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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21309 results · page 384 of 711

Methods Dead-EndMedicine

Prospective evaluation of the CASST score to guide elective tracheostomy following oral cancer surgery: challenges and clinical misalignment.

Gulamani A, Shamim F, Khan S et al. · 2026 · International journal of oral and maxillofacial surgery

The Clinical Assessment Scoring System for Tracheostomy (CASST) was developed to predict the need for elective tracheostomy in head and neck cancer surgery, but evidence on its external performance remains limited. This prospective study…

View details →DOI: 10.1016/j.ijom.2026.04.009
Methods Dead-EndMedicine

Propensity Score-Matched Comparison of Patient-Reported Outcomes Between Crowe I Developmental Dysplasia of the Hip and Primary Osteoarthritis Following Total Hip Arthroplasty.

Saluja A, Eschert J, Ren R et al. · 2026 · The Journal of arthroplasty

Background Total hip arthroplasty (THA) is commonly performed for Crowe I developmental dysplasia of the hip (DDH) and primary osteoarthritis (OA), but comparative survivorship and patient-reported outcome measure (PROM) data remain…

View details →DOI: 10.1016/j.arth.2026.06.023
Negative / Null Result ReportOpen accessMedicine

Residential radon exposure and lung cancer histology and stage: a population-based ecological study in Central Germany.

Ernst P, Rachow T, Henn S et al. · 2026 · Journal of cancer research and clinical oncology

Purpose Residential radon exposure is recognised as one of the leading environmental risk factors for lung cancer and acts synergistically with tobacco smoking. Thuringia, Germany, exhibits high geogenic radon potential; however,…

View details →DOI: 10.1007/s00432-026-06524-7
Negative / Null Result ReportMedicine

The impact of drains on postoperative seroma and infection after mastectomy: A retrospective study in Danish women with breast cancer.

Palshof FK, Korsholm RHR, Duriaud HM et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Postoperative drains are commonly used after mastectomy to reduce seroma formation, but evidence of the benefit remains unclear. We evaluated the effect of postoperative drains on seroma formation and infection after…

View details →DOI: 10.1016/j.ejso.2026.111970
Negative / Null Result ReportMedicine

Hematopoietic progenitor cells (HPCs) mobilization following high-intensity interval exercise in cancer patients undergoing bone marrow transplantation: preliminary results from a randomized controlled trial.

Zarekar T, Ahmadizad S, Hajifathali A et al. · 2026 · Stem cell research & therapy

Background and objective Hematopoietic progenitor cells (HPCs) mobilization is essential for successful bone marrow transplantation but may be impaired in cancer patients due to prior treatments. High-intensity interval exercise (HIIE) has…

View details →DOI: 10.1186/s13287-026-05084-4
Negative / Null Result ReportMedicine

Amplicon sequencing reveals impact of imidacloprid residues on diversity profile of grape fructosphere microbiota.

Deore P, Upadhyay A, Thekkumpurath AS et al. · 2026 · World journal of microbiology & biotechnology

In grape, fructosphere microbiota play an important role in nutrient cycling, pathogen suppression, berry quality, and fermentation processes. Insecticide imidacloprid (IM) is used to manage several insect pests of grape. However, the…

View details →DOI: 10.1007/s11274-026-05095-6
Negative / Null Result ReportMedicine

Reliability and readability of five AI chatbots for concussion health advice across retrieval augmented and pretrained models.

Huang H, Zhang C, Hu H et al. · 2026 · Scientific reports

Generative AI is rapidly entering patient education workflows, yet its safety profile for concussion management remains undefined. Utilizing the CHART framework, this cross-sectional audit assessed five platforms, specifically isolating…

View details →DOI: 10.1038/s41598-026-51281-9
Negative / Null Result ReportMedicine

Clinical Outcome of EMG-Based Pelvic Floor Biofeedback in Patients With Constipation-Impact of Prior Anorectal Manometry/Balloon Expulsion Test for Patient Selection. A Retrospective Study.

Kochhar S, Channapragada T, Shenoy V et al. · 2026 · Neurogastroenterology and motility

Introduction Pelvic floor biofeedback therapy (BFT) is the mainstay treatment for dyssynergic defecation, a condition defined by the Rome criteria. This retrospective study compares outcomes between patients referred for EMG-based BFT…

View details →DOI: 10.1111/nmo.70373
Negative / Null Result ReportMedicine

Autonomous dental implant robotics for transcrestal maxillary sinus floor elevation: workflow development and clinical trueness evaluation.

