Negative / Null Result ReportMedicine
Pucha KA, Ma TC, York W et al. · 2023 · Parkinsonism & related disorders
Introduction Impaired autophagy is a pathogenic mechanism in the synucleinopathies. Sirolimus, a potent mTOR inhibitor and autophagy activator, had no beneficial effects in a randomized placebo-controlled trial in patients with multiple…
View details →DOI: 10.1016/j.parkreldis.2023.105821 Negative / Null Result ReportOpen accessMedicine
Thompson KP, Sykes J, Chandakkar P et al. · 2022 · Orphanet journal of rare diseases
Background Vascular malformations in hereditary hemorrhagic telangiectasia (HHT) lead to chronic recurrent bleeding, hemorrhage, stroke, heart failure, and liver disease. There is great interest in identifying novel therapies for epistaxis…
View details →DOI: 10.1186/s13023-022-02539-8 Negative / Null Result ReportMedicine
Allen PM, Dedi S, Kumar D et al. · 2012 · Perception
We manipulated the accommodative response using positive and negative lenses to study any association between symptoms of pattern glare and accommodation. Two groups of eighteen young adults were selected from seventy-eight on the basis…
View details →DOI: 10.1068/p7390 Negative / Null Result ReportOpen accessMedicine
Komarow HD, Wang J, Eisch R et al. · 2025 · The journal of allergy and clinical immunology. Global
Background Indolent systemic mastocytosis is a clonal mast cell disease that results in an increase in mast cells in the skin, bone marrow, and other organ systems. IL-6 has been shown to promote mast cell maturation, proliferation, and…
View details →DOI: 10.1016/j.jacig.2025.100498 Negative / Null Result ReportOpen accessMedicine
Guo JY, Lin HY · 2023 · Chinese journal of traumatology = Zhonghua chuang shang za zhi
The Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin (SCARLET) trial has many defects, and thus cannot be the terminator of recombinant thrombomodulin (rTM). On the contrary, it provides sufficient evidence for further research.…
View details →DOI: 10.1016/j.cjtee.2023.04.006 Negative / Null Result ReportMedicine
de Ruiter MB, Groot PFC, Deprez S et al. · 2023 · Neuro-oncology
Background Reducing radiation dose to the hippocampus with hippocampal avoidance prophylactic cranial irradiation (HA-PCI) is proposed to prevent cognitive decline. It has, however, not been investigated whether hippocampal atrophy is…
View details →DOI: 10.1093/neuonc/noac148 Negative / Null Result ReportMedicine
Abrams D, Montesi SB, Moore SKL et al. · 2020 · Critical care medicine
Objectives Recurring issues in clinical trial design may bias results toward the null, yielding findings inconclusive for treatment effects. This study evaluated for powering bias among high-impact critical care trials and the associated…
View details →DOI: 10.1097/ccm.0000000000004568 Negative / Null Result ReportOpen accessMedicine
Stockton S, Catalano P, Cohen SJ et al. · 2023 · The oncologist
Background Patients with advanced esophageal cancer carry poor prognoses; limited data exist to guide second-line therapy in the metastatic setting. Paclitaxel has been used yet is associated with limited efficacy. There is preclinical…
View details →DOI: 10.1093/oncolo/oyad096 Failed Experiment ReportOpen accessMedicine
Jansen D, Deleu S, Caenepeel C et al. · 2025 · Gut microbes
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent colonic inflammation. Standard treatments focus on controlling inflammation but remain ineffective for one-third of patients. This underscores the need for…
View details →DOI: 10.1080/19490976.2025.2499575 Failed Experiment ReportOpen accessMedicine
Limon D, Amiel A, Even Haim S et al. · 2024 · Neuro-oncology advances
Background Atypical and anaplastic meningiomas account for 20% of all meningioma cases. Solitary fibrous tumor (SFT) is a type of soft tissue sarcoma with similar attributes to meningioma. For patients with refractory or recurrent disease…
