Mechanisms of chemotherapy-induced oocyte death through activation of TAp63α.
Gutfreund N; Tuppi M; Schäfer B; Klinger FG; Kirchhof A; Hofmann A; Dikic I; Dötsch V · 2025 · Reproduction (Cambridge, England)
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
In brief Induction of DNA double-strand breaks results in oocyte death caused by the activation of TAp63α. This study investigates which chemotherapeutic drugs activate p63 and which cause oocyte death without p63 activation. Abstract…
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Metadata source: Europe PMC · DOI 10.1530/rep-24-0225