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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21314 results · page 402 of 711

Negative / Null Result ReportMedicine

Sac Excision at the Time of Surgery Can Predict Hernia Recurrences and a Need for Reoperation in Patients.

Levine, Lyons, Chatha et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques

Paraesophageal hernias are a prevalent medical condition often treated with surgical intervention, and decisions regarding hernia sac management are involved. Sac excision during PEH repair has emerged as a viable and safe management…

View details →DOI: 10.1097/sle.0000000000001470
Negative / Null Result ReportMedicine

Diversion proctitis during staged restorative proctocolectomy with ileal pouch anal anastomosis is not associated with subsequent cuffitis.

Dharia, Plietz, Hahn et al. · 2026 · International journal of colorectal disease

The aim of this study was to assess the impact of diversion proctitis (DP) between the first and second surgical stage on pouch outcomes in patients with ulcerative colitis (UC) who underwent three-stage restorative proctocolectomy (RPC)…

View details →DOI: 10.1007/s00384-026-05182-y
Negative / Null Result ReportMedicine

Police Reporting After Sexual Assault: Victim and Assault Characteristics That Predict Reporting Among Victims Who Seek Medical Forensic Care.

Goodman-Williams, Smith, Volz et al. · 2026 · Journal of interpersonal violence

Many sexual assault victims choose not to report their assault to police, and identifying characteristics that predict non-reporting can highlight areas for improvement in the criminal legal system's response to sexual assault. In the…

View details →DOI: 10.1177/08862605261455557
Negative / Null Result ReportMedicine

Water cooling to prevent electrocoagulation syndrome after endoscopic resection of colorectal neoplasm.

Zhipeng, Bing, Dongli et al. · 2026 · The American journal of gastroenterology

With the increasing frequency of electrocoagulation hemostasis used in endoscopic submucosal dissection (ESD), the incidence of postoperative bleeding is gradually decreasing, while the incidence of post-ESD electrocoagulation syndrome…

View details →DOI: 10.14309/ajg.0000000000004089
Negative / Null Result ReportMedicine

Pregabalin enhances the proliferative potential of pancreatic cancer in vitro but not in mice with pancreatic cancer.

Itaya, Sano, Kajiwara et al. · 2026 · BMC pharmacology & toxicology

We previously reported that mirogabalin, a selective voltage-gated calcium channel α2δ1/α2δ2 ligand, increases the proliferative potential of pancreatic cancer. However, the risk of pregabalin, a non-selective…

View details →DOI: 10.1186/s40360-026-01176-2
Negative / Null Result ReportMedicine

A Cross-Cultural Examination of Intrasexual Competition: The Links Between Mating Competition, Aggression, Appearance Enhancement, and Sexuality.

Meskó, Davis, Arnocky et al. · 2026 · Archives of sexual behavior

In the context of mating, individuals of the same sex often act as rivals in the pursuit, attraction, and retention of desirable partners. This study explored the relationships between intrasexual competition and various aspects of human…

View details →DOI: 10.1007/s10508-026-03464-8
Negative / Null Result ReportMedicine

Effects of 100% oxygen during deferred cord clamping on oxidative stress markers: a sub-study of a randomized controlled trial.

Katheria, Lakshminrusimha, Morales et al. · 2026 · Pediatric research

We sought to evaluate oxidative changes in premature infants receiving 100% oxygen compared with 30% during deferred cord clamping (DCC). Premature infants born at 22 0/7 to 28 6/7 weeks received DCC in conjunction with either 30% (LO…

View details →DOI: 10.1038/s41390-026-05199-7
Negative / Null Result ReportMedicine

Predictors of challenging initial intubation and association with outcomes in congenital diaphragmatic hernia.

Beverstock, Hagan, Fernandes et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

To assess for differences in congenital diaphragmatic hernia patient characteristics between those requiring single or multiple intubation attempts, and to determine the relationship between number of intubation attempts and time to…

View details →DOI: 10.1038/s41372-026-02759-x
Negative / Null Result ReportMedicine

Does the Addition of Images to the Medication Dosage Calculation Exam Improve Metacognitive Components and Performance? A Randomized Prospective Study.

