Negative / Null Result ReportMedicine
Talhelm J, Srivastava S, Ostrander J et al. · 2026 · Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Falls by subjects riding a ski lift while in transit are rare but can cause significant injury. Falls can occur at variable heights and can occur to small children to adults of both genders. The current study was designed to investigate…
View details →DOI: 10.1177/09544119261456914 Negative / Null Result ReportMedicine
Clemens NH, Boucher AN, Vaughn S et al. · 2026 · Journal of learning disabilities
Students in grades 2 through 4 with significant word reading difficulties were randomly assigned to one of two 10-week interventions. In the Dual Treatment condition, decoding instruction emphasized regularity in spelling-sound…
View details →DOI: 10.1177/00222194261417589 Negative / Null Result ReportMedicine
Kaba M, Eyüboğlu GB, Karadas M · 2026 · Polymers
This study aimed to assess the effect of etching protocols on the bonding performance of three universal adhesives to dentin under different aging conditions. Specimens were obtained from human molars and randomly allocated to 6 groups ( n…
View details →DOI: 10.3390/polym18121516 Negative / Null Result ReportOpen accessMedicine
Alfakih A, Nadeau NJ, Watt PJ · 2026 · Ecology and evolution
Widely distributed animals may exhibit substantial plastic physiological, morphological and behavioural responses to environmental changes. One such extraordinary form of plasticity is colour change, which varies substantially among most…
View details →DOI: 10.1002/ece3.73005 Negative / Null Result Report
Ofori I · 2026 · Preprint
Abstract In the current dynamic and competitive business landscape, firms are under increasing pressure to improve their cost efficiency while simultaneously embracing sustainable supply chain practices. The main objective of the study was…
View details →DOI: 10.21203/rs.3.rs-9580593/v1 Negative / Null Result Report
Suwanlee S, Kamsaenrat W, Pimvong P et al. · 2026 · Preprint
Abstract Moringa oleifera Lam. leaves are rich in nutrients and possess high levels of antioxidant compounds, demonstrating potential as a functional feed ingredient for promoting animal health and productivity. However, Moringa oleifera…
View details →DOI: 10.21203/rs.3.rs-9532985/v1 Negative / Null Result ReportMedicine
Sariali̇oğlu A, Oluç T · 2026 · BMC psychology
Background Blood sampling is one of the invasive procedures in a hospital setting that can cause fear, anxiety, and stress in children. Aim The study aimed to determine the effect of the Liquid Motion Bubbler Timer Soothing Sensory Toy on…
View details →DOI: 10.1186/s40359-026-04943-2 Negative / Null Result Report
Yidana P, Bangase EA, Billa G · 2026 · Preprint
Abstract Despite the growing global discourse on alternative credentials such as micro-credentials and skill-based certifications, empirical evidence on their influence on demand for traditional higher education in African contexts remains…
View details →DOI: 10.21203/rs.3.rs-9772176/v1 Negative / Null Result Report
SAHIN D · 2026 · Preprint
Abstract This study examines the motivational factors shaping ısers’ continuance intention toward generative artificial intelligence (GAI) by integrating the Uses and Gratifications theory (U&G) with the Unified Theory of Acceptance and…
View details →DOI: 10.21203/rs.3.rs-8840209/v1 Negative / Null Result ReportOpen accessMedicine
Layton KL, Edwards TL, Foster TM · 2026 · Journal of the experimental analysis of behavior
Translational research investigating traditional differential reinforcement of alternative behavior (DRA) suggests that such procedures increase the persistence of target behavior relative to when the alternative behavior is first…
View details →DOI: 10.1002/jeab.70117 Negative / Null Result Report
Betz M · 2026 · Preprint
Abstract This study estimates the geographic variation in the fertility effects of state-level abortion bans on birth rates across urban, micropolitan, and rural areas. Using restricted county-level birth data from the National Center for…
View details →DOI: 10.21203/rs.3.rs-9349136/v1 Negative / Null Result Report
Setyawan H, Andhika Akbar Rahma R, Nur Kusuma N et al. · 2026 · Preprint
Background: Workplace fatigue is a significant factor that can impact worker safety and productivity, particularly in industrial environments with high levels of noise exposure. Various types of hearing protection, such as earmuffs and…
View details →DOI: 10.12688/f1000research.180021.1 Abandoned HypothesisOpen accessMedicine
Bair H · 2026 · NPJ digital medicine
Li et al. report that clinician last authorship is associated with greater "impact" in AI deployment trials. This commentary argues that current evidence is insufficient to attribute this to clinical leadership per se. Concerns include…
View details →DOI: 10.1038/s41746-026-02911-z Negative / Null Result ReportOpen accessMedicine
Li H, Meng W, Xiao H et al. · 2025 · BMC plant biology
BACKGROUND: Elevated temperature and enhanced ultraviolet B (UV-B) radiation are two major global climate change issues of concern today, but their effects on high-elevation rice paddy ecosystems are of limited understanding. A Two-year…
View details →DOI: 10.1186/s12870-025-07816-9 Negative / Null Result ReportMedicine
