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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 228 of 724

Negative / Null Result ReportMedicine

Association between exposure to pyrethroids and chlorpyrifos at age 5 years and IQ at age 7 years among children from the Odense Child Cohort, a prospective birth cohort study.

Normann SS, Andersen HR, Lund LC et al. · 2025 · Environmental research

Background Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults…

View details →DOI: 10.1016/j.envres.2025.120853
Negative / Null Result ReportMedicine

Connections matter: Exploring the relationship between belonging and psychosocial well-being in type 1 diabetes in Iran.

Razeghi M, Abdoli S, Mardanian Dehkordi L · 2024 · Applied nursing research : ANR

Aim Identify the relationship between a sense of belonging and psychosocial well-being in individuals with type 1 diabetes (T1D) in Iran. Background Understanding this relationship is vital for tailored nursing interventions to enhance…

View details →DOI: 10.1016/j.apnr.2024.151843
Negative / Null Result ReportOpen accessMedicine

Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans.

Gao Y, Hsu V, Kil A et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Previous animal studies show association between osteocalcin (OC) and type 2 diabetes-related quantitative traits (QTs), with some suggesting these effects being mediated by adipokines. Replication in humans has been inconsistent.…

View details →DOI: 10.1210/clinem/dgaf460
Negative / Null Result ReportMedicine

It is time to appreciate the value of processed foods

Fitzgerald M · 2024 · Trends in Food Science & Technology.

The messaging around processed food recently is that it is unhealthy and associated with the onset of chronic disease. However, food is processed for many reasons that range from preservation to safety, and then more recently in response…

Negative / Null Result ReportOpen accessMedicine

Stewardship Behaviour Among Residents of the Great Barrier Reef Region and the Role of Self-Efficacy.

Dousset J, Curnock MI, Wang JZ et al. · 2026 · Environmental management

As the Great Barrier Reef (GBR, the Reef) faces unprecedented threats, reducing anthropogenic pressures and fostering stewardship within coastal communities are among the strategic priorities identified in the Australian and Queensland…

View details →DOI: 10.1007/s00267-026-02525-x
Negative / Null Result ReportOpen accessMedicine

Lung Tissue Compliance Interacts with Smooth Muscle and Drives Hyperresponsiveness in Mice with Experimental Asthma.

Hecht S, Rojas-Ruiz A, Boucher M et al. · 2025 · Lung

Introduction A recent study on BALB/c and C57BL/6 mice demonstrated a clear lack of association between the in vivo response to nebulized methacholine and the degree of airway narrowing ex vivo in a model of asthma induced by a daily…

View details →DOI: 10.1007/s00408-025-00840-4
Negative / Null Result ReportMedicine

Plasma Inflammatory Biomarkers Lack Strong Association With Cognitive Outcomes Among Young Adults With Perinatal HIV Exposure and/or Acquisition.

McHenry MS, Huo Y, Williams PL et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)

Background Our objective was to evaluate the association between inflammatory biomarkers and NIH Toolbox cognitive outcomes in young adults with perinatal HIV exposure but uninfected (YAPHEU) and those with perinatal HIV (YAPHIV), with or…

View details →DOI: 10.1097/qai.0000000000003771
Negative / Null Result Report

Specimen-tailored “lived” climate reveals precipitation onset and amount best predict specimen phenology, but only weakly predict estimated reproduction across a clade

Bontrager M, Worthy SJ, Leventhal L et al. · 2025 · Preprint

Summary Herbarium specimens are broadly distributed in space and time, enabling investigation of climate impacts on phenology and fitness. We reconstructed specimen “lived” climate from knowledge of germination cues and collection dates…

View details →DOI: 10.1101/2025.02.03.636077
Negative / Null Result ReportMedicine

Is Obesity a Factor in Lethal Opioid Toxicity?

Hunter JWS, Van Den Heuvel C, Stephenson L et al. · 2025 · The American journal of forensic medicine and pathology

Abstract Both obesity and opioid abuse are increasing in numbers globally. As these entities may be associated with significant respiratory compromise, it was hypothesized that synergism may occur and that as a result of this obese…

View details →DOI: 10.1097/paf.0000000000001029
Negative / Null Result ReportMedicine

Evaluation of response to clopidogrel in patients with CYP2C19*2/*3 polymorphisms and its association with miR-19b expression.

Eskandarian S, Zafarani A, Tandel P et al. · 2025 · Molecular biology reports

Background Clopidogrel is a widely used antiplatelet drug for treating acute coronary syndrome. Its metabolism primarily involves the CYP2C19 isoenzyme, with CYP2C192 and CYP2C193 alleles associated with reduced metabolic activity.…

View details →DOI: 10.1007/s11033-025-10482-7
Negative / Null Result ReportOpen accessMedicine

Is glucose-6-phosphate dehydrogenase deficiency associated with COVID-19 infection, severity, and death? A cohort study from the Brazilian Amazon.