Weil-Lotan, Solnica, Benbenishty et al. · 2026 · Nurse educator

Accurate dosage calculation is vital for patient safety, making effective instructional methods a priority in nursing education. This study investigated whether embedding images of medications or syringes in medication calculation exams…

View details →DOI: 10.1097/nne.0000000000002215
Negative / Null Result ReportMedicine

Efficacy of AC-T Versus TAC Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer: A Retrospective Analysis.

Mirzania, Anari, Emami et al. · 2026 · International journal of breast cancer

Locally advanced breast cancer (LABC) remains a major therapeutic challenge, with neoadjuvant chemotherapy (NAC) serving as a cornerstone of management. However, direct evidence comparing the efficacy of sequential (AC-T) and concurrent…

View details →DOI: 10.1155/ijbc/6630563
Negative / Null Result ReportMedicine

Effects of different durations of high-intensity interval training or continuous training with/without metformin on lipid profile and malondialdehyde level in a rat model of polycystic ovary syndrome.

Zolfaghari, Nouri Habashi, Aghazadeh · 2026 · Veterinary research forum : an international quarterly journal

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder. Exercise is one of the interventions that leads to PCOS improvement. This study aimed to investigate the potential of different durations of high-intensity interval training…

View details →DOI: 10.30466/vrf.2025.2050200.4623
Negative / Null Result ReportMedicine

Acupuncture Versus Clomiphene for Ovulation Induction in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Clinical Trial.

Hafizi, Azizi, Mahmoudinia et al. · 2026 · Health science reports

There is evidence of the beneficial effects of acupuncture in the treatment of polycystic ovary syndrome (PCOS). This study aimed to compare acupuncture with clomiphene in ovulation induction among infertile women with PCOS. This…

View details →DOI: 10.1002/hsr2.72673
Negative / Null Result ReportMedicine

Comparison of Single-Freezing Temperature-Guided and Conventional Time-to-Isolation-Guided Protocols of Cryoballoon in Atrial Fibrillation Ablation.

Liu, Zheng, Li et al. · 2026 · Cardiology research

The study aimed to compare the efficacy and safety of simplified single-freezing protocol with achieving -40 °C within 60 s of freezing as the observation index and the conventional time-to-isolation (TTI)-guided double-freezing…

View details →DOI: 10.14740/cr2202
Negative / Null Result ReportMedicine

Multidimensional Assessment of Fall Risk Using the Timed Up and Go Test and Complementary Measures in a Charcot-Marie-Tooth Type 1A Neuropathy.

Ferrandon-Berne, Pelletier Visa, Dobija et al. · 2026 · Archives of rehabilitation research and clinical translation

To investigate the relationship between the occurrence of falls and the time taken to perform the Timed Up and Go (TUG) test in a population of patients with Charcot-Marie-Tooth disease type 1A (CMT1A). We conducted a longitudinal,…

View details →DOI: 10.1016/j.arrct.2025.100581
Negative / Null Result ReportMedicine

Effect of buserelin acetate at artificial insemination on pregnancy per AI in dairy cows inseminated with sexed semen.

Costa, de Oliveira, do Couto et al. · 2026 · Brazilian journal of veterinary medicine

This study determined whether administration of buserelin acetate (BA), a gonadotropin-releasing hormone agonist, during timed artificial insemination (TAI) improves pregnancy per AI (P/AI) of dairy cows inseminated with sexed semen. A…

View details →DOI: 10.29374/2527-2179.bjvm003726
Negative / Null Result ReportMedicine

A Comparison of Tegileridine Fumarate versus Sufentanil on the Quality of Postoperative Recovery After Laparoscopic Sleeve Gastrectomy: A Preliminary Randomized Controlled Trial.

Zheng, Chen, Sui et al. · 2026 · Drug design, development and therapy

Laparoscopic sleeve gastrectomy (LSG) is associated with substantial postoperative pain and a high rate of postoperative nausea and vomiting. Tegileridine fumarate, a biased µ-opioid receptor agonist, may offer effective analgesia…

View details →DOI: 10.2147/dddt.s611241
Negative / Null Result ReportMedicine

Efficacy and Safety of Ultrasound-Guided Erector Spinae Plane Block at Different Injection Depths for Percutaneous Kyphoplasty: A Randomized Controlled Trial.

