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Failure-mode index

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A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19866 results in Negative / Null Result Report · page 409 of 663

Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Impact of transradial versus transfemoral access for preprocedural coronary angiography on TAVR-associated complications

Baravan Al-Kassou, Hasanin Al-Shaikh, Adem Aksoy et al. · 2023 · International Journal of Cardiology: Heart & Vasculature

Background: Vascular injury and bleeding complications remain frequent after transcatheter aortic valve replacement (TAVR). Whether the access-site of preprocedural coronary angiography (CAG) affects TAVR-related complications is not known. The aim of this study was to evaluate the impact of transradial (TRA) versus transfemoral access (TFA) for preprocedural CAG on outcomes in patients undergoing subsequent TAVR. Methods: The study cohort included 1002 patients undergoing transfemoral TAVR, of whom 39.4% (395/1002) had undergone radial and 60.6% (607/1002) femoral access for pre-TAVR CAG. The

View details →DOI: 10.1016/j.ijcha.2023.101205
Negative / Null Result ReportOpen accessBusiness

Customers’ Perception regarding Assurance of Bancassurance Channel

Choudhury Mousumi, Singh Ranjit · 2016 · Acta Universitatis Sapientiae: Economics and Business

Bancassurance has evolved as a strong distribution channel in India. Bancassurance means that the insurance company and the bank come together to offer insurance products from the counter of the banks to the bank’s customer. The present study attempts to analyse customers’ perception regarding assurance of bancassurance channel in providing insurance-related services. The study also tries to find out the impact of various demographic variables on customers’ perception regarding assurance of bancassurance channel. The study finds that customers consider bancassurance channel having high assuran

View details →DOI: 10.1515/auseb-2016-0005
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

Zolpidem Administration and Risk of Hepatocellular Carcinoma: A Case-Control Study in Taiwan

Shih-Wei Lai, Shih-Wei Lai, Cheng-Li Lin et al. · 2017 · Frontiers in Pharmacology

Background/Objectives: Previous studies showed that zolpidem use could be associated with increased cancer risk, but the role of zolpidem on hepatocellular carcinoma (HCC) risk remains undetermined. The study purpose was to examine the association between HCC risk and zolpidem use in Taiwan.Methods: Using the database from the Taiwan National Health Insurance Program, we designed a case-control study which consisted of 77986 subjects aged 20 years or older with newly diagnosed HCC as the case group, and 77986 subjects without HCC as the control group, from 2000 to 2011. Ever use of zolpidem wa

View details →DOI: 10.3389/fphar.2017.00767
Negative / Null Result ReportOpen accessPublic aspects of medicine

Association between the parenting self-efficacy and anthropometric indexes in under 2-year-old children, Qazvin-Iran

Sonia Oveisi, Roghaye Keshavarz Sadegh, Sina Hosainzade et al. · 2025 · Discover Social Science and Health

Abstract Background Parenting self-efficacy (PSE) describes the beliefs and attitudes of parents on their capabilities to perform well on parenting tasks. Considering its direct relation to the physical and mental development of the children, we evaluated PSE in Iranian parents and investigated its potential effects on children's growth as a reflection of their self-regulation. Methods This investigation was conducted in 2019 in Takestan, Iran, and aimed to assess PSE in 300 parents of children under 2 years old. Families filled out a demographic questionnaire and a PSE questionnaire containin

View details →DOI: 10.1007/s44155-025-00196-3
Negative / Null Result ReportOpen accessMedicine

low birth weight risk factors in Basra city

Zainab Almussa · 2021 · The Medical Journal of Basrah University

Abstract: Introduction: Low birth weight is the best indicator of the impact in the health system and the best predictor of mortality and morbidity in the neonatal, post neonatal and childhood periods. Objectives: This study was planned to study the association between birth weight and selected risk factors in Basrah governorate with special reference to: Socio demographic factors, Present obstetric history, Past obstetric history, History of Ante Natal Care, and Medical history. Methods: This is hospital- based cross sectional study was conducted on 362 infants delivered and /or admitted to A

View details →DOI: 10.33762/mjbu.2021.129962.1070
Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology

Association of dietary and lifestyle inflammatory indices with type 2 diabetes risk in Iranian adults

Mahdieh Hosseinzadeh, Niloufar Saber, Sakineh Shab Bidar et al. · 2024 · BMC Endocrine Disorders

Abstract Background Type 2 diabetes mellitus (T2DM) is often linked to chronic inflammation, which can be influenced by both lifestyle and dietary choices. However, the relationship between the inflammatory potential of diet and lifestyle factors and the risk of developing T2DM remains unclear. The present study aimed to investigate the associations of the empirical dietary inflammatory index (EDII), dietary inflammatory score (DIS), and lifestyle inflammatory score (LIS) with the risk of T2DM among Iranian adults. Methods The current study was conducted on 5714 individuals from Yazd Health St

