Negative / Null Result ReportOpen accessPsychology
Aiste Dirzyte, Aidas Perminas, Aiste Skarnulyte et al. · 2024 · European Journal of Mental Health
Introduction: While personality traits and early maladaptive schemas (EMSs) can affect an individual’s behavior and well-being, the links between these constructs are under-researched, especially in non-clinical samples. Aims: Two studies were conducted to address these links, intending to explore their specifics, as previous research evidenced various associations’ models. Methods: In Study 1, the sample consisted of 120 respondents (65.0% females) living in the UK and the USA. In Study 2, the sample consisted of 244 respondents (68.0% females) living in Lithuania. In both studies, most of th
Negative / Null Result ReportOpen accessMedicine
Nicholette D Palmer, Lingyi Lu, Thomas C Register et al. · 2021 · PLoS ONE
Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher 1,25-dihydroxyvitamin D (1,25(OH)2D3) concentrations and bone mineral density (BMD), and paradoxically reduced burdens of calcified atherosclerotic plaque (subclinical atherosclerosis). To identify genetic factors contributing to vitamin D and BMD measures, association analysis of >14M variants was conducted in a maximum of 697 African American-Diabetes Heart Study participants with type 2 diabetes (T2D). The most significant association signals w
View details →DOI: 10.1371/journal.pone.0251423 Negative / Null Result ReportOpen accessMedicine
Jianxun Fang, Yuze Cao, Jun Ni · 2024 · European Journal of Medical Research
Abstract Background Intracranial aneurysm (IA) accounts for a substantial source of non-traumatic subarachnoid hemorrhage, with inflammation postulated as a potential factor in its pathogenesis. The present study aims at evaluating the association between circulating inflammatory cytokines and risk of IA under a bidirectional two-sample Mendelian randomization (MR) design. Methods For primary analysis, summary statistics of inflammatory regulators was obtained from a genome-wide association study (GWAS) comprising 8293 Finnish participants. Summary data of IA were extracted from a GWAS which c
View details →DOI: 10.1186/s40001-023-01609-2 Failed Experiment ReportOpen accessMedicine
Nicholas J Douville, Lisa Bastarache, Emily Bertucci-Richter et al. · 2024 · PLoS ONE
Background Kidney dysfunction is a common complication in septic patients. Studies have identified numerous risk factors for sepsis-associated acute kidney injury (S-AKI), yet there is wide variability in the incidence even among patients with similar risk factors, suggesting the presence of additional uncharacterized risk factors, including genetic differences. The expansion of biobanks, advances in genotyping, and standardized diagnostic criteria have enabled large-scale, hypothesis-generating studies into the genetic mechanisms underlying S-AKI. We hypothesize that the genetic pathway behin
View details →DOI: 10.1371/journal.pone.0311318 Negative / Null Result ReportOpen accessMedicine
Franziska Emmerling, Carolien Martijn, Hugo J E M Alberts et al. · 2017 · PLoS ONE
Cognitive effort and self-control are exhausting. Although evidence is ambiguous, behavioural studies have repeatedly suggested that control-demanding tasks seem to deplete a limited cache of self-regulatory resources leading to performance degradations and fatigue. While resource depletion has indirectly been associated with a decline in right prefrontal cortex capacity, its precise neural underpinnings have not yet been revealed. This study consisted of two independent experiments, which set out to investigate the causal role of the right dorsolateral prefrontal cortex (DLPFC) in a classic d
View details →DOI: 10.1371/journal.pone.0174331 Negative / Null Result ReportOpen accessPsychology
Alberto Manzi, Yana Durmysheva, Shannon K. Pinegar et al. · 2019 · Frontiers in Psychology
Recent research by Vohs et al. (2013) garnered media attention after reporting that disordered environments increase creativity. The present research was designed to conceptually replicate and extend this finding by exploring the effect of workspace disorder on creativity. Participants were randomly assigned to work at a neatly organized (Order condition) or a messy desk (Disorder condition), where they completed several paper-and-pencil and computerized tasks, including two validated creativity measures (Abbreviated Torrance Test for Adults; ATTA; Goff and Torrance, 2002; Alternative Uses Tas
