangoi, Ricardo Salvador · 1997 · Ciência Rural
This experiment was conducted in Ames, Iowa, USA, to compare dry matter accumulation patterns of maize genotypes contrasting in height and leafiness, and to test whether reduction in plant height an leaf number through the use of dwarfing genes or earliness can improve grain dry matter allocation. Five plant genotypes were tested: a full season hybrid adapted to central lowa (NK 4525), a short season hybrid adapted to northern Minnesota (C1070), and three dwarf lines (156-A, 302-E and I17- A). The dwarves contained, respectively, the homozygous, independent, recessive dwarfing genes d3, d1 and
View details →DOI: 10.1590/s0103-84781997000100001 Negative / Null Result ReportOpen accessMedicine
Benedikt J. Wiggli, Reno Frei, Reto Laffer et al. · 2017 · Swiss Medical Weekly
PURPOSE Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding mortality attributed to SA BSI caused by methicillin-sensitive S. aureus (MSSA) strains. In the unusual setting of a very low MRSA prevalence institution, we investigated incidence, mortality and trends of BSI caused by MSSA over the last 20 years. OBJECTIVE To evaluate and demonstrate trends in incidence and mortality of MSSA BSI as well as risk factors
View details →DOI: 10.4414/smw.2017.14508 Failed Experiment ReportOpen accessMedicine
Fernando Naclerio, Eneko Larumbe-Zabala, Robert Cooper et al. · 2015 · PLoS ONE
We investigated the effects of ingesting a multi-ingredient (53 g carbohydrate, 14.5 g whey protein, 5 g glutamine, 1.5 g L-carnitine-L-tartrate) supplement, carbohydrate only, or placebo on intermittent performance, perception of fatigue, immunity, and functional and metabolic markers of recovery. Sixteen amateur soccer players ingested their respective treatments before, during and after performing a 90-min intermittent repeated sprint test. Primary outcomes included time for a 90-min intermittent repeated sprint test (IRS) followed by eleven 15 m sprints. Measurements included creatine kina
View details →DOI: 10.1371/journal.pone.0125188 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
George D. Fulk, Regina Bell, Keenan Batts et al. · 2026 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sleep–wake disruption is common after stroke and may impede recovery. The Sleep Regularity Index (SRI) quantifies the probability that an individual is in the same sleep or wake state at the same clock time on consecutive days. This study evaluates SRI during poststroke recovery, estimating associations with stroke outcomes and characterizing transitions between SRI states over time. Methods We analyzed data from 71 participants who were part of a larger ongoing study exploring the impact of nonobstructive sleep apnea sleep disorders post stroke. Data were collected at 10, 60, and 9
View details →DOI: 10.1161/jaha.125.048392 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
A. DeMichele, A. C. Dueck, D. Hlauschek et al. · 2025 · Breast Cancer Research
Abstract Background The PALLAS trial investigated the addition of palbociclib to standard adjuvant endocrine therapy to reduce breast cancer recurrence. This pre-specified analysis was conducted to determine whether adjuvant palbociclib benefited patients diagnosed with lower risk stage IIA disease compared to those with higher stage disease. Methods PALLAS was an international, multicenter, randomized, open-label, phase III trial, representing a public–private partnership between Pfizer, the Austrian Breast Cancer Study Group, and the U.S. ALLIANCE Foundation. Patients diagnosed with stage II
View details →DOI: 10.1186/s13058-024-01941-3 Negative / Null Result ReportOpen accessMedicine
Hiroyuki Daida, Tomoyuki Takura, Tetsuya Shiina et al. · 2022 · BMJ Open
Objectives Follow-up invasive coronary angiography (FUICA) after percutaneous coronary intervention (PCI) has been shown to increase the rate of early coronary revascularisation without reducing the incidence of subsequent myocardial infarction or death. However, no studies have evaluated the cost-effectiveness of FUICA in patients after coronary stenting. Therefore, this study aimed to evaluate the cost-effectiveness of FUICA after PCI.Design Retrospective observational cohort study.Setting 497 hospitals.Participants and interventions Overall, 558 patients who underwent coronary artery stenti
View details →DOI: 10.1136/bmjopen-2022-061617 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Andrew P. McBride, Thibault Lafosse, Alex N. Karanja et al. · 2025 · BMC Musculoskeletal Disorders
Abstract Background Long term studies have shown the Latarjet procedure to be successful in preventing re-dislocation in primary and recurrent anterior inferior shoulder instability. It provides stability through the sling effect of the conjoint tendon and the bone block. It is unclear whether augmentation with capsular repair provides an added benefit or leads to restricted range of external rotation. The primary aim of this study is to evaluate the effect of capsular repair in the open Latarjet procedure on rotational range of active external rotation in 90 degrees abduction (RoM-ER90). The
View details →DOI: 10.1186/s12891-025-08278-8 Negative / Null Result ReportOpen accessPhysiology
Chunwei Ma, Chunwei Ma, Yongcai Zhao et al. · 2022 · Frontiers in Physiology