Alwadani B · 2026 · Healthcare (Basel, Switzerland)
Purpose Variation in knee MRI diagnostic yield is often interpreted as reflecting imaging effectiveness. However, in real-world healthcare systems, diagnostic yield may instead be driven by referral behavior and patient selection.…
View details →DOI: 10.3390/healthcare14121628 Negative / Null Result ReportOpen accessMedicine
Bahadır-Varol A, Solgun B, Küreli G et al. · 2026 · Molecular neurobiology
Acute stress and inflammatory mediators are linked to stress-related mental disorders, yet sex-specific differences in the molecular pathways connecting them remain poorly understood. Male and female C57BL/6 mice underwent predator stress…
View details →DOI: 10.1007/s12035-026-05908-7 Failed Experiment ReportOpen accessMedicine
Artyszak A, Gozdowski D, Litwińczuk-Bis M · 2026 · Plants (Basel, Switzerland)
In 2017-2019, in a field experiment in Sahryń, Poland (50°40'42″ N, 23°47'35″ E), the effect of foliar application of various forms of silicon (calcium silicate-CS, sodium metasilicate-SM, and micronized silica-MS) and the timing of their…
View details →DOI: 10.3390/plants15101449 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Aline Cecy Rocha de Lima, Wandrey Roberto dos Santos Brito, Luciana Cristina Coelho Pantoja Santos et al. · 2026 · Brazilian Journal of Infectious Diseases
Introduction: Fas and FasL are known modulators of cellular apoptosis in immunoregulation of the innate immune response, as well as in the elimination of defective cells, and may be associated with antiviral activity of HTLV-1 – infected cells. Understanding the immunological mechanisms involved in the progression of HTLV-1 – associated diseases may contribute to predicting the clinical prognosis of infected individuals. Objective: To evaluate mRNA expression of the apoptotic modulators FAS and FASL in patients infected with HTLV-1. Methods: A total of 54 HTLV-1 – infected individuals were eva
View details →DOI: 10.1016/j.bjid.2026.105460 Negative / Null Result ReportOpen accessTechnology
Sara Havrlišan, Martina Tokić, Štefanija Klarić et al. · 2026 · Tehnički Glasnik
This research analyses the impact of infill density and layer thickness on the tensile strength of test samples fabricated using FDM 3D printing, with a particular focus on comparing samples produced with and without an adhesion layer. A two-factor factorial experimental design was employed, consisting of two levels and three replications. The infill density (20% and 50%) and layer thickness (0.1 mm and 0.2 mm) were defined as input variables, while tensile strength served as the output variable. Statistical methods, such as ANOVA, were used to analyse the experimental data and evaluate the si
View details →DOI: 10.31803/tg-20251030095053 Negative / Null Result ReportOpen accessDentistry
Marcela Charantola Rodrigues, Rafael Francisco Lia Mondelli, Gabriela Ulian Oliveira et al. · 2013 · Journal of Applied Oral Science
Objective: To evaluate the in vitro changes on the enamel surface after a micro-abrasion treatment promoted by different products. Material and Methods: Fifty (50) fragments of bovine enamel (15 mm × 5 mm) were randomly assigned to five groups (n=10) according to the product utilized: G1 (control)= silicone polisher (TDV), G2= 37% phosphoric acid (3M/ESPE) + pumice stone (SS White), G3= Micropol (DMC Equipment), G4= Opalustre (Ultradent) and G5= Whiteness RM (FGM Dental Products). Roughness and wear were the responsible variables used to analyze these surfaces in four stages: baseline, 60 s an
View details →DOI: 10.1590/1678-7757201302117 Negative / Null Result ReportOpen accessMedicine
Chao-Lun Lai, Ching-Fen Wu, Raymond Nien-Chen Kuo et al. · 2015 · PLoS ONE
The clinical outcomes of different limus-based drug-eluting stents (DES) in a real-world setting have not been well defined. The aim of this study was to investigate the clinical outcomes of three different limus-based DES, namely sirolimus-eluting stent (SES), Endeavor zotarolimus-eluting stent (E-ZES) and everolimus-eluting stent (EES), using a national insurance claims database. We identified all patients who received implantation of single SES, E-ZES or EES between January 1, 2007 and December 31, 2009 from the National Health Insurance claims database, Taiwan. Follow-up was through Decemb
View details →DOI: 10.1371/journal.pone.0122860 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Suzana Müller, Carlos Fernando de Magalhães Francesconi, Ismael Maguilnik et al. · 2007 · Arquivos de Gastroenterologia
BACKGROUND: The cleansing of the colon for a colonoscopy exam must be complete so as to allow the visualization and inspection of the intestinal lumen. The ideal cleansing agent should be easily administered, have a low cost, and minimum collateral effects. Sodium picosulfate together with the magnesium citrate is a cathartic stimulant and mannitol is an osmotic laxative, both usually used for this purpose. AIMS: Assess the colon cleanliness comparing the use of mannitol and sodium picosulfate as well as evaluate the level of patient satisfaction, the presence of foam, pain, and abdominal dist
View details →DOI: 10.1590/s0004-28032007000300013 Negative / Null Result ReportOpen accessMedicine
