Negative / Null Result ReportMedicine
Berry A, Watson M, Moore M et al. · 2026 · Epilepsy & behavior : E&B
Background and objectives Functional/dissociative seizures (FDS) are frequently treated with one-to-one therapeutic interventions. However, data describing patient-reported outcome measures (PROMs) following group-based therapy remain…
View details →DOI: 10.1016/j.yebeh.2026.111164 Failed Experiment ReportMedicine
Bagińska M, Morawska-Tota M, Pałka T et al. · 2026 · Journal of clinical medicine
Background/Objectives : Bone tissue undergoes continuous remodelling processes that are closely controlled by mechanical stimuli and metabolic as well as inflammatory factors. Although the beneficial effects of regular physical activity on…
View details →DOI: 10.3390/jcm15124662 Negative / Null Result ReportOpen accessMedicine
Barberán-Bernardos L, Ariza-Gracia MA, Büchler P et al. · 2026 · Life (Basel, Switzerland)
This study aims to characterize diurnal changes in corneal geometry of the anterior and posterior cornea in healthy eyes using global and sector-based metrics, and to explore their associations with lifestyle-related factors. A prospective…
View details →DOI: 10.3390/life16050711 Failed Experiment ReportMedicine
Ariizumi T, Oike N, Murayama Y et al. · 2026 · Discover oncology
Background Giant cell tumor of bone (GCTB) is a locally aggressive tumor that rarely metastasizes, although a small subset undergoes malignant transformation. H3F3A driver mutations have been recognized as characteristic molecular features…
View details →DOI: 10.1007/s12672-026-05196-6 Negative / Null Result ReportMedicine
Cheng CW, Fang WF, Yang YM et al. · 2026 · Immunopharmacology and immunotoxicology
Background Hydroxychloroquine (HCQ) is a commonly used immunomodulatory drug in various autoimmune diseases; however, its role in autoimmune thyroid diseases (AITDs) remains unclear. Objective This study aimed to evaluate the potential…
View details →DOI: 10.1080/08923973.2026.2692421 Negative / Null Result ReportMedicine
Volpe G, Bonanata M, Peyla A et al. · 2026 · Ophthalmology and therapy
Introduction Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the standard of care for neovascular age-related macular degeneration (nAMD) and other retinal vascular diseases. However, transient post-injection…
View details →DOI: 10.1007/s40123-026-01431-z Negative / Null Result ReportMedicine
Genç E, Bilekyiğit Kurt C, Evrim Karadağ Saygi N et al. · 2026 · Journal of pediatric endocrinology & metabolism : JPEM
Objectives Musculoskeletal abnormalities are common to mucopolysaccharidoses (MPS) and can negatively affect the patient's quality of life. Data on course of musculoskeletal findings of MPS type IVA and VI are very insufficient. This study…
View details →DOI: 10.1515/jpem-2025-0665 Negative / Null Result Report
Fahmy A, Abdelfatah N, Keriakos N · 2026 · Preprint
Abstract Background Sepsis is a life-threatening condition characterized by an overwhelming systemic response to infection, often resulting in profound hemodynamic instability and multi-organ dysfunction. One of the critical aspects of…
View details →DOI: 10.21203/rs.3.rs-9760697/v1 Negative / Null Result ReportMedicine
Martikainen A, Eloranta AM, Schwab U et al. · 2026 · Trials
Background Lifestyle interventions can reduce the risk of becoming an overweight adult and reduce the risk of health problems. The aim was to investigate the effects of obesity treatment on BMI-for-age, metabolic markers, and quality of…
View details →DOI: 10.1186/s13063-026-09768-3 Failed Experiment ReportMedicine
Holden A, Burns P, Devenny A et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Improved survival in cystic fibrosis (CF) has shifted clinical focus toward late complications, including altered body composition, bone health and cardiopulmonary fitness. The effects of Elexacaftor/Tezacaftor/Ivacaftor (ETI)…
