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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 399 of 675

Negative / Null Result ReportMedicine

Clinically indicated versus routine replacement of peripheral intravenous cannulas in elderly patients: Secondary analysis of a multi-center randomized controlled trial in mainland China.

Jiang, Wang, Wei et al. · 2026 · Geriatric nursing (New York, N.Y.)

Peripheral Intravenous Cannulas (PIVCs) are extensively used for infusion therapy. Although current evidence suggests that adult patients may have PIVCs removed based on clinical indications, the indication in elderly patients remains…

View details →DOI: 10.1016/j.gerinurse.2026.104100
Negative / Null Result ReportMedicine

CT Perfusion Blood Flow Provides an Early Response Marker for Progression-free Survival in a Prospective Randomized Clinical Trial of Metastatic Renal Cell Carcinoma.

Ng, Chen, Wei et al. · 2026 · Technology in cancer research & treatment

IntroductionThere is currently no biomarker for progression-free survival (PFS) for patients undergoing treatment for metastatic renal cell carcinoma (RCC). The aim of our study was to evaluate computed tomography perfusion (CTp) blood…

View details →DOI: 10.1177/15330338261462414
Negative / Null Result ReportMedicine

The Utility of Large Language Models to Assist With Emergency Triage Decisions Within Otolaryngology.

Hack, Attal, Steckbeck et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

To determine whether contemporary large language models can match clinician performance in evaluating the urgency of emergency otolaryngology referrals. Blinded cross-sectional diagnostic reasoning study. Simulated emergency referral…

View details →DOI: 10.1002/ohn.70313
Negative / Null Result ReportMedicine

Relation between forearm flexor-pronator muscle elasticity and ulnar collateral ligament laxity of the elbow joint in high school pitchers with and without medial elbow tenderness: evaluation using shear wave elastography.

Tajika, Shitara, Hatori et al. · 2026 · JSES international

The forearm flexor-pronator muscle contributes to the dynamic stabilizer against valgus stress at the elbow during pitching motion. This study used shear wave ultrasonography to assess the relation between the elasticity of each forearm…

View details →DOI: 10.1016/j.jseint.2026.101719
Negative / Null Result ReportMedicine

Differences in gut microbiome of Hanwoo (Korean indigenous cattle) calves as driven by bovine rotavirus and bovine coronavirus infection.

Ku, Lee, Jung et al. · 2026 · Journal of animal science and technology

The gut microbiome of cattle suppresses pathogens and aids host immunity. However, the gut microbiome of newborn calves is still developing; therefore, diarrhea caused by pathogen infection is common. Rapid changes in the gut microbiome…

View details →DOI: 10.5187/jast.2025.e29
Negative / Null Result ReportMedicine

External Validation of a Deep Learning-Based Artificial Intelligence System for Ultrasound Diagnosis of Thyroid Nodules: A Two-Center Retrospective Study.

Tang, Xu, Zhao et al. · 2026 · Journal of clinical ultrasound : JCU

To investigate the performance of an artificial intelligence (AI) diagnostic system for thyroid nodule sonography based on deep learning convolutional neural network (CNN). We retrospectively included 485 thyroid nodules with definite…

View details →DOI: 10.1002/jcu.70275
Negative / Null Result ReportMedicine

Comparative Assessment of Dimensional Accuracy and Fit of Aligners Manufactured by Direct Printing and Thermoforming: An in vitro Study.

Felix, Nagesh · 2026 · Turkish journal of orthodontics

The objective of the study was to compare the accuracy and fit of direct-printed and thermoformed aligners. The in vitro study included a pre-treatment scan as a reference model. Thirteen successive treatment stages were digitally planned…

View details →DOI: 10.4274/turkjorthod.2026.2025.153
Negative / Null Result ReportMedicine

The Impact of Preoperative Blood Glucose Control on Corneal Recovery and Visual Function After Phacoemulsification in Diabetic Cataract Patients.

Ye, Lin, Lu et al. · 2026 · Annali italiani di chirurgia

Diabetic patients are at an increased risk for cataract and may experience delayed postoperative recovery due to diabetes-related ocular tissue vulnerability. However, the impact of preoperative glycemic control on early surgical outcomes…

View details →DOI: 10.62713/aic.4554
Negative / Null Result ReportMedicine

Heterogeneous Systemic IgG Responses to Porphyromonas gingivalis Gingipains in Advanced Periodontitis.

Büttner, Derman, Simonis et al. · 2026 · Clinical and experimental dental research

To evaluate serum IgG responses against Porphyromonas gingivalis gingipains RgpB and Kgp in patients with stage III and IV periodontitis and examine associations with clinical periodontal parameters. This exploratory cross-sectional study…

View details →DOI: 10.1002/cre2.70391
Negative / Null Result ReportMedicine

Learning Curve for Transbronchial Lung Cryobiopsy in Interstitial Lung Disease Diagnosis: A Multicenter Experience.

