A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21165 results · page 23 of 706
Martin Andersson, Sierdjan Koster · 2010 · Journal of Economic Geography
This article assesses the spatial–temporal persistence of a dynamic phenomenon: start-ups. Two mechanisms that explain persistence in start-up rates are distinguished: (i) determinants of start-ups that are spatially ‘sticky’ and durable…
Chris Blake, I. K. Baldry, Joss Bland‐Hawthorn et al. · 2013 · Monthly Notices of the Royal Astronomical Society
We present the first application of a ‘multiple-tracer’ redshift-space distortion (RSD) analysis to an observational galaxy sample, using data from the Galaxy and Mass Assembly (GAMA) survey. Our data set is an r < 19.8 magnitude-limited…
Henrik Kleven, Camille Landais, Emmanuel Saez et al. · 2013 · The Quarterly Journal of Economics
Abstract This article analyzes the effects of income taxation on the international migration and earnings of top earners using a Danish preferential foreigner tax scheme and population-wide Danish administrative data. This scheme,…
Brian A. Walker, Christopher P. Wardell, Lorenzo Melchor et al. · 2012 · Blood
We have used whole exome sequencing to compare a group of presentation t(4;14) with t(11;14) cases of myeloma to define the mutational landscape. Each case was characterized by a median of 24.5 exonic nonsynonymous single-nucleotide…
Kimon Divaris, K. L. Monda, K. E. North et al. · 2013 · Human Molecular Genetics
Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden and is a major cause of tooth loss. Here, we present the results of a genome-wide association study of CP that was…
Susan M. Sawyer, Melissa Whitelaw, Daniel Le Grange et al. · 2016 · PEDIATRICS
BACKGROUND AND OBJECTIVE: Adolescents with atypical anorexia nervosa (AN) have lost significant weight but are not underweight. This study aimed to describe the physical and psychological morbidity of adolescents diagnosed with atypical…
Chelsea Rae Austin, Ryan J. Wilson · 2016 · Journal of the American Taxation Association
ABSTRACT We expect firms with the greatest exposure to reputational damage among consumers will engage in lower levels of tax avoidance to minimize unwanted scrutiny that could impair the firms' reputation. We identify a set of firms with…
Stephan Meier, Charles Sprenger · 2014 · The Review of Economics and Statistics
The preferences assumed to govern intertemporal trade-offs are generally considered to be stable economic primitives, though evidence on this stability is notably lacking. We present evidence from a large field study conducted over two…
Michelle L. O’Donoghue, Ruchira Glaser, Matthew A. Cavender et al. · 2016 · JAMA
IMPORTANCE: p38 Mitogen-activated protein kinase (MAPK)-stimulated inflammation is implicated in atherogenesis, plaque destabilization, and maladaptive processes in myocardial infarction (MI). Pilot data in a phase 2 trial in non-ST…
Leonard B. Saltz, Stephen Clarke, Eduardo Díaz‐Rubio et al. · 2023 · Journal of Clinical Oncology
Purpose To evaluate the efficacy and safety of bevacizumab when added to first-line oxaliplatin-based chemotherapy (either capecitabine plus oxaliplatin [XELOX] or fluorouracil/folinic acid plus oxaliplatin [FOLFOX-4]) in patients with…
Thulani H. Palpagama, Henry J. Waldvogel, Richard L. M. Faull et al. · 2019 · Frontiers in Molecular Neuroscience
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. HD patients present with movement disorders, behavioral and psychiatric symptoms and cognitive decline. This review summarizes the contribution of microglia and astrocytes to HD pathophysiology. Neuroinflammation in the HD brain is characterized by a reactive morphology in these glial cells. Microglia and astrocytes are critical in regulating neuronal activity and maintaining an optimal milieu for neuronal function. Previous studies provide evidence that activated microglia and reactive astrocytes contribute to HD pa
Urko M. Marigorta, Arcadi Navarro · 2013 · PLoS Genetics