Qian J, Zi-Zheng W, Teng X et al. · 2026 · BMC oral health

Purpose To evaluate the trueness and safety of an autonomous dental implant robotic system (ADIRS) for transcrestal maxillary sinus floor elevation (TSFE), to compare outcomes between flat and sloped sinus floor morphologies, and to…

View details →DOI: 10.1186/s12903-026-08381-9
Negative / Null Result ReportOpen accessMedicine

Spinal Versus General Anesthesia for Lumbar Discectomy: Patient-Centered Analysis of Satisfaction with Anesthesia Service.

Rimaitis M, Bilskienė D, Rimaitis K et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives: Spinal (SA) and general anesthesia (GA) are both available for lumbar disc hernia (LDH) surgery. Patient satisfaction with anesthesia service is under-investigated and may help identify areas requiring…

View details →DOI: 10.3390/medicina62030524
Negative / Null Result ReportMedicine

Short Versus Extended Duration of Triple Antithrombotic Therapy After Percutaneous Coronary Intervention in Patients Requiring Oral Anticoagulation: A Retrospective Single-Center Study.

Kurpad KP, Vorla M, Bin-Farooq T et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background Balancing ischemic and bleeding risks in patients undergoing percutaneous coronary intervention (PCI) who require anticoagulation remains a clinical challenge. While dual antithrombotic therapy (DAT) with a P2Y12 inhibitor and…

View details →DOI: 10.1002/ccd.70667
Negative / Null Result ReportMedicine

Pediatric Robotic Cochlear Implantation: Hearing Outcomes.

Marie A, Leclere JC, Fleming Y et al. · 2026 · Audiology & neuro-otology

Introduction Cochlear implantation is the standard of care for children with severe-to-profound sensorineural hearing loss, offering substantial improvements in speech intelligibility, tonal audiometry perception, language acquisition, and…

View details →DOI: 10.1159/000551887
Negative / Null Result ReportMedicine

Coronary artery calcium and multiparametric cardiovascular risk assessment in non-dialysis chronic kidney disease.

Đuran I, Komazec N, Ljubičić B et al. · 2026 · Biomolecules & biomedicine

Cardiovascular disease is a leading cause of mortality in chronic kidney disease (CKD), but whether impaired renal function independently increases coronary artery calcium (CAC) burden in patients with comparable cardiovascular referral…

View details →DOI: 10.17305/bb.2026.14105
Negative / Null Result ReportMedicine

Generativity in Physician Assistants: Insights Amid a Preceptor Shortage.

Chung K · 2026 · The journal of physician assistant education : the official journal of the Physician Assistant Education Association

Introduction Amid a preceptor shortage, this pilot study examined the relationship between generativity, a psychosocial construct reflecting concern for guiding the next generation, and demographic characteristics among physician…

View details →DOI: 10.1097/jpa.0000000000000751
Negative / Null Result ReportMedicine

Tigecycline Use in Pediatrics: A Comprehensive Analysis of Clinical, Laboratory, and Microbiological Factors.

Arga G, Öcal D, Özdemir H et al. · 2026 · Turkish archives of pediatrics

Objective This study aimed to evaluate the indications and clinical and microbiological outcomes of tigecycline use in pediatric patients and to analyze the factors associated with treatment success and mortality. Methods The patients…

View details →DOI: 10.65717/turkarchpediatr.2026.25440
Negative / Null Result ReportOpen accessMedicine

Effectiveness of dexmedetomidine versus fentanyl on postoperative pain and recovery after pediatric tonsillectomy: A retrospective cohort study.

Jallad M, AlAnazi B, Aloqbawi A et al. · 2026 · Saudi journal of anaesthesia

Background Pediatric tonsillectomy is commonly associated with significant postoperative pain. Opioids remain a mainstay for perioperative analgesia but carry risks of respiratory depression and prolonged recovery, especially in patients…

View details →DOI: 10.4103/sja.sja_788_25
Negative / Null Result ReportMedicine

Association Between Frailty and Short-Term Treatment-Related Adverse Events in Patients With Overactive Bladder.

Iwagami S, Yamamoto H, Miyai H et al. · 2026 · Lower urinary tract symptoms

Objectives To evaluate whether frailty at treatment initiation is associated with treatment-related adverse events in patients with newly diagnosed overactive bladder (OAB). Methods This retrospective, single-center cohort study included…

View details →DOI: 10.1111/luts.70060
Negative / Null Result ReportMedicine

Species-level reporting of Coagulase-negative staphylococci with MALDI-TOF does not impact clinical outcomes.