View details →DOI: 10.3389/fpsyg.2018.02662 Failed Experiment ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Carlos Cruchaga, Jose M. Vidal-Taboada, Mario Ezquerra et al. · 2009 · Neurobiology of Disease
Two different H1 sub-haplotypes at chromosome 17q21, H1C and H1E′A, have been associated with progressive supranuclear palsy (PSP) and cortical basal degeneration (CBD). We analyzed the SNPs included in the H1C and H1E′A haplotypes in a large Spanish PSP/CBD series and their interaction with age at onset (AAO). Survival analysis of rs1880753 marker was consistently associated with disease risk and with an earlier age at onset under an additive model. Its location at 160 kb and 50 kb upstream of tau and CRHR1 genes, respectively, suggests that it might act as a cis-element that regulates gene e
View details →DOI: 10.1016/j.nbd.2008.09.027 Negative / Null Result ReportOpen accessMedicine
Toshiki Saito, Kosuke Motoki, Rui Nouchi et al. · 2019 · PLoS ONE
Emotion plays important and diverse roles across various social relations. Although the social functions of emotion have attracted increased attention, the effects of positive emotions such as pride on impression formation remain poorly understood. Drawing on social projection theory, this study examined how incidental experiences of pride influenced the impressions of those who made a blunder, along with two other characteristics: the person's warmth and competence. Participants were designated randomly to receive inductions of pride, awe, or a neutral emotion. Subsequently, they were asked t
View details →DOI: 10.1371/journal.pone.0220883 Negative / Null Result ReportOpen accessMedicine
Nicholas P Carruth, Jairo A Ramos, Akira Miyake · 2023 · PLoS ONE
This article reports a preregistered study in which we attempted to replicate the results of an influential study on the ego-depletion effect reported by Job, Dweck, and Walton in 2010. The original Job et al. study (Study 1, N = 60) provided evidence that the ego-depletion effect-a performance decrease on a self-control task after performing another self-control task-occurs only for individuals who hold a belief that their willpower is limited. This moderation of the ego-depletion effect by one's willpower mindset (limited vs. nonlimited) has been interpreted as evidence against a prevalent l
View details →DOI: 10.1371/journal.pone.0287911 Negative / Null Result ReportOpen accessBiotechnology
Haoyang Zhao, Mengfan Yang, Yujiao Liu et al. · 2025 · npj Microgravity
Abstract Disuse osteoporosis, caused by mechanical unloading, is linked to dysregulated TGFβ and BMP signaling. This study explores their roles and evaluates BMP9 as a potential therapy. A hindlimb unloading (HLU) mouse model was used to assess bone changes and signaling alterations. In vitro, a Rotary Cell Culture System (RCCS) with 3D printing simulated microgravity. BMP9 was overexpressed in bone marrow stromal cells (BMSCs) and osteocytes treated with TGFβ1. HLU mice showed reduced bone density, microstructural integrity, and dysregulated signaling (increased p-Smad2/3, decreased p-Smad1/5
View details →DOI: 10.1038/s41526-025-00510-y Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Daniel Wiswede, Jascha Rüsseler · 2021 · Frontiers in Human Neuroscience
Introduction: The present study was conducted to verify a promising experimental setup which demonstrated an inversed Stroop-effect (much faster responses for incongruent relative to congruent Stroop trials) following a mismatching tone. In the matching condition, which was an almost exact replication of the original study, participants were required to indicate whether word color and word meaning were matching, whereas in the response conflict condition, instruction was the same as in a classical Stroop task and required the participants to respond to the word color. As in the original study,
View details →DOI: 10.3389/fnhum.2021.680885 Methods Dead-EndOpen accessMedicine (General)
Di Benedetto M, Greenwood KM, Isaac F · 2012 · Patient Preference and Adherence
Fadia Isaac1, Kenneth Mark Greenwood2, Mirella Di Benedetto31Cairnmillar Institute School of Psychology Counselling and Psychotherapy, Camberwell, Victoria, Australia; 2School of Psychology and Social Science Faculty of Computing, Health and Science, Edith Cowan University, Joondalup, Western Australia, Australia; 3School of Health Sciences, Royal Melbourne Institute of Technology University, Bundoora, Victoria, AustraliaBackground: Individuals’ attitudes towards depression and its treatments may influence their likelihood of seeking professional help and adherence to treatment when depr
