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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21165 results · page 24 of 706

Negative / Null Result ReportOpen accessMedicine

Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock: a prospective observational study

Rainer Meierhenrich, Elisa Steinhilber, Christian Eggermann et al. · 2010 · Critical Care

INTRODUCTION: Since data regarding new-onset atrial fibrillation (AF) in septic shock patients are scarce, the purpose of the present study was to evaluate the incidence and prognostic impact of new-onset AF in this patient group. METHODS: We prospectively studied all patients with new-onset AF and all patients suffering from septic shock in a non-cardiac surgical intensive care unit (ICU) during a 13 month period. RESULTS: During the study period, 687 patients were admitted to the ICU, of which 58 patients were excluded from further analysis due to pre-existing chronic or intermittent AF. In

View details →DOI: 10.1186/cc9057Cited by 236
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

The demand and supply of external finance for innovative firms

A. Mina, Henry Lahr, Alan Hughes · 2013 · Industrial and Corporate Change

Access to finance has figured prominently in the debate on barriers to firm growth, even though existing empirical research has not found conclusive evidence of a "finance gap." Moreover, it is not clear to what extent innovation…

View details →DOI: 10.1093/icc/dtt020Cited by 236
Negative / Null Result ReportOpen accessSocial Sciences

COMPARING STUDENT PERFORMANCE: ONLINE VERSUS BLENDED VERSUS FACE-TO-FACE

David Larson, Chung-Hsien Sung · 2019 · Online Learning

The purpose of this research was to perform a three way comparison of delivery modes for an introductory Management Information Systems course to determine if there existed a difference in student success among the delivery modes. The research compares student exam and final grade results in this class that was taught by the same instructor using face-to-face, blended and online delivery modes. An Analysis of Variance test was used on the exam and final grade data to determine if a significant difference existed. Additionally, a discussion of this class in relation to student satisfaction, lea

View details →DOI: 10.24059/olj.v13i1.1675Cited by 235
Negative / Null Result ReportOpen accessMedicine

Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study

Gabrielle Campbell, Wayne Hall, Amy Peacock et al. · 2018 · The Lancet Public Health

BACKGROUND: Interest in the use of cannabis and cannabinoids to treat chronic non-cancer pain is increasing, because of their potential to reduce opioid dose requirements. We aimed to investigate cannabis use in people living with chronic…

View details →DOI: 10.1016/s2468-2667(18)30110-5Cited by 233
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Reconstructing the origin and spread of horse domestication in the Eurasian steppe

Vera Warmuth, Anders Eriksson, Mim A. Bower et al. · 2012 · Proceedings of the National Academy of Sciences

Despite decades of research across multiple disciplines, the early history of horse domestication remains poorly understood. On the basis of current evidence from archaeology, mitochondrial DNA, and Y-chromosomal sequencing, a number of…

View details →DOI: 10.1073/pnas.1111122109Cited by 232
Negative / Null Result ReportOpen accessSocial Sciences

How customer engagement in the live-streaming affects purchase intention and customer acquisition, E-tailer's perspective

Run Zheng, Zhuyuan Li, Sang-Gyun Na · 2022 · Journal of Retailing and Consumer Services

In the emerging retail market, e-tailers operating in developing economies have to cope with the rapid use of the Internet, new electronic purchasing methods and online selling platforms. However, e-tailers do not understand the effect…

View details →DOI: 10.1016/j.jretconser.2022.103015Cited by 232
Negative / Null Result ReportOpen accessEnvironmental Science

Evidence for Direct Electron Transfer by a Gram-Positive Bacterium Isolated from a Microbial Fuel Cell

Kelly Wrighton, J. Cameron Thrash, Ryan A. Melnyk et al. · 2011 · Applied and Environmental Microbiology

Despite their importance in iron redox cycles and bioenergy production, the underlying physiological, genetic, and biochemical mechanisms of extracellular electron transfer by Gram-positive bacteria remain insufficiently understood. In…

View details →DOI: 10.1128/aem.05365-11Cited by 232
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Rent-sharing, Holdup, and Wages: Evidence from Matched Panel Data

David Card, Francesco Devicienti, Agata Maida · 2013 · The Review of Economic Studies

