Failed Experiment ReportOpen accessComputer Science
Alan Lee, Harry Tong · 2025 · arXiv
We propose reinforcement learning (RL) strategies tailored for reasoning in large language models (LLMs) under strict memory and compute limits, with a particular focus on compatibility with LoRA fine-tuning. Building on early policy gradient methods with baseline subtraction, we design critic-free methods that operate on a small, informative subset of output tokens to reduce memory usage and stabilize training. We introduce S-GRPO, a stochastic variant of Group Relative Policy Optimization, and T-SPMO, a token-level prefix matching approach for fine-grained credit assignment. Applied to Qwen2
Failed Experiment ReportOpen accessComputer Science
Zixian Huang, Kaichen Yang, Xu Huang et al. · 2026 · arXiv
A widely adopted strategy for model enhancement is to use synthetic data generated by a stronger model for supervised fine-tuning (SFT). However, for emerging reasoning models like Qwen3-8B, this approach often fails to improve reasoning capabilities and can even lead to a substantial drop in performance. In this work, we identify substantial stylistic divergence between teacher generated data and the distribution of student as a major factor impacting SFT. To bridge this gap, we propose a Teacher-Student Cooperation Data Synthesis framework (TESSY), which interleaves teacher and student model
Failed Experiment ReportOpen accessComputer Science
Chen-Rong Liu, Chuang Li, Runxia Tao et al. · 2026 · arXiv
Conventional noise analysis in atomic-ensemble sensing assumes a continuous-medium approximation, thereby treating the atomic system as a deterministic dielectric. Here, we demonstrate that this assumption breaks down due to the discrete, particulate nature of the ensemble, giving rise to an intrinsic "atomic granularity noise" (AGN) that fundamentally competes with the optical measurement noise (OMN, typically photon shot noise). By introducing a discrete-atom statistical framework, we derive a unified noise-scaling law governed by a single dimensionless resource ratio, $\mathcal{R} = \bar{N}
Failed Experiment Report
Isaac Unah · 2026 · SSRN Electronic Journal
The paper argues that Eritrea's Constitution — ratified after a costly independence struggle and designed to establish democracy, rule of law, and human rights — has never been implemented in nearly 30 years. The failure is attributed…
View details →DOI: 10.2139/ssrn.6289978 Failed Experiment ReportMedicine
Yang, Han, Cui et al. · 2026 · Pharmacology research & perspectives
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first-in-human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE). This was a single…
View details →DOI: 10.1002/prp2.70277 Failed Experiment ReportMedicine
Xu, Hu, Cai · 2026 · PloS one
The layout of the image and the positional distribution of the objects directly affect the audience's visual focus and the effect of the message conveyed. By setting up a specific layout structure, the viewer's attention can be more…
View details →DOI: 10.1371/journal.pone.0352418 Failed Experiment ReportMedicine
Lizwan, Cynthia Chia · 2026 · Journal of cardiothoracic surgery
Early chest drain removal and discharge are standard in enhanced-recovery protocols after video-assisted thoracoscopic surgery (VATS) lobectomy, but rare wound complications may arise. We report a 71-year-old man who underwent uneventful…
View details →DOI: 10.1186/s13019-026-04483-1 Failed Experiment ReportMedicine
Harder K, Thöle M · 2026 · Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Objective The aim of this study was to evaluate the therapeutic success of a conservative treatment approach for macrodontic molars in guinea pigs. To this end, longitudinal data from conservative management were analyzed and parameters of…
View details →DOI: 10.1055/a-2773-8335 Failed Experiment ReportMedicine
Abukhalaf, Al-Ihribat, Sabarna et al. · 2026 · International journal of surgery case reports
Pancreaticoduodenal artery (PDA) pseudoaneurysms are rare vascular complications, accounting for approximately 2% of all visceral artery aneurysms. They are often associated with chronic pancreatitis and have a high risk of rupture, which…
View details →DOI: 10.1097/rc9.0000000000000525 Failed Experiment ReportMedicine
Enomoto, Tamura, Iwama et al. · 2026 · Surgical neurology international
Apical petrositis is a rare but serious infection, often accompanied by osteomyelitis, that may cause cranial neuropathies and typically responds to antibiotics. However, surgical intervention may be required when medical therapy fails or…
View details →DOI: 10.25259/sni_1231_2025 Failed Experiment ReportMedicine
Zhou, Xia, Zhao et al. · 2026 · European journal of pharmacology
