Negative / Null Result ReportOpen accessMedicine (General)
Jo Howard, Sophie A. Lee, Baba Inusa et al. · 2019 · Trials
Abstract Design This randomised crossover trial compared nocturnal auto-adjusting continuous positive airway pressure (APAP) and nocturnal oxygen therapy (NOT) in adults and children with sickle cell anaemia, with patient acceptability as the primary outcome. Secondary outcomes included pulmonary physiology (adults), safety, and daily pain during interventions and washout documented using tablet technology. Methods Inclusion criteria were age > 8 years and the ability to use an iPad to collect daily pain data. Trial participation was 4 weeks; week 1 involved baseline data collection and week 3
View details →DOI: 10.1186/s13063-019-3461-x Negative / Null Result ReportOpen accessMedicine
Lin C, Mei YM, Yan Y et al. · 2026 · Head & face medicine
AIM: To evaluate the adjunctive clinical efficacy of manual root planing following ultrasonic subgingival debridement (SD) in the treatment of generalized severe periodontitis. MATERIAL AND METHODS: Twenty-nine patients diagnosed with…
View details →DOI: 10.1186/s13005-026-00622-0 Negative / Null Result ReportOpen accessMedicine
Bilinç Doğruöz Karatekin, Şeyhmus Yasin, Yasemin Yumuşakhuylu et al. · 2021 · Bagcilar Medical Bulletin
Objective:Sarcopenia and osteoporosis share common risk factors and biological pathways. In the present study, patients with postmenopausal osteoporosis were screened for sarcopenia using the algorithm proposed by the European Working Group on Sarcopenia in Older People (EWGSOP) and balance impairment was investigated in sarcopenic patients.Method:Fifty three postmenopausal osteoporotic patients were evaluated for sarcopenia as per the algorithm proposed by the EWGSOP. Among the parameters included in the algorithm, gait speed was assessed using the timed up&go test (TUG), Jamar hand dynamomet
View details →DOI: 10.4274/bmb.galenos.2021.03.034 Negative / Null Result ReportOpen accessEducation (General)
Nur Maziyah Ulya · 2016 · Nadwa
This study aims to analyze: (1) The difference of students‟ achievement between students studying at cooperative learning class and those studying at conventional learning class; (2) The difference of students‟ achievement between the introvers and the extroverts; (3) The interactive influence between learning method and students‟ personality type toward students‟ achievement in Arabic language. This research used experimental design conducted at MAN 1 Semarang.. The result of this research shows that: (1) There is significant difference in students‟ achievement between students studying at th
View details →DOI: 10.21580/nw.2016.10.1.867 Negative / Null Result ReportOpen accessPharmacy and materia medica
Comfort Nanbam Sariem, Maxwell Patrick Dapar, Nenman Musa Lenka et al. · 2022 · INNOVATIONS in Pharmacy
Background: The prolonged multi-drug treatment regimen for tuberculosis (TB) can lead to non-adherence and unsuccessful treatment outcomes. Educational and psychological health models can be used to design cognitive and behavioral interventions to improve adherence and treatment outcomes. Objective: To determine the effect of cognitive and behavioral interventions on TB treatment outcomes. Methods: The quasi-experimental study conducted in six TB treatment centers involved reinforced medication education and adherence counseling (MEAC), designed from a structured validated psychometric scale.
