Preemptive Propofol Administration in Spinal Cord Injury: Effects on Pain‐Induced Hypertension, Neuroinflammation, and Functional Recovery in Rats
Qun Cheng; Xiang‐Yu Fang; Rong‐En Qiu · 2025 · Kaohsiung Journal of Medical Sciences
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Abstract
ABSTRACT Spinal cord injury (SCI) triggers secondary damage, including pain‐induced hypertension, inflammation, and hemorrhage, impairing recovery. This study evaluated the efficacy of general anesthesia with preemptive propofol administration in mitigating secondary damage in SCI rats. SCI was induced in rats using a contusion model. Propofol (100 mg/kg) was administered intraperitoneally either 30 min before (preemptive) or 30 min after intermittent tail shock. Systolic blood pressure (SBP), body weight, food intake, inflammatory markers (interleukin‐1 beta [IL‐1β], interleukin‐6 [IL‐6]), he
Abstract by Qun Cheng; Xiang‐Yu Fang; Rong‐En Qiu, Kaohsiung Journal of Medical Sciences (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/kjm2.70011