Negative / Null Result ReportOpen accessMedicine
Cherubino Paolo, Sala Andrea, Casalone Rosario et al. · 2005 · Journal of Translational Medicine
Abstract Background Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblasts has been associated with improved contractile function in animal models and in humans with acute myocardial ischemia. Since heart infarction is most prevalent in individuals of over 40 years of age, we tested whether culture methods available in our laboratory were adequate to obtain sufficient numbers of differentiated skeletal myoblasts from muscle biopsy specimens
View details →DOI: 10.1186/1479-5876-3-21 Negative / Null Result ReportOpen accessPsychology
A. Norvilas, Miller J. C. · 2010 · Psichologija
D. Fernandez-Duque ir I. M. Thornton (2000) tariamai atrado, kad asmuo gali užfiksuoti pakitimą ir be sąmonės įsiterpimo. Tačiau šį atradimą gerokai menkina vienas pačių autorių pripažintas metodologinis trūkumas – kontrolinių bandymų nebuvimas. Siekdami tiksliau nustatyti, ar norint pastebėti pakitimą reikia sąmonės tarpininkavimo, ar jo užfiksavimas gali vykti ir be sąmonės įsiterpimo, dar kartą tyrėme, kaip matomame objekte aptinkamas pasikeitimas, tačiau šį kartą tyrėmė dvejopai: vienu atveju be kontrolinių bandymų, kaip ir D. Fernandez-Duque ir I. M. Thorntonas, o kitu atveju atlikome ir
View details →DOI: 10.15388/psichol.2010.0.2574 Negative / Null Result ReportOpen accessInternal medicine
Elisabeth A. Rosenthal, David R. Crosslin, Adam S. Gordon et al. · 2021 · BMC Medical Genomics
Abstract Background Elevated triglycerides (TG) are associated with, and may be causal for, cardiovascular disease (CVD), and co-morbidities such as type II diabetes and metabolic syndrome. Pathogenic variants in APOA5 and APOC3 as well as risk SNVs in other genes [APOE (rs429358, rs7412), APOA1/C3/A4/A5 gene cluster (rs964184), INSR (rs7248104), CETP (rs7205804), GCKR (rs1260326)] have been shown to affect TG levels. Knowledge of genetic causes for elevated TG may lead to early intervention and targeted treatment for CVD. We previously identified linkage and association of a rare, highly cons
View details →DOI: 10.1186/s12920-020-00854-2 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Zhou Tao, Han Yanxing, Dang Ying et al. · 2009 · Retrovirology
Abstract Background Isolation of novel retroviral restriction factors will open new avenues for anti-HIV/AIDS treatment. Although HIV-1 replication is restricted by APOBEC3G/APOBEC3F, TRIM5α, and CD317, none defend HIV-1 infection under natural conditions. Previously, we demonstrated a host factor from the human T cell line CEM.NKR that potently restricted wild-type HIV-1 replication. Interestingly, this restriction resembled the APOBEC3G/APOBEC3F pattern in that viral replication was inhibited from the second round of replication cycle at a post-entry step. Results Here, we further characteri
View details →DOI: 10.1186/1742-4690-6-31 Negative / Null Result ReportOpen accessMedicine
Marta Schirripa, Wu Zhang, Dongyun Yang et al. · 2018 · PLoS ONE
BACKGROUND:Macrophages play a crucial role in the interaction between tumor and immune system, and iNOS is known as a surrogate marker of M1 macrophages activation. The goal of the study was to investigate the role of iNOS polymorphisms as prognostic marker in mCRC patients. MATERIALS AND METHODS:Functional significant polymorphisms in the promoter of INOS gene were analyzed by PCR-based and direct DNA sequencing in 4 cohorts of patients receiving bevacizumab based first-line chemotherapy: two evaluation cohorts (TRIBE ARM A and ARM B) and two validation cohorts (FIRE 3 arm A and MOMA). The re
View details →DOI: 10.1371/journal.pone.0193640 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Megan Polden, Trevor J. Crawford · 2022 · Brain Sciences
It has been reported that performing bilateral eye movements for a short period can lead to an enhancement of memory retrieval and recall (termed the “saccade induced retrieval effect (SIRE)”). The source of this effect has been debated within the literature and the phenomenon has come under scrutiny as the robustness of the effect has recently been questioned. To date investigations of SIRE have largely been restricted to younger adult populations. Here, across two experiments, we assess the robustness and generalisability of the SIRE specifically in relation to disease and ageing. Experiment