View details →DOI: 10.1186/s12902-024-01673-7
Negative / Null Result ReportOpen accessMedicine

Frequency of human papilloma virus genotypes among woman with genital lesions, in Sanandaj, Iran

Hajibagheri K, Abaszade A, Afrasiabian Sh et al. · 2018 · مجله علمی دانشگاه علوم پزشکی کردستان

Background and Aim: Genital wart is the most common sexually transmitted infection and its role in cervical cancer has been confirmed. The aim of this study was to determine the presence of human papillomavirus (HPV) and the frequency of its genotypes in the patients with genital lesions referring to the clinics in Sanandaj, Iran. Material and Method: This descriptive analytical study included 50 women with genital lesions referring to the clinics in Sanandaj City from February 2016 to February 2017. Biopsy samples were examined for four genotypes (HPV 16, 18 (high risk) and HPV 11, 6 (Low ris

Negative / Null Result ReportOpen accessDentistry

Is there any Association between Dental Caries and Body Mass Index among 8–10 Years Pediatric Clinic Attenders in Chandigarh Area? A Correlation Study

Leena Verma, Ravi Sharma, Sidhi Passi et al. · 2023 · Journal of South Asian Association of Pediatric Dentistry

Aim: To evaluate the correlation between dental caries and obesity in 8–10 years school children of Chandigarh, India. Materials and methods: Around 100 children of the age range of 8–10 years who attended the Pediatrics OPD of Dr Harvansh Singh Judge Institute of Dental Sciences & Hospital, Chandigarh, India were selected. Four groups were made group I—25 healthy teeth and nonobese (HNO) children, group II—25 carious teeth and nonobese (CNO) children, group III—25 healthy teeth and obese (HO) children, and group IV—carious teeth and obese (CO) children. Caries score was recorded after careful

View details →DOI: 10.5005/jp-journals-10077-3265
Negative / Null Result ReportOpen accessMedicine (General)

Taste sensitivity and nutritional status of elderly woman attending the Municipal Activity Center for the Elderly, Curitiba, PR.

Daniela Cristina Batista Pieroni, Naylla do Carmo Carlins, Pamela Polato et al. · 2017 · O Mundo da Saúde

Aging is associated with a decline in sensory acuity that may lead to impaired nutritional status. Thus, the study aimed to evaluate gustatory sensitivity in relation to the nutritional status of elderly women participating in an Activity Center for the Elderly (ACE). For that, an observational, analytical cross-sectional study was performed with elderly participants of an ACE, in Curitiba, PR. An anamnesis was applied to know and characterize the evaluated population, then an evaluation of the nutritional status was made through anthropometry. The taste sensitivity evaluation was carried out

Negative / Null Result ReportOpen accessEnvironmental sciences

FREQUENCY OF SOME ENVIRONMENTAL FACTORS WITH POTENTIAL RELATIONS TO BREAST DISEASES AMONG A GROUP OF EGYPTIAN FEMALES

El Sobky, Abeer, F, El Bokhary, M, AwadAllah, Hala, I et al. · 2018 · Journal of Environmental Science

This study was conducted to highlight the significant environmental factors that may have impacts on breast benign and malignant diseases. This study was carried out on one hundred females who came to radiology department to perform mammographic examination. A complete personal and family history of patients was taken, clinical examination was done, all cases were asked to fill a questionnaire about how often they deal with each item of the environmental factors including (alcohol, caffeine, smoking, use of some material that are commonly used in daily life and known to have estrogenic effect

View details →DOI: 10.21608/jes.2018.30843
Negative / Null Result ReportOpen accessAgriculture

Measuring Maize Seedling Drought Response in Search of Tolerant Germplasm

Dirk Hays, Steve Hague, Seth C. Murray et al. · 2013 · Agronomy

To identify and develop drought tolerant maize (Zea mays L.), high-throughput and cost-effective screening methods are needed. In dicot crops, measuring survival and recovery of seedlings has been successful in predicting drought tolerance but has not been reported in C4 grasses such as maize. Seedlings of sixty-two diverse maize inbred lines and their hybrid testcross progeny were evaluated for germination, survival and recovery after a series of drought cycles. Genotypic differences among inbred lines and hybrid testcrosses were best explained approximately 13 and 18 days after planting, res

View details →DOI: 10.3390/agronomy3010135
Negative / Null Result ReportOpen accessNutrition. Foods and food supply

Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study

Suming Dai, Ping Wang, Sijia Wang et al. · 2025 · Frontiers in Nutrition

BackgroundExisting epidemiological studies investigated the association between a single vitamin and hypertension. However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat-soluble vitamin levels and blood pressure.MethodsA total of 2052 participants with essential hypertension were sampled nationwide. The plasma concentrations of fat-soluble vitamins (A, E, D, and K) were assessed using liquid chromatography coupled with the mass spectrometry method. Participants wer

View details →DOI: 10.3389/fnut.2024.1502139
Negative / Null Result ReportOpen accessPublic aspects of medicine

Dietary and lifestyle inflammatory scores and risk of incident diabetes: a prospective cohort among participants of Tehran lipid and glucose study

Farshad Teymoori, Hossein Farhadnejad, Ebrahim Mokhtari et al. · 2021 · BMC Public Health

Abstract Background Inflammation is a precursor of chronic disease, which is affected by lifestyle and dietary habits. Recently empirical dietary inflammatory patterns (EDIP), dietary inflammation scores (DIS), and lifestyle inflammation scores (LIS) were developed to indicate lifestyle and dietary contributions in systemic inflammation. The current study aimed to investigate the associations between these indices and the incidence of diabetes among Tehranian adults. Methods A total of 4624 individuals, aged 20–75 years, who were free of diabetes at baseline (2008–2011), were followed for 5.71

View details →DOI: 10.1186/s12889-021-11327-1
Negative / Null Result ReportOpen accessMedicine

Mammographic breast density and its association with urinary estrogens and the fecal microbiota in postmenopausal women.

Gieira S Jones, Heather Spencer Feigelson, Roni T Falk et al. · 2019 · PLoS ONE

Background Breast density, as estimated by mammography, is a strong risk factor for breast cancer in pre- and postmenopausal women, but the determinants of breast density have not yet been established. The aim of this study was to assess if urinary estrogens or gut microbiota alterations are associated with mammographic density in postmenopausal women. Methods Among 54 cancer-free, postmenopausal controls in the Breast and Colon Health study, we classified low- versus high-density women with Breast Imaging Reporting and Data System (BI-RADS, 5th edition) mammographic screening data, then asses

View details →DOI: 10.1371/journal.pone.0216114
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

History of Cancer and Atrial Cardiopathy: A Secondary Analysis of the ARCADIA Clinical Trial

Babak B. Navi, Mitchell S. V. Elkind, Cenai Zhang et al. · 2025 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Approximately 50% of strokes in patients with cancer are classified as cryptogenic after standard evaluation. Atrial cardiopathy could explain some cancer‐related cryptogenic strokes. However, the relationship between cancer and atrial cardiopathy is uncertain. Methods AND RESULTS We conducted a post hoc cross‐sectional analysis of baseline data collected from participants enrolled in ARCADIA (Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke), a clinical trial conducted from 2018 to 2023 at 185 sites. The analytical cohort presented herein included

View details →DOI: 10.1161/jaha.124.040543
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Triage body temperature and its influence on patients with acute myocardial infarction

Shih-Hao Chen, Hung-Chieh Chang, Po-Wei Chiu et al. · 2023 · BMC Cardiovascular Disorders

Abstract Background Fever can occur after acute myocardial infarction (MI). The influence of body temperature (BT) after hospital arrival on patients with acute MI has rarely been investigated. Methods Patients who were diagnosed with acute MI in the emergency department (ED) of a tertiary teaching hospital between 1 January 2020 and 31 December 2020 were enrolled. Based on the tympanic temperature obtained at the ED triage, patients were categorized into normothermic (35.5°C-37.5°C), hypothermic ( 37.5°C) groups. The primary outcome was in-hospital cardiac arrest (IHCA), while the secondary o

View details →DOI: 10.1186/s12872-023-03372-y
Negative / Null Result ReportOpen accessChemistry

PCSK9 concentrations in different stages of subclinical atherosclerosis and their relationship with inflammation

Tóth Štefan, Olexa Peter, Hertelyová Zdenka et al. · 2020 · Open Chemistry

The aim of this study was to detect the concentrations of PCSK9 in various subclinical stages of atherosclerosis and to highlight its relationship with inflammation. One hundred and fifty-nine healthy patients were divided into three groups, based on the extent of atherosclerotic changes in the carotid artery: a group without identifiable atherosclerosis, cIMT>75‰ and an asymptomatic plaque group. The PCSK9 was measured by ELISA and hsCRP by the immunoturbidimetric method. Vascular changes were identified by a carotid ultrasound. PCSK9 was elevated, when comparing the healthy group with the cI

View details →DOI: 10.1515/chem-2020-0147
Negative / Null Result ReportOpen accessMedicine (General)

Correlation Between Duration of Screen Time and Method of Handling Smartphone Towards The Incidence of De Quervain’s Syndrome among The Medical Students of Diponegoro University.

