Negative / Null Result ReportMedicine
Amthor L, Jaeckle A, Kampmeier J et al. · 2025 · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Sitagliptin, an inhibitor of dipeptidyl peptidase-4 widely used in type 2 diabetes therapy, impairs the barrier formed by retinal endothelial cells (REC) during prolonged exposure. Because diabetic macular edema is treated with inhibitors…
View details →DOI: 10.1055/a-2708-3562 Negative / Null Result Report
Villard M, Espinosa-Carrasco G, Hernandez J · 2025 · Preprint
ABSTRACT Lymphodepletion, which is currently used as adjuvant for adoptive cytotoxic T cell immunotherapy in cancer, promotes the breakdown of peripheral CD8 + T cell tolerance. Under lymphopenic conditions, naive T cells proliferate due…
View details →DOI: 10.1101/2025.09.08.672311 Negative / Null Result Report
Abhyankar SD, Luo Q, Hartman GD et al. · 2025 · Preprint
The APOE genotype influences metabolic and neurodegenerative outcomes, with APOE4 carriers at higher risk for Alzheimer’s disease (AD) and metabolic dysfunction. This study examines how long-term dietary interventions affect systemic…
View details →DOI: 10.1101/2025.07.30.667671 Negative / Null Result ReportMedicine
Pavicich MA, Maldonado ML, Nguyen TN et al. · 2025 · International Journal of Food Microbiology
Apple fruit is widely consumed worldwide, but fungal contamination in the postharvest stage presents a significant food safety concern. This study evaluates the production and accumulation of Alternaria mycotoxins, including alternariol…
Negative / Null Result ReportMedicine
Hoe B, Heimbürger SMN, Gasbjerg LS et al. · 2026 · Diabetes, obesity & metabolism
Aims In type 1 diabetes, glucose-dependent insulinotropic polypeptide (GIP) increases glucagon secretion during low plasma glucose and improves time in the glycaemic range during daytime. To explore the glucose-stabilising potential of GIP…
View details →DOI: 10.1111/dom.70373 Negative / Null Result ReportMedicine
Seekings AH, Billington E, Mahmood S et al. · 2026 · Virology
H7N7 low-pathogenicity avian influenza virus (H7N7-LPAIV) incursions preceded emergence of H7N7 high-pathogenicity (HP)AIV at several European layer hen outbreaks. Evidence from a UK layer H7N7-HPAIV (2008) outbreak informed in vivo…
View details →DOI: 10.1016/j.virol.2025.110733 Negative / Null Result ReportMedicine
Carvalho AVS, Hoeper ES, Dúran-Carabali LE et al. · 2026 · The Journal of nutritional biochemistry
Neonatal hypoxia-ischemia (HI) is one of the main causes of perinatal death and is commonly associated with neurological damage which are usually observed on motor and cognitive domains. Plinia trunciflora or "jabuticaba" is a native…
View details →DOI: 10.1016/j.jnutbio.2025.110162 Negative / Null Result ReportMedicine
Nair-Shalliker V, Smith DP, Gebski V et al. · 2026 · British journal of cancer
Background The ProsD trial aimed to determine if oral vitamin D supplementation could prevent prostate cancer (PC) progression in men on active surveillance (AS). Methods ProsD is a phase-II double-blinded randomized trial of newly…
View details →DOI: 10.1038/s41416-025-03278-w Negative / Null Result ReportOpen accessMedicine
Gu Q, Silva CS, Twaddle NC et al. · 2026 · International journal of molecular sciences
Arsenic induces apoptosis in both cancerous and non-cancerous cells. The mechanism of arsenic-induced apoptosis is complex. We previously demonstrated that the antioxidant acetyl L-carnitine prevented sodium arsenite-induced apoptosis in…
View details →DOI: 10.3390/ijms27073263 Negative / Null Result Report
Nguyen PV, Vu DM, Do BN et al. · 2025 · Preprint
(1) Malaria remains a significant health threat to military and civilian personnel de-ployed to endemic regions. Despite recommended chemoprophylaxis, compliance var-ies substantially, potentially impacting clinical outcomes when…
View details →DOI: 10.20944/preprints202509.0966.v1 Negative / Null Result Report