View details →DOI: 10.24926/iip.v13i4.5031 Negative / Null Result ReportOpen accessAgriculture (General)
LI Yexin, LYU Gang, WANG Daohan et al. · 2023 · Guan'gai paishui xuebao
【Objective】 Restoring coal mining waste dumps is a way to alleviate their detrimental impact on environment. In this paper, we present the results of an experimental study on distribution and stability of soil aggregates in a reclaimed coal mining overburden dump. 【Method】 The experiment was carried out at a reclaimed coal mine dump site in a grassland region in northern China. We measured the development of fissures from Zone I (GF) to Zone three (GFIII) in the fissure zone. The composition and distribution soil aggregates in these zones were determined using dry-wet sieve method. Aggregate s
View details →DOI: 10.13522/j.cnki.ggps.2021419 Negative / Null Result ReportOpen accessVocational rehabilitation. Employment of people with disabilities
Zahid Mehmood, Zubair Ahmad, Asad Ullah et al. · 2023 · The Rehabilitation Journal
Background: Understanding students' perception of the educational environment and their cognitive load in this context is crucial for optimizing the effectiveness of e-learning platforms. Objective: To compare educational environment perception and cognitive load in under-graduates Doctor of Physical Therapy (DPT) and post-graduate Master in Science of Physical Therapy (MSPT) students having online learning experiences. Methodology: In this comparative cross-sectional study, data was collected through non-probability convenient sampling from n=274 under-graduates DPT (n=225) and post-graduates
View details →DOI: 10.52567/trj.v7i02.224 Negative / Null Result ReportOpen accessArchaeology
Solodovnikov K.N., Kravchenko G.G., Rykun M.P. · 2018 · Вестник археологии, антропологии и этнографии
This paper is aimed at scrutinizing the dependence between the morphological features of the Eneolithic — Early Bronze population and the geographical and bioclimatic conditions in the Altai valleys and intermountain basins. Across the territory of the Altai highlands, we have identified several local-territorial groups of archaeological sites dating to the period under study. Most of them belong to the Afanasyevо culture, with the rest being represented by the Kurota, Aragol and Ulita cultural types that have been recently designated from the Afanasyevо culture. For each group, in accordance
View details →DOI: 10.20874/2071-0437-2018-43-4-120-135 Negative / Null Result ReportOpen accessMedicine
Qais A. AL-Oqaily · 2016 · The Iraqi Journal of Medical Sciences
Background:Several studies have demonstrated the role of hematological parameters like hemoglobin (Hb), white blood cells (WBC) count and platelet count in the assessment of patients with coronary artery disease; some studies suggest an additional role of platelet indices in the prognosis of patients with coronary artery disease. Objective:To assess complete blood count and platelet indices in patients with coronary artery disease. Methods: Blood sample of 42 newly diagnosed ischemic heart disease patients including 20 patients with myocardial infarction (MI) and 22 patients with unstable angi
Negative / Null Result ReportOpen accessSurgery
Qing-Quan Chen, Qing-Quan Chen, Han-Lin Chen et al. · 2025 · Frontiers in Surgery
BackgroundThe incidence of secondary displacement in fractures of the greater tuberosity of the humerus remains high, irrespective of whether conservative or surgical treatment is administered. However, the specific risk factors contributing to secondary displacement of the greater tuberosity of the humerus have not been previously reported. The primary objective of this study was to analyze the risk factors associated with secondary displacement of the greater tuberosity of the humerus and to summarize corresponding guidelines for clinical diagnosis and treatment.MethodsA retrospective analys
View details →DOI: 10.3389/fsurg.2025.1474983 Negative / Null Result ReportOpen accessMedicine
LI Yongxu, LIN Libin, LU Taotao et al. · 2023 · 康复学报
ObjectiveTo observe the effect of swimming exercise preconditioning on neurological function and expression levels of brain derived neurotrophic factor (BDNF), serine-threonine kinase (Akt) and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) proteins in perihematoma tissues of mice with intracerebral hemorrhage (ICH).MethodsA total of 60 male C57BL/6 mice were randomly divided into sham group, ICH 7 d group, SEP+ICH 7 d group (preconditioning group 1), ICH 14 d group and SEP+ICH 14 d group (preconditioning group 2), with 12 cases in each group. The preconditioning group 1
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Daniele Faria Miguel, Maria Teresa Terreri, Rosa Maria Rodrigues Pereira et al. · 2020 · Advances in Rheumatology