Feingold KR · 2000
Abnormalities in lipid metabolism are very commonly observed in patients who are obese. Approximately 60-70% of patients with obesity are dyslipidemic. The lipid abnormalities in patients who are obese include elevated serum TG, VLDL,…
Negative / Null Result ReportOpen accessMedicine
Molly Moore Jeffery, Lucas Oliveira J e Silva, Fernanda Bellolio et al. · 2022 · BMJ Open
Objectives Evaluate the associations between patients taking ACE inhibitors and angiotensin receptor blockers (ARBs) and their clinical outcomes after an acute viral respiratory illness (AVRI) due to COVID-19.Design Retrospective cohort.Setting The USA; 2017–2018 influenza season, 2018–2019 influenza season, and 2019–2020 influenza/COVID-19 season.Participants People with hypertension (HTN) taking an ACEi, ARB or other HTN medications, and experiencing AVRI.Main outcome measures Change in hospital admission, intensive care unit (ICU) or coronary care unit (CCU), acute respiratory distress (ARD
View details →DOI: 10.1136/bmjopen-2021-060305 Negative / Null Result ReportOpen accessSurgery
Engin Kölükçü, Şahin Kılıç, Doğan Atılgan et al. · 2018 · Journal of Urological Surgery
Objective:The association of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with postoperative tumor stage and Fuhrman nuclear grade was investigated in patients with renal cell carcinoma (RCC).Materials and Methods:Data of 123 patients, who were operated due to RCC, in our clinic was analysed. NLR and PLR were evaluated in patients who were classified according to tumor stage (T1 and T2 low stage, T3 and T4 high stage) and Fuhrman nuclear grade (grade 1 and 2 low-grade, grade 3 and 4 high-grade). NLR and PLR were compared using Levene’s test between t
View details →DOI: 10.4274/jus.2133 Negative / Null Result ReportOpen accessPediatrics
LI Yue, XIE Zhiwei, TANG Yanjing, LI Benshang · 2026 · Linchuang erke zazhi
Objective Antigen escape, particularly CD19 loss, limits the efficacy of CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy in children with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). PAX5 gene variations have been shown to disrupt CD19 expression stability and increase relapse risk. This study aimed to compare the therapeutic efficacy of two CD19/CD22 dual-targeting CAR-T strategies, namely co-infusion versus bicistronic construct, in children with R/R B-ALL harboring PAX5 gene variations. Methods A retrospective analysis was conducted on the clinical dat
View details →DOI: 10.12372/jcp.2026.26e0038 Negative / Null Result ReportOpen accessDentistry
Mohammad Tavakoli, Ensiyeh Bateni, Mansour Rismanchian et al. · 2012 · Dental Research Journal
Background: The greater surface of bioactive glass nanoparticles presents an incomparable and promising feature similar to the biological apatite. Nanoparticles improve cellular adhesion, enhance osteoblast proliferation and differentiation, and increase biomineralization for periodontal regeneration and dental implants. Considering the fact that interaction between periodontal cells and bone graft materials are important for periodontal lesion regeneration, the present study was undertaken to investigate the genotoxicity of a novel synthesized nanoscale bioactive glass and compared it with No
View details →DOI: 10.4103/1735-3327.99831 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Pedro Davila-Piñón, Pedro Davila-Piñón, Alba Nogueira-Rodríguez et al. · 2024 · Frontiers in Oncology
BackgroundPolyDeep is a computer-aided detection and classification (CADe/x) system trained to detect and classify polyps. During colonoscopy, CADe/x systems help endoscopists to predict the histology of colonic lesions.ObjectiveTo compare the diagnostic performance of PolyDeep and expert endoscopists for the optical diagnosis of colorectal polyps on still images.MethodsPolyDeep Image Classification (PIC) is an in vitro diagnostic test study. The PIC database contains NBI images of 491 colorectal polyps with histological diagnosis. We evaluated the diagnostic performance of PolyDeep and four e
View details →DOI: 10.3389/fonc.2024.1393815 Negative / Null Result ReportOpen accessMedicine
Lara Kakabas, Krzysztof Piersiala, Aeneas Kolev et al. · 2023 · Scientific Reports
Abstract A history of allergies has been said to be associated with a lower risk of head and neck cancer compared to the general population. However, it is not known whether having an allergic sensitization influences the prognosis and advancement of cancer disease. Thus, the aim of the study was to investigate the relationship between allergic sensitization and oral cancer advancement and patient survival. Allergen-specific IgE antibodies were investigated by ImmunoCAP™ Rapid in consecutive 80 patients with oral cancer. ImmunoCAP Rapid system tests a mix of representative inhalant allergens s
View details →DOI: 10.1038/s41598-023-48879-8 Negative / Null Result Report
Chebe PC, Martens K · 2026 · Preprint
Abstract The construct of sense of place (SoP) has gained growing interdisciplinary attention for its ability to capture the intricate relationship between people and their environments, a key consideration in urban planning. Despite this…
View details →DOI: 10.21203/rs.3.rs-9766699/v1 