Genome-wide association studies (GWAS) have detected many disease associations. However, the reported variants tend to explain small fractions of risk, and there are doubts about issues such as the portability of findings over different ethnic groups or the relative roles of rare versus common variants in the genetic architecture of complex disease. Studying the degree of sharing of disease-associated variants across populations can help in solving these issues. We present a comprehensive survey of GWAS replicability across 28 diseases. Most loci and SNPs discovered in Europeans for these cond
Paulina Aleksandrowicz, Andrea Marzi, Nadine Biedenkopf et al. · 2011 · The Journal of Infectious Diseases
Virus entry into host cells is the first step of infection and a crucial determinant of pathogenicity. Here we show that Ebola virus-like particles (EBOV-VLPs) composed of the glycoprotein GP(1,2) and the matrix protein VP40 use…
James D. Hamilton, Jing Cynthia Wu · 2015 · International Economic Review
We develop a simple model of futures arbitrage that implies that if purchases by commodity index funds influence futures prices, then the notional positions of the index investors should help predict excess returns in these contracts. We…
Andreas Wimmer, Yuval Feinstein · 2010 · American Sociological Review
Why did the nation-state proliferate across the world over the past 200 years, replacing empires, kingdoms, city-states, and the like? Using a new dataset with information on 145 of today’s states from 1816 to the year they achieved…
Athena Linos, Athanassios Petralias, Costas A. Christophi et al. · 2011 · Environmental Health
BACKGROUND: Hexavalent chromium is a known carcinogen when inhaled, but its carcinogenic potential when orally ingested remains controversial. Water contaminated with hexavalent chromium is a worldwide problem, making this a question of significant public health importance. METHODS: We conducted an ecological mortality study within the Oinofita region of Greece, where water has been contaminated with hexavalent chromium. We calculated gender, age, and period standardized mortality ratios (SMRs) for all deaths, cancer deaths, and specific cancer types of Oinofita residents over an 11-year perio
Alain Devalle, Enrico Onali, Riccardo Magarini · 2010 · Journal of International Financial Management and Accounting
Abstract Since 2005, European‐listed companies have been required to prepare their consolidated financial statements in accordance with the International Financial Reporting Standards (IFRS). We examine whether value relevance increased…
David A. Springate, Rosa Parisi, Evangelos Kontopantelis et al. · 2016 · British Journal of Dermatology
BACKGROUND: The burden of psoriasis across many world regions is high and there is a recognized need to better understand the epidemiology of this common skin disorder. OBJECTIVES: To examine changes in the prevalence and incidence of psoriasis, and mortality rates over a 15-year period. METHODS: Cohort study involving analysis of longitudinal electronic health records between 1999 and 2013 using the U.K. Clinical Practice Research Datalink (CPRD). RESULTS: The prevalence of psoriasis increased steadily from 2·3% (2297 cases per 100 000) in 1999 to 2·8% (2815 per 100 000) in 2013, which does n
Nancy Chooi Ping Low, Erika N. Dugas, Erin K. O’Loughlin et al. · 2012 · BMC Psychiatry
BACKGROUND: Stressful life events are associated with mood disorders in adults in clinical settings. Less described in the literature is the association between common life stressors and a wide range of psychopathology in young adolescents. This study uses a large non-clinical sample of young adolescents to describe the associations among worry or stress about common life events/difficulties, mental health and substance use. METHODS: Data on lifetime stress or worry about common life events/difficulties (i.e., romantic breakups, family disruption, interpersonal difficulties, and personal stres
Graeme Blair, C. Christine Fair, Neil Malhotra et al. · 2012 · American Journal of Political Science
Policy debates on strategies to end extremist violence frequently cite poverty as a root cause of support for the perpetrating groups. There is little evidence to support this contention, particularly in the Pakistani case. Pakistan's…
