e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 406 of 724

Negative / Null Result ReportMedicine

Distal Radius Allograft for Posterior Glenoid Bone Loss: A Cadaveric Graft Matching Study and Biomechanical Study.

Testa EJ, Fallon RT, Badida R et al. · 2026 · The American journal of sports medicine

Background Posterior glenoid reconstruction for shoulder instability is commonly performed with distal tibia allograft (DTA), but with variable results. Recent evidence shows that distal radius allograft (DRA) has a radius of curvature…

View details →DOI: 10.1177/03635465251400313
Negative / Null Result ReportMedicine

Short-term Treatment with Metformin During Puberty Mitigates Metabolic Dysfunctions Programmed by Neonatal Overfeeding in Male Rats.

Raposo SR, Lopes RP, Barbosa LF et al. · 2026 · Archives of medical research

Objective To address the major public health problems of increased body weight and obesity, causing conditions such as hypertension and diabetes. Early obesity in childhood and adolescence has more severe long-term health consequences. The…

View details →DOI: 10.1016/j.arcmed.2026.103386
Negative / Null Result ReportOpen accessMedicine

Preliminary Assessment of Pisotriquetral Joint Kinematics Following Transverse Carpal Ligament Release: A Cadaveric Pilot Study.

Israeli R, Steinmetz C, Gannot G et al. · 2026 · Cureus

Introduction Transverse carpal ligament (TCL) release is the standard treatment for carpal tunnel syndrome; however, its potential to alter carpal biomechanics is unclear. Specifically, it has been hypothesized that TCL transection may…

View details →DOI: 10.7759/cureus.101067
Negative / Null Result ReportMedicine

4-year overall survival after the introduction of adjuvant therapy for patients with stage III melanoma: A population-based study.

Janssen JC, Schurink AW, Verhoef C et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Background Adjuvant systemic therapy for resected stage III melanoma was introduced in clinical practice following the improved recurrence free survival in randomized controlled trials. However, after ten years of follow-up, adjuvant…

View details →DOI: 10.1016/j.ejca.2025.116202
Negative / Null Result ReportMedicine

Harvesting of Peroneus Longus Tendon Autograft.

Liang C, He J · 2025 · Journal of visualized experiments : JoVE

Autografts are always used in anterior cruciate ligament (ACL) reconstruction. Traditional sources, such as hamstring tendons, bone-patellar tendon-bone, and quadriceps tendon, are popular choices but may result in muscle imbalances and…

View details →DOI: 10.3791/66390
Negative / Null Result ReportMedicine

Medial Patellofemoral Ligament Reconstruction in Adolescent Patellofemoral Instability With High Tibial Tubercle-Trochlear Groove Intervals: A Comparison of With or Without Tibial Tubercle Osteotomy.

Grewal RS, Berger GK, Pennock AT et al. · 2026 · Journal of pediatric orthopedics

Background Patellofemoral instability is common in adolescent patients and is frequently associated with increased tibial tuberosity-trochlear groove (TT-TG) distances. Medial patellofemoral ligament (MPFL) reconstruction is a standard…

View details →DOI: 10.1097/bpo.0000000000003200
Negative / Null Result ReportMedicine

Efficacy of a Phase III Cardiac Rehabilitation Program on Physical Exercise in Patients with Ischemic Heart Disease: A Cluster Randomized Controlled Trial.

Santaularia N, Arnau A, Torà N et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention

Purpose Our purpose was to assess the efficacy of a phase III cardiac rehabilitation (CR) program, based on counseling in the maintenance of physical exercise, on the time spent on physical exercise per week in patients with ischemic heart…

View details →DOI: 10.1097/hcr.0000000000000993
Negative / Null Result ReportOpen accessMedicine

The Variability and Determinants of Serotiny in <i>Pinus Yunnanensis</i>.

Liu Y, Lin H, Yu D et al. · 2026 · Ecology and evolution

Serotiny, a key fire-adaptive trait, enables certain plants to retain seeds in closed cones until triggered by fire, thus facilitating post-fire regeneration. Although serotiny has been observed in many species, the physiological and…

View details →DOI: 10.1002/ece3.72838
Negative / Null Result ReportOpen accessMedicine

Does Pain Self-efficacy influence Initial Forward Bending in Adults with Chronic Low Back Pain following Exercise? A Cohort Study.

