Tissue distribution, excretion and effects on genotoxicity of tritium following oral administration to rats
Jei Ha Lee; Cha Soon Kim; Soo Im Choi; Rae-Kwon Kim; Ji Young Kim; Seon Young Nam; Young Woo Jin; In Gyu Kim · 2019 · Nuclear Engineering and Technology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Tritium is an important nuclide that must be monitored for radiation safety management. In this study, HTO was orally administered to rats at the level of 37 kBq (1 μCi) or 370 kBq (10 μCi) to examine tissue distribution and excretion levels. After sacrifice, wet and dry tissue samples were weighed and analyzed for tissue free-water tritium (TFWT) and organically bound tritium (OBT). The mean tissue concentrations of TFWT (OBT) were 30.9 (17.8) and 4.4 (8.1) Bq/g on days 7 and 13 at the 37 kBq level and 30.8 (64.6) Bq/g on day 17 at the 370 kBq level. To assess the cytogenetic damage due to tr
Abstract by Jei Ha Lee; Cha Soon Kim; Soo Im Choi; Rae-Kwon Kim; Ji Young Kim; Seon Young Nam; Young Woo Jin; In Gyu Kim, Nuclear Engineering and Technology (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.net.2018.09.013