A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21309 results · page 389 of 711
Hwang S, Kim PH, Kim H et al. · 2026 · Preprint
Abstract Purpose Selumetinib is approved for the treatment of inoperable plexiform neurofibromas (PN) in patients with neurofibromatosis type 1 (NF1). However, its efficacy in treating NF1-associated diffuse neurofibromas (NF1-DN) or optic…
Aglen T, Matre KH, Selles RW et al. · 2026 · Journal of hand therapy : official journal of the American Society of Hand Therapists
Background Collagenase treatment can improve finger extension and hand function in patients with Dupuytren's disease. The role of hand therapy in enhancing or prolonging these effects remains unclear. Purpose The primary aim was to examine…
Steen JP, Jaiswal KS, Dilipkumar J et al. · 2026 · The journal of pain
The measurement performance of the Short-Form Brief Pain Inventory (BPI-SF) across IASP-recognized pain mechanisms remains unclear. We evaluated the reliability and structural validity of BPI-SF across clinician-assigned predominant…
Ghofranian A, Baird M, Reckhow J et al. · 2026 · Minerva obstetrics and gynecology
Background Luteal phase E2 priming is commonly used in patients with DOR to 30 synchronize follicular development before controlled ovarian hyperstimulation (COH). Some protocols 31 incorporate a GnRH antagonist during the luteal phase to…
Kongkhuntian P, Aunmeungtong W, Khongkhunthian P · 2026 · Clinical implant dentistry and related research
Objective This study aimed to compare the effect of PTFE tape wrapping and PTFE-coated titanium alloy screws on the removal torque after cyclic loading and on preload values under repetitive tightening. Methods A total of 60 titanium…
Tournu E, Tourdot-Maréchal R, Coelho C · 2026 · International journal of food microbiology
Phytosanitary and copper treatments in viticulture are essential to protect vines against biotic and abiotic stresses. However, residues from these treatments can persist in grape musts and wines, potentially raising risks to consumer…
McClure Z, Fuller-Tyszkiewicz M, Messer M et al. · 2026 · The International journal of eating disorders
Objective Although a range of evidence-based treatments for eating disorders exist, treatment response varies substantially. The ability to match individuals to a treatment which they are most likely to benefit from may help improve…
Khatri D, Poudel S, Pun Magar L et al. · 2026 · Frontiers in plant science
Soybean meal quality for monogastric animals is limited by low sulfur-containing amino acids, especially methionine and cysteine, while oil oxidative stability is restricted by the high polyunsaturated fatty acid content. This two-year…
Wall A, Fisher JA, Watkinson EK et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
Background Early warning scores like the National Early Warning Score 2 (NEWS2) identify patient deterioration but do not incorporate clinician-intuitive assessment. Previous research suggests facial expressions can be critical indicators…
Larsen LJ, Dornbusch MR, Hines-Snider C et al. · 2026 · Plant disease
Seed rot and damping-off of alfalfa ( Medicago sativa L.) is caused by a soilborne disease complex resulting in thin initial stands of plants with continuing damage during wet soil conditions decreasing forage yields and winter survival.…
Giese H, Gaissmaier W, Kuss O et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making
BackgroundTime-to-event outcomes from randomized controlled trials (RCTs) are often communicated without clearly conveying how treatment effects evolve over time. This can limit clinicians' ability to interpret results and support patient…
Müller D, Gillani A, Hirschmann MT et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose Accurate risk adjustment in total knee arthroplasty (TKA) is essential for outcome prediction and quality assessment. Most existing prediction models rely solely on patient demographics and comorbidities and do not account for…
Jiang PP, Huang HY, Zhao L et al. · 2026 · Pediatric research
Background Fortification of human milk for very preterm infants (VPIs) with alternatives to conventional bovine milk-based fortifiers remains minimally studied. This trial tested whether fortification with protein-rich bovine colostrum…
Bourdin A, Dureau S, Algret N et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose To report safety outcomes of transscleral fine-needle aspiration biopsy (FNAB) followed by irradiation for uveal melanoma (UM) in a tertiary ocular oncology center over 10 years, and assess whether FNAB modified the overall…
Vardanega R, Lüdtke FL, Loureiro L et al. · 2026 · Journal of agricultural and food chemistry
