Negative / Null Result ReportMedicine
Barbarot S, Aubert H, Boivin M et al. · 2026 · The British journal of dermatology
Background New primary preventive therapeutic strategies for atopic dermatitis (AD) are needed. Atopic diseases are associated with disrupted gut microbial balance in early life, suggesting that optimizing microflora through intervention…
View details →DOI: 10.1093/bjd/ljaf414 Negative / Null Result Report
Altvater EE, Kojh D, Huang R et al. · 2025 · Preprint
ABSTRACT In metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis is the most important prognostic factor, and fibrosis can lead to hepatic cirrhosis and cancer. In the liver toll-like receptor 4 (TLR4) signaling…
View details →DOI: 10.1101/2025.09.25.678670 Negative / Null Result Report
Battaglia-Vieni A, Marchant V, Tejedor-Santamaria L et al. · 2025 · Preprint
Background: /Objectives: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality and increased susceptibility to progression to chronic kidney disease (CKD), especially in the…
View details →DOI: 10.20944/preprints202504.2175.v1 Negative / Null Result ReportMedicine
Amthor L, Jaeckle A, Kampmeier J et al. · 2025 · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Sitagliptin, an inhibitor of dipeptidyl peptidase-4 widely used in type 2 diabetes therapy, impairs the barrier formed by retinal endothelial cells (REC) during prolonged exposure. Because diabetic macular edema is treated with inhibitors…
View details →DOI: 10.1055/a-2708-3562 Negative / Null Result Report
Villard M, Espinosa-Carrasco G, Hernandez J · 2025 · Preprint
ABSTRACT Lymphodepletion, which is currently used as adjuvant for adoptive cytotoxic T cell immunotherapy in cancer, promotes the breakdown of peripheral CD8 + T cell tolerance. Under lymphopenic conditions, naive T cells proliferate due…
View details →DOI: 10.1101/2025.09.08.672311 Negative / Null Result Report
Kalafut KC, Cormerais Y, Cissé MY et al. · 2025 · Preprint
The nutrient-sensing mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls cellular and organismal growth and metabolism, while aberrant activation is linked to human disease, including metabolic disease. Cellular…
View details →DOI: 10.1101/2025.10.01.679861 Negative / Null Result Report
Jordhani M, Ruci D, Jordhani P et al. · 2025 · Preprint
Background: Hydroxychloroquine (HCQ) is a disease-modifying antirheumatic drug used in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other autoimmune diseases. Although HCQ reduces SARS-CoV-2 replication in vitro at…
View details →DOI: 10.20944/preprints202509.1673.v1 Negative / Null Result Report
Ryan BC, Griffith KE, Geczi CN et al. · 2025 · Preprint
Stargardt disease (STGD1) is the most common inherited macular dystrophy, caused by loss-of-function mutations in ABCA4 that result in bisretinoid-containing lipofuscin accumulation in the retinal pigment epithelium (RPE), and progressive…
View details →DOI: 10.1101/2025.10.25.684461 Negative / Null Result ReportOpen accessMedicine
Caltabiano A, Voruganti A, Nesi J et al. · 2026 · JMIR serious games
Background Exposure and response prevention is a first-line intervention for obsessive-compulsive disorder (OCD), yet many individuals with contamination concerns do not access care. Virtual reality exposure-based therapy (VRET) may…
View details →DOI: 10.2196/78169 Negative / Null Result Report
Rau KK, Harrison BJ, Venkat G et al. · 2025 · Preprint
Pain resulting from tissue damage, including surgical incision, is often only partially responsive to standard treatments focusing on inflammation, suggesting additional mechanisms are involved. Tissue damage leads to expression in dorsal…
View details →DOI: 10.1101/2025.02.11.637320 Negative / Null Result Report
Heller DT, Benites NM, Amick EM et al. · 2025 · Preprint