View details →DOI: 10.1093/noajnl/vdae154 Abandoned HypothesisOpen accessMedicine
Kwon SB, Megjhani M, Nametz D et al. · 2023 · Resuscitation plus
Background Despite significant progress in cardiopulmonary resuscitation and post-cardiac arrest care, favorable outcome in out-of hospital sudden cardiac arrest patients remains low. One of the main reasons for mortality in these patients…
View details →DOI: 10.1016/j.resplu.2023.100450 Negative / Null Result ReportMedicine
Gandhy SU, Karzai FH, Bilusic M et al. · 2024 · European urology oncology
Background The emergence of positron emission tomography (PET) in prostate cancer is impacting clinical practice, but little is known about PET imaging as a tool to determine treatment failure in metastatic castration-resistant prostate…
View details →DOI: 10.1016/j.euo.2023.09.010 Negative / Null Result ReportOpen accessMedicine
Gagnon J, Quansah JE, Saleh G et al. · 2022 · Psychopathology
Introduction Splitting, as a defense mechanism in Kernberg's theory, plays a significant role in the development and maintenance of polarized and oscillating representations of self/other characteristics of borderline personality disorder…
View details →DOI: 10.1159/000525006 Negative / Null Result ReportOpen accessMedicine
Imamura Y, Kiyota N, Tahara M et al. · 2024 · Cancer medicine
Background In a randomized phase II/III trial (JCOG1008), weekly cisplatin (40 mg/m 2 ) was non-inferior to 3-weekly cisplatin (100 mg/m 2 ) for postoperative high-risk head and neck cancer. We investigated how acute kidney injury (AKI), a…
View details →DOI: 10.1002/cam4.70235 Negative / Null Result ReportOpen accessMedicine
Wüst LN, Cajochen C, Lasauskaite R · 2025 · Neurobiology of sleep and circadian rhythms
A chronotype is defined as a preference for certain behaviours (e.g., sleep and wake) to occur at specific times of day. It is therefore also temporally linked with cognitive performance across the day. In an exploratory analysis, we…
View details →DOI: 10.1016/j.nbscr.2025.100125 Negative / Null Result ReportOpen accessMedicine
Metsch LR, Feaster DJ, Gooden LK et al. · 2025 · Open forum infectious diseases
Background People with HIV (PWH) who use cocaine are less likely to achieve virologic suppression ( Methods Project RETAIN recruited 360 cocaine-using PWH who were not virologically suppressed in Miami, FL, and Atlanta, GA. Patients were…
View details →DOI: 10.1093/ofid/ofaf104 Negative / Null Result ReportOpen accessMedicine
Ackermans N, Taylor C, Tam R et al. · 2019 · Multiple sclerosis journal - experimental, translational and clinical
Objective The objective of this paper is to evaluate potential dose-dependent adverse effects of gadolinium-based contrast agents (GBCAs) on MS progression. Methods Outcomes from a cohort of 612 secondary progressive MS (SPMS) patients,…
View details →DOI: 10.1177/2055217318823796 Negative / Null Result ReportMedicine
Domsic RT, Gao S, Laffoon M et al. · 2021 · Rheumatology (Oxford, England)
Objectives Clinical trials in early diffuse cutaneous systemic sclerosis (SSc) using the modified Rodnan skin score (mRSS) as the primary outcome measure have most often been negative. We wanted to assess how the definition of disease…
View details →DOI: 10.1093/rheumatology/keab075 Negative / Null Result ReportOpen accessMedicine
Kremer L, Bus JD, Webb LE et al. · 2021 · Scientific reports
Affective states can be inferred from responses to ambiguous and threatening stimuli, using Judgement Bias Tasks (JBTs) and Attention Bias Tasks (ABTs). We investigated the separate and interactive effects of personality and housing…
View details →DOI: 10.1038/s41598-021-01843-w Negative / Null Result ReportOpen accessMedicine
Mason MG, Richardson EJ, Giarrusso C et al. · 2025 · Journal of the experimental analysis of behavior