Rent-sharing by workers can reduce the incentives for investment if some of the returns to sunk capital are captured in higher wages. We propose a simple measure of this "holdup" effect based on the size of the wage offset for…

View details →DOI: 10.1093/restud/rdt030Cited by 231
Negative / Null Result ReportOpen accessHealth Professions

No Visible Dental Staining in Children Treated with Doxycycline for Suspected Rocky Mountain Spotted Fever

Suzanne Todd, F. Scott Dahlgren, Marc Traeger et al. · 2015 · The Journal of Pediatrics

ObjectiveTo evaluate whether cosmetically relevant dental effects occurred among children who had received doxycycline for treatment of suspected Rocky Mountain spotted fever (RMSF).Study designChildren who lived on an American Indian…

View details →DOI: 10.1016/j.jpeds.2015.02.015Cited by 231
Negative / Null Result ReportPsychology

Effects and noneffects of input in bilingual environments on dual language skills in 2 ½-year-olds

Silvia Place, Erika Hoff · 2015 · Bilingualism Language and Cognition

Recent findings suggest some properties of input in dual-language environments that influence its value for bilingual development, but the extant data base is small and sometimes inconclusive. The present study sought additional evidence…

View details →DOI: 10.1017/s1366728915000322Cited by 231
Negative / Null Result ReportOpen accessEngineering

A conceptual model for the adoption of autonomous robots in supply chain and logistics industry

Mohamed Dawood Shamout, Rabeb Ben-Abdallah, Muhammad Turki Alshurideh et al. · 2022 · Uncertain Supply Chain Management

The arrival of the era of robots and autonomous machines is undisputable. It is anticipated that the future business environment will be characterized by a variety of intelligent systems and autonomous robots. In 2017, the International Federation of Robotics reported that momentum gained by robotic technologies is strong and that the sales volumes of both service and industrial robots is expected to grow. Building on this projection, the present study proposes a set of prerequisites or key determinants for the adoption of autonomous robots in the supply chain and logistics industry: technolog

View details →DOI: 10.5267/j.uscm.2021.11.006Cited by 230
Negative / Null Result ReportOpen accessNeuroscience

DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases

Conceição Bettencourt, Davina J. Hensman Moss, Michael Flower et al. · 2016 · Annals of Neurology

OBJECTIVE: The polyglutamine diseases, including Huntington's disease (HD) and multiple spinocerebellar ataxias (SCAs), are among the commonest hereditary neurodegenerative diseases. They are caused by expanded CAG tracts, encoding glutamine, in different genes. Longer CAG repeat tracts are associated with earlier ages at onset, but this does not account for all of the difference, and the existence of additional genetic modifying factors has been suggested in these diseases. A recent genome-wide association study (GWAS) in HD found association between age at onset and genetic variants in DNA r

View details →DOI: 10.1002/ana.24656Cited by 230
Negative / Null Result ReportEconomics, Econometrics and Finance

Efficient market hypothesis in European stock markets

María Rosa Borges · 2010 · European Journal of Finance

This paper reports the results of tests on the weak-form market efficiency applied to stock market indexes of UK, France, Germany, Spain, Greece and Portugal, from January 1993 to December 2007. We use a runs test, and joint variance ratio…

View details →DOI: 10.1080/1351847x.2010.495477Cited by 230
Negative / Null Result ReportOpen accessMedicine

Balloon kyphoplasty for the treatment of acute vertebral compression fractures: 2-year results from a randomized trial

Steven Boonen, Jan Van Meirhaeghe, L. Bastian et al. · 2011 · Journal of Bone and Mineral Research

Vertebral fractures are often painful and lead to reduced quality of life and disability. We compared the efficacy and safety of balloon kyphoplasty to nonsurgical therapy over 24 months in patients with acute painful fractures. Adults…

View details →DOI: 10.1002/jbmr.364Cited by 230
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Effect of Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus

A. Michael Lincoff, Jean‐Claude Tardif, Gregory G. Schwartz et al. · 2014 · JAMA

IMPORTANCE: No therapy directed against diabetes has been shown to unequivocally reduce the excess risk of cardiovascular complications. Aleglitazar is a dual agonist of peroxisome proliferator-activated receptors with insulin-sensitizing…