Pre-sensory (ps), peripherally-generated spontaneous activity (SA) is important for establishing basic topography of central components of sensory pathways. However, roles for psSA in sculpting connections at the single neuron level and in…
View details →DOI: 10.1101/2025.08.28.672917 Negative / Null Result ReportMedicine
Kik OE, Zaviska F, Lesage G et al. · 2026 · Water research
This study investigated the electro-oxidation (EO) of three priority micropollutants: carbamazepine (CBZ), diuron (DIU), and perfluorooctane sulfonate (PFOS), in secondary-treated wastewater using boron-doped diamond (BDD) anodes. Although…
View details →DOI: 10.1016/j.watres.2025.125158 Negative / Null Result ReportMedicine
Bidon M, Saito T, Skjaerven KH et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)
Methylmercury (MeHg) is a pervasive neurotoxicant threatening aquatic ecosystems. Selenium (Se) has been reported to protect fish against the adverse MeHg toxicity, yet molecular investigations of their interaction in the brain remain…
View details →DOI: 10.1016/j.aquatox.2026.107706 Negative / Null Result ReportMedicine
Birsen I, Erdogan K, Ozsoy O et al. · 2026 · Tissue & cell
Inflammatory bowel disease (IBD) is a systemic condition that can also lead to extraintestinal complications, including liver damage. Disruptions in the gut-liver axis and inflammatory mediators play a key role in this process. Apelin, a…
View details →DOI: 10.1016/j.tice.2025.103276 Negative / Null Result ReportMedicine
Dai T, Dai Q, Ding Y et al. · 2026 · Neurochemical research
Conversion of microglia to a branching state is considered a potential strategy to ameliorate neuroinflammation. Inhibition of histone deacetylases (HDACs) may convert microglia to a branching state and thus prevent neuroinflammation.…
View details →DOI: 10.1007/s11064-026-04688-9 Negative / Null Result Report
Abhyankar SD, Luo Q, Hartman GD et al. · 2025 · Preprint
The APOE genotype influences metabolic and neurodegenerative outcomes, with APOE4 carriers at higher risk for Alzheimer’s disease (AD) and metabolic dysfunction. This study examines how long-term dietary interventions affect systemic…
View details →DOI: 10.1101/2025.07.30.667671 Negative / Null Result ReportMedicine
Pavicich MA, Maldonado ML, Nguyen TN et al. · 2025 · International Journal of Food Microbiology
Apple fruit is widely consumed worldwide, but fungal contamination in the postharvest stage presents a significant food safety concern. This study evaluates the production and accumulation of Alternaria mycotoxins, including alternariol…
Negative / Null Result ReportMedicine
Hoe B, Heimbürger SMN, Gasbjerg LS et al. · 2026 · Diabetes, obesity & metabolism
Aims In type 1 diabetes, glucose-dependent insulinotropic polypeptide (GIP) increases glucagon secretion during low plasma glucose and improves time in the glycaemic range during daytime. To explore the glucose-stabilising potential of GIP…
View details →DOI: 10.1111/dom.70373 Negative / Null Result ReportMedicine
Seekings AH, Billington E, Mahmood S et al. · 2026 · Virology
H7N7 low-pathogenicity avian influenza virus (H7N7-LPAIV) incursions preceded emergence of H7N7 high-pathogenicity (HP)AIV at several European layer hen outbreaks. Evidence from a UK layer H7N7-HPAIV (2008) outbreak informed in vivo…
View details →DOI: 10.1016/j.virol.2025.110733 Negative / Null Result ReportMedicine
Carvalho AVS, Hoeper ES, Dúran-Carabali LE et al. · 2026 · The Journal of nutritional biochemistry
Neonatal hypoxia-ischemia (HI) is one of the main causes of perinatal death and is commonly associated with neurological damage which are usually observed on motor and cognitive domains. Plinia trunciflora or "jabuticaba" is a native…
View details →DOI: 10.1016/j.jnutbio.2025.110162 Negative / Null Result ReportMedicine
Nair-Shalliker V, Smith DP, Gebski V et al. · 2026 · British journal of cancer