Indra Hidayat, Erna Setiawati, Tanti Ajoe Kesoema et al. · 2023 · Jurnal Kedokteran Diponegoro

Background: Smartphone with all of its benefits make the majority of its users become too attached with the device that can fulfil their various needs. Due to its accessibility, an increase of daily screen time has also been observed which may have negative impacts on health, one of them being De Quervain’s Syndrome. De Quervain’s Syndrome is a type of Repetitive Strain Injury, affecting the thumb and wrist caused by a repetitious activity that puts burden or trauma to the aforementioned body parts. Objective: To assess the correlation between duration of screen time and method of handling sma

View details →DOI: 10.14710/dmj.v12i6.39048
Negative / Null Result ReportOpen accessHistory of scholarship and learning. The humanities

The Effect of Robotics and Coding Education on Girls’ STEM Motivation, Attitude and Career Aspirations

Salih Gülen, İsmail Dönmez, Fatma Betül Şengönül et al. · 2025 · SAGE Open

STEM education aims to develop 21st-century skills, support economic growth and promote gender equality in STEM fields. It is known that gender stereotypes play a significant role in the formation of STEM identity. The most important factor preventing some high school-level female students from pursuing STEM careers is their lack of participation in STEM activities. Female students in high schools have limited opportunities to explore or learn about STEM careers due to the emphasis on verbal and religious courses in their curriculum. However, it is known that women can work more autonomously i

View details →DOI: 10.1177/21582440251382631
Negative / Null Result ReportOpen accessMedicine

Microperimetry – A New Tool for Assessing Retinal Sensitivity in Macular Diseases

Memota Laishram, Krishnagopal Srikanth, AR Rajalakshmi et al. · 2017 · Journal of Clinical and Diagnostic Research

Introduction: Macular disease is the leading cause of low vision in the Western world. Drusen and pigmentary irregularities are common among the rural Northern Indian population. The disease process leads to loss of central vision, metamorphopsia, macropsia or micropsia and colour vision defect. Aim: To study the retinal sensitivity changes in macular diseases using microperimetry. Materials and Methods: It was an observational study, conducted in the Department of Ophthalmology at a rural tertiary care hospital. This study was started from December 2014 until June 2016, in all patients with m

View details →DOI: 10.7860/jcdr/2017/25799.10213
Negative / Null Result ReportOpen accessDiseases of the respiratory system

Systemic inflammatory response to inhaled endotoxin does not correlate with airway response

Amika K. Sood, Allison J. Burbank, Michael Lawson et al. · 2019 · Respiratory Research

Abstract Background Endotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation challenge reproducibly triggers neutrophilic inflammation in the airways and in peripheral blood. Sputum induction is currently the only available method for assessing airway neutrophilia but is laborious and time-consuming. This analysis examined the correlation between systemic and airway inflammatory responses to endotoxin to determine if peripheral blood could serve as a surrogate marker for neutrophilic airway inflammation. Methods We

View details →DOI: 10.1186/s12931-019-1227-3
Negative / Null Result ReportOpen accessNuclear engineering. Atomic power

Evaluation of influence of dissolved oxygen on corrosion behaviors of FeCrW model alloys in 360 °C water

Jun Yeong Jo, Chi Bum Bahn, Hwasung Yeom · 2024 · Nuclear Engineering and Technology

The dissolved oxygen in a coolant can affect the oxidation properties of structural materials. A desirable oxide phase formation is achieved by manipulating the oxygen level in the coolant, which can mitigate structural material degradation in nuclear power plants. Therefore, the role of dissolved oxygen in the corrosion of structural materials in aqueous environments needs to be understood. In this study, a short-term corrosion test (up to 300 h) of Ferritic/Martensitic steels (F/M steels; FeCrW model alloys), namely, Fe12Cr1W, Fe9Cr1W, and Fe9Cr, in stagnant water at 360 °C was performed in

View details →DOI: 10.1016/j.net.2024.06.002
Negative / Null Result ReportOpen accessBiochemistry

Alteration in prooxidant-antioxidant balance associated with selenium concentration in patients with congenital hypothyroidism

Rostami Shilan, Fathollahpour Asadollah, Abdi Mohammad et al. · 2018 · Journal of Medical Biochemistry