Hypoxic training improves the microcirculation function of human skeletal muscle, but its mechanism is still unclear. Silent information regulator 2 homolog 3 (Sirt3) can improve mitochondrial function and oxidative status. We aimed to examine the role of Sirt3 in the process of hypoxic training, which affects skeletal muscle microcirculation. C57BL/6 mice were assigned to control (C), hypoxic training (HT), Sirt3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP), and 3-TYP + hypoxic training (3-TYP + HT) groups (n = 6/group). Sirt3 inhibition was induced by intraperitoneal injection of Sir
View details →DOI: 10.3389/fphys.2022.921763 Negative / Null Result ReportOpen accessMedicine
Scott R Ceresnak, Robert H Pass, Anne M Dubin et al. · 2019 · PLoS ONE
Background In previous pilot work we demonstrated that a novel automated signal analysis tool could accurately identify successful ablation sites during Wolff-Parkinson-White (WPW) ablation at a single center. Objective We sought to validate and refine this signal analysis tool in a larger multi-center cohort of children with WPW. Methods A retrospective review was performed of signal data from children with WPW who underwent ablation at two pediatric arrhythmia centers from 2008-2015. All patients with WPW ≤ 21 years who underwent invasive electrophysiology study and ablation with ablation si
View details →DOI: 10.1371/journal.pone.0217282 Negative / Null Result ReportOpen accessAgriculture (General)
Wagner Gonçalves Vieira Junior, Lucas da Silva Alves, Jadson Belém de Moura et al. · 2025 · AgriEngineering
Although considered relatively sustainable, mushroom production generates significant waste at the end of cultivation. This study investigated the reuse of Spent Mushroom Substrate (SMS) to formulate new substrates for Pleurotus ostreatus cultivation. Substrates with high (higher bran content) and low (lower bran content) nitrogen levels were prepared and supplemented with 5%, 10%, or 20% SMS across three successive cycles P. ostreatus crops. Cultivation performance was evaluated based on biological efficiency, number of mushrooms, fresh weight, and number of clusters. Substrates were chemical
View details →DOI: 10.3390/agriengineering7100342 Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Hiye-Ja Lee, Kyung-Ja Kang, Seung-Hun Park et al. · 2012 · Healthcare Informatics Research
ObjectivesBody weight, body mass index (BMI), body fat, and blood pressure are important indicators of a person's health. In this experimental study, we evaluated the effectiveness of an integrated personalized health care system, Health Improvement and Management System (HIMS)-everyday, which instantly provides subjects with biofeedback on their measured body weight, BMI, body fat and blood pressure using a database that stores subjects-customized information.MethodsThe subjects of this study used the system once or twice a week for 8 weeks. We analyzed the changes in their body weight, BMI,
View details →DOI: 10.4258/hir.2012.18.3.199 Negative / Null Result ReportOpen accessNursing
Šidlauskaitė Vaida, Eglė Pankaitė · 2019 · Reabilitacijos Mokslai: Slauga, Kineziterapija, Ergoterapija
Background. Women breast cancer accounts for 25% of the new cases of cancer diagnosed worldwide and takes the leading place. After breast surgery pain occurs in the wound of the breast, in the armpit area and the hand that reduces the mobility of the shoulder joint, weakens the arm muscle strength, impairs flow of the lymph, which can affect the quality of life and disturb the psycho-emotional state. Physical therapy is applied dealing with these problems. The aim of the research was to estimate the effect of physical therapy on the arm function and psycho-emotional state in women after breast
View details →DOI: 10.33607/rmske.v1i16.744 Negative / Null Result ReportOpen accessPsychology
Dwi Apriliani, S. NikmahBaqiyyatus, Rizka Febila et al. · 2020 · Entrepreneurship Bisnis Manajemen Akuntansi (E-BISMA)
This research was conducted to determine the effect of satisfaction, brand image and trust on customer loyalty at member cards. This research method uses questionnaire data collection techniques with the respondent data of 100 people. The…
View details →DOI: 10.37631/e-bisma.v0i0.214 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Takuya Tajima, Nami Yamaguchi, Makoto Nagasawa et al. · 2019 · BMC Musculoskeletal Disorders
Abstract Background Bone tunnel enlargement following primary anterior cruciate ligament (ACL) reconstruction with soft tissue graft might be a severe disadvantage for revision surgery. The postoperative rehabilitation protocol including the non-weight-bearing periods were different depending on the surgeon or institute. To determine the relationship between femoral bone tunnel enlargement and the postoperative non-weight-bearing period after double-bundle ACL reconstruction with hamstring grafts. Methods Forty-two patients who underwent primary double-bundle ACL reconstruction with hamstring
View details →DOI: 10.1186/s12891-019-2653-6 Negative / Null Result ReportOpen access
D. Widayanti, Ika Wahyuni, Triska Dewi Pramitasari · 2022 · Jurnal Mahasiswa Entrepreneurship (JME)
Food and beverage companies are one of the business sectors that continue to experience growth. Food and beverage companies are also in great demand by investors because they are a sector that can survive in the midst of Indonesia's…
View details →DOI: 10.36841/jme.v1i4.2112 Negative / Null Result ReportOpen access
Hari Mohan Singh, V. Patel, Group C · 2021 · International Journal of Advanced Research
Aim: To assess the effectiveness of pranayama to relieve stress at selected areas. Methodology: study design: one group pre-test post–test research design1. Place and duration of study: The study was conducted in selected areas of…
View details →DOI: 10.21474/ijar01/13733 