Background The ProsD trial aimed to determine if oral vitamin D supplementation could prevent prostate cancer (PC) progression in men on active surveillance (AS). Methods ProsD is a phase-II double-blinded randomized trial of newly…
View details →DOI: 10.1038/s41416-025-03278-w Negative / Null Result ReportOpen accessMedicine
Gu Q, Silva CS, Twaddle NC et al. · 2026 · International journal of molecular sciences
Arsenic induces apoptosis in both cancerous and non-cancerous cells. The mechanism of arsenic-induced apoptosis is complex. We previously demonstrated that the antioxidant acetyl L-carnitine prevented sodium arsenite-induced apoptosis in…
View details →DOI: 10.3390/ijms27073263 Negative / Null Result Report
Nguyen PV, Vu DM, Do BN et al. · 2025 · Preprint
(1) Malaria remains a significant health threat to military and civilian personnel de-ployed to endemic regions. Despite recommended chemoprophylaxis, compliance var-ies substantially, potentially impacting clinical outcomes when…
View details →DOI: 10.20944/preprints202509.0966.v1 Negative / Null Result Report
Frühaf J, Bartoníček J, Fojtík P et al. · 2026 · Preprint
Abstract Purpose The aim of this study is to describe the basic pathoanatomical characteristics of a stable Maisonneuve fracture and mid-term results of its nonoperative treatment. Methods The study included 17 prospectively collected…
View details →DOI: 10.21203/rs.3.rs-9048287/v1 Negative / Null Result ReportMedicine
Mori K, Asahi T, Kataoka K et al. · 2025 · Biochemical and biophysical research communications
Mechanical stretch critically influences skeletal muscle physiology, yet its role in myoblast differentiation and the associated molecular mechanisms have not been fully clarified. This study investigated the effects of uniaxial cyclic…
View details →DOI: 10.1016/j.bbrc.2025.152350 Negative / Null Result ReportMedicine
Khajehzadehshoushtar S, Delfinis LJ, Rahman FA et al. · 2025 · The Journal of physiology
The degree to which mitochondrial-linked programmed cell death pathways contribute to skeletal muscle atrophy during cancer remains unknown. Here we combined a novel and robust mouse model of metastatic ovarian cancer with chronic…
View details →DOI: 10.1113/jp287912 Negative / Null Result ReportMedicine
Yin R, Fredenburgh JC, Weitz JI · 2025 · Journal of thrombosis and haemostasis : JTH
Background Milvexian, an oral factor (F)XIa inhibitor, is undergoing phase 3 evaluation for acute coronary syndrome. Such patients often require percutaneous coronary intervention (PCI). The PCI catheters trigger clotting by inducing…
View details →DOI: 10.1016/j.jtha.2025.06.028 Negative / Null Result ReportOpen accessMedicine
Drumeva GO, Plane AF, Petrenyov DR et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Ivabradine (IVAB) is an effective drug in patients with heart failure (HF). However, data in the context of chemotherapy-induced cardiomyopathy are limited. This study investigated the cardioprotective potential of IVAB in a…
View details →DOI: 10.1186/s40959-026-00469-z Negative / Null Result ReportOpen accessMedicine
Romanelli MA, Nogueira-Souza PD, Gomes DS et al. · 2026 · ACS omega
Snakebite-induced acute kidney injury (sAKI) is a severe clinical complication associated with Bothrops envenomation that can lead to kidney failure. Alternative therapies are needed due to the limitations of antivenom, including variable…
View details →DOI: 10.1021/acsomega.5c09974 Negative / Null Result Report
Gordon-Fennell L, Farero R, Jones J et al. · 2025 · Preprint
ABSTRACT Uncovering the neurobiological processes underlying substance use disorder informs future therapeutic interventions. Prior research implicates the corticotropin releasing factor (CRF) system as a major player in a wide variety of…
View details →DOI: 10.1101/2025.02.25.640140 