Cebulla C, Hamdan A, Poonawala H et al. · 2026 · Diagnostic microbiology and infectious disease

Background Coagulase-negative Staphylococci (CoNS) are common blood culture contaminants, yet distinguishing true infection from contamination remains challenging. In January 2023, we implemented routine species-level CoNS reporting. This…

View details →DOI: 10.1016/j.diagmicrobio.2026.117479
Negative / Null Result ReportMedicine

Early, frequent, yet reversible: acute kidney injury after hematopoietic stem cell transplantation in pediatric Fanconi anemia and long-term renal outcomes.

Askarian F, Karimizadeh Z, Kalantari A et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Acute kidney injury (AKI) is an understudied complication in pediatric Fanconi anemia (FA) patients undergoing hematopoietic stem cell transplantation (HSCT). This study evaluates AKI incidence, risk factors, renal trajectories,…

View details →DOI: 10.1007/s00467-026-07390-8
Negative / Null Result ReportMedicine

Should nintedanib be continued after acute exacerbation of idiopathic pulmonary fibrosis? A retrospective observational study using a nationwide database in Japan.

Shuto H, Hagiwara A, Kudoh R et al. · 2026 · Respiratory medicine and research

Background Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) carries a high risk of short-term mortality, and optimal management strategies remain unclear. Although recent studies have suggested that antifibrotic therapy…

View details →DOI: 10.1016/j.resmer.2026.101293
Negative / Null Result ReportMedicine

<i>Staphylococcus aureus</i> inhibits the NLRP3 inflammasome in macrophages to varying degrees during early and late stages of infection.

Bhagat S, Kaur K, Petronglo JR et al. · 2026 · Infection and immunity

Staphylococcus aureus ( S. aureus ) is a highly virulent pathogen responsible for chronic infections such as osteomyelitis. Although its interaction with the host immune system has been widely studied, the specific role of inflammasomes in…

View details →DOI: 10.1128/iai.00200-26
Negative / Null Result ReportMedicine

Combining structural and microvascular parameters via machine learning for enhanced diagnosis of normal-tension glaucoma among highly myopic eyes: a prospective cross-sectional diagnostic accuracy study.

He CZ, Qiu Q, Lai H et al. · 2026 · BMC ophthalmology

This study aimed to evaluate whether a combination of optical coherence tomography (OCT) and OCT angiography (OCTA) parameters could improve the discrimination between clinically diagnosed normal-tension glaucoma (NTG) and non-glaucomatous…

View details →DOI: 10.1186/s12886-026-05065-4
Negative / Null Result ReportMedicine

Long-term outcomes of tacrolimus conversion to sirolimus in kidney transplant recipients: an eight-year follow-up.

Tawhari I, Park S, Yamani F et al. · 2026 · Frontiers in nephrology

Objective Calcineurin inhibitors, such as tacrolimus, are associated with long-term nephrotoxicity and renal allograft dysfunction despite evidence of improved kidney transplantation outcomes. Consequently, minimizing calcineurin inhibitor…

View details →DOI: 10.3389/fneph.2026.1813146
Negative / Null Result ReportMedicine

Chronic Mild Unpredictable Stress Selectively Downregulates Exon I Bdnf mRNA in the Rat Frontal Cortex Independently of Anhedonia.

Stepanichev M, Peregud D, Manolova A et al. · 2026 · Cell biochemistry and function

Chronic stress is often a precursor to depression. Multiple brain mechanisms underlying the development of depression involve alterations in neurotrophin signaling. In the present study, male Wistar rats were exposed to chronic mild…

View details →DOI: 10.1002/cbf.70225
Negative / Null Result ReportMedicine

The Use of Non-Contrast Abbreviated MRI for the Detection of Recurrent Hepatocellular Carcinoma in Postoperative Surveillance.

Chen J, Zhu Y, Zheng D et al. · 2026 · Journal of magnetic resonance imaging : JMRI

Background MRI is sensitive for detecting hepatocellular carcinoma (HCC), but its routine use is hindered by low accessibility. Purpose To evaluate the performance of non-contrast abbreviated MRI (NC-AMRI) alone and in combination with…

View details →DOI: 10.1002/jmri.70356
Negative / Null Result ReportMedicine

Attention Networks and Speech Disfluencies among Monolingual Dutch and Bilingual Dutch-Turkish Speaking Children: A Pilot Study.

Aslan G, Eggers K · 2026 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction This pilot study investigated whether attention skills influence speech disfluencies in school-aged children, comparing monolingual Dutch (MONO) speakers and bilingual Dutch-Turkish speakers (BIL). Disfluencies frequently…

View details →DOI: 10.1159/000551501