Methods Dead-EndOpen accessMedicine (General)
Xiaohui Yang, Yue Meng, Huiyan Feng et al. · 2025 · Frontiers in Medicine
BackgroundEndometriosis is a chronic gynecological condition that can result in pelvic pain and infertility, thereby significantly impacting women's reproductive health. Psychological disorders such as anxiety and depression are common in women with endometriosis and can have a detrimental effect on their quality of life. Conventional postoperative care primarily focuses on medical and surgical aspects; however, there is a growing need to address the psychological wellbeing of patients as part of comprehensive postoperative care. Music listening interventions have emerged as a promising adjunc
View details →DOI: 10.3389/fmed.2025.1626575 Abandoned HypothesisOpen accessMedicine
Kathleen F Brookfield, Michael C Cheung, Relin Yang et al. · 2009 · PLoS ONE
OBJECTIVE: Patient chances for cure and palliation for a variety of malignancies may be greatly affected by the care provided by a treating hospital. We sought to determine the effect of volume and teaching status on patient outcomes for five gynecologic malignancies: endometrial, cervical, ovarian and vulvar carcinoma and uterine sarcoma. METHODS: The Florida Cancer Data System dataset was queried for all patients undergoing treatment for gynecologic cancers from 1990-2000. RESULTS: Overall, 48,981 patients with gynecologic malignancies were identified. Endometrial tumors were the most common
View details →DOI: 10.1371/journal.pone.0004049 Negative / Null Result ReportOpen access
Dwi Gemina, Tini Kartini, Pra Gemini · 2021 · JURNAL AKUNIDA
Cooperatives are directed as a collective community effort to increase the level of economic prosperity together. The research objective was to analyze the effect of external capital, business volume and total assets on the residual…
View details →DOI: 10.30997/jakd.v7i2.4283 Replication FailureOpen accessMedicine
Md Habibul Ghani, Md. Shahed Morshed, Tahniyah Haq et al. · 2023 · Bangabandhu Sheikh Mujib Medical University Journal
Hypovitaminosis D (<20 ng/mL) is thought to increase insulin resistance and meta-inflammation contributing to the pathogenesis of diabetes mellitus (DM). Correcting vitamin D deficiency in people with prediabetes might halt its progression to DM. The aim of this study was to examine the effect of vitamin D supplementation on insulin resistance, glycemic status, and inflammation in prediabetic adults with vitamin D deficiency. This doubleblind randomized placebo-controlled trial was done among 27 newly detected prediabetic adults with hypovitaminosis D randomly assigned to 60,000 IU of vitamin
View details →DOI: 10.3329/bsmmuj.v15i3.62956 Negative / Null Result ReportOpen accessSports medicine
Max K Dummar, Michael S Crowell, Will Pitt et al. · 2024 · International Journal of Sports Physical Therapy
# Background Concussions are often accompanied by balance disturbances. Clinically accurate evaluation systems are often expensive, large, and inaccessible to most clinicians. The Sway Balance Mobile Application (SWAY) is an accessible method to quantify balance changes. # Purpose To determine the known groups and convergent validity of the SWAY to assess balance after a concussion. # Study Design Case-Control Study. # Methods Twenty participants with acute concussion and twenty controls were recruited. At initial, one-week, and final return to activity (RTA) evaluations, all participants comp
View details →DOI: 10.26603/001c.92234 Replication FailureOpen accessBiotechnology
Nozomi Maniwa, Samuel Porfirio Xavier, Sergio Luis Scombatti de Souza et al. · 2024 · Journal of Functional Biomaterials
Background: A comprehensive investigation to associate the use of polynucleotides and hyaluronic acid with bovine bone in maxillary sinus lift procedures in rabbits has not been performed yet. The aim was to evaluate the influence of this novel association on the processes of bone regeneration in maxillary sinus augmentation. Methods: In this prospective, randomized, within-animal model, maxillary sinus augmentation was performed bilaterally in 12 rabbits. Deproteinized bovine bone material (DBBM) was used as filler material. A hyaluronic acid–polynucleotide gel was aggregated at the test site
View details →DOI: 10.3390/jfb15120361 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Yiding XIAO, Zhujun LI, Bozhi HU et al. · 2025 · Neurologia Medico-Chirurgica
For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant peripheral nerve sheath tumors. We retrospectively collected data on malignant peripheral nerve sheath tumor cases from the Surveillance, Epidemiology, and End Results database. Overall, 926 malignant peripheral nerve sheath tumor cases occurred in soft tissues, with surgical resection performed in 783 cases. After excluding cases with distant metastasis, incomplete f
View details →DOI: 10.2176/jns-nmc.2025-0104 Negative / Null Result ReportOpen accessMedicine
H. Pinnock, J. Hanley, L. McCloughan et al. · 2013 · British medical journal