Background: There is a paucity of studies regarding oxidative balance and selenium (Se) status in congenital hypothyroidism. Recently, more attention has been given to the use of Se supplementation as a new treatment for thyroid disorders. Oxidative stress increases in different thyroid disorders and causes many pathological outcomes. The present study aimed to determine the serum prooxidant-antioxidant balance (PAB), Se, thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentration in congenital hypothyroidism (CH) patients and the association of their probable change with hematolo

Negative / Null Result ReportOpen accessPediatrics

Evaluating the readability, understandability, quality, and popularity of online materials about epilepsy in children

Fatma Sargin, Mehmet Alçı, Büşra Kaygusuz Aydemir et al. · 2026 · BMC Pediatrics

Abstract Background Childhood epilepsy is one of the most common neurological disorders worldwide, significantly affecting cognitive, emotional, and social development. As caregivers often seek medical guidance online, the readability, understandability, and quality of internet-based patient education materials (IPEMs) are crucial for health literacy and decision-making. This study evaluates the readability, understandability, quality, and popularity of online pediatric epilepsy materials in relation to established health communication standards. Methods A Google search using the term ‘epileps

View details →DOI: 10.1186/s12887-026-06602-2
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Huanhuan Zuo, Xiaochen Xie, Jiahuan Peng et al. · 2019 · Analytical Cellular Pathology

Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the

View details →DOI: 10.1155/2019/5189165
Negative / Null Result ReportOpen accessNursing

Spiritual well-being and hope in the preoperative period of cardiac surgery

Simone Maria Muniz da Silva Bezerra, Eduardo Tavares Gomes, Paulo César da Costa Galvão et al. · Revista Brasileira de Enfermagem

ABSTRACT Objective: To characterize relations between spiritual well-being and hope of patients in the preoperative period of cardiac surgery. Method: Exploratory cross-sectional study with quantitative approach, performed in the infirmaries of a reference hospital in cardiology. We evaluated 69 patients hospitalized in preoperative period of myocardial revascularization, valve repair or replacement. Results: We verified that patients hold relevant scores of hope and welfare in all areas, being the existential well-being significantly lower than the religious one. The average of the spiritual

View details →DOI: 10.1590/0034-7167-2016-0642
Negative / Null Result ReportOpen accessInfectious and parasitic diseases

The Decreased Treg Cells Number Associated with Retinal Lesion Size in Ocular Toxoplasmosis

Ovi Sofia, Muna Amalia, Herryanto Thomassawa et al. · 2024 · Interdisciplinary Perspectives on Infectious Diseases

Introduction. The imbalance of the immune response is an important factor contributing to the incidence of ocular toxoplasmosis (OT). Regulatory T cells (Treg) play a key role in maintaining the balance between Th1 and Th17 immune responses, while interleukin-27 (IL-27) levels are related to the differentiation of Th17 cells. This study analyzes the differences in the number of Treg cells and the level of IL-27 between OT patients and seropositive individuals without ocular lesions and its correlation with retinal lesion size. Methods. This analytic observational study, conducted for 8 months,

View details →DOI: 10.1155/2024/3495376
Negative / Null Result ReportOpen accessOrthopedic surgery

Does preoperative mental health affect length of hospital stay and functional outcomes following arthroplasty surgery? A registry-based cohort study

Neal Singleton, Vaughan Poutawera · 2017 · Journal of Orthopaedic Surgery

Aim: It has been reported in the literature that patients with poor preoperative mental health are more likely to have worse functional outcomes following primary total hip and knee arthroplasty. We could find no studies investigating whether preoperative mental health also affects length of hospital stay following surgery. The aim of this study was to determine whether preoperative mental health affects length of hospital stay and long-term functional outcomes following primary total hip and knee arthroplasty. We also aimed to determine whether mental health scores improve after arthroplasty

View details →DOI: 10.1177/2309499017718902
Negative / Null Result ReportOpen accessGynecology and obstetrics

Subjective Dry Eye Symptoms in Pregnant Women–A SPEED Survey

Divya Anantharaman, Aiswaryah Radhakrishnan, Vidhyalakshmi Anantharaman · 2023 · Journal of Pregnancy

Aim. Multisystemic physiological changes in pregnancy can result in tear film and refractive changes in the eye. We report dry eye prevalence in pregnant women using Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire. Methods. The SPEED questionnaire was self-administered cross-sectionally to 428 pregnant women (mean age: 26.8±4.4 years) with clinically confirmed pregnancy from two obstetric clinics in Chennai, India. Subjects with predisposing risk factors for dry eye were excluded from the study. Subjects were categorized as normal, moderate, and severe dry eye based on the SPE

View details →DOI: 10.1155/2023/3421269