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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21294 results · page 343 of 710

Negative / Null Result ReportMedicine

Type I Atelocollagen Interposition Within the ACL Graft During ACL Reconstruction: An Exploratory Clinical and MRI-Based Study.

Jung, Lee, Jung et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Atelocollagen, a purified collagen derivative, has demonstrated potential benefits in various orthopedic applications; however, its role in anterior cruciate ligament (ACL) reconstruction remains unclear. This…

View details →DOI: 10.3390/medicina62061176
Negative / Null Result ReportMedicine

Remaining Root Filling Material in Oval Canals After Retreatment Using MicroMega Remover and Reciproc Blue Systems with and Without Passive Ultrasonic Irrigation: A Micro-CT Study.

Konus, Oztekin · 2026 · Journal of clinical medicine

Background/Objectives : The aim of this study was to compare the effectiveness of the Reciproc Blue (RB) and MicroMega Remover (MR) systems in removing root canal filling material and to evaluate the effect of passive ultrasonic irrigation…

View details →DOI: 10.3390/jcm15124822
Negative / Null Result ReportMedicine

Antimicrobial effect of 1064 nm Nd:YAG laser with flat-top homogeneous beam profile on oral fungal and bacterial biofilms: an in vitro study.

Grzech-Leśniak, Pyrkosz, Szwajkowski et al. · 2026 · Lasers in medical science

This in vitro study aimed to evaluate the antimicrobial effects of a 1064 nm Nd:YAG laser delivered through a novel handpiece designed to provide a flat-top, homogeneous energy distribution profile (MarcoM handpiece) against key oral…

View details →DOI: 10.1007/s10103-026-04921-5
Negative / Null Result ReportMedicine

Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.

Alshaibani, Kamadjaja, Sitalaksmi et al. · 2026 · Journal of molecular histology

Tooth extraction is a common procedure often followed by alveolar bone resorption, which may compromise future implant placement, prosthetic rehabilitation, esthetics, and periodontal support. Hydroxyapatite-chitosan (HA-Chi) scaffolds…

View details →DOI: 10.1007/s10735-026-10874-4
Negative / Null Result ReportMedicine

Metformin and renal dosimetry in patients undergoing [ 177 Lu]Lu-PSMA therapy: reduced kidney absorbed dose without impact on tumor dosimetry.

Siegmund, Delker, Widjaja et al. · 2026 · European journal of nuclear medicine and molecular imaging

Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy (RPT) is an established treatment for advanced prostate cancer, but renal radiation exposure remains a major safety concern, as no clinically established…

View details →DOI: 10.1007/s00259-026-08030-x
Negative / Null Result ReportMedicine

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Nomura, Kimata, Ito et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: To directly compare the capabilities of hybrid-type iterative reconstruction (IR) with the newly developed deep learning reconstruction (DLR) for the inner ear on high-definition CT (HDCT) obtained using the…

View details →DOI: 10.3390/diagnostics16121756
Negative / Null Result ReportMedicine

Rural medical disparities in multimodal glioblastoma treatment.

Momii, Hata, Fudaba et al. · 2026 · Scientific reports

Glioblastoma continues to have a poor prognosis, although recent advancements in multimodal treatments have gradually improved outcomes. However, treatment options have become increasingly complex and highly specialized. In rural areas,…

View details →DOI: 10.1038/s41598-026-48867-8
Negative / Null Result ReportMedicine

Diagnosis of Small Focal Liver Lesions (≤2 cm): A Deep Learning Approach Based on B-Mode Ultrasound and Contrast-Enhanced Ultrasound.

Xu, Wei, Zhang et al. · 2026 · Ultrasound in medicine & biology

To develop and validate a deep learning (DL) model based on feature fusion with B-mode ultrasound (BMUS) and contrast enhanced ultrasound (CEUS) images for non-invasive diagnosis of benign and malignant focal liver lesions (FLLs),…

View details →DOI: 10.1016/j.ultrasmedbio.2026.01.002
Negative / Null Result ReportMedicine

Impact of hydrophobic ion pair type and self-nanoemulsifying drug delivery systems composition on the oral delivery of salmon calcitonin.

Al-Maghrabi, Müllertz, Rades · 2026 · Journal of controlled release : official journal of the Controlled Release Society

Salmon calcitonin (sCT) is a peptide with poor enzymatic stability and permeability, limiting its oral delivery. This study investigated how hydrophobic ion pair (HIP) type and self-nanoemulsifying drug delivery systems (SNEDDS)…

View details →DOI: 10.1016/j.jconrel.2026.115131
Negative / Null Result ReportMedicine

A multicenter randomized controlled trial comparing metallic stents with 10- versus 14-mm diameter for distal biliary obstruction caused by unresectable pancreatic carcinoma.

Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy

Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…

View details →DOI: 10.1016/j.gie.2026.06.037
Abandoned HypothesisMedicine

Formaldehyde metabolism in the biocatalytic upgrading of lignin.

Lalande AT, Eltis LD · 2026 · Current opinion in biotechnology

Formaldehyde is a toxic metabolite generated in the bacterial catabolism of lignin-derived aromatic compounds (LDACs) through the oxidative O-demethylation of methoxylated aromatics. Microbial cell factories designed to convert LDACs to…

View details →DOI: 10.1016/j.copbio.2026.103526
Negative / Null Result ReportMedicine

The Impact of Glucagon-Like Peptide 1 Receptor Agonists Versus Diabetes Mellitus on Endoscopic Procedures: A Case-Control Study From a Large Tertiary Care Health System.