Objective To test the effectiveness of telemonitoring integrated into existing clinical services such that intervention and control groups have access to the same clinical care. Design Researcher blind, multicentre, randomised controlled…
View details →DOI: 10.1136/bmj.f6070 Negative / Null Result ReportOpen accessMedicine
Sungha Park, Sang-Hyun Ihm, In-Jeong Cho et al. · 2023 · Clinical Hypertension
Abstract Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving
View details →DOI: 10.1186/s40885-023-00249-2 Negative / Null Result ReportOpen accessDentistry
Ahmed Hassan Kamil Mustafa, Ahmed Mohammed Suleiman · 2020 · International Journal of Dentistry
Background. Bell’s palsy is an acute idiopathic facial nerve paralysis of sudden onset. It is the most common cause of lower motor neuron facial nerve paralysis with an annual incidence of 15–30 per 100,000 population. The objective of this work is to study the grade of the attack and the associated symptoms of Bell’s palsy in a group of Sudanese patients. The study type is an analytical prospective-based study. The study was carried out at Khartoum Teaching Dental Hospital, Khartoum General Teaching Hospital. In this prospective of the study, 48 patients with Bell’s palsy were evaluated using
View details →DOI: 10.1155/2020/2160256 Negative / Null Result ReportOpen accessMedicine
Vera Dias, Eunsung Junn, M. Maral Mouradian · 2013 · Journal of Parkinson’s Disease
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential in neurons interfere with several biological processes, ultimately leading to cell death. Evidence has been developed for oxidative and nitrative damage to key cellular components in the PD substantia nigra. A number of sources and mechanisms for the generation of reactive oxygen species (ROS) are recognized including the metabolism of dopamine itself, mitochondrial dysfunction, iron, neuroinflammatory cells, calcium
View details →DOI: 10.3233/jpd-130230 Negative / Null Result ReportOpen accessMedicine
Lisa Baquet, Helge Hasselmann, Stefan Patra et al. · 2018 · PeerJ
Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist
View details →DOI: 10.7717/peerj.6037 Methods Dead-EndOpen accessMedicine
Elizabeth R Sharp, Christian B Willberg, Peter J Kuebler et al. · 2011 · PLoS ONE
HIV-1 vertically infected children in the USA are living into adolescence and beyond with the widespread use of antiretroviral drugs. These patients exhibit striking differences in the rate of HIV-1 disease progression which could provide insights into mechanisms of control. We hypothesized that differences in the pattern of immunodomination including breadth, magnitude and polyfunctionality of HIV-1 specific CD8+ T cell response could partially explain differences in progression rate.In this study, we mapped, quantified, and assessed the functionality of these responses against individual HIV
View details →DOI: 10.1371/journal.pone.0021135 Short NoteOpen accessImmunologic diseases. Allergy
Fanny Luterbacher, Fanette Bernard, Frédéric Baleydier et al. · 2021 · Frontiers in Immunology
Rituximab (RTX) is an anti-CD20 monoclonal antibody that targets B cells—from the immature pre-B-cell stage in the bone marrow to mature circulating B cells—while preserving stem cells and plasma cells. It is used to treat autoimmune diseases, hematological malignancies, or complications after hematopoietic stem cell transplantation (HSCT). Its safety profile is acceptable; however, a subset of patients can develop persistent hypogammaglobulinemia and associated severe complications, especially in pediatric populations. We report the unrelated cases of two young men aged 17 and 22, presenting
View details →DOI: 10.3389/fimmu.2021.773853 Negative / Null Result ReportOpen access
Nelly Masnila, R. Mayasari, Firmansyah Firmansyah et al. · 2021 · International Journal of Business, Management and Economics
This study aimed to determine the relationship and effect of the GGG variable on the quality of the financial reports in municipal governments in Indonesia by implementing the IIAG (The Ibrahim Index of African Governance) indicator. The…
View details →DOI: 10.47747/ijbme.v2i4.385 Negative / Null Result Report
Yoga Wahyu Pratama, Fransiska Prihatini, Orissa Octaria et al. · 2025 · Mars : Jurnal Teknik Mesin, Industri, Elektro Dan Ilmu Komputer
The use of technology in data management has become the key to improving the efficiency and effectiveness of company performance. PT Indofood CBP Sukses Makmur Tbk has implemented a computerized employee attendance system through the…
View details →DOI: 10.61132/mars.v3i5.1099 Negative / Null Result ReportOpen access
Okunlola D. O, Otinwa G.O · 2024 · African Journal of Social Issues
The purpose of this research was to investigate effects of two massage therapy techniques on the rate of perceived exertion and performance recovery among adolescent footballers in Lagos state. Pre-test post-test experimental research…
View details →DOI: 10.4314/ajosi.v7i1.7 Negative / Null Result Report