Abstract Background Urinary parameters, anti-dsDNA antibodies and complement tests were explored in patients with childhood-Systemic Lupus Erythematosus (cSLE) early-onset lupus nephritis (ELN) from a large multicenter cohort study. Methods Clinical and laboratory features of cSLE cases with kidney involvement at presentation, were reviewed. Disease activity parameters including SLEDAI-2 K scores and major organ involvement at onset and follow up, with accrued damage scored by SLICC-DI, during last follow up, were compared with those without kidney involvement. Autoantibodies, renal function a
View details →DOI: 10.1186/s42358-020-0114-4 Negative / Null Result ReportOpen accessDentistry
Ravi Bhujbal, Neelima A Malik, Nilesh Kumar et al. · 2018 · Journal of Dental Research, Dental Clinics, Dental Prospects
Background. Surgical removal of mandibular third molars results in pain, swelling and bony defects, causing prolonged postoperative recovery. The growth factors present in platelet-rich plasma (PRP) can accelerate the healing, thereby shortening postoperative recovery period. This study was undertaken to evaluate the role of PRP in postoperative socket healing, pain, swelling and bone regeneration following surgical removal of impacted mandibular third molars. Methods. The present case‒control study was conducted on 20 patients with identical bilateral mandibular third molar impaction. PRP was
View details →DOI: 10.15171/joddd.2018.024 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Buket Akcan, Asim Örem, Yahya Altinkaynak et al. · 2022 · Frontiers in Nutrition
Background and ObjectiveDue to the frequency of meal ingestion, individuals spend the majority of the day, ~18 h, in a status of post-prandial (PP) stress. Remnant-like lipoprotein particles (RLPs) are predominant in PP phase playing an important role in the development of atherosclerosis. Endothelial progenitor cells (EPCs) have been suggested to play a role in vessel wall homeostasis and in reducing atherosclerosis. However, there is no information about peripheral blood EPCs number following PP stress. We investigated the association between circulating EPCs levels and extent of PP lipemia
View details →DOI: 10.3389/fnut.2022.822131 Negative / Null Result ReportOpen accessVeterinary medicine
Virginia Rega, Stefanie Brause, Sabine BR Kästner et al. · 2025 · Journal of Feline Medicine and Surgery
Objectives The objective of this study was to compare the use of the feline Glasgow Composite Measured Pain Scale (CMPS-f) at home and in a veterinary hospital. The hypothesis was that pain-free cats would score higher in the CMPS-f when in a stressful situation than when calm and relaxed; that is, healthy but stressed cats could appear to be in discomfort or pain. Methods Healthy, non-painful adult cats owned by clinical staff were included in a prospective clinical trial with two observers (caregiver [CG] and researcher). Cats were scored by their CG at home (H), after arrival at the clinic
View details →DOI: 10.1177/1098612x251385847 Negative / Null Result Report
Fang P · 2026 · Preprint
Abstract Objective. To track and characterize the trajectory of an individual's physical and mental health using an exploratory single-case design. Methods. Grounded in self-study methodology, this study adopted a single-case, longitudinal…
View details →DOI: 10.21203/rs.3.rs-10028679/v1 Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Siemer, Lutz, Brusse-Keizer, Marjolein G J, Postel, Marloes G et al. · 2020 · Journal of Medical Internet Research
BackgroundBlended face-to-face and web-based treatment is a promising way to deliver smoking cessation treatment. Since adherence has been shown to be an indicator of treatment acceptability and a determinant for effectiveness, we explored and compared adherence and predictors of adherence to blended and face-to-face alone smoking cessation treatments with similar content and intensity. ObjectiveThe objectives of this study were (1) to compare adherence to a blended smoking cessation treatment with adherence to a face-to-face treatment; (2) to compare adherence within the blended treatment to
View details →DOI: 10.2196/17207 Negative / Null Result ReportOpen accessSurgery
Yasuhiro Nagatani MD, Naoki Segi MD, Sadayuki Ito MD et al. · 2026 · Global Spine Journal
Study Design Retrospective cohort study. Objectives Successful bone fusion is crucial for favorable posterior lumbar interbody fusion (PLIF) outcomes. While trabecular bone remodeling (TBR) indicates osseointegration, its interpretation remains uncertain. This study aimed to clarify the clinical significance of distinct TBR types—fine TBR (fTBR) and sclerotic TBR (sTBR)—as seen on computed tomography (CT) scans and to evaluate their predictive value for segment stabilization and complete bone fusion and their relationship with interbody cage materials. Methods Seventy-one patients who underwen
