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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 230 of 724

Negative / Null Result ReportOpen accessMedicine (General)

Height Estimation Using Anthropometric Parameters of the Upper Limbs in the Indigenous Population of Bushehr

Nahid Jashirenezhad, Sahar Almasi Turk, Marzieh Mahmoodi et al. · 2025 · Iranian South Medical Journal

Background: Identifying individuals based on their height is of great importance, especially in cases such as accidents or burns where identifying individuals is challenging. Therefore, the aim of this study was to investigate upper extremity parameters in a population of Bushehr in a relative formulation to predict their stature using anatomical indices. Materials and Methods: The project involved men and women aged 18 to 50 who were themselves born and both they and two generations before them also lived there. The indices of arm, forearm, hand, upper extremity, and stature were measured in

Negative / Null Result ReportOpen accessBiology (General)

Age-Dependent Changes in Bone Architecture, Patterning, and Biomechanics During Skeletal Regeneration

Kevin Hoffseth, Emily Busse, Josue Jaramillo et al. · 2021 · Frontiers in Cell and Developmental Biology

Mouse digit amputation provides a useful model of bone growth after injury, in that the injury promotes intramembranous bone formation in an adult animal. The digit tip is composed of skin, nerves, blood vessels, bones, and tendons, all of which regenerate after digit tip amputation, making it a powerful model for multi-tissue regeneration. Bone integrity relies upon a balanced remodeling between bone resorption and formation, which, when disrupted, results in changes to bone architecture and biomechanics, particularly during aging. In this study, we used recently developed techniques to evalu

View details →DOI: 10.3389/fcell.2021.749055
Negative / Null Result ReportOpen accessDentistry

Knowledge of correct prescription of radiographs among dentists in Yazd, Iran

Fatemeh Ezoddini Ardakani, Vahid Sarayesh · 2008 · Journal of Dental Research, Dental Clinics, Dental Prospects

Background and aims. While the use of X-ray is increasing, professional responsibility of dentists entitles them to have sufficient and correct knowledge of using radiographs. The aim of this study was to assess the level of knowledge of correct prescription of radiographs among dentists in Yazd, Iran. Materials and methods. This was a descriptive cross-sectional study