View details →DOI: 10.3390/brainsci12101299 Negative / Null Result ReportOpen accessMedicine
Nicholas P. Carruth, Jairo A. Ramos, Akira Miyake · 2023 · PLoS ONE
This article reports a preregistered study in which we attempted to replicate the results of an influential study on the ego-depletion effect reported by Job, Dweck, and Walton in 2010. The original Job et al. study (Study 1, N = 60) provided evidence that the ego-depletion effect—a performance decrease on a self-control task after performing another self-control task—occurs only for individuals who hold a belief that their willpower is limited. This moderation of the ego-depletion effect by one’s willpower mindset (limited vs. nonlimited) has been interpreted as evidence against a prevalent l
Negative / Null Result ReportOpen accessMotor vehicles. Aeronautics. Astronautics
Azadeh DinparastDjadid, John D. Lee, Chris Schwarz et al. · 2018 · International Journal of Automotive Engineering
Vehicles with SAE Level 2 or 3 automation rely on the driver to intervene and resume control when failures occur. In cases which the driver must steer upon regaining control, the initial conditions of the vehicle’s state variables can affect the success of the drivers' recovery. Hence, a model to determine the consequences of these initial states could help identify the requirements of shared control to guarantee a smooth recovery after an automation failure. Such a modeling tool should be simple, such as a two-point visual continuous control model of steering. Data to validate such a model we
View details →DOI: 10.20485/jsaeijae.9.4_208 Negative / Null Result ReportOpen accessMedicine
Danni A. Gadd, Hannah M. Smith, Donncha Mullin et al. · 2024 · Clinical Epigenetics
Abstract Background Plasma growth differentiation factor 15 (GDF15) and N‐terminal proB‐type natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-proBNP may provide new routes for risk stratification. Results In the Generation Scotland cohort (N ≥ 16,963), GDF15 levels were associated with incident dementia, ischaemic stroke and type 2 diabetes, whereas NT-proBNP levels were associated with incident ischaemic heart disease, ischaemic stroke and type 2 diabetes (all PFDR 95%) with levels of GDF15 an
View details →DOI: 10.1186/s13148-024-01734-7 Negative / Null Result ReportOpen accessPhysiology
Mahmoud A. Mohammad, Inka C. Didelija, Barbara Stoll et al. · 2020 · Physiological Reports
Abstract Background Age‐dependent changes in the intestinal gene expression of enzymes involved in the metabolism of citrulline and arginine are well characterized. Enteroids, a novel ex‐vivo model that recreates the three‐dimensional structure of the intestinal crypt‐villus unit, have shown to replicate molecular and physiological profiles of the intestinal segment from where they originated (“location memory”). Objective The present study tested the hypothesis that enteroids recapitulate the developmental changes observed in vivo regarding citrulline production in pigs (“developmental memory
View details →DOI: 10.14814/phy2.14565 Negative / Null Result ReportOpen accessInternal medicine
Banasik Karina, Hollensted Mette, Andersson Ehm et al. · 2012 · BMC Medical Genetics
Abstract Background Variations within the FOXA family have been studied for a putative contribution to the risk of type 2 diabetes (T2D), and recently the minor T-allele of FOXA2 rs1209523 was reported to associate with decreased fasting plasma glucose levels in a study using a weighted false discovery rate control procedure to enhance the statistical power of genome wide association studies in detecting associations between low-frequency variants and a given trait. Thus, the primary aim of this study was to investigate whether the minor T-allele of rs1205923 in FOXA2 associated with 1) decrea
View details →DOI: 10.1186/1471-2350-13-10 Negative / Null Result ReportOpen accessPsychology
Aiste DIRZYTE, Aidas PERMINAS, Aiste SKARNULYTE et al. · 2024 · European Journal of Mental Health
Introduction: While personality traits and early maladaptive schemas (EMSs) can affect an individual’s behavior and well-being, the links between these constructs are under-researched, especially in non-clinical samples. Aims: Two studies were conducted to address these links, intending to explore their specifics, as previous research evidenced various associations’ models. Methods: In Study 1, the sample consisted of 120 respondents (65.0% females) living in the UK and the USA. In Study 2, the sample consisted of 244 respondents (68.0% females) living in Lithuania. In both studies, most of th