Tong, Guo, Xia et al. · 2026 · Respiration; international review of thoracic diseases

Transbronchial lung cryobiopsy (TBLC) is increasingly used to diagnose interstitial lung disease (ILD). However, the learning curve associated with this technique remains unclear. This retrospective analysis included the first 100 patients…

View details →DOI: 10.1159/000553097
Negative / Null Result ReportMedicine

Comparison of Milan versus up-to-seven criteria for liver resection in hepatocellular carcinoma: a multi-center study on risk factors and long-term outcomes.

Chen, Xu, Yan et al. · 2026 · Surgical endoscopy

This multi-center study aimed to evaluate the clinical validity of the "up-to-seven" criteria (sum of tumor number and largest diameter ≤ 7) as an expanded threshold for curative liver resection in hepatocellular…

View details →DOI: 10.1007/s00464-026-12710-y
Negative / Null Result ReportMedicine

Robotic vs. open liver resection after neoadjuvant therapy for hepatocellular carcinoma: a propensity score-matched analysis of short- and long-term outcomes.

Zhang, Li, Chen et al. · 2026 · Surgical endoscopy

Neoadjuvant therapy is recommended for hepatocellular carcinoma at advanced stages. It is unknown whether robotic liver resection (RLR) is superior to open liver resection (OLR) after neoadjuvant therapy. We analyzed consecutive RLR and…

View details →DOI: 10.1007/s00464-026-12682-z
Negative / Null Result ReportMedicine

Association of ultra-processed foods (UPFs) with hypertriglyceridemic waist (HTGW) phenotype, oxidative stress, and inflammation in Iranian adults: a cross-sectional study.

Rostamian, Moabedi, Poursalehi et al. · 2026 · Food & function

In this study, we evaluated the association between UPFs with HTGW in relation to oxidative stress and inflammation in Iranian adults, as no previous study had assessed these altogether. This cross-sectional study consisted of a sample of…

View details →DOI: 10.1039/d5fo05626h
Negative / Null Result ReportMedicine

Microplastic contamination in coastal environments: Assessing the role of rainfall and stormwater inputs.

Giuretis, Wootton, Gillanders et al. · 2026 · Marine pollution bulletin

Stormwater is increasingly recognised as a contributor to microplastic contamination in aquatic environments. Yet, the contribution of rainfall in flushing microplastics through urban drainage systems into coastal environments remains less…

View details →DOI: 10.1016/j.marpolbul.2026.120011
Negative / Null Result ReportMedicine

Embedding LLMs in the patient portal to summarize acute minor illness information: a three-arm experimental study.

Esmaeilzadeh · 2026 · International journal of medical informatics

Patient portals provide direct access to clinical encounter data; however, comprehension barriers, especially for patients with limited health literacy, frequently prevent meaningful use, even for common acute conditions. Large language…

View details →DOI: 10.1016/j.ijmedinf.2026.106547
Negative / Null Result ReportMedicine

Predictors of Adenosine-Induced Sinus Pause Duration for Supraventricular Tachycardia in the Emergency Department: The Role of Body Mass Index and Symptom Duration.

Ozatak, Sonmez, Ozatak et al. · 2026 · The Journal of emergency medicine

Intravenous adenosine is the standard first-line therapy for stable supraventricular tachycardia (SVT). However, transient post-cardioversion sinus pauses frequently complicate its use, causing clinical anxiety. Patient-specific factors…

View details →DOI: 10.1016/j.jemermed.2026.04.034
Negative / Null Result ReportMedicine

Sex and Age Differences in Procedural and Medium-Term Electrical Performance Outcomes of Dual-Chamber Leadless Pacemakers.

Jia, Zhang, Pradeep et al. · 2026 · Journal of cardiovascular electrophysiology

Studies regarding sex and age differences in clinical outcomes of DCLP patients remain limited. This was a retrospective, single-center study, which evaluated the consecutive patients who underwent Aveir DCLP implantation between January…

View details →DOI: 10.1111/jce.70407
Negative / Null Result ReportMedicine

Evaluation of physicochemical and antibacterial properties of an experimental adhesive resin containing casein phosphopeptide-amorphous calcium phosphate.

Balkaya, Göçer, Demirbuğa · 2026 · Odontology

This study aimed to evaluate the polymerization, contact angle, surface tension, antibacterial activity, and bonding properties of experimental adhesives modified with the addition of casein phosphopeptide-amorphous calcium phosphate…

View details →DOI: 10.1007/s10266-026-01445-w
Negative / Null Result ReportMedicine

Comparative Evaluation of Bond Strength of Bioflx Crowns with Resinous and Nonresinous Luting Agents on Primary Teeth: An In Vitro Study.