View details →DOI: 10.1001/jama.2014.3321Cited by 229
Negative / Null Result ReportEconomics, Econometrics and Finance

Portfolio Manager Compensation in the U.S. Mutual Fund Industry

Linlin Ma, Yuehua Tang, Juan-Pedro Gómez · 2018 · The Journal of Finance

ABSTRACT We study compensation contracts of individual portfolio managers using hand‐collected data of over 4,500 U.S. mutual funds. Variations in the compensation structures are broadly consistent with an optimal contracting equilibrium.…

View details →DOI: 10.1111/jofi.12749Cited by 229
Negative / Null Result ReportOpen accessMedicine

Response definition criteria for ELISPOT assays revisited

Zoe Moodie, Leah Price, Cécile Gouttefangeas et al. · 2010 · Cancer Immunology Immunotherapy

No consensus has been reached on how to determine if an immune response has been detected based on raw data from an ELISPOT assay. The goal of this paper is to enable investigators to understand and readily implement currently available…

View details →DOI: 10.1007/s00262-010-0875-4Cited by 229
Negative / Null Result ReportPsychology

Randomized controlled trial of a positive affect intervention for people newly diagnosed with HIV.

Judith T. Moskowitz, Adam W. Carrico, Larissa G. Duncan et al. · 2017 · Journal of Consulting and Clinical Psychology

OBJECTIVE: We conducted a randomized controlled trial to determine whether IRISS (Intervention for those Recently Informed of their Seropositive Status), a positive affect skills intervention, improved positive emotion, psychological…

View details →DOI: 10.1037/ccp0000188Cited by 229
Negative / Null Result ReportOpen accessPsychology

Web Accessibility Theory and Practice: An Introduction for University Faculty

David A. Bradbard, Cara Peters · 2010 · The Journal of Educators Online

This study sought to examine instructor immediacy and presence in an online learning environment in relation to student affective learning, cognition, and motivation. It found a statistically significant positive relationship between…

View details →DOI: 10.9743/jeo.2010.1.1Cited by 229
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Dropping the Books and Working Off the Books

Rita Cappariello, Roberta Zizza · 2010 · Labour

Abstract The paper empirically tests the relationship between underground labour and schooling achievement for Italy, a country ranking badly in both respects when compared with other high‐income economies, with a marked duality between…

View details →DOI: 10.1111/j.1467-9914.2010.00479.xCited by 229
Negative / Null Result ReportOpen accessComputer Science

Forecasting and trading cryptocurrencies with machine learning under changing market conditions

Hélder Sebastião, Pedro Godinho · 2021 · Financial Innovation

This study examines the predictability of three major cryptocurrencies-bitcoin, ethereum, and litecoin-and the profitability of trading strategies devised upon machine learning techniques (e.g., linear models, random forests, and support vector machines). The models are validated in a period characterized by unprecedented turmoil and tested in a period of bear markets, allowing the assessment of whether the predictions are good even when the market direction changes between the validation and test periods. The classification and regression methods use attributes from trading and network activi

View details →DOI: 10.1186/s40854-020-00217-xCited by 229
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Microbial Community Succession and Response to Environmental Variables During Cow Manure and Corn Straw Composting

Qingxin Meng, Wei Yang, Mengqi Men et al. · 2019 · Frontiers in Microbiology

In composting system, the composition of microbial communities is determined by the constant change in the physicochemical parameters. This study explored the dynamics of bacterial and fungal communities during cow manure and corn straw composting using high throughput sequencing technology. The relationships between physicochemical parameters and microbial community composition and abundance were also evaluated. The sequencing results revealed the major phyla included Proteobacteria, Bacteroidetes, Firmicutes, Chloroflexi and Actinobacteria, Ascomycota and Basidiomycota. Linear discriminant a

View details →DOI: 10.3389/fmicb.2019.00529Cited by 229
Negative / Null Result ReportMedicine

Psychoactive bacteriaLactobacillus rhamnosus(JB-1) elicits rapid frequency facilitation in vagal afferents