Angga Kurniawan, Nelson Lajuni, Tasrim Tasrim et al. · 2026 · EKUITAS (Jurnal Ekonomi dan Keuangan)
This study aims to analyze the effects of Electronic Word of Mouth Effect, Brand Image, and Email Marketing on Purchase Intention in the context of purchasing official MotoGP merchandise. It was conducted among respondents who are members…
View details →DOI: 10.24034/j25485024.y2025.v9.i4.7457 Negative / Null Result ReportMedicine
de-la-Llave-Rincón, Ambite-Quesada, Pacho-Hernández et al. · 2026 · Pain research & management
To determine the influence of sensitization-associated and neuropathic-like symptoms and clinical features in conditioned pain modulation (CPM) activity in women with episodic or chronic migraine. A cross-sectional study including 70 women…
View details →DOI: 10.1155/prm/8331529 Negative / Null Result ReportMedicine
Yersel, Ucan, Tekce · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists
This in vitro study aimed to evaluate the effect of layer thickness, printing orientation angle, and resin type on the radiopacity of 3D-printed dental resins. Three dental 3D-printed resins (VarseoSmile TriniQ, Crowntec, and Primeprint…
View details →DOI: 10.1111/jopr.70163 Negative / Null Result ReportMedicine
Na Z, Guo X, DuMei Y · 2026 · Medicine
Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and microstructural destruction of bone tissue, leading to fragile bones and susceptibility to fractures, significantly affecting the quality of life of…
View details →DOI: 10.1097/md.0000000000048754 Negative / Null Result ReportMedicine
Pennings VHM, Verwijk E, de Bie RMA et al. · 2026 · Journal of Parkinson's disease
BackgroundDespite the frequent decline in verbal fluency after STN-DBS surgery, the cause of decline remains unclear.ObjectiveThis study investigates whether mental speed and executive dysfunctions are underlying mechanisms of the phonemic…
View details →DOI: 10.1177/1877718x261455458 Negative / Null Result ReportOpen accessMedicine
Chen CD, Aguero C, Melloni A et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Alzheimer's disease (AD) biomarkers are assessed on their ability to detect AD pathophysiology in vivo, with confirmation of AD neuropathology only at autopsy. Methods Positron emission tomography (PET), plasma, and cognitive…
View details →DOI: 10.1002/alz.71092 Negative / Null Result ReportMedicine
Karunakaran KB, Purushottam M, Balakrishnan N et al. · 2026 · Translational psychiatry
Depressive disorder (DD), Alzheimer's disease (AD), and schizophrenia (SZ) are evolutionarily relevant traits that disrupt neural networks supporting affect and cognition. While genome-wide association studies have identified risk-related…
View details →DOI: 10.1038/s41398-026-04198-w Negative / Null Result ReportOpen accessMedicine
Thapa M, Adhikari GP, Saroj GC et al. · 2026 · BMC ophthalmology
BACKGROUND: To evaluate reliability and agreement of non-contact tonometry (NCT) and trans-palpebral tonometry (TPT) compared with Goldmann-applanation tonometry (GAT). METHODS: A total of 224 eyes from 112 patients were included between…
View details →DOI: 10.1186/s12886-026-04821-w Negative / Null Result Report
Wang F, Chen L, Xu X et al. · 2026 · Preprint
Abstract Background This study aimed to apply a 3D vertical cephalometric analysis to evaluate vertical skeletal relationships in adult patients. Methods The CBCT data of ninety-seven first-visit adult patients were retrospectively…
View details →DOI: 10.21203/rs.3.rs-8984975/v1 Negative / Null Result ReportMedicine
Khalid H, Tsai WS, Lamanna F et al. · 2026 · The British journal of ophthalmology
Background/aims To characterise the distribution of retinal non-perfusion and its relationship with neovascularisation elsewhere (NVE) and visual acuity (VA) in referable diabetic retinopathy (DR) using ultra-widefield fluorescein…
View details →DOI: 10.1136/bjo-2025-329361 Negative / Null Result Report
Sun C, Zhang B, Tong C et al. · 2026 · Preprint
Abstract Objective: This study investigated post-SMILE changes in corneal refractive power, axial length, and anterior chamber depth, and examined the relationship between anterior chamber depth change and corneal ablation depth. Biometric…
View details →DOI: 10.21203/rs.3.rs-9633033/v1 Negative / Null Result ReportMedicine
Yan Z, Chen T, Ma X et al. · 2026 · Psychology research and behavior management
Purpose Impaired cognitive flexibility is a core feature of obsessive-compulsive disorder (OCD) and may contribute to symptom persistence and variabe therapeutic outcomes. However, traditional measures may adequately capture how cognitive…
View details →DOI: 10.2147/prbm.s598045 Abandoned HypothesisMedicine
Jalan R, Patel VC, Shoaie S · 2026 · The lancet. Gastroenterology & hepatology
This Viewpoint examines the evolving role of rifaximin in cirrhosis, arguing that therapeutic drift has outpaced evidence and antimicrobial stewardship. While rifaximin is effective for secondary prevention of recurrent overt hepatic…
View details →DOI: 10.1016/s2468-1253(26)00076-2 