Negative / Null Result ReportMedicine
Kitowski A, Heise C, Sperling S et al. · 2026 · British journal of pharmacology
Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to…
View details →DOI: 10.1111/bph.70468 Negative / Null Result Report
Grossmann I, Rudnev M, Clark CJ et al. · 2026 · Preprint
Experts and pundits routinely forecast societal trends, yet these predictions often fall short, leading to poor policy decisions. What distinguishes accurate forecasters? In a three-year longitudinal tournament (N = 520), we tested whether…
View details →DOI: 10.31234/osf.io/c5kx4_v1 Negative / Null Result ReportMedicine
Talathi R, Hubbard RA, Somasundar P et al. · 2026 · Surgery
Background The Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (STRASS 2) trial is evaluating the impact of neoadjuvant chemotherapy versus surgery in patients with high-risk, resectable…
View details →DOI: 10.1016/j.surg.2026.110187 Negative / Null Result ReportMedicine
Zhao A, Chen W, Liang Y et al. · 2026 · Cancer treatment and research communications
Objective To compare and analyze the efficacy and safety of an overall strategy of immunotherapy combined with chemoradiotherapy in patients with limited-stage small cell lung cancer (LS-SCLC)-including induction immunotherapy plus…
View details →DOI: 10.1016/j.ctarc.2026.101275 Negative / Null Result ReportMedicine
Sarica C, Darmani G, Ramezanpour H et al. · 2026 · Science translational medicine
Transcranial ultrasound stimulation (TUS) is a promising noninvasive technique for modulating deep brain targets and circuits with high spatial precision. For its successful clinical translation, confirmation of target engagement, together…
View details →DOI: 10.1126/scitranslmed.ady1883 Negative / Null Result ReportMedicine
Riestra JM, Levin-Carrion Y, Sutar R et al. · 2026 · Human psychopharmacology
Treatment-resistant depression (TRD) remains a formidable challenge in psychiatry, with nearly one-third of patients with major depressive disorder (MDD) failing to respond adequately to first-line pharmacological treatments.…
View details →DOI: 10.1002/hup.70039 Negative / Null Result ReportMedicine
Nandi D, Gajarski RJ, Zhao H et al. · 2026 · Pediatric transplantation
Purpose Human Leukocyte Antigen (HLA) sensitization can adversely impact heart transplant (HTx) outcomes. We evaluated the effect of panel-reactive antibody (PRA) and desensitization (DS) strategies on outcomes of pediatric HTx recipients…
View details →DOI: 10.1111/petr.70315 Negative / Null Result ReportMedicine
Silva-García J, Eurolo I, Fuentes-Flores R et al. · 2026 · Brain research
Ischemic stroke is a leading cause of death and disability worldwide. Among survivors, one-third live with permanent impairments, and two-thirds experience upper limb dysfunction. Despite advances in acute care, no universally effective…
View details →DOI: 10.1016/j.brainres.2026.150321 Negative / Null Result Report
Hayashi T, Go M, Kawasumi K et al. · 2026 · Preprint
Abstract Introduction Maintaining dose intensity is essential for the efficacy of adjuvant S-1 chemotherapy in gastric cancer. Although pharmacist interventions can reduce toxicity and improve adherence, multicenter evidence regarding…
View details →DOI: 10.21203/rs.3.rs-9098687/v1 Negative / Null Result ReportMedicine
Saloojee H, Gramanie MC, Mwale R et al. · 2026 · Medical teacher
Background Generative artificial intelligence (AI) tools are entering clinical training faster than curricula and assessments can adapt. It is currently unknown whether point-of-care access to large language models (LLMs) improves…
View details →DOI: 10.1080/0142159x.2026.2652061 Negative / Null Result ReportMedicine
An DW, Wang Y, Cheng YB et al. · 2026 · Hypertension (Dallas, Tex. : 1979)
Background Whether central systolic blood pressure (cSBP) compared with brachial systolic blood pressure (bSBP) improves risk stratification remains debated. This study investigated whether cSBP is more closely associated with total and…
View details →DOI: 10.1161/hypertensionaha.126.26778 Negative / Null Result ReportMedicine
Durmuş Ece BŞ, Yozgat Z, Işık MU et al. · 2026 · Journal francais d'ophtalmologie
Purpose To determine the effect of trabecular meshwork (TM) peeling on gonioscopy-assisted transluminal trabeculotomy (GATT) surgical outcomes in patients with open-angle glaucoma. Methods In this retrospective cross-sectional study,…
View details →DOI: 10.1016/j.jfo.2026.104822 Negative / Null Result ReportMedicine
Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry
Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…
View details →DOI: 10.1016/j.jdent.2026.106759 Negative / Null Result ReportMedicine
Vedrenne-Cloquet M, de Montmollin E, Gaudemer A et al. · 2026 · Journal of educational evaluation for health professions
Purpose To assess the effectiveness of a short multimodal workshop, including stress-management and communication-skills training, on objective structured clinical examination (OSCE) performance and exam-related anxiety among medical…
View details →DOI: 10.3352/jeehp.2026.23.19 Negative / Null Result Report
Tortajada M, Rodriguez-Larios J, Martínez-Pérez V et al. · 2026 · Preprint
Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in Working Memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…
View details →DOI: 10.31234/osf.io/u8cxe_v1 Negative / Null Result ReportMedicine
Badulescu S, Gill H, Shah H et al. · 2026 · Med (New York, N.Y.)