McManus F, Pranata A, Simpson JA et al. · 2025 · International journal of sports physical therapy

Background/purpose Chronic low back pain affects how individuals bend. Whether pain self-efficacy, a term describing one's confidence in their ability to perform activities despite experiencing pain, affects how much people with chronic…

View details →DOI: 10.26603/001c.146051
Negative / Null Result ReportOpen accessMedicine

Woody seeds and seedlings are unresponsive to herbivore kairomones.

Headrick KC, Pellegrini BA, Santiago EM et al. · 2026 · AoB PLANTS

Herbivory is particularly threatening to young plants that lack the resources needed to survive an attack. Seeds and seedlings should thus benefit greatly from using pre-attack cues to induce defence before damage. Locomotion mucus from…

View details →DOI: 10.1093/aobpla/plag013
Negative / Null Result ReportOpen accessMedicine

Does civilian oversight impact police legitimacy?

Schiff KJ, Schiff DS, Moy BJ et al. · 2025 · PNAS nexus

Does the implementation of external oversight in policing improve public perceptions of police legitimacy? Civilian review boards (CRBs) are frequently promoted as mechanisms to enhance the legitimacy of police agencies by providing…

View details →DOI: 10.1093/pnasnexus/pgaf267
Negative / Null Result ReportOpen accessMedicine

Magnetic Seizure Therapy vs Electroconvulsive Therapy in Schizophrenia: Prefrontal-Amygdala Plasticity and Cognitive Safety.

Li J, Jin T, Chi Y et al. · 2025 · Neuropsychiatric disease and treatment

Purpose Reducing electroconvulsive therapy (ECT)'s cognitive burden without compromising efficacy is critical. Although magnetic seizure therapy (MST) shows comparable symptom remission in schizophrenia, its neuroanatomical…

View details →DOI: 10.2147/ndt.s531892
Negative / Null Result ReportOpen accessMedicine

Further evidence that averageness and femininity, rather than symmetry and masculinity, predict facial attractiveness judgments.

Lee P, Li J, Rafiee Y et al. · 2025 · Scientific reports

Facial attractiveness influences important social outcomes and most studies investigating possible predictors of facial attractiveness have tested for effects of shape symmetry, averageness (i.e., the converse of distinctiveness), and…

View details →DOI: 10.1038/s41598-025-86974-0
Replication FailureMedicine

First Constraints on Nuclear Coupling of Axionlike Particles from the Binary Neutron Star Gravitational Wave Event GW170817.

Zhang J, Lyu Z, Huang J et al. · 2021 · Physical review letters

Light axion fields, if they exist, can be sourced by neutron stars due to their coupling to nuclear matter, and play a role in binary neutron star mergers. We report on a search for such axions by analyzing the gravitational waves from the…

View details →DOI: 10.1103/physrevlett.127.161101
Negative / Null Result ReportMedicine

Isokinetic shoulder strength adaptations to weighted jump rope training in CrossFit athletes: A pre-post study.

Torres-Banduc MA, Thapa RK, Pérez MA et al. · 2025 · Shoulder & elbow

Background The isokinetic shoulder profile is commonly used to assess injury risk in overhead sports. CrossFit athletes are vulnerable to shoulder injuries due to high-load, high-repetition demands. This exploratory study aimed to evaluate…

View details →DOI: 10.1177/17585732251409407
Negative / Null Result ReportOpen accessMedicine

Infants Do Not Reliably Track When Bilingual Speakers Switch Languages.

Potter CE, Lew-Williams C · 2025 · Behavioral sciences (Basel, Switzerland)

It is a widely held belief that bilingual infants benefit from hearing each of their languages spoken by different people, as speakers could serve as a cue for separating the two languages. However, it is not yet known whether infants…

View details →DOI: 10.3390/bs15101427
Negative / Null Result ReportOpen accessMedicine

Non-image-forming vision as measured through ipRGC-mediated pupil constriction is not modulated by covert visual attention.

Vilotijević A, Mathôt S · 2024 · Cerebral cortex (New York, N.Y. : 1991)

In brightness, the pupil constricts, while in darkness, the pupil dilates; this is known as the pupillary light response (PLR). The PLR is driven by all photoreceptors: rods and cones, which contribute to image-forming vision, and…

View details →DOI: 10.1093/cercor/bhae107
Replication FailureOpen accessMedicine

Cognitive control training as an add-on treatment for late-life depression: A multicenter randomized controlled trial.

