Negative / Null Result ReportOpen accessMedicine
Stracquadanio S, Nicolosi A, Marino A et al. · 2024 · Diagnostics (Basel, Switzerland)
Background The rise of multi-drug-resistant Gram-negative bacteria necessitates the development of new antimicrobial agents. Cefiderocol shows promising activity by exploiting bacterial iron transport systems to penetrate the outer…
View details →DOI: 10.3390/diagnostics14202318 Negative / Null Result ReportOpen accessMedicine
Bui TI, Farnsworth CW, Anderson NW · 2024 · Journal of clinical microbiology
Many emergency departments (ED) use rapid human immunodeficiency virus (HIV) antibody tests as screening tools, despite limited sensitivity for detecting acute HIV infections. In a 4-year retrospective analysis of 1,192 patients, we…
View details →DOI: 10.1128/jcm.00620-24 Negative / Null Result ReportOpen accessMedicine
Lamarre J, Wilson DR · 2025 · The Journal of experimental biology
Docosahexaenoic acid (DHA), a long-chain omega-3 fatty acid (n3-LCPUFA), is an integral component of vertebrate brains. Vertebrates maintain their DHA levels through biosynthesis using alpha-linolenic acid (ALA; omega-3 precursor) or by…
View details →DOI: 10.1242/jeb.250429 Negative / Null Result ReportOpen accessMedicine
Walker UA, Nettermann K, Walker S et al. · 2025 · PloS one
Objectives To evaluate if self-assessed rheumatic disease activity in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or ankylosing spondyloarthritis (AS) is linked to local weather. Methods In this prospective,…
View details →DOI: 10.1371/journal.pone.0333022 Negative / Null Result ReportOpen accessMedicine
Verdecchia P, Coiro S, Bartolini C et al. · 2025 · American journal of hypertension
Background Different definitions of white-coat hypertension (WCH) may explain its variable outcome across studies. Methods In an Italian study started in 1986, we followed 3,153 people with (office blood pressure (BP) >=140/90 mmHg) and…
View details →DOI: 10.1093/ajh/hpaf136 Negative / Null Result ReportMedicine
Falck RS, Cosco TD, Wister AV et al. · 2024 · Maturitas
Objectives To explore whether the association between physical activity (PA) and cognition is moderated by neighbourhood disadvantage, and whether this relationship varies with age. Study design A longitudinal analysis of the Canadian…
View details →DOI: 10.1016/j.maturitas.2024.108088 Negative / Null Result ReportMedicine
Poyntz-Wright IP, Harrison XA, Pedersen S et al. · 2024 · The Science of the total environment
Environmental DNA (eDNA) is a technique increasingly used for monitoring organisms in the natural environment including riverine macroinvertebrates. However, the effectiveness of eDNA for monitoring riverine macroinvertebrates compared…
View details →DOI: 10.1016/j.scitotenv.2024.173621 Negative / Null Result ReportMedicine
Li SL, Lin HL, Mi HF et al. · 2024 · Practical laboratory medicine
Objectives To evaluate the diagnostic performance of different brands of immunochromatographic test (ICT) reagents for Chlamydia trachomatis using homogenized samples to provide a reference for reagent quality control. Methods Eight…
View details →DOI: 10.1016/j.plabm.2024.e00412 Negative / Null Result ReportMedicine
Schilter KF, Kapoor S, Smith BA et al. · 2024 · Laboratory medicine
Objective The aim of this study was to compare the performance of direct amplification of viral nucleic acid from transport medium to extracted nucleic acid for polymerase chain reaction (PCR), sequencing, and genotyping applications.…
View details →DOI: 10.1093/labmed/lmad075 Failed Experiment ReportOpen accessMedicine
Sakaki K, Murakami T, Fujimoto H et al. · 2025 · Frontiers in endocrinology
Background Insulinomas, the most common functional pancreatic neuroendocrine tumors, cause hypoglycemia due to excessive insulin production, leading to severe clinical symptoms like coma or death. Resection surgery is the major curative…
View details →DOI: 10.3389/fendo.2025.1556813 Failed Experiment ReportOpen accessMedicine
Mac PA, Anderson KD, Dakul DA · 2026 · Scientific reports
Schistosomiasis and soil-transmitted helminthiasis elimination programmes depend heavily on microscopic diagnostics, yet these methods may fail to detect low-intensity infections that sustain transmission. Molecular techniques could reveal…
View details →DOI: 10.1038/s41598-026-44877-8 Negative / Null Result ReportMedicine
Maestrini I, Viganò A, Di Stefano G et al. · 2024 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Background The association between paroxysmal hemicrania (PH) and trigeminal neuralgia-the so-called PH-tic syndrome-has rarely been described. However, a correct diagnosis is crucial since both disorders require specific treatments.…
View details →DOI: 10.1007/s10072-024-07470-3 Negative / Null Result ReportMedicine
Craver R, Collier S, Anderson M · 2024 · Fetal and pediatric pathology
Background: We investigated the utilization of cell free microbial DNA (cfDNA) at a Children's Hospital. Materials and Methods: cfDNA results were assessed regarding the contribution to therapeutic decisions. Results: Of 80 tests on 59…
View details →DOI: 10.1080/15513815.2024.2315434 Negative / Null Result Report
Rosenzopf H, Röhrig L, Goldenberg G et al. · 2024 · Preprint
Introduction For limb apraxia ‒ a heterogeneous disorder of higher motor cognition following stroke ‒ an enduring debate has arisen regarding the existence of dissociating neural correlates for finger and hand gestures in the left…
View details →DOI: 10.1101/2024.01.23.576674 Negative / Null Result ReportMedicine
Fruhauf F, Cibula D, Kocian R et al. · 2024 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Objectives To assess the diagnostic performance of ultrasonography in pre-operative assessment of lymph nodes in patients with cervical cancer, to compare the outcomes for pelvic and para-aortic regions, and to detect macrometastases and…
