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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21266 results · page 229 of 709

Negative / Null Result ReportOpen accessMedicine

The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy.

Loos E, Van Stiphout L, Lucieer F et al. · 2025 · Scientific reports

Little is known about the evolution of vestibular dysfunction and health-related quality of life in bilateral vestibulopathy patients over time. Furthermore, it is unknown whether etiology influences the evolution. A retrospective study…

View details →DOI: 10.1038/s41598-025-92109-2
Negative / Null Result ReportMedicine

The protective effects of hyperoxic pre-treatment in human-derived adipose tissue mesenchymal stem cells against in vitro oxidative stress and a rat model of renal ischaemia-reperfusion.

Ahmadi Somaghian S, Pajouhi N, Dezfoulian O et al. · 2024 · Archives of physiology and biochemistry

Objective Improvement of cell survival is essential for achieving better clinical outcomes in stem cell therapy. We investigated the effects of hyperoxic pre-treatment (HP) on the viability of human adipose stromal stem cells (ASCs).…

View details →DOI: 10.1080/13813455.2023.2238918
Negative / Null Result ReportMedicine

The effect of the plasma methotrexate concentration during high-dose methotrexate therapy in childhood acute lymphoblastic leukemia.

Liao C, Nie J, Xu XJ et al. · 2024 · Leukemia & lymphoma

Two hundred and thirty-one acute lymphoblastic leukemia (ALL) children with 1376 high-dose methotrexate (HD-MTX) courses (3-5 g/m 2 ) were enrolled to analyze the influence of the plasma MTX concentration ( C MTX ) in ALL. The 24-h target…

View details →DOI: 10.1080/10428194.2023.2266075
Negative / Null Result ReportOpen accessMedicine

Androgen Receptor Signaling Inhibitors for Metastatic Hormone Sensitive Prostate Cancer in Asians: Indirect Comparison.

Chen W, Yoshida S, Fujii Y · 2026 · Cancer reports (Hoboken, N.J.)

Background Androgen receptor signaling inhibitors (ARSI) combined with androgen deprivation therapy (ADT) have demonstrated significant survival benefits in metastatic hormone-sensitive prostate cancer (mHSPC) in several clinical trials.…

View details →DOI: 10.1002/cnr2.70496
Negative / Null Result ReportMedicine

Predictors of Durable Remission After Successful Surgery for Cushing Disease: Results From the Multicenter RAPID Registry.

Findlay MC, Tenhoeve S, Alt J et al. · 2024 · Neurosurgery

Background and objective Cushing disease (CD) affects mortality and quality of life along with limited long-term remission, underscoring the need to better identify recurrence risk. The identification of surgical or imaging predictors for…

View details →DOI: 10.1227/neu.0000000000003042
Negative / Null Result ReportMedicine

Assessing the Quality of Metagenomic Next-Generation Sequencing for Pathogen Detection in Lower Respiratory Infections.

Diao Z, Zhang Y, Chen Y et al. · 2023 · Clinical chemistry

Background Laboratory-developed metagenomic next-generation sequencing (mNGS) assays are increasingly being used for the diagnosis of infectious disease. To ensure comparable results and advance the quality control for the mNGS assay, we…

View details →DOI: 10.1093/clinchem/hvad072
Negative / Null Result ReportOpen accessMedicine

Association Between Patient Sex and Familial Hypercholesterolemia and Long-Term Cardiovascular Risk Factor Management 5 Years After Acute Coronary Syndrome.

Krasieva K, Gencer B, Locatelli I et al. · 2024 · Circulation. Cardiovascular quality and outcomes

Background Long-term control of cardiovascular risk factors after acute coronary syndrome (ACS) is the cornerstone for preventing recurrence. We investigated the extent of cardiovascular risk factor management in males and females with and…

View details →DOI: 10.1161/circoutcomes.123.010790
Negative / Null Result ReportOpen accessMedicine

Refining the clinical utility of [<sup>177</sup>Lu]Lu/[<sup>225</sup>Ac]Ac-PSMA tandem RLT in patients with metastatic castration resistant prostate cancer.

Widjaja L, Hornfeck J, Siegmund SC et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose This study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([ 177 Lu]Lu/[ 225 Ac]Ac-PSMA tandem RLT) and to explore clinical and imaging-based…

View details →DOI: 10.1007/s00259-025-07632-1
Negative / Null Result ReportMedicine

Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report.

El-Haffaf I, Laverdière J, Albert M et al. · 2024 · Canadian journal of physiology and pharmacology

Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of…

View details →DOI: 10.1139/cjpp-2023-0109
Negative / Null Result ReportOpen accessMedicine

Nuclear protein 1 is a cell death regulator in primary human airway epithelial cells and reduced in idiopathic pulmonary fibrosis.

Zöller M, Mastalerz M, Dick E et al. · 2026 · Scientific reports

The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS…

View details →DOI: 10.1038/s41598-026-51510-1
Negative / Null Result ReportOpen accessMedicine

Rapid response to BRAF/MEK inhibitor therapy within 2 weeks for high-grade glioma with leptomeningeal metastasis: illustrative case.