Tasgaonkar, Rathi, Agrawal et al. · 2026 · International journal of clinical pediatric dentistry

Preserving primary teeth with crowns is vital in pediatric dentistry, especially for those compromised by dental caries, previous treatments, or malformations. To address the limitations of traditional esthetic crowns, Bioflx crowns have…

View details →DOI: 10.5005/jp-journals-10005-3480
Negative / Null Result ReportMedicine

Virtual Reality Glasses vs Conventional Behavior Management Techniques for Anxiety and Pain Control in 6-10-year-old Children: A Randomized Controlled Trial.

Rathee, Bhardwaj, Gupta et al. · 2026 · International journal of clinical pediatric dentistry

Anxiety and pain often lead to a challenging situation in a dental clinic. This study aimed to compare the efficacy of virtual reality (VR) glasses to conventional techniques for anxiety control in children. Jio Dive VR glasses (passive)…

View details →DOI: 10.5005/jp-journals-10005-3493
Negative / Null Result ReportMedicine

Endoscopic and Histological Features of Esophagitis in Children With Duodenogastric Reflux.

Teke, Ergen, Basaran et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

Duodenogastric reflux (DGR), the backward flow of duodenal contents into the stomach, is often overlooked in children. This study aimed to evaluate the endoscopic and histopathological changes in the esophagus associated with DGR in…

View details →DOI: 10.1111/ped.70449
Negative / Null Result ReportMedicine

Quantitative Analysis of the Intracellular Efficacy of Conventional Antileishmanial Drugs Against Leishmania tropica : A Translational Approach Using the THP-1 Macrophage-Amastigote Model.

Yıldırım, Aksoy, Özbilgin · 2026 · Turkiye parazitolojii dergisi

This study aimed to quantitatively assess the intracellular susceptibility of Leishmania tropica ( L. tropica ) to conventional antileishmanial drugs using the parasite rescue and transformation assay (PRTA), which involves controlled…

View details →DOI: 10.4274/tpd.galenos.2026.82474
Negative / Null Result ReportMedicine

A Comparative Analysis of the Hinotori and da Vinci Robotic Systems in Total Hysterectomy for Benign Uterine Gynecological Diseases Using Propensity Score Matching.

Torii, Oshima, Aoki et al. · 2026 · Asian journal of endoscopic surgery

The hinotori surgical robot system, the first Japanese-made robotic-assisted surgical system to receive Japanese regulatory approval in 2020, is now being applied clinically in gynecology. This study aimed to comprehensively compare the…

View details →DOI: 10.1111/ases.70327
Negative / Null Result ReportMedicine

Clinical and radiological outcomes of unilateral biportal endoscopy and percutaneous endoscopic interlaminar discectomy for highly downward-migrated lumbar disc herniation: a retrospective study.

Liu, Zhang, Zhang et al. · 2026 · BMC surgery

To compare the clinical efficacy and safety of unilateral biportal endoscopy (UBE) versus percutaneous endoscopic interlaminar discectomy (PEID) in the treatment of highly downward-migrated lumbar disc herniation (HDM-LDH). A retrospective…

View details →DOI: 10.1186/s12893-026-03933-w
Negative / Null Result ReportMedicine

Accuracy of palatal orthodontic miniscrew placement: Static vs dynamic computer-guided techniques in a randomized clinical trial.

Brilli, Giansanti, Altieri et al. · 2026 · Clinical oral investigations

This randomized clinical trial compared the accuracy of palatal paramedian miniscrew placement using static computer-assisted surgery (s-CAS) and dynamic computer-assisted surgery (d-CAS). Forty subjects (11-17 years) requiring palatal…

View details →DOI: 10.1007/s00784-026-06975-9
Negative / Null Result ReportMedicine

Identification of broadly expressed nervous system-related genes as effective RNAi targets in the brown marmorated stink bug, Halyomorpha halys.

Panda, Koch, Amineni · 2026 · Pest management science

The brown marmorated stink bug, Halyomorpha halys (BMSB), is an invasive polyphagous pest causing major losses in fruit and field crops in Europe and the Americas. With insecticide options increasingly limited by resistance and regulatory…

View details →DOI: 10.1002/ps.71021
Negative / Null Result ReportMedicine

Modeling the Effects of Gravity and Patient Positioning on Stone Migration During Ureteroscopy with Laser Lithotripsy in a Physics-Based Simulator.

Velasquez Ospina, Gordon, Ojalvo et al. · 2026 · Urologia internationalis

Introduction Residual lower pole fragments are a common limitation of ureteroscopy, yet the optimal patient positioning to minimize stone migration remains undefined. This study aimed to evaluate the impact of Trendelenburg (HeadTilt) and…

View details →DOI: 10.1159/000552687
Negative / Null Result ReportMedicine

No differential effects among cooling strategies on post-exercise core temperature recovery in male athletes.

Caballero, Navarro, Vanos et al. · 2026 · Temperature (Austin, Tex.)

Personal cooling strategies are used to lower body core temperature. This controlled cross-over trial evaluates the efficacy of cooling strategies following exercise-induced heat exposure resulting in increased body temperature. Ten…

View details →DOI: 10.1080/23328940.2026.2631850