Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect
Armin D. Tavakkoli, BA; Megan A. Clark, BE; Alireza Kheirollah, PhD; Austin M. Sloop, MS; Haille E. Soderholm, BA; Noah J. Daniel, MS; Arthur F. Petusseau, PhD; Yina H. Huang, PhD · 2024 · Advances in Radiation Oncology
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Purpose: Ultra High Dose-Rate (UHDR) radiation has been reported to spare normal tissue, compared with Conventional Dose-Rate (CDR) radiation. However, important work remains to be done to improve the reproducibility of the FLASH effect. A better understanding of the biologic factors that modulate the FLASH effect may shed light on the mechanism of FLASH sparing. Here, we evaluated whether sex and/or the use of 100% oxygen as a carrier gas during irradiation contribute to the variability of the FLASH effect. Methods and Materials: C57BL/6 mice (24 male, 24 female) were anesthetized using isofl
Abstract by Armin D. Tavakkoli, BA; Megan A. Clark, BE; Alireza Kheirollah, PhD; Austin M. Sloop, MS; Haille E. Soderholm, BA; Noah J. Daniel, MS; Arthur F. Petusseau, PhD; Yina H. Huang, PhD, Advances in Radiation Oncology (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.adro.2024.101492