Kawaguchi Y, Hana T, Hasegawa H et al. · 2025 · Journal of neurosurgery. Case lessons

Background High-grade gliomas, particularly isocitrate dehydrogenase-wildtype glioblastomas (GBMs), are highly aggressive brain tumors with limited treatment options and poor outcomes. A subset of these tumors, including epithelioid GBM,…

View details →DOI: 10.3171/case25247
Negative / Null Result ReportMedicine

Gender-Affirming Hormone Therapy Is Associated with Increased Odds of Screening for Sexually Transmitted Infections in a Clinical Cohort of Transgender and Nonbinary Adults.

Pletta DR, Mayer KH, Chen JT et al. · 2024 · Transgender health

Purpose Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was…

View details →DOI: 10.1089/trgh.2023.0159
Negative / Null Result ReportMedicine

A true reflection of executive functioning or a representation of task-specific variance? Re-evaluating the unity/diversity framework.

Sambol S, Suleyman E, Scarfo J et al. · 2023 · Acta psychologica

The unity/diversity framework, originally published by Miyake et al. (2000) has become the most cited model of executive functioning. Consequently, when researchers operationalise executive function (EF) they often exclusively assess the…

View details →DOI: 10.1016/j.actpsy.2023.103934
Negative / Null Result ReportOpen accessMedicine

Derived hematological indices during peripheral blood stem cell mobilization in the plerixafor era: insightful dynamics but limited predictive value.

Murugesan M, Niveditha LP, Sindhu ER et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Derived hematological indices reflect immune activation, but their dynamics during the plerixafor era and their predictive value for stem cell yield remain unclear. Objectives To assess changes in derived hematological…

View details →DOI: 10.1016/j.htct.2026.106474
Negative / Null Result ReportOpen accessMedicine

Impact of Introduction of Code Blue Response System in a Cardiorespiratory Center: Before-After Study.

Kumar S, Kumar A, Ameta N et al. · 2026 · Annals of cardiac anaesthesia

Background In-hospital cardiac arrest demands immediate response to improve survival outcomes. The Code Blue Response System (CBRS) was designed to streamline emergency interventions by reducing response times. This study aimed to evaluate…

View details →DOI: 10.4103/aca.aca_102_25
Negative / Null Result ReportOpen accessMedicine

The recent clinical trial of losmapimod for the treatment of facioscapulohumeral muscular dystrophy.

Bloch RJ, Traficante M, Mariot V et al. · 2025 · Neuromuscular disorders : NMD

Facioscapulohumeral muscular dystrophy is a progressive muscle disorder that is likely linked to aberrant DUX4 expression. Losmapimod, a p38 kinase inhibitor, was utilized to suppress DUX4 and its downstream effects. Phase I/II clinical…

View details →DOI: 10.1016/j.nmd.2025.105422
Negative / Null Result Report

Methotrexate and Prednisolone compared to placebo and prednisolone in the treatment of Erythema Nodosum Leprosum - an international multicentre, double-blind randomised controlled clinical trial - MaPs in ENL

de Barros B, Sultana F, Maximus N et al. · 2026 · Preprint

ABSTRACT Background Erythema nodosum leprosum (ENL) is a severe inflammatory complication of leprosy that often requires prolonged corticosteroid therapy which is associated with adverse effects. Methotrexate is an affordable…

View details →DOI: 10.64898/2026.05.19.26353561
Negative / Null Result ReportOpen accessMedicine

The Injection of Tranexamic Acid Alone is Not Effective in Reducing Transfusion Requirements Following Total Joint Arthroplasty.

Legnani C, Ventura A, Oriani G · 2026 · Journal of clinical practice and research

A retrospective study was conducted to evaluate the need for perioperative autotransfusions and the amount of blood loss by comparing patients receiving different tranexamic acid (TXA) regimens following total joint replacement (TJR). A…

View details →DOI: 10.14744/cpr.2026.62805
Negative / Null Result ReportMedicine

Pilot Study of Gallic Acid Cream as a Potential Treatment for Plaque Psoriasis.

Greenway RR, Coulter AA, Zhang D et al. · 2026 · Journal of medicinal food

Gallic acid, a catechin polyphenol in tea, completely inhibited angiogenesis in assays of human tissue at 10 -3 M. Psoriasis is a skin disease caused by excessive secretion of angiogenenic factors by keratinocytes and stromal skin cells.…

View details →DOI: 10.1177/1096620x261458593
Negative / Null Result Report

Silicon and arbuscular mycorrhizal fungi differentially regulate structural defence and nutritional quality in maize–herbivore interactions

Kasige RH, Johnson SN, Frew A · 2026 · Preprint

Abstract Background and aims. Plant susceptibility to insect herbivores is shaped by interacting soil-based biotic and abiotic factors, particularly arbuscular mycorrhizal (AM) fungi and silicon (Si) availability. AM fungi influence plant…

View details →DOI: 10.21203/rs.3.rs-9812768/v1