Vander Zwalmen Y, Vrijsen JN, Meuleman B et al. · 2026 · Internet interventions

Background Late-life depression (LLD) is a prevalent and debilitating condition associated with a poor long-term prognosis and high rates of chronicity. Cognitive control impairments are common in LLD and contribute to symptom persistence,…

View details →DOI: 10.1016/j.invent.2026.100951
Negative / Null Result ReportOpen accessMedicine

Fascia-Focused Versus Conventional Physiotherapy for Chronic Low Back Pain and Comorbid Depression in Psychosomatic Inpatients.

Overmann L, Steinmeier K, Brandl A et al. · 2026 · Journal of clinical medicine

Background: Chronic low back pain (CLBP) and depression often co-occur. This study compared a fascia-focused physiotherapeutic program with a conventional physiotherapeutic and relaxation-based program in psychosomatic inpatients with CLBP…

View details →DOI: 10.3390/jcm15103698
Negative / Null Result ReportOpen accessMedicine

Cerebral "Dirty-Appearing" White Matter in Relation to Cognitive Decline and Dementia Risk in Community-Dwelling Older Adults.

Eiling I, Sigurdsson S, Kuhn-Keller JA et al. · 2026 · Neurology

Background and objectives Cerebral "dirty-appearing" or "diffusely abnormal" white matter (DAWM) represents subtle white matter abnormalities that are associated with progression of cerebral small vessel disease (cSVD), but the association…

View details →DOI: 10.1212/wnl.0000000000218036
Negative / Null Result ReportOpen accessMedicine

Impact of Stroke History on the Risk of Recurrent Hip Fracture or Major Osteoporotic Fractures among Patients with Incident Hip Fracture: A Nationwide Cohort Study.

Hjelholt TJ, Johnsen SP, Brynningsen PK et al. · 2023 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Considerable uncertainty prevails regarding risk factors for recurrent fracture among older patients with hip fracture. We aimed to investigate the relationship between prefracture stroke history, baseline mobility, and the risk of…

View details →DOI: 10.1002/jbmr.4760
Negative / Null Result ReportOpen accessMedicine

Oral bisphosphonates and risk of incident osteoarthritis in individuals with osteoporosis: a target trial emulation.

Hatano M, Kimura Y, Okada A et al. · 2026 · RMD open

Objectives Owing to the underrepresentation of early-stage disease in randomised trials and inconsistent clinical evidence, using oral bisphosphonates to prevent incident osteoarthritis in adults with osteoporosis lacks consensus. We aimed…

View details →DOI: 10.1136/rmdopen-2026-006832
Negative / Null Result ReportOpen accessMedicine

Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence.

Nielsen MB, Çolak Y, Benn M et al. · 2024 · Cardiovascular research

Aims Adiponectin may play an important protective role in heart failure and associated cardiovascular diseases. We hypothesized that plasma adiponectin is associated observationally and causally, genetically with risk of heart failure,…

View details →DOI: 10.1093/cvr/cvad162
Negative / Null Result ReportOpen accessMedicine

Can trade and security alliance help reduce interstate war?

Choi SW · 2024 · PloS one

This study explains how the gap between theory and empirical research hinders scientific progress in the area of international political economy. To demonstrate this point, I use Chen's Extended Dependence Theory, which challenges liberal…

View details →DOI: 10.1371/journal.pone.0304482
Negative / Null Result ReportMedicine

Analysis of retinal blood vessel diameters in patients with COPD undergoing a pulmonary rehabilitation program.

Vaes AW, Spruit MA, Goswami N et al. · 2022 · Microvascular research

Background Regular exercise positively affects cardiovascular physiology, translating into the adequate capacity of microvascular blood vessels to dilate in response to acute bouts of exercise. However, this remains unstudied in patients…

View details →DOI: 10.1016/j.mvr.2021.104238
Negative / Null Result ReportOpen accessMedicine

The impact of state and trait general and social anxiety on theory of mind.

Foulds C, Khudiakova V, Surtees ADR · 2026 · Scientific reports

Theory of mind is an important skill to function in society. There is evidence that anxiety can impair the ability to use this skill effectively; however, current research is inconclusive, uses heterogeneous measures of theory of mind, and…

View details →DOI: 10.1038/s41598-026-36718-5