5′-upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration
Carlos Cruchaga; Jose M. Vidal-Taboada; Mario Ezquerra; Elena Lorenzo; Pablo Martinez-Lage; Marta Blazquez; Eduardo Tolosa; Pau Pastor · 2009 · Neurobiology of Disease
WASTE classifies this as Failed Experiment Report · AI classification, approximate
An experimental approach did not work as intended — learn what to avoid before investing the same effort.
Abstract
Two different H1 sub-haplotypes at chromosome 17q21, H1C and H1E′A, have been associated with progressive supranuclear palsy (PSP) and cortical basal degeneration (CBD). We analyzed the SNPs included in the H1C and H1E′A haplotypes in a large Spanish PSP/CBD series and their interaction with age at onset (AAO). Survival analysis of rs1880753 marker was consistently associated with disease risk and with an earlier age at onset under an additive model. Its location at 160 kb and 50 kb upstream of tau and CRHR1 genes, respectively, suggests that it might act as a cis-element that regulates gene e
Abstract by Carlos Cruchaga; Jose M. Vidal-Taboada; Mario Ezquerra; Elena Lorenzo; Pablo Martinez-Lage; Marta Blazquez; Eduardo Tolosa; Pau Pastor, Neurobiology of Disease (2009) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Chronic stress induces insulin resistance and enhances cognitive impairment in AD
Negative / Null Result ReportSimilarities (and Differences) in the Learning Patterns of Single-Word Reading of an Alphabetic Orthography in Monolingual and Bilingual Primary School Children: A Cross-Sectional Study
Negative / Null Result ReportThe Impact of Acute Aerobic Exercise on General and Food-Related Inhibitory Function Among Young Adults with Obesity: An Event-Related Potential (ERP) Study
Negative / Null Result ReportEffects of simvastatin on white matter integrity in healthy middle‐aged adults
Negative / Null Result ReportRepetitive temporal interference stimulation improves jump performance but not the postural stability in young healthy males: a randomized controlled trial
Negative / Null Result ReportImpact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1016/j.nbd.2008.09.027