View details →DOI: 10.1136/ijgc-2024-005341 Failed Experiment ReportMedicine
Li XE · 2026 · The Canadian veterinary journal = La revue veterinaire canadienne
A 3-year-old neutered male domestic shorthair cat was evaluated for hematuria. Ultrasonography and CT scanning identified moderate right-side hydronephrosis associated with right proximal and distal ureteral strictures, as well as partial…
Failed Experiment Report
Camon C, Kip E, Lord R et al. · 2026 · Preprint
Menopausal hormone therapy (MHT) is prescribed for climacteric symptoms including hot flushes and weight gain and contains estrogens such as 17 beta-estradiol (17βE2). However, estrogen receptor activation by MHT may increase reproductive…
View details →DOI: 10.64898/2026.01.26.701850 Failed Experiment ReportMedicine
Kang A, Tian X, Mi Z et al. · 2026 · Environmental science & technology
Improving carbon productivity is essential for simultaneously achieving sustainable development goals and tackling climate change. While the Global Value Chains (GVCs) division enhances productive efficiency, its impact on carbon…
View details →DOI: 10.1021/acs.est.5c12491 Negative / Null Result Report
Yamamoto Y, Takeuchi K, Tabe S et al. · 2026 · Preprint
Summary The specific contribution of tissue-resident macrophages (TRMs) to pancreatic ductal adenocarcinoma (PDAC) progression remains unclear. Here, we found that a high abundance of TRM-derived tumor-associated macrophages (TRM-TAMs) is…
View details →DOI: 10.64898/2026.05.08.723679 Negative / Null Result Report
Rajan A, Prakash S, Singh D et al. · 2026 · Preprint
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by α-Synuclein (α-Syn) aggregation, dopaminergic neuronal loss, and chronic neuroinflammation. Chlorogenic acid (CA), a dietary polyphenol abundant in…
View details →DOI: 10.64898/2026.04.19.719432 Negative / Null Result Report
Fulghum K, Hayir A, Ankeriasniemi R et al. · 2026 · Preprint
ABSTRACT Alzheimer’s disease and related tauopathies are escalating public health threats, particularly in the context of obesity and metabolic dysfunction, which accelerate cerebral glucose hypometabolism, tau pathology,…
View details →DOI: 10.64898/2026.06.03.729999 Negative / Null Result ReportMedicine
Xing L, Lu B, Zhu X et al. · 2026 · Inflammation and regeneration
Background Mesenchymal stromal cells (MSCs) possess therapeutic potential largely reliant on intact mitochondrial function to maintain reparative function. However, obesity compromises MSC metabolism and reparative capacity. MOTS-c, a…
View details →DOI: 10.1186/s41232-026-00431-7 Negative / Null Result ReportMedicine
Zheng B · 2026 · Current molecular medicine
Background/objective Patients with renal artery stenosis (RAS) exhibit increased risk of cardiovascular death and all-cause death. Our previous finding showed that the presence of RAS is associated with poor coronary collateral development…
View details →DOI: 10.2174/0115665240462936260429182901 Negative / Null Result Report
Welles JE, Garifallou JP, Gonzalez MV et al. · 2026 · Preprint
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease for which the mechanisms linking lipid dysregulation to fibrosis remain poorly defined. Hepatic phosphatidylcholine (PC) content is reduced in MASH, but…
View details →DOI: 10.64898/2026.05.13.723926 Negative / Null Result ReportMedicine
Luda KM, Agerholm M, Sonne SB et al. · 2026 · Molecular metabolism
Background White adipose tissue (WAT) plays a central role in maintaining systemic metabolic homeostasis by buffering lipid flux throughout the body. Impairment of this lipid-buffering capacity is a hallmark of obesity and has also been…
View details →DOI: 10.1016/j.molmet.2026.102394 Negative / Null Result Report
Ahlinder J, Waldmann P · 2026 · Preprint
Optimum contribution selection (OCS) balances genetic gain and inbreeding by optimizing parental contributions to the next generation, but current implementations rely on point estimates of breeding values that discard the uncertainty…
View details →DOI: 10.64898/2026.03.15.711440 Negative / Null Result Report
Aguila L, Castillo R, Pérez-García F et al. · 2026 · Preprint
Haploid embryos constitute a valuable model for genetic and epigenetic studies; however, their developmental competence is reduced compared with diploid counterparts. This study evaluated whether supplementation of the culture medium with…
View details →DOI: 10.20944/preprints202603.0776.v1 Negative / Null Result ReportMedicine
Wang H, Kang L, Mu Y et al. · 2026 · Archives of animal nutrition
Light weaning body weight (LWBW) piglets exhibit inferior growth performance, and their energy requirement vary dynamically with increasing body weight. Although high-energy diets improve growth, they risk impairing liver health.…
View details →DOI: 10.1080/1745039x.2026.2646893 Negative / Null Result ReportMedicine
Walsh RW, Meledeo MA, Nicolson SE et al. · 2026 · Transfusion
Background Hypocalcemia is correlated with poor outcomes in trauma patients and is considered the fourth component in the "diamond of death" alongside acidosis, coagulopathy, and hypothermia. Study design and methods We characterized the…
View details →DOI: 10.1111/trf.70176 Negative / Null Result ReportMedicine
Pelletier M, Yang J, Joshi M et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Background Transforming Growth Factor Beta (TGFβ) plays a dual role in cancer, acting as a tumor suppressor early in disease but promoting progression and immune evasion when dysregulated. In pancreatic ductal adenocarcinoma (PDAC),…
View details →DOI: 10.1158/1078-0432.ccr-26-0805 