View details →DOI: 10.1016/j.jcf.2026.05.013 Failed Experiment Report
Bhat YA, Mocavini I, O’Donnell E et al. · 2026 · Preprint
The Bre1 ubiquitin conjugating enzyme catalyzes the monoubiquitylation of histone H2B-K120/K123 at promoter proximal nucleosomes, contributing to transcriptional regulation. These same nucleosomes are targeted by the yeast SWR1C chromatin…
View details →DOI: 10.64898/2026.04.22.720199 Failed Experiment ReportMedicine
Cabrera GJ, Farías P, Sáez CG · 2026 · Journal of voice : official journal of the Voice Foundation
Introduction Parkinson's disease (PD) is frequently associated with voice and speech impairments that negatively affect communication and quality of life. Although several studies have identified vocal variables with potential clinical…
View details →DOI: 10.1016/j.jvoice.2026.06.007 Failed Experiment ReportMedicine
Celik M, Polat ME, Ceviz K et al. · 2026 · World journal of urology
Purpose Vasculogenic erectile dysfunction (ED) is associated with endothelial dysfunction and oxidative stress. This study evaluated the clinical efficacy of radial-type low-intensity extracorporeal shockwave therapy (Li-ESWT) and its…
View details →DOI: 10.1007/s00345-026-06560-5 Negative / Null Result ReportOpen accessMedicine
Asbi T, Mayer Y, Sarikov R et al. · 2026 · The Saudi dental journal
Maxillectomy produces extensive oral and maxillofacial defects that disrupt normal physiology and often require obturator prostheses for functional and aesthetic rehabilitation. Although these devices are routinely used, their influence on…
View details →DOI: 10.1007/s44445-026-00128-0 Negative / Null Result ReportMedicine
Stoll PD, Thol F, Spuck N et al. · 2026 · The Journal of craniofacial surgery
Introduction Orthognathic surgery is traditionally considered painful, often prompting opioid use. In the context of rising opioid-related harm, this study assessed postoperative pain levels, factors influencing analgesic requirements, and…
View details →DOI: 10.1097/scs.0000000000012621 Negative / Null Result ReportMedicine
Lafitte E, Sfumato P, Walz J et al. · 2026 · World journal of urology
Introduction Preoperative anemia (PA) and red blood cell transfusion (RBT) are associated with decreased survival in several cancers. In muscle-invasive bladder cancer (MIBC), anemia is frequent and may be worsened by neoadjuvant…
View details →DOI: 10.1007/s00345-026-06437-7 Negative / Null Result Report
Kim D · 2026 · Preprint
The effect of political Governor or party on Renewable Portfolio Standard adoption is examined across 50 U.S. states from 2001 to 2024. Using fixed-effects panel regression with clustered standard errors, it is found that persistent…
View details →DOI: 10.20944/preprints202602.1705.v1 Negative / Null Result ReportMedicine
Jones A, Johnco C, Beyersmann E et al. · 2026 · Child psychiatry and human development
Poor reading ability is associated with internalising symptoms in children; however, little research has been done with adolescents. The current study used self- and parent-report data from two cohorts of the Longitudinal Study of…
View details →DOI: 10.1007/s10578-026-02048-w Negative / Null Result ReportMedicine
Majidi S, Rouhi A · 2026 · BMC primary care
Background Obsessive-Compulsive Disorder (OCD) is one of the psychiatric disorders which characterized by unwanted thoughts (obsessions) and repetitive behaviors (compulsions). Mental health problems can affect job performance of…
View details →DOI: 10.1186/s12875-026-03349-8 Negative / Null Result ReportMedicine
Yaemrattanakul W, Manachamni K, Ruangrattanapong J et al. · 2026 · BMC psychology
Background Healthcare undergraduate students often face high cognitive and emotional stress, negatively affecting their working memory and well-being. Mindfulness-based practices, such as sitting meditation and body scan, are proposed to…
View details →DOI: 10.1186/s40359-026-04923-6 Negative / Null Result ReportMedicine