This experiment explored a rodent model of functional class formation by assessing the transfer of a novel discriminative function across class members. Following simple successive discrimination reversal training and consistently strong…
View details →DOI: 10.1002/jeab.70055 Negative / Null Result ReportMedicine
Chamberlain DB, Chamberlain JM · 2017 · Annals of emergency medicine
Study objective We demonstrate the application of a Bayesian approach to a recent negative clinical trial result. A Bayesian analysis of such a trial can provide a more useful interpretation of results and can incorporate previous…
View details →DOI: 10.1016/j.annemergmed.2016.08.449 Negative / Null Result ReportOpen accessMedicine
Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…
View details →DOI: 10.3390/jcm13082422 Negative / Null Result ReportMedicine
Puvvada SD, Guillén-Rodríguez JM, Rivera XI et al. · 2017 · Oncology
Objective Aggressive lymphomas (aNHL) including diffuse large B-cell lymphoma (DLBCL) have poor outcomes in relapsed refractory patients. Prior studies have demonstrated that loss of major histocompatibility complex class II (MHCII)…
View details →DOI: 10.1159/000479230 Negative / Null Result ReportOpen accessMedicine
Regel A, Sepriano A, Baraliakos X et al. · 2017 · RMD open
To assess the efficacy and safety of non-biological therapies in patients with axial spondyloarthritis (axSpA) to inform the update of the Assessment of SpondyloArthritis international Society (ASAS)/European League Against Rheumatism…
View details →DOI: 10.1136/rmdopen-2016-000397 Negative / Null Result ReportOpen accessMedicine
Abdelrahman KM, Hackshaw KV · 2021 · Biomedicines
Neuropathic pain affects 7-10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake…
View details →DOI: 10.3390/biomedicines9060674 Negative / Null Result ReportOpen accessMedicine
Witzel S, Statland JM, Steinacker P et al. · 2024 · European journal of neurology
Background and purpose Rasagiline might be disease modifying in patients with amyotrophic lateral sclerosis (ALS). The aim was to evaluate the effect of rasagiline 2 mg/day on neurofilament light chain (NfL), a prognostic biomarker in ALS.…
View details →DOI: 10.1111/ene.16154 Negative / Null Result ReportMedicine
Kitchin SS, Lakshmanan S, Kinninger A et al. · 2023 · The British journal of cardiology
Atrial fibrillation (AF) is a common arrhythmia associated with poor outcomes. N-3 fatty acids have been shown to provide significant cardiovascular risk reduction, but they may exacerbate the risk of AF. The pathway by which N-3 fatty…
View details →DOI: 10.5837/bjc.2023.022 Negative / Null Result ReportOpen accessMedicine
Konishi K · 2024 · Entropy (Basel, Switzerland)
We comment on the so-called negative result experiments (also known as null measurements, interaction-free measurements, and so on) in quantum mechanics (QM), in the light of the new general understanding of the quantum-measurement…
View details →DOI: 10.3390/e26110958 Negative / Null Result ReportOpen accessMedicine
Yarnall S, Saben JL, Sun N et al. · 2025 · Journal of genetic counseling
This observational study aimed to capture patients' experiences after reviewing carrier screening (CS) and/or noninvasive prenatal cell-free DNA testing (NIPT) results with Natera's Educational Virtual Assistant (NEVA). Patients, partners…
View details →DOI: 10.1002/jgc4.70125 Negative / Null Result ReportMedicine
Van Der Pol B, Ippolito J, Gao R et al. · 2026 · Sexually transmitted diseases
Background Extragenital (oropharyngeal and anorectal) Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (or gonococci [GC]) infections are underdiagnosed. Here we report sensitivity and specificity estimates that were obtained from the…
View details →DOI: 10.1097/olq.0000000000002244 