The RNA-binding activity of the Drosophila Brat protein is necessary for viability and mRNA regulation.
Connacher; Hu; Roden; Toledo; DesMarais; O'Connor; Lipshitz; Goldstrohm · 2026 · RNA biology
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Abstract (excerpt)
Brain tumor (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo…
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Metadata source: PubMed · DOI 10.1080/15476286.2026.2682069