This study investigated whether coencapsulation of cannabidiol (CBD) and piperine (PIP) in food-grade nanostructured lipid carriers (NLCs) enhances the CBD oral bioavailability. NLCs containing long-chain fatty acids were formulated with…
Unal RU, Ozhan O, Balkaya ES et al. · 2026 · Scientific reports
Sepsis frequently leads to cardiac dysfunction driven by oxidative stress (OS), inflammation, and conduction abnormalities. Nebivolol (NEB), a selective β1-blocker with vasodilatory and antioxidant properties, has shown organ-protective…
Perez SB, Lau JA · 2026 · Ecology
Identifying the factors mediating the resilience and invariability of plant communities and their associated ecosystem functions is critical to understand the ecological impacts of climate change. Prior work has explored how classic…
Wanjiku C · 2026 · Preprint
Abstract Background Timely initiation of breastfeeding within one hour of birth reduces neonatal mortality and supports optimal child development. Women who deliver by cesarean section (CS) face disproportionate barriers to early…
Biswas A, Zidan H, Kolodzey L et al. · 2026 · Regional anesthesia and pain medicine
Background Video-assisted thoracoscopic surgery (VATS) offers numerous advantages over open surgery; nevertheless, it remains associated with significant postoperative pain. Multiple regional anesthesia techniques have been explored, and…
Kominsky E, Ansari M, Moore M et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
Objective To determine the association of positive margins and adjuvant radiotherapy on overall survival in parotid gland adenoid cystic carcinoma. Study design Retrospective cohort analysis. Setting National Cancer Database from 2004 to…
Buldur M, Sezer B · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology
Background/aim Artificial intelligence-based chatbot systems are increasingly used for dental emergency guidance, yet the clinical value of sequential consultation remains unclear. This study investigated whether response order influences…
Ekhaguere OA, Kesman R, Reiter J et al. · 2026 · The Journal of pediatrics
Objective To evaluate whether static ultrasound improves first-attempt, nontraumatic lumbar puncture (LP) success compared with the traditional landmark technique in infants admitted to a neonatal intensive care unit (NICU). Study design…
Nguyen NMC, Ryu H, Park JY et al. · 2026 · Preprint
Abstract Methylorubrum extorquens formate dehydrogenase I (Me-FDH1) is a tungsten-dependent heterodimeric enzyme with high activity for CO2/formate interconversion, making it an attractive biocatalyst for carbon capture, formate…
Vranceanu AM, Szapary C, Crean M et al. · 2026 · The Gerontologist
Background and objectives We tested the feasibility and preliminary effects of the Mindfulness Self-Compassionate Care (MASC) program for dementia caregivers' stress triggered by the care recipients' neuropsychiatric symptoms. Research…
Song BM, Ford CA, Schneider AM et al. · 2026 · The Journal of arthroplasty
Background Inflammatory arthritis (IA) has been considered an absolute indication for patellar resurfacing (PR) in total knee arthroplasty (TKA), yet limited data supports this. The purpose of this study was (1) to compare outcomes of TKA…
Seo S, Lee S, Lee N et al. · 2026 · Preprint
Choice overload occurs when an ever-growing number of options impairs decision quality, because evaluating options taxes cognitive resources. We investigated whether reducing cognitive demand could mitigate overload by encouraging greater…
Sileika E, Cerkauskaite D, Bausys A et al. · 2026 · International journal of colorectal disease
Background The optimal interval between neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME) in locally advanced rectal cancer (LARC) remains controversial. This randomized controlled trial evaluated whether prolonging…
Blackman J, Friesen D, Sikkel MB et al. · 2026 · Applied clinical informatics
Objectives The objective of this study is to evaluate whether ChatGPT models can reliably apply the DISCERN instrument, a 16-question human-scored rubric developed in 1999 to evaluate consumer health information, and assess the impact of…
Stewart KM, Sawicki GS, Young AJ et al. · 2026 · Journal of biomechanics
Individuals post-stroke with hemiparetic gait often experience impaired mobility, which can be restored using powered exoskeletons. Specifically, hip exoskeletons can deliver positive work to the leg to help initiate leg swing; however, it…
Norling M, Eriksson N, Westerberg E et al. · 2026 · Muscle & nerve
Introduction/aims Physical activity and sleep influence fatigue in myasthenia gravis (MG), and digital health technologies (DHT) enable objective monitoring of these behaviors in daily life. Using this approach, we evaluated whether a…