Dias ALB, Nascimento JR, Brito-Sousa JD et al. · 2025 · PloS one

Background Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections,…

View details →DOI: 10.1371/journal.pone.0331729
Negative / Null Result ReportOpen accessMedicine

An open-label, single-arm, dose-escalating concentration-QT study to investigate the cardiac effects and safety of paroxetine in healthy adults.

van Dijkman SC, Félices M, Pandurangavittal B et al. · 2026 · British journal of clinical pharmacology

Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack…

View details →DOI: 10.1002/bcp.70398
Negative / Null Result ReportMedicine

Update on the utilization of complementary therapies by adolescents with asthma in an urban population.

Soffer GK, Feinberg T, Kroll H et al. · 2025 · The Journal of asthma : official journal of the Association for the Care of Asthma

Objectives To assess the prevalence and perceived efficacy of complementary and alternative medicine (CAM) use among urban adolescents with asthma, building on a previous landmark study, and to determine if CAM use varied by asthma…

View details →DOI: 10.1080/02770903.2025.2475451
Negative / Null Result ReportOpen accessMedicine

Long-term and short-term exposure to outdoor air pollution and its association with glycolipid metabolic disorders.

Zhou C, Cui GY, Tang YH et al. · 2025 · World journal of diabetes

Background The association between ambient air pollution and glycolipid metabolic disorders (GMDs, including diabetes mellitus and dyslipidemia) is still not well understood, especially when it comes to the different effects of long-term…

View details →DOI: 10.4239/wjd.v16.i12.110028
Negative / Null Result ReportOpen accessMedicine

Genetic Variants in Vitamin-D Metabolism Genes (rs1155563, rs12785878 and rs10500804) among Females with Type-2 Diabetes Mellitus in Saudi Arabia.

Alharazy S · 2024 · Pakistan journal of medical sciences

Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…

View details →DOI: 10.12669/pjms.40.8.9318
Negative / Null Result ReportOpen accessMedicine

Computationally efficient whole-genome quantile regression at biobank scale.

Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America

Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…

View details →DOI: 10.1073/pnas.2513007122
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Intraoperative Hypotension and Postoperative Acute Kidney Injury in Patients Undergoing Pancreaticoduodenectomy: A Retrospective Cohort Study.

Gu Y, Zhang W, Zhou J et al. · 2025 · International journal of nephrology

Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients…

View details →DOI: 10.1155/ijne/5568151
Negative / Null Result ReportOpen accessMedicine

<i>XPO5</i> Polymorphism in Colon Cancer Patients: A Cross-Sectional Study.

Agbektas T, Genc HC, Zontul C et al. · 2025 · International journal of molecular sciences

(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls)…

View details →DOI: 10.3390/ijms27010345
Negative / Null Result ReportMedicine

Comparison of susceptibility of Pseudomonas aeruginosa isolated from keratitis to antibiotics and multipurpose disinfecting solutions.

Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…

View details →DOI: 10.1016/j.clae.2024.102288
Negative / Null Result ReportOpen accessMedicine

Relationship between the anxiety of labor companion and labor satisfaction among laboring women.

Nasirzadeh A, Mohammadzadeh F, Kazeminia S et al. · 2025 · Scientific reports

The presence of a known labor companion was shown to improve childbirth satisfaction. However, a companion's anxiety might affect the satisfaction of laboring women. Therefore, this study aimed to evaluate the relationship between the…

View details →DOI: 10.1038/s41598-025-04754-2
Negative / Null Result ReportMedicine

Lack of Association Between Immunotherapy and Improvement of Survival for Non-small Cell Lung Cancer Patients With Hemodialysis: A Nationwide Retrospective Cohort Study.

Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer

Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…

View details →DOI: 10.1016/j.cllc.2023.11.003
Negative / Null Result ReportOpen accessMedicine

Peripheral immune system activity in young psychiatry patients.

Seizer L, Löchner J, Renner TJ · 2026 · Brain, behavior, & immunity - health

The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This…

View details →DOI: 10.1016/j.bbih.2025.101143
Negative / Null Result ReportOpen accessMedicine

Implicit Bias and Recognition of Biases Among Vascular Surgeons.

Howard KA, Witrick B, Clark A et al. · 2026 · The Journal of surgical research

Introduction Implicit bias can influence behavior and decision-making, such as treatment decisions in clinical settings. Given documented Black-White disparities in vascular care, the purpose of this study was to describe the prevalence…

View details →DOI: 10.1016/j.jss.2026.02.004
Negative / Null Result ReportOpen accessMedicine

Mechanosensitivity and Adipose Thickness as Determinants of Pressure to Reach Deep Fasciae in Cervical and Thoracolumbar Regions.

Pires S, Freitas M, Pinho F et al. · 2025 · Sensors (Basel, Switzerland)

Objective We aimed to quantify the mechanical pressure required to reach the deep cervical and thoracolumbar fasciae, to examine its association with pressure pain threshold (PPT) and adipose tissue thickness, and to determine whether PPT…

View details →DOI: 10.3390/s25165073