Background Evidence suggests that glucagon-like peptide 1 receptor agonists (GLP-1RAs) might have pro-cognitive effects. No prior study has evaluated the efficacy and safety of a GLP-1RA for the treatment of cognitive dysfunction in adults…
View details →DOI: 10.1016/j.medj.2025.100916 Negative / Null Result ReportMedicine
Muller M, Agrawal A, Thomas N et al. · 2026 · Substance use & addiction journal
Background Patients with opioid use disorder (OUD) are frequently hospitalized and often need post-acute care, but face high rates of rejection from post-acute and long-term care (PALTC) facilities. This study aimed to assess the impact of…
View details →DOI: 10.1177/29767342261426150 Negative / Null Result ReportMedicine
Munazir M, Kausar N, Qureshi R et al. · 2026 · Scientific reports
Untreated municipal wastewater is widely used for irrigation in peri-urban agriculture where freshwater is limited, yet its effects on edible vegetable crops remain context dependent. This study evaluated the morphological, physiological,…
View details →DOI: 10.1038/s41598-026-50486-2 Replication FailureMedicine
Liang XQ, Han L, Yan T et al. · 2026 · Journal of anesthesia
Purpose Postoperative pulmonary complications are common and associated with worse long-term outcomes. In our previous trial, prophylactic penehyclidine inhalation reduced pulmonary complications in high-risk patients. Herein, we tested…
View details →DOI: 10.1007/s00540-026-03735-7 Replication FailureMedicine
Toft M, Hansen MS, Vestergaard JD et al. · 2026 · British journal of sports medicine
Objective To evaluate whether individualised treatment using the Copenhagen Achilles Rupture Treatment Algorithm (CARTA) is superior to default operative or non-operative strategies. Methods We conducted a multicentre, three-arm,…
View details →DOI: 10.1136/bjsports-2025-110210 Replication FailureMedicine
Chau IJ, Dixon PR, Lin V et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective To identify patient characteristics associated with improvements in speech recognition scores (SRS) and Cochlear Implant Quality of Life (CIQOL-35) scores following cochlear implantation. Study design Multi-institutional…
View details →DOI: 10.1097/mao.0000000000004755 Negative / Null Result ReportMedicine
Peters S, Tan DSW, Gerber DE et al. · 2026 · Nature cancer
Over 50% of persons with unresectable stage III non-small cell lung cancer (NSCLC) treated with standard-of-care concurrent chemoradiotherapy (CCRT) and durvalumab consolidation progress or die within 18 months. Here adults with untreated,…
View details →DOI: 10.1038/s43018-026-01161-y Negative / Null Result ReportMedicine
Schulz JV, Doerflinger JT, Behm C et al. · 2026 · Health psychology : official journal of the Division of Health Psychology, American Psychological Association
Objective This study compares three models of parental human papillomavirus (HPV) vaccination intentions across United States, United Kingdom, and Germany: A model based on the theory of planned behavior (TPB), a model incorporating…
View details →DOI: 10.1037/hea0001596 Negative / Null Result ReportOpen accessMedicine
Yang Y, He Y, Lin B et al. · 2026 · Health care science
Background The aim of this study was to investigate the clinical value of combined detection of preoperative serum calcitonin (Ctn) and carcinoembryonic antigen (CEA) for diagnosing medullary thyroid carcinoma (MTC), as well as predicting…
View details →DOI: 10.1002/hcs2.70074 Negative / Null Result ReportMedicine
Drago E, Lavarello C, Alongi A et al. · 2026 · Clinical and experimental rheumatology
Objectives Development and psychometric evaluation of a disease-specific, paediatric-targeted multidimensional questionnaire for the assessment of juvenile fibromyalgia syndrome (JFS) in routine clinical practice. Methods The Juvenile…
View details →DOI: 10.55563/clinexprheumatol/0v4aqh Negative / Null Result ReportMedicine
Genuth G, Stavrou P, Brown C et al. · 2026 · Foot & ankle international
Background Acute lateral ankle sprains are among the most common musculoskeletal injuries, accounting for up to 20% of all sports-related injuries and a leading cause of time lost from athletic participation. Although most cases respond to…
View details →DOI: 10.1177/10711007261422252 Negative / Null Result Report
Hebisch J, Van Puyenbroeck P, Schwabe L et al. · 2025 · Preprint
A bstract Brainstem arousal systems including the locus coeruleus noradrenaline system, respond transiently to behaviorally relevant events. Locus coeruleus activity also drives dilations of the pupil, which are often observed during…
View details →DOI: 10.64898/2025.12.23.696068 Negative / Null Result ReportMedicine
Dertsiz Kozan B, Utlu B · 2026 · International ophthalmology
Purpose To investigate the effects of Mitomycin-C (MMC) use and duration of application on surgical outcomes in patients who underwent 3 snip punctoplasty for epiphora. Material and methods Demographic characteristics, follow-up period,…
View details →DOI: 10.1007/s10792-026-03970-7 Negative / Null Result Report
Shi Z, Chen X, Chun Y et al. · 2026 · Preprint
Abstract Objective To evaluate the efficacy, safety, and prognostic factors of chimeric antigen receptor-T cell (CAR-T) therapy in patients with relapsed/refractory ileocecal lymphoma and provide evidence for salvage therapy. Methods This…
View details →DOI: 10.21203/rs.3.rs-8776621/v1 Negative / Null Result ReportMedicine
Pérez-Fernández N, Arbizu L · 2026 · Journal of clinical medicine
Background : Differentiating Ménière's disease (MD) from vestibular migraine (VM) remains difficult because current diagnostic frameworks are predominantly clinical and incorporate pure-tone thresholds, risking incorporation bias. We asked…
View details →DOI: 10.3390/jcm15051908 