Frühaf J, Bartoníček J, Fojtík P et al. · 2026 · Preprint
Abstract Purpose The aim of this study is to describe the basic pathoanatomical characteristics of a stable Maisonneuve fracture and mid-term results of its nonoperative treatment. Methods The study included 17 prospectively collected…
View details →DOI: 10.21203/rs.3.rs-9048287/v1 Negative / Null Result ReportMedicine
Mori K, Asahi T, Kataoka K et al. · 2025 · Biochemical and biophysical research communications
Mechanical stretch critically influences skeletal muscle physiology, yet its role in myoblast differentiation and the associated molecular mechanisms have not been fully clarified. This study investigated the effects of uniaxial cyclic…
View details →DOI: 10.1016/j.bbrc.2025.152350 Negative / Null Result ReportMedicine
Khajehzadehshoushtar S, Delfinis LJ, Rahman FA et al. · 2025 · The Journal of physiology
The degree to which mitochondrial-linked programmed cell death pathways contribute to skeletal muscle atrophy during cancer remains unknown. Here we combined a novel and robust mouse model of metastatic ovarian cancer with chronic…
View details →DOI: 10.1113/jp287912 Negative / Null Result ReportMedicine
Yin R, Fredenburgh JC, Weitz JI · 2025 · Journal of thrombosis and haemostasis : JTH
Background Milvexian, an oral factor (F)XIa inhibitor, is undergoing phase 3 evaluation for acute coronary syndrome. Such patients often require percutaneous coronary intervention (PCI). The PCI catheters trigger clotting by inducing…
View details →DOI: 10.1016/j.jtha.2025.06.028 Negative / Null Result ReportOpen accessMedicine
Drumeva GO, Plane AF, Petrenyov DR et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Ivabradine (IVAB) is an effective drug in patients with heart failure (HF). However, data in the context of chemotherapy-induced cardiomyopathy are limited. This study investigated the cardioprotective potential of IVAB in a…
View details →DOI: 10.1186/s40959-026-00469-z Negative / Null Result ReportOpen accessMedicine
Romanelli MA, Nogueira-Souza PD, Gomes DS et al. · 2026 · ACS omega
Snakebite-induced acute kidney injury (sAKI) is a severe clinical complication associated with Bothrops envenomation that can lead to kidney failure. Alternative therapies are needed due to the limitations of antivenom, including variable…
View details →DOI: 10.1021/acsomega.5c09974 Negative / Null Result Report
Gordon-Fennell L, Farero R, Jones J et al. · 2025 · Preprint
ABSTRACT Uncovering the neurobiological processes underlying substance use disorder informs future therapeutic interventions. Prior research implicates the corticotropin releasing factor (CRF) system as a major player in a wide variety of…
View details →DOI: 10.1101/2025.02.25.640140 Negative / Null Result ReportOpen accessMedicine
Vercalsteren E, Karampatsi D, Buizza C et al. · 2025 · Nutrients
Background/objectives : Being overweight increases the predisposition to obesity and type 2 diabetes (T2D), which significantly elevate stroke risk and the likelihood of severe post-stroke disability. Dietary nitrate (NO 3 - )…
View details →DOI: 10.3390/nu17152434 Negative / Null Result Report
De Carli G, Giombini E, Colosi A et al. · 2025 · Preprint
To determine whether patient-to-doctor transmission of measles occurred in an emergency department (ED) despite isolation precautions and full personal protective equipment (PPE) during the COVID-19 pandemic, an epidemiological and…
View details →DOI: 10.20944/preprints202504.1296.v1 Negative / Null Result ReportMedicine
Gutfreund N, Tuppi M, Schäfer B et al. · 2025 · Reproduction (Cambridge, England)
In brief Induction of DNA double-strand breaks results in oocyte death caused by the activation of TAp63α. This study investigates which chemotherapeutic drugs activate p63 and which cause oocyte death without p63 activation. Abstract…
View details →DOI: 10.1530/rep-24-0225 Negative / Null Result ReportMedicine
Guzzo I, Becilli M, Cappoli A et al. · 2025 · Pediatric nephrology (Berlin, Germany)