Liu, Yu, Gao et al. · 2026 · Drug design, development and therapy

To compare the analgesic efficacy and safety of deep, superficial and combined deep-superficial erector spinae plane block (ESPB) combined with subanesthetic-dose esketamine in patients undergoing percutaneous kyphoplasty (PKP). A total of…

View details →DOI: 10.2147/dddt.s601168
Negative / Null Result ReportMedicine

Monthly versus Bimonthly Bioelectrical Impedance Analysis for Dry Weight Assessment and Intradialytic Hypotension: A Randomized Crossover Trial.

Mokkongphai, Pattharanitima, Jeerangsapasuk et al. · 2026 · Kidney diseases (Basel, Switzerland)

Intradialytic hypotension (IDH) is a major complication during hemodialysis (HD), leading to arrhythmias and increased mortality. Inaccurate dry weight (DW) adjustment contributes to IDH. Bioelectrical impedance analysis (BIA) is commonly…

View details →DOI: 10.1159/000551997
Negative / Null Result ReportMedicine

Comparison of clinical outcomes between cruciate-retaining and posterior-stabilized total knee arthroplasty in patients with mild to moderate patellofemoral joint osteoarthritis.

Jia, Xu, Xu et al. · 2026 · Frontiers in surgery

The clinical results of a total knee arthroplasty (TKA) without patellar resurfacing for knee osteoarthritis have been reported; however, not regarding comparison patellofemoral joint (PFJ) clinical outcomes using different prosthesis…

View details →DOI: 10.3389/fsurg.2026.1840494
Negative / Null Result ReportMedicine

The role of immersive extended reality for the development and evaluation of clinical reasoning in health professions education: A scoping review.

Lansley, McSweeney, Rutere et al. · 2026 · Medical teacher

Immersive extended reality (iXR) technologies are increasingly adopted within health professions education. However, existing evidence has largely focused on technical skill acquisition or learner satisfaction, with limited examination of…

View details →DOI: 10.1080/0142159x.2026.2688559
Negative / Null Result ReportMedicine

Effect of ultrasound-guided bilateral rectus sheath block on postoperative pain control after robotic single-site gynecologic surgery: a randomized study.

Moon, Cho, Kim et al. · 2026 · Ewha medical journal

Rectus sheath block (RSB) is a simple abdominal wall block that can be readily applied. This study evaluated the postoperative analgesic efficacy of ultrasound-guided bilateral RSB in robotic single-site gynecologic surgery. Sixty patients…

View details →DOI: 10.12771/emj.2026.01396
Negative / Null Result ReportMedicine

Analysis of Intraoperative Complications and Outcomes Associated With Obesity During Elective Laparoscopic Cholecystectomy.

Coates, Bak, Rajagopalan et al. · 2026 · World journal of surgery

As obesity becomes more common, understanding its risks in routine operations is increasingly important. This study assessed the impact of obesity on intraoperative complications during elective laparoscopic cholecystectomy. Retrospective…

View details →DOI: 10.1002/wjs.70470
Negative / Null Result ReportMedicine

Influence of simulated tear flow on ocular penetration of transfersomes.

Barbalho, Brugger, Gratieri et al. · 2026 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Transfersomes are deformable lipid vesicles extensively evaluated for transdermal drug delivery. However, the ocular penetration mechanism of transfersomes is poorly understood as the effect of tear flow, which by altering osmotic…

View details →DOI: 10.1016/j.ejpb.2026.115154
Negative / Null Result ReportMedicine

The potential role of dynein heavy chain genes in the pathophysiology of undescended testis.

Kılıç, Turkgenc, Baltrak et al. · 2026 · Pediatric surgery international

Failures of testicular descent may result in the condition known as an undescended testis (UDT). While mechanical and hormonal causes have been researched quite extensively, not much is known about the underlying genetics. Developmental…

View details →DOI: 10.1007/s00383-026-06506-3