Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility
Ovcaric Mick; Lea Rod; Sundholm James; Curtain Robert; MacMillan John; Griffiths Lyn · 2005 · BMC Medical Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are responsible for a number of neurological disorders. KCNN3 is a neuronal small conductance calcium-activated potassium channel gene that contains two polyglutamine tracts, encoded by polymorphic CAG repeats in the gene. This gene plays a critical role in determining the firing pattern of neurons and acts to regulate intracellular calcium channels. Methods The present association study tested whether le
Abstract by Ovcaric Mick; Lea Rod; Sundholm James; Curtain Robert; MacMillan John; Griffiths Lyn, BMC Medical Genetics (2005) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1471-2350-6-32