View details →DOI: 10.1177/21925682251385533 Negative / Null Result ReportOpen accessMedicine
Ted Lee, Heiko Yang, David Haneuer et al. · 2018 · Hospital Practices and Research
Background: Iatrogenic urethral injury is a well-known risk of urinary catheter insertion. Associated morbidities include stricture formation, catheter associated infection, risk for instrumentation, and extended length of stay. Yet, insufficient attention is paid to its prevention. Objective: This study aimed to assess the effectiveness of a computerized ordering system in reducing iatrogenic urethral injuries in men at high risk for iatrogenic urethral injury from traumatic catheterization. Methods: A pre-post study was performed to assess the impact of a computerized ordering system that re
View details →DOI: 10.15171/hpr.2018.06 Negative / Null Result ReportOpen accessPsychiatry
S. Javed, R. K. Gaur, A. Ibrahim et al. · 2017 · Sri Lanka Journal of Psychiatry
Background Dementia is a common, disabling disorder of the elderly. With the steady growth in the older population, the rate of dementia is expected to increase two fold by 2030 and three fold by 2050. Dementia of Alzheimer Type (DAT) and vascular dementia (VD) are among the most common types of dementia. Behavioral and psychological symptoms of dementia (BPSD) are associated with increased patient morbidity and carer burden. Aims The objective of this study was to compare symptoms of BPSD in patients with DAT and VD and to explore the correlates of BPSD in patients with DAT and VD. Methods Pe
View details →DOI: 10.4038/sljpsyc.v8i1.8136 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Kai Zhou, Anqiang Wang, Jingtao Wei et al. · 2022 · Frontiers in Oncology
BackgroundHepatoid adenocarcinoma of the stomach (HAS) is a rare type of gastric cancer, but the role of perioperative chemotherapy is still poorly understood. The aim of this retrospective study was to investigate the associations between perioperative chemotherapy and prognosis of HAS.MethodWe retrospectively analyzed patients with locally advanced HAS who received radical surgery in Peking University Cancer Hospital between November 2009 and October 2020. Patients were divided into neoadjuvant chemotherapy-first (NAC-first) group and surgery-first group. The relationships between perioperat
View details →DOI: 10.3389/fonc.2021.789104 Negative / Null Result ReportOpen accessDentistry
Ika Devi, Erliera Sufarnap, Finna et al. · 2023 · Dental Journal
Background: Chitosan has an antimicrobial effect in oral hygiene control. Orthodontists sometimes prescribe mouthwash to adolescent patients. Copper-nickel-titanium (CuNiTi) orthodontic archwire is widely used in orthodontic treatment. Chitosan’s effects on the CuNiTi properties of orthodontic archwire are not generally known. Purpose: This study aimed to measure the acidity, copper ion release, deflection, and surface roughness of CuNiTi orthodontic archwire immersed in artificial saliva and 2% chitosan. Methods: This study comprised experimental laboratory research. Forty-two CuNiTi orthodon
View details →DOI: 10.20473/j.djmkg.v56.i1.p41-47 Negative / Null Result ReportOpen accessMedicine
Ghalib A Akinlabi, Paul L Kaufman, Julie A Kiland · 2021 · PLoS ONE
Purpose In earlier experiments in Nigeria, aqueous extract of Pleurotus tuber-regium (PT) had been shown to lower intra ocular pressure (IOP) in a feline model. The aim of the current study was to determine whether PT had the same or a similar IOP-lowering effect in ocularly normal non-human primates. Methods Four monkeys were treated twice daily for 4 days with 2 x 20 μl drops of 50 mg/ml PT (pH = 4.3). The monkeys were sedated with 5-10 mg/kg ketamine HCl IM. PT was administered to the right eye and BSS to the left eye. Baseline IOP was measured just prior to beginning treatment, and on day
View details →DOI: 10.1371/journal.pone.0256422 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
O. A. Saygina, T. S. Sukhinina, M. A. Terenicheva et al. · 2026 · Рациональная фармакотерапия в кардиологии
Aim. To study the safety of using the intravenous beta-blocker (BB) esmolol in the early stages of ST-segment elevation myocardial infarction (STEMI) before primary percutaneous coronary intervention (PCI) based on an analysis of the incidence and clinical significance of adverse events (acute heart failure, hypotension, bradycardia, disorders of atrioventricular conduction (AV conduction), etc.) compared with the control group.Material and methods. The presented study is part of the randomized controlled trial ESMO-VASCMI (ClinicalTrials.gov NCT number 06376630) on the study of the cardioprot
View details →DOI: 10.20996/1819-6446-2025-3241 Negative / Null Result ReportOpen accessMedicine