This study aimed to investigate the anti-tumor effects and mechanisms of propranolol (Prop) in mice with colorectal cancer (CRC) combined with chronic stress, as well as its potential impact when used in combination with high-mobility…
View details →DOI: 10.1016/j.ejphar.2026.179065 Failed Experiment ReportMedicine
Terry, Isenberg, Gomoll et al. · 2026 · Video journal of sports medicine
Multifocal cartilage defects about the knee have become increasingly prevalent. When left untreated, these injuries may progress to diffuse knee osteoarthritis. Operative management for patients with multifocal chondral defects typically…
View details →DOI: 10.1177/26350254261419144 Failed Experiment ReportMedicine
Wang, Yu · 2026 · SAGE open medical case reports
A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…
View details →DOI: 10.1177/2050313x261454853 Failed Experiment ReportMedicine
Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques
Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…
View details →DOI: 10.1016/j.jvscit.2026.102270 Failed Experiment ReportMedicine
Connacher, Hu, Roden et al. · 2026 · RNA biology
Brain tumor (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo…
View details →DOI: 10.1080/15476286.2026.2682069 Failed Experiment ReportMedicine
LaRue-Nolan, Flores, Vera et al. · 2026 · Molecular and cellular biology
Nuclear envelope (NE) proteins are essential for maintaining nuclear morphology, a central process controlling cellular phenotypes. While these proteins and structures are largely characterized in developmental biology, their function and…
View details →DOI: 10.1080/10985549.2026.2670710 Failed Experiment ReportMedicine
Krida, Tang, Mangalath et al. · 2026 · Nature communications
Thin-shell structures, found in biological systems such as beetle carapaces and widely used in aerospace and civil engineering, achieve remarkable strength-to-mass ratios given their slenderness and curved geometries. However, their…
View details →DOI: 10.1038/s41467-026-73343-2 Failed Experiment ReportMedicine
Versyck, Tollenaere, Schelfaut et al. · 2026 · Journal of spine surgery (Hong Kong)
Cervical kyphotic deformity is a recognized complication following posterior cervical spine surgery, particularly after laminectomy. However, post-laminoplasty kyphosis remains an underreported entity. We present a case of progressive…
View details →DOI: 10.21037/jss-2025-1-227 Failed Experiment ReportMedicine
Cho, Lionakis, Khillan · 2026 · Laboratory animal research
Gene targeting via CRISPR/Cas9 has become a powerful tool to create animal models for human genetic disorders. Although CRISPR/Cas9 mediated gene editing is relatively simple, factors such as mouse strain, breeding performance, and quality…
View details →DOI: 10.1186/s42826-026-00281-x Failed Experiment ReportMedicine
Feroze-Bakht, Espinoza, Sosa et al. · 2026 · Pharmaceutics
Background/Objectives: Carprofen (CP) is a potent non-steroidal anti-inflammatory drug whose clinical use is limited by systemic adverse effects associated with oral administration. The aim of this study was to develop and evaluate a…
View details →DOI: 10.3390/pharmaceutics18060672 Failed Experiment ReportMedicine
Hengirmen Acu, Erbaş · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: Methotrexate-induced oxidative stress is mechanistically linked not only to hepatocellular injury but also to DNA damage, indicating that oxidative stress, hepatotoxicity, and genotoxicity represent interconnected…
View details →DOI: 10.3390/ph19060887 Failed Experiment ReportMedicine
Baier, Miao, Schirrmacher et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background : Zirconium-89 ( 89 Zr) is a key PET radionuclide and the limited in vivo stability of its clinically used 89 Zr-DFO complexes has driven the pursuit of improved chelator architectures. Among these, DFO* has attracted particular…
View details →DOI: 10.3390/ph19060813 Failed Experiment ReportMedicine
White AB, Reid R, Graham GD et al. · 2026 · Journal of pediatric orthopedics
Background This prospective observational cohort study evaluates the clinical, radiographic, and functional differences between pins and screw fixation for displaced pediatric lateral condyle fractures of the elbow. Methods Skeletally…
View details →DOI: 10.1097/bpo.0000000000003310 Failed Experiment ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Sameh Ahmed Abdel-bary, Eslam Safwat, Hany Ali Hussein et al. · 2014 · The Egyptian Journal of Radiology and Nuclear Medicine