Bahdi, Bachu, Aldzhyan et al. · 2026 · Journal of clinical gastroenterology

While glucagon-like peptide 1 receptor agonists (GLP1-RAs) increase the risk of gastric food retention (GFR) and inadequate bowel preparation (IBP), the confounding role of diabetes mellitus is still questioned. Here, we compare the…

View details →DOI: 10.1097/mcg.0000000000002414
Negative / Null Result ReportMedicine

Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms.

Baskar, Patel, Rose et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

The incidence of neuroendocrine neoplasms (NENs) is rising, particularly among younger patients, but data comparing early-onset (EO-NENs) and average-onset (AO-NENs) remain limited. Using the National Inpatient Sample (2016-2020), we…

View details →DOI: 10.1007/s00520-026-10919-0
Negative / Null Result ReportMedicine

Association between Epstein-Barr Virus viremia and cardiac function in children and young adults with perinatally acquired HIV.

Curtis, McCrary, Daud et al. · 2026 · Cardiovascular journal of Africa

Epstein-Barr virus (EBV) affects greater than 95% of the global population, and when acquired at an early age, results in poor control of viral replication and increased risk to subsequent chronic illnesses. To analye the association…

View details →DOI: 10.5830/cvja-2025-109
Negative / Null Result ReportMedicine

Minimally invasive stabilisation of anterior pelvic ring injuries through anterior infix versus percutaneous anterior retrograde pubic screw: a prospective comparative cohort study.

Goda El-Hamalawy, Abdelmoneim, Al-Sayed et al. · 2026 · Archives of orthopaedic and trauma surgery

Management of unstable anterior pelvic ring fractures has shifted toward minimally invasive fixation techniques. This prospective randomized cohort study compares anterior subcutaneous internal fixator with percutaneous retrograde pubic…

View details →DOI: 10.1007/s00402-026-06380-7
Negative / Null Result ReportMedicine

A Randomised Controlled Trial Comparing Spray Versus Paint Application of Iodine Skin Antisepsis in Head and Neck Surgery.

Fussey, Manzie, Nanayakkara et al. · 2026 · ANZ journal of surgery

It is unknown whether the method of application of povidone iodine solution for skin antisepsis affects its efficacy. The primary aim of this study was to compare the efficacy of spray-on aqueous povidone iodine solution in preventing…

View details →DOI: 10.1111/ans.70772
Negative / Null Result ReportMedicine

Comparison of head-related injuries between standing electric scooter riders and pedestrians involved in motor vehicle collisions in Japan.

Sakamoto · 2026 · Traffic injury prevention

While previous research suggests that e-scooter riders and pedestrians may exhibit similar injury patterns due to a shared standing posture, direct comparisons using unified datasets are lacking. This study aims to identify the distinctive…

View details →DOI: 10.1080/15389588.2026.2682440
Negative / Null Result ReportMedicine

Scavenging of Reactive Carbonyl Species by Dihydromyricetin and Its Thermal Degradation Products Through Consumption of Hot-Brewed and Cold-Brewed Vine Tea.

Wang, Wang, Zhang et al. · 2026 · Journal of agricultural and food chemistry

Reactive carbonyl species (RCS) are highly reactive molecules linked to chronic diseases. Dihydromyricetin (DMY), a high-activity RCS scavenger, exhibited MGO- and ACR-scavenging rates of 70.1% (0.5 h) and 70.3% (2 h) at 37 °C,…

View details →DOI: 10.1021/acs.jafc.6c06554
Negative / Null Result ReportMedicine

Two methods of intentional cranial modification from Early Holocene Songhuajiang in Northeast China.

Yin, Bae, Ni · 2026 · Journal of anthropological sciences = Rivista di antropologia : JASS

Since its appearance at the terminal Pleistocene, intentional cranial modification ("ICM") and its implications have generated considerable scientific debate regarding how or why such a tradition arose. Here, we report on newly discovered…

View details →DOI: 10.4436/jass.10404
Negative / Null Result ReportMedicine

Multi-omics analysis reveals Parabacteroides distasonis and Kineothrix alysoides as potential key bacterial species associated with anemia in sows.

Sun, Chen, Yang et al. · 2026 · Journal of animal science and biotechnology

Sow anemia has been reported to be associated with reduced reproductive performance. Additionally, anemia may alter gut microbiota composition. However, the gut microbiota and metabolic signatures specifically linked to sow anemia status…

View details →DOI: 10.1186/s40104-026-01443-6
Negative / Null Result ReportMedicine

The Effect of The Changes in Cylinder Power and Axis of Toric Soft Contact Lenses on Vision of Astigmatic Subjects.

Aprina, Rahayu, Prihartono et al. · 2026 · Korean journal of ophthalmology : KJO

To investigate the effect of higher cylindrical power and axis misalignment of toric SCL in mild and moderate astigmatism on visual acuity, contrast sensitivity, visual satisfaction, and vision acceptability. 20 astigmatic participants…

View details →DOI: 10.3341/kjo.2025.0168
Negative / Null Result ReportMedicine

Effect of visual disruption on the lower limb kinematic and kinetic characteristics in athletes after anterior cruciate ligament reconstruction.

Yu, Yu, Sun et al. · 2026 · Frontiers in bioengineering and biotechnology

Proprioceptive deficits following anterior cruciate ligament (ACL) injury increase reliance on visual input in athletes after ACL reconstruction (ACLR). Visual disruption may therefore alter movement patterns and increase re-injury risk.…

View details →DOI: 10.3389/fbioe.2026.1767092