Azucena Pérez‐Burgos, Bingxian Wang, Yukang Mao et al. · 2012 · American Journal of Physiology-Gastrointestinal and Liver Physiology

Mounting evidence supports the influence of the gut microbiome on the local enteric nervous system and its effects on brain chemistry and relevant behavior. Vagal afferents are involved in some of these effects. We previously showed that…

View details →DOI: 10.1152/ajpgi.00128.2012Cited by 229
Negative / Null Result ReportOpen accessMedicine

Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases

Masanari Kuwabara, Koichiro Niwa, Ichiro Hisatome et al. · 2017 · Hypertension

Whether asymptomatic hyperuricemia in the absence of comorbidities increases the risk for cardiometabolic disorders and chronic kidney disease remains controversial. This study was conducted to clarify the association between asymptomatic…

View details →DOI: 10.1161/hypertensionaha.116.08998Cited by 228
Negative / Null Result ReportOpen accessMedicine

Variations in Eyeball Diameters of the Healthy Adults

Inessa Bekerman, Paul Gottlieb, Michael Vaiman · 2014 · Journal of Ophthalmology

The purpose of the current research was to reevaluate the normative data on the eyeball diameters. Methods. In a prospective cohort study, the CT data of consecutive 250 adults with healthy eyes were collected and analyzed, and sagittal, transverse, and axial diameters of both eyeballs were measured. The data obtained from the left eye and from the right eye were compared. The correlation analysis was performed with the following variables: orbit size, gender, age, and ethnic background. Results. We did not find statistically significant differences correlated with gender of the patients and t

View details →DOI: 10.1155/2014/503645Cited by 228
Negative / Null Result ReportOpen accessPsychology

Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder

Karen J. Parker, Joseph P. Garner, Robin A. Libove et al. · 2014 · Proceedings of the National Academy of Sciences

The neuropeptide oxytocin (OXT) and its receptor (OXTR) regulate social functioning in animals and humans. Initial clinical research suggests that dysregulated plasma OXT concentrations and/or OXTR SNPs may be biomarkers of social…

View details →DOI: 10.1073/pnas.1402236111Cited by 228
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Endogenous Production Networks

Daron Acemoğlu, Pablo Azar · 2020 · Econometrica

We develop a tractable model of endogenous production networks. Each one of a number of products can be produced by combining labor and an endogenous subset of the other products as inputs. Different combinations of inputs generate…

View details →DOI: 10.3982/ecta15899Cited by 228
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Limits of long-term selection against Neandertal introgression

Martin Petr, Svante Pääbo, Janet Kelso et al. · 2019 · Proceedings of the National Academy of Sciences

Several studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans. A striking observation in support of this is an apparent monotonic decline in Neandertal ancestry observed in modern humans in Europe over the past 45,000 years. Here, we show that this decline is an artifact likely caused by gene flow between modern human populations, which is not taken into account by statistics previously used to estimate Neandertal ancestry. When we apply a statistic that avoids assumptions about modern human demography by taking advantage of two high-cover

View details →DOI: 10.1073/pnas.1814338116Cited by 228
Negative / Null Result ReportOpen accessMedicine

Comparative clinical evaluation of coronally advanced flap with or without platelet rich fibrin membrane in the treatment of isolated gingival recession

Thamaraiselvan Murugan, Sugumari Elavarasu, Thangakumaran Suthanthiran et al. · 2014 · Journal of Indian Society of Periodontology

AIM: The aim of this study was to determine whether the addition of an autologous platelet rich fibrin (PRF) membrane to a coronally advanced flap (CAF) would improve the clinical outcome in terms of root coverage, in the treatment of…

View details →DOI: 10.4103/0972-124x.145790Cited by 227
Negative / Null Result ReportOpen accessSocial Sciences

Institutional Motivations in the Adoption of Innovations: The Case of E-Government

Kyu-Nahm Jun, Christopher Weare · 2010 · Journal of Public Administration Research and Theory

This article examines the institutional motivations underlying innovation. Although attention to motivation played a role in early theorizing on innovation, the phenomenon is understudied empirically. A clearer understanding of the…

View details →DOI: 10.1093/jopart/muq020Cited by 226