Stankovičová V, Nováček VL, Rozsíval P · 2026 · Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti
Aim The aim of this study was to assess the effect of Rexon-Eye therapy, based on quantum molecular resonance (QMR) technology, optical parameters, tear film stability, and patients' subjective symptoms. Material and methods A total of 30…
View details →DOI: 10.31348/2026/3 Negative / Null Result ReportMedicine
Mancarella M, Novara L, Carignano S et al. · 2026 · The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
Objectives Uterine leiomyomas may cause disorders such as bleeding and bulky symptoms impacting on quality of life; a recent therapeutic option is relugolix, a GnRH antagonist effective in controlling bleeding and reducing the size of…
View details →DOI: 10.1080/13625187.2026.2615974 Negative / Null Result ReportMedicine
Thomas L, Hazell G, Baczynska K et al. · 2026 · Photochemistry and photobiology
Far-UVC (200-235 nm) has emerged as a safe and effective modality to inactivate pathogens in an indoor setting. trans-urocanic acid (UCA) is a chromophore that resides in the stratum corneum of the skin and is converted into the more…
View details →DOI: 10.1111/php.70118 Negative / Null Result ReportOpen accessMedicine
McLintock C, Uprety S, McKelvie J et al. · 2026 · International ophthalmology
Background We aim to evaluate the effect of pharmacological pupil dilation on spherical and toric intraocular lens (IOL) power calculations using biometric measurements from the Anterion optical biometer. Methods This was a prospective…
View details →DOI: 10.1007/s10792-026-03939-6 Negative / Null Result Report
Wieber N, Haney S, Lazarcik J et al. · 2026 · Preprint
Antibiotic resistance genes (ARGs) are an emerging class of environmental contaminants with significant implications for public health. Previous studies have linked fungicide exposure to elevated levels of ARGs in soil microbiomes, but…
View details →DOI: 10.64898/2026.06.02.729574 Negative / Null Result Report
Djasarie NRA, Idris I, Arsyad A et al. · 2026 · Preprint
Overweight has become a global health problem, reaching 1 billion cases in 2022. In Indonesia, its prevalence increased from 8.8% in 2013 to 21.8% in 2018, contributing to cardiovascular risk through elevated plasma and renal endothelin-1…
View details →DOI: 10.20944/preprints202605.0148.v1 Negative / Null Result Report
Singh K, Berneburg N, May A et al. · 2026 · Preprint
Background: /Objectives: Long-term clinical data on direct posterior composite restorations are scarce. This study evaluated their performance after almost three decades using selected FDI criteria. Temporal changes were tracked across…
View details →DOI: 10.20944/preprints202605.0934.v1 Negative / Null Result ReportOpen accessMedicine
Reinprayoon U, Yaisawang S, Israsena N et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
Purpose Descemet Membrane Endothelial Keratoplasty (DMEK) is a surgical intervention for restoring endothelial function in Fuchs endothelial corneal dystrophy (FECD). However, changes in corneal biomechanical properties assessed using…
View details →DOI: 10.2147/opth.s598840 Negative / Null Result Report
Howlett MR, Cary VE, Maitta RW · 2026 · Preprint
Abstract Immature platelets represent the youngest platelets in circulation. They are also present in all platelet units given to patients. However, there is limited knowledge of what occurs to these platelets during routine blood…
View details →DOI: 10.21203/rs.3.rs-9204379/v1 Failed Experiment ReportMedicine
Kuruppu J, Purdy JB, Pauls C et al. · 2026 · Open forum infectious diseases
Background Some people with HIV (PWH) have a poor immunologic response to antiretroviral therapy (ART). Such immunologic nonresponders are at increased risk for HIV and non-HIV related complications. Immune exhaustion may contribute to…
View details →DOI: 10.1093/ofid/ofag203 