View details →DOI: https://doi.org/10.5708/ejmh.19.2024.0015 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Nikola Jajcay, David Tomeček, Iveta Fajnerová et al. · 2026 · Frontiers in Computational Neuroscience
An increasing number of studies are currently focusing on “personality neuroscience,” a term denoting the research aimed at neuroimaging correlates of inter-individual temperament and character variability. Among other methods, a graph theoretical analysis of the functional connectivity in resting-state functional magnetic resonance imaging data was applied in a study by, reporting novel functional connectivity correlates of personality traits. The current paper presents a conceptual replication of the results of this study and discusses the related challenges, including an extension of the or
View details →DOI: 10.3389/fncom.2026.1796308 Negative / Null Result ReportOpen accessMedicine
Kim JS · 2026 · Journal of exercise rehabilitation
This study analyzed the effects of an 8-week Pilates exercise program on health-related physical fitness and spinal morphology in female college students. As a result of performing 8 weeks of Pilates exercise program, there was a…
View details →DOI: 10.12965/jer.2652170.085 Negative / Null Result ReportOpen accessMedicine
Muhammad Muaaz Aslam, Peter John, Kang-Hsien Fan et al. · 2019 · BMC Research Notes
Abstract Objective Type 1 diabetes (T1D) and rheumatoid arthritis (RA) are autoimmune diseases. It is known that certain genetic loci and factors that increase the overall autoimmunity risk can be shared among different autoimmune diseases. We sought to replicate seven T1D-related SNPs (single nucleotide polymorphisms) that have been previously reported to be associated with RA susceptibility in a small set of mixed family-based and case–control Pakistani sample in a relatively large and independent RA case–control sample from the same population. Seven T1D-associated SNPs (GLIS3/rs7020673, BA
View details →DOI: 10.1186/s13104-019-4590-8 Negative / Null Result ReportOpen accessPsychiatry
Jonas Weijers, Jonas Weijers, Wolfgang Viechtbauer et al. · 2018 · Frontiers in Psychiatry
A previous study observed that reported childhood abuse moderated psychotic and emotional reactivity to stress among patients with non-affective psychotic disorder. However, that study used a type of analysis unsuited for skewed data. This study aimed (1) to replicate the study and (2) to examine whether we would obtain similar results using a statistical approach better suited to skewed data. Fifty-nine patients with non-affective psychotic disorder were examined for up to 6 days using an intensive diary method to assess levels of negative affect, psychosis, and daily-life stress. A mixed-lin
View details →DOI: 10.3389/fpsyt.2018.00639 Negative / Null Result ReportOpen accessDentistry
Damla Erkal, Turgut Felek, Oana-Paula Butean et al. · 2025 · BMC Oral Health
Abstract Introduction This study hypothesized that large language models (LLMs) would underperform compared to expert clinicians in diagnosing and managing complex endodontic anomalies, such as dens invaginatus, when provided with periapical radiographs. Although LLMs have shown promise in dental education and basic diagnostics, their effectiveness in nuanced clinical reasoning has remained unclear. Methods Nineteen anonymized periapical radiographs depicting challenging endodontic conditions were paired with clinical vignettes. Six advanced LLMs and one expert endodontist independently answer
View details →DOI: 10.1186/s12903-025-06987-z Negative / Null Result ReportOpen accessBiology (General)
Sahaana Chandran, Jan Vinjé, Kimberly Huynh et al. · 2026 · Applied and Environmental Microbiology
ABSTRACT Human intestinal enteroid (HIE) and zebrafish larva (ZF) models support the replication of certain strains of human norovirus (HuNoV), the leading cause of viral gastroenteritis worldwide. The replication of 17 HuNoV-positive stool specimens (nine genotypes) from patients ranging from 5 months to 83 years old was evaluated in both HIE and ZF models. The yolk of 3-day post-fertilization ZF larvae was microinjected with 3 nL 10% clarified stool suspension. Each day post-infection (dpi), 10 larvae were pooled as one sample, and two specimens were collected daily until 5 dpi. Viral RNA wa
View details →DOI: 10.1128/aem.00152-26 