Background High panel reactive antibody (PRA) titers are a significant challenge for patients undergoing kidney transplantation. Currently, no desensitization protocol has proven effective in preventing mid- and long-term graft loss. In…
View details →DOI: 10.1007/s00467-025-06884-1 Negative / Null Result ReportMedicine
Moran MC, Tammone Santos A, Dominguez P et al. · 2025 · Veterinary immunology and immunopathology
Brucella ovis (B. ovis) is the etiological agent of ram-contagious epididymitis, the leading cause of reproductive disorders in flocks worldwide. Although the attenuated B. melitensis Rev.1 strain gives heterologous protection against this…
View details →DOI: 10.1016/j.vetimm.2025.110997 Negative / Null Result ReportOpen accessMedicine
Seco-Cervera M, Gisbert-Ferrándiz L, Macias-Ceja DC et al. · 2025 · PloS one
Epigenetics has emerged as a modulator of inflammation-related diseases and changes in miRNA expression have been associated with regional location, inflamed mucosa and disease activity in Crohn´s disease (CD). We analyse here the…
View details →DOI: 10.1371/journal.pone.0329685 Negative / Null Result ReportOpen accessMedicine
Casadevall A · 2025 · The Journal of clinical investigation
Invasive fungal infections carry high morbidity and mortality, but there are no fungal vaccines. In this issue of the JCI, Okaa et al. report that endonuclease 2 (Eng2), an antigen shared by the Blastomyces, Histoplasma, and Coccidioides…
View details →DOI: 10.1172/jci199451 Negative / Null Result ReportOpen accessMedicine
Cao L, Hu J, Mao X et al. · 2026 · Frontiers in oncology
Background Malignant phyllodes tumors (MPTs) of the breast are rare fibroepithelial neoplasms characterized by aggressive clinical behavior and limited evidence guiding systemic therapy in the metastatic setting. Immune checkpoint…
View details →DOI: 10.3389/fonc.2026.1778276 Negative / Null Result ReportOpen accessMedicine
Castro LA, Chen DE, O'Scannlain A et al. · 2026 · Journal of the mechanical behavior of biomedical materials
Elastic fibers are critical for proper mechanical function of large arteries such as the aorta. Fragmentation, degradation, or reduced amounts of elastic fibers are associated with aortic diseases such as stiffening-induced hypertension…
View details →DOI: 10.1016/j.jmbbm.2026.107340 Negative / Null Result ReportMedicine
Fage C, Loison S, Zwygart AC et al. · 2025 · Antiviral research
Influenza viruses pose a significant threat due to annual epidemics and pandemic potential. Resistance to current antivirals underscores the need for new drugs and strategies to prevent its emergence. We previously developed two novel…
View details →DOI: 10.1016/j.antiviral.2025.106174 Negative / Null Result ReportOpen accessMedicine
Jacob A, Mahmoud A, Eldweik L et al. · 2025 · BMJ neurology open
Background Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing autoimmune disease of the central nervous system (CNS). Management during pregnancy is challenging due to limited safety data for disease-modifying therapies.…
View details →DOI: 10.1136/bmjno-2025-001286 Negative / Null Result ReportOpen accessMedicine
Tekin-Taş Z, Özger HS, Sultanova F et al. · 2025 · Infectious diseases & clinical microbiology
Objective Real-time multiplex polymerase chain reaction (PCR) test increases the detection of viral respiratory tract infections. This study aimed to evaluate the effect of real-time multiplex PCR on antibiotic use in viral respiratory…
View details →DOI: 10.36519/idcm.2025.729 Negative / Null Result ReportMedicine
Cajado AG, Lopes MH, Rangel GFP et al. · 2025 · European journal of pharmacology
Irinotecan-based anticancer therapy induces intestinal mucositis, increasing the risk of sepsis and patient death. The phosphoinositide 3-kinases (PI3K) are involved in cancer and inflammatory diseases, but their role in intestinal…
View details →DOI: 10.1016/j.ejphar.2025.178165 