Gillian C. Barnett, Charlotte E. Coles, Rebecca Elliott et al. · 2011 · The Lancet Oncology
BACKGROUND: Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset. METHODS: 92 (of 98 attempted) SNPs in 46 genes were successfully genotyped in 1613 patients: 976 received adjuvant breast radiotherapy in the Cambridge breast IMRT trial (ISRCTN21474421, n=942) or in a prospective study of breast toxicity at the Chris
Frederic T. Billings, Patricia A. Hendricks, Jonathan S. Schildcrout et al. · 2016 · JAMA
IMPORTANCE: Statins affect several mechanisms underlying acute kidney injury (AKI). OBJECTIVE: To test the hypothesis that short-term high-dose perioperative atorvastatin would reduce AKI following cardiac surgery. DESIGN, SETTING, AND…
Godfrey Tan, John V. Guttag · 2026 · arXiv (Cornell University)
The performance seen by individual clients on a wireless local area network (WLAN) is heavily influenced by the manner in which wireless channel capacity is allocated. The popular MAC protocol DCF (Distributed Coordination Function) used…
Sarah J. Short, Tobias Stalder, Kristine Marceau et al. · 2016 · Psychoneuroendocrinology
Characterization of cortisol production, regulation and function is of considerable interest and relevance given its ubiquitous role in virtually all aspects of physiology, health and disease risk. The quantification of cortisol concentration in hair has been proposed as a promising approach for the retrospective assessment of integrated, long-term cortisol production. However, human research is still needed to directly test and validate current assumptions about which aspects of cortisol production and regulation are reflected in hair cortisol concentrations (HCC). Here, we report findings fr
Matt C. Estep, Michael R. McKain, Dilys M. Vela Díaz et al. · 2014 · Proceedings of the National Academy of Sciences
The role of polyploidy, particularly allopolyploidy, in plant diversification is a subject of debate. Whole-genome duplications precede the origins of many major clades (e.g., angiosperms, Brassicaceae, Poaceae), suggesting that polyploidy…
David T. Levy, Kenneth E. Warner, K. Michael Cummings et al. · 2018 · Tobacco Control
BACKGROUND: The 2018 National Academies of Sciences, Engineering, and Medicine Report found substantial evidence that electronic cigarette use (vaping) by youth is strongly associated with an increased risk of ever using cigarettes…
Noémie Travier, Miranda J. Velthuis, Charlotte N. Steins Bisschop et al. · 2015 · BMC Medicine
BACKGROUND: Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within 6 weeks after diagnosis, on preventing an increase in fatigue. METHODS: This multi-centre controlled trial randomly assigned 204 breast cancer patients to usual care (n = 102) or supervised aerobic and resistance exercise (n = 102). By design, all patients received chemotherapy
Tran D. Keys, George Farkas, Margaret Burchinal et al. · 2013 · Child Development
This article examines associations between observed quality in preschool center classrooms for approximately 6,250 three- to five-year-olds and their school readiness skills at kindergarten entry. Secondary analyses were conducted using…
Ann Huff Stevens, Douglas L. Miller, Marianne Page et al. · 2015 · American Economic Journal Economic Policy
It is well known that mortality rates are pro-cyclical. In this paper, we attempt to understand why. We find little evidence that cyclical changes in individuals' own employment-related behavior drives the relationship; own-group…
Rainer Meierhenrich, Elisa Steinhilber, Christian Eggermann et al. · 2010 · Critical Care
INTRODUCTION: Since data regarding new-onset atrial fibrillation (AF) in septic shock patients are scarce, the purpose of the present study was to evaluate the incidence and prognostic impact of new-onset AF in this patient group. METHODS: We prospectively studied all patients with new-onset AF and all patients suffering from septic shock in a non-cardiac surgical intensive care unit (ICU) during a 13 month period. RESULTS: During the study period, 687 patients were admitted to the ICU, of which 58 patients were excluded from further analysis due to pre-existing chronic or intermittent AF. In