Background: Hyperdynamic circulatory state in liver cirrhosis is characterized by increased splanchnic blood flow and renal vasoconstriction. Aim: To evaluate the relationship between renal resistive indices (RI) and HCV liver cirrhosis severity and RI value in predicting 6 month survival of those patients. Also we aimed to assess the effect of midodrine on RI. Patients and methods: 120 patients with HCV liver cirrhosis and 40 healthy controls were enrolled in the study. INR, total bilirubin, albumin, creatinine and sodium were measured in all patients. Both patients and controls underwent abd
View details →DOI: 10.1016/j.ejrnm.2014.06.006 Failed Experiment ReportOpen accessMedicine (General)
Qun Cheng, Xiang‐Yu Fang, Rong‐En Qiu · 2025 · Kaohsiung Journal of Medical Sciences
ABSTRACT Spinal cord injury (SCI) triggers secondary damage, including pain‐induced hypertension, inflammation, and hemorrhage, impairing recovery. This study evaluated the efficacy of general anesthesia with preemptive propofol administration in mitigating secondary damage in SCI rats. SCI was induced in rats using a contusion model. Propofol (100 mg/kg) was administered intraperitoneally either 30 min before (preemptive) or 30 min after intermittent tail shock. Systolic blood pressure (SBP), body weight, food intake, inflammatory markers (interleukin‐1 beta [IL‐1β], interleukin‐6 [IL‐6]), he
View details →DOI: 10.1002/kjm2.70011 Failed Experiment ReportOpen accessMedicine
Zhang T, Xiang J, Yu N et al. · 2026 · Frontiers in microbiology
Mastitis in dairy cows is one of the most prevalent infectious diseases in the dairy industry, leading to reduced milk production, increased production costs, and substantial economic losses. Antibiotics are commonly used to prevent and…
View details →DOI: 10.3389/fmicb.2026.1811623 Failed Experiment ReportOpen accessPublic aspects of medicine
Jacqueline A. Benson MPH, Matthew Wilson MS, Aidan J. Flynn MS et al. · 2025 · Inquiry: The Journal of Health Care Organization, Provision, and Financing
The strongest risk factor for readmission to the hospital is impaired physical function. We sought to determine the usability and feasibility of a post-hospital behavioral intervention to improve mobility in older adults with significant morbidity and functional impairment. We conducted a two-arm pragmatic pilot randomized trial of a behavioral economics-informed intervention to increase daily steps in Veterans, age 60 or older, receiving home health (HH) services post-discharge. The intervention group received a multicomponent behavioral economics-informed intervention, including daily step c
View details →DOI: 10.1177/00469580251384787 Failed Experiment ReportOpen accessMedicine
Nicholas J Douville, Lisa Bastarache, Emily Bertucci-Richter et al. · 2024 · PLoS ONE
Background Kidney dysfunction is a common complication in septic patients. Studies have identified numerous risk factors for sepsis-associated acute kidney injury (S-AKI), yet there is wide variability in the incidence even among patients with similar risk factors, suggesting the presence of additional uncharacterized risk factors, including genetic differences. The expansion of biobanks, advances in genotyping, and standardized diagnostic criteria have enabled large-scale, hypothesis-generating studies into the genetic mechanisms underlying S-AKI. We hypothesize that the genetic pathway behin
View details →DOI: 10.1371/journal.pone.0311318 Failed Experiment ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Carlos Cruchaga, Jose M. Vidal-Taboada, Mario Ezquerra et al. · 2009 · Neurobiology of Disease
Two different H1 sub-haplotypes at chromosome 17q21, H1C and H1E′A, have been associated with progressive supranuclear palsy (PSP) and cortical basal degeneration (CBD). We analyzed the SNPs included in the H1C and H1E′A haplotypes in a large Spanish PSP/CBD series and their interaction with age at onset (AAO). Survival analysis of rs1880753 marker was consistently associated with disease risk and with an earlier age at onset under an additive model. Its location at 160 kb and 50 kb upstream of tau and CRHR1 genes, respectively, suggests that it might act as a cis-element that regulates gene e
View details →DOI: 10.1016/j.nbd.2008.09.027 Failed Experiment ReportOpen accessPsychology
Gaoxing Mei, Mofen Cen, Xu Luo et al. · 2021 · Frontiers in Psychology
Prolonged exposure to an oriented stimulus causes a subsequent test stimulus to be perceived as tilted in the opposite direction, a phenomenon referred to as the tilt aftereffect (TAE). Previous studies have demonstrated that high-level cognitive functions such as attention can modulate the TAE, which is generally well-known as a low-level perceptual process. However, it is unclear whether working memory load, another high-level cognitive function, could modulate the TAE. To address this issue, here we developed a new paradigm by combining a working memory load task with a TAE task. Participan
View details →DOI: 10.3389/fpsyg.2021.618712