A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21707 results · page 263 of 724
Ma Y, Mayes MD, Guo X et al. · 2024 · Preprint
Abstract Objective This study aimed to examine whether a reported SSc-associated SNP rs2841277 in the PLD4 gene identified in an Asian population was also associated with SSc in US Caucasians. Methods The US Caucasian cohort consisting of…
Velaga SB, Alagorie AR, Nittala MG et al. · 2025 · Ophthalmology science
Purpose To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design Longitudinal cohort study. Subjects The study reviewed 1332 eyes…
Belica I, Blasko F, Sleziak I et al. · 2025 · Biological psychology
Resting heart rate variability (HRV) reflects rhythmic changes in heart rate over time associated with autonomic nervous system (ANS) activity. It has served as a predictor of health and the development of various diseases. Therefore, it…
Govender V, Govender K, Moodley D · 2026 · BMC infectious diseases
BACKGROUND: Maintaining viral suppression in the postpartum period is critical for preventing HIV transmission to sexual partners and breastfed infants. Despite systemic viral suppression, genital HIV shedding may still occur in some…
Kambara M, Ikawa F, Hidaka T et al. · 2025 · Neurosurgery
Background and objectives Some reports suggest that older patients with traumatic brain injury (TBI) are more likely to experience acute intracranial hemorrhage, resulting in poor outcomes. However, the association between precise…
Rodriguez JA, Palermo NE, Song W et al. · 2026 · Diabetes technology & therapeutics
Continuous glucose monitors (CGMs) are becoming increasingly available, yet the relationship between CGM metrics and hemoglobin A1c (HbA1c) among individuals with prediabetes and normoglycemia remains unclear. We examined associations…
de Luis D, Primo D, Izaola O et al. · 2024 · European review for medical and pharmacological sciences
Objective Sarcopenia is a condition characterized by muscle mass loss. Skeletal muscle is capable of producing and secreting different molecules called myokines, and apelin is one of them. The literature contains contradictory data on the…
Leibold P, Lteif C, Duarte JD · 2025 · Frontiers in genetics
Introduction Hypertension (HTN) is a leading risk factor for several cardiovascular diseases. While some previous studies reported that CYP3A5 variants were associated with decreased blood pressure and risk of HTN, others reported no…
Solanki JD, Joshi DR, Atodaria KA et al. · 2025 · Journal of family medicine and primary care
Introduction Cardiovascular health is adversely affected by menopausal transition with reduced heart rate variability (HRV) as a manifest. Electrocardiogram (ECG) based 5 min HRV has worsening trend from premenopausal to postmenopausal…
Chang RC, Olbrich H, Wang YF et al. · 2026 · JID innovations : skin science from molecules to population health
Bullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies to collagen type 17 ( COL17A1 ) and is a recognized immune-related adverse event in patients receiving immune checkpoint inhibitors (ICIs). We…
Goldenholz DM, Cheng JC, Chang C et al. · 2025 · Preprint
ABSTRACT Importance Medication adherence is widely emphasized in epilepsy management, with a belief that missing even single doses can trigger seizures. However, scientific evidence supporting this specific claim is limited, particularly…
Simonin EM, Switkowski KM, Rifas-Shiman SL et al. · 2026 · Frontiers in pediatrics
Introduction There are currently no known biomarkers associated with the diagnosis of infant colic, a common early disorder of gut brain interaction (DGBI) that has been found to predict adverse health outcomes, including atopy, migraines…
Soltanizadeh A, Tirgar A, Zamanian Y et al. · 2025 · Frontiers in oncology
Background Apelin, a peptide implicated in various physiological processes, has been shown to be involved in cancer development and progression. However, its role in breast cancer remains unclear. This study aimed to investigate serum…
McEvoy LK, Zhang B, Nguyen S et al. · 2026 · Aging
Epigenetic clocks of biological aging have been associated with cognitive impairment and dementia. Less is known about whether they are associated with an older-appearing brain or with an atrophy pattern associated with dementia. We…
Cristiani R, Hansson F, Senorski EH et al. · 2025 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose To evaluate factors associated with revision anterior cruciate ligament reconstruction (ACLR) within 5 years of primary ACLR in children and adolescents. Methods Children and adolescents (age Results A total of 1888 patients (mean…
Silva MJA, Figueira LRT, Sardinha DM et al. · 2025 · Frontiers in genetics
Coronavirus disease 2019 (COVID-19) is a multisystemic disease caused by SARS-CoV-2 that can lead to several pulmonary illnesses according to the immunological contexts of the individual. Haplotypes consist of single-nucleotide…
Ma Y, Mayes MD, Guo X et al. · 2024 · Scientific reports
This study aimed to examine whether a reported SSc-associated SNP rs2841277 in the PLD4 gene identified in an Asian population was also associated with SSc in European American (EA). The EA cohort consisting of 1005 SSc patients and 961…
Reveley M, Owen GR, Tumba N et al. · 2026 · Developmental neurobiology
Autism spectrum disorder (ASD) has recently been described as a synaptopathy where dysregulation at the level of the synapse is thought to evoke an excitation-inhibition (E/I) imbalance implicated in its pathogenesis. The mechanisms…
Salas J, Sheth P, Cohen BE et al. · 2025 · General hospital psychiatry
Background Posttraumatic stress disorder (PTSD) is associated with risk for cardiovascular disease (CVD). Improved physical health often follows large decreases in PTSD severity, but it is not known if better CVD outcomes follow PTSD…
Dyer AH, Dolphin H, Morrison L et al. · 2026 · EBioMedicine
Background Both low-grade systemic inflammation and acute inflammatory events may contribute to Alzheimer Disease (AD) progression. However, studies examining the prognostic utility of systemic inflammatory biomarkers in AD, and how…
Cantilena A, Han KL, Cai Y et al. · 2026 · Cytotherapy
Children with B-cell acute lymphoblastic leukemia (B-ALL) are increasingly treated with immunotherapeutic agents such as blinatumomab and inotuzumab. Thus, those who present in relapse for chimeric antigen receptor (CAR) T-cell therapy are…
Howard KA, Witrick B, Clark A et al. · 2024 · Preprint
ABSTRACT Background Implicit bias can influence behavior and decision-making. In clinical settings, implicit bias may influence treatment decisions and contribute to health disparities. Given documented Black-White disparities in vascular…
Skelton K, Moritz C, Day KA et al. · 2025 · Ecology and evolution
Behavioural and physiological adaptations are important for maintaining stable hydric states and viable body temperatures under challenging conditions experienced in variable terrestrial environments. For example, reptiles from arid…
Kilicaslan MB, Dikme O, Girgin MC et al. · 2026 · BMC gastroenterology
Aims This study aimed to investigate the relationship between admission serum lipase levels, prognostic clinical scoring systems, and in-hospital mortality in patients presenting to the emergency department with acute pancreatitis. Methods…
Abedalqader T, Migliorini A, Cerecedo LG et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives: Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed metabolic and bariatric surgeries worldwide. Marginal ulcers (MU) are a common complication following RYGB, yet their pathophysiology and the…
Antunes RA, Souza MDCB, Souza MM et al. · 2024 · Fertility and sterility
Objective To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates. Design A retrospective cohort study. Setting A private…
Pogorielova OS, Korniienko VV, Chumachenko YD et al. · 2025 · Cardiology research and practice
This study probes the relationship between serum matrix metalloproteinase-9 (MMP-9) levels, the genetic variant rs17576 in the MMP-9 gene, and the extent of coronary atherosclerosis among Ukrainian patients diagnosed with coronary artery…
Petre-Mandache B, Burada E, Cucu MG et al. · 2024 · Current oncology (Toronto, Ont.)
Colorectal cancer (CRC) is a major public health problem worldwide, currently ranking third in cancer incidence and second in mortality. Multiple genes and environmental factors have been involved in the complex and multifactorial process…
Duvenci Birben O, Yenibertiz D, Akkurt ES et al. · 2025 · BMC pulmonary medicine
Background/aim Pneumonia is a significant cause of morbidity and mortality within the first year after autologous hematopoietic stem cell transplantation in patients with multiple myeloma (MM), and nutritional status may influence…
Sæle RG, Aslaksen PM, Svartdal F et al. · 2026 · BMC psychology
BACKGROUND: Procrastination, the tendency to delay tasks despite negative consequences, is a widespread issue linked to poor mental health and reduced daily functioning. While often attributed to self-regulation failures, the specific…