Shurong Huang, Zhe Su, Huiping Su et al. · 2022 · Scientific Reports
Abstract Estrogen can promote the acceleration of bone maturation and phthalate esters (PAEs) have estrogen-mimicking effects. We investigated whether PAEs are associated with the acceleration of bone age (BA) in girls with early onset of puberty (EOP). This case–control study enrolled 254 girls with EOP from the Endocrinology Department at Shenzhen Children’s Hospital between December 2018 and August 2019. Ultra-performance liquid chromatography and tandem mass spectrometry were used to analyze the 10 metabolites of PAEs (mPAEs) in urine samples. BA was measured using an artificial intelligen
View details →DOI: 10.1038/s41598-022-19470-4 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Edvan de Queiroz Crusoe, Fabiana Higashi, Maria Paula Nalesso Camargo Padilha et al. · 2014 · Revista Brasileira de Hematologia e Hemoterapia
Background: Induction therapy followed by high-dose chemotherapy and autologous transplantation is the standard treatment for suitable patients with multiple myeloma. Objective: The aim of this study was to assess whether induction therapy with thalidomidecontaining regimens was associated with improved results compared to vincristine, doxorubicin, and dexamethasone, and whether cyclophosphamide, thalidomide, and dexamethasone were associated with better results than thalidomide and dexamethasone. Methods: The records of 152 patients who underwent autologous transplantation at this institution
View details →DOI: 10.5581/1516-8484.20140008 Negative / Null Result ReportOpen accessSpecial aspects of education
Élida de Fátima Diniz Souza, Ana Paula Ramos Machado, José Danúzio Leite de Oliveira et al. · 2025 · BMC Medical Education
Abstract Background In Brazil, residency programmes in Family and Community Medicine (FCM) and Multiprofessional Residency in Family Health (MRFH) are two-year specialisation courses, funded by the federal government, which aim to train professionals to work in Primary Health Care (PHC). The aim of this study was to draw up an inventory of the assessed competences of the residency programmes in the state of Paraíba, Brazil. Our study’s hypothesis is that self-assessment of competences can be a useful tool for monitoring the development of competences in the training of health professionals, co
View details →DOI: 10.1186/s12909-025-07521-z Negative / Null Result ReportOpen accessMedicine
Christine B. French, Sharon L. McDonnell, Reinhold Vieth · 2019 · Journal of Medical Case Reports
Abstract Background Vitamin D nutrition research requires accurate measures of circulating 25-hydroxyvitamin D. Our objectives were to test whether a diurnal fluctuation in blood-spot concentrations of 25-hydroxyvitamin D can be demonstrated statistically in a single individual, and whether such fluctuation is affected by the pre-dose versus post-dose timing of the blood draw. Case presentation The participant in this case study was a generally healthy Caucasian woman in her 40s who has taken 5000 IU vitamin D3 supplement at midday for over 1 year. Each blood sample was drawn individually from
View details →DOI: 10.1186/s13256-018-1948-9 Negative / Null Result ReportOpen accessSpecial aspects of education
Wei Han Hong, Jamunarani Vadivelu, Esther Gnanamalar Sarojini Daniel et al. · 2015 · Medical Education Online
Background: Studies have shown the importance of metacognition in medical education. Metacognitive skills consist of two dimensions: knowledge of metacognition and regulation of metacognition. Aim: This study hypothesizes that the knowledge and regulation of metacognition is significantly different at the beginning and end of the academic year, and a correlation exists between the two dimensions of metacognitive skills with academic performance. Methods: The Metacognitive Skills Inventory comprising 52 Likert-scale items was administered to 159 first-year medical students at the University of
View details →DOI: 10.3402/meo.v20.27561 Negative / Null Result ReportOpen accessOrthopedic surgery
Steven M. Hadley BA, John J. Peabody MD, Sarah Westvold MPH et al. · 2024 · Foot & Ankle Orthopaedics
Category: Ankle; Trauma Introduction/Purpose: It remains unclear whether ankle fracture pattern as described by the Weber classification—a reproducible method describing the level of fracture with respect to the distal tibiofibular syndesmosis—impacts outcomes. Patient Reported Outcome Measurement Information System (PROMIS) is a validated measure of outcomes after foot and ankle surgery. To our knowledge, no study has compared PROMIS scores between Weber subtypes. Our study thus examines whether Weber fracture subtype impacts surgical outcomes as measured by PROMIS scores. We hypothesize that
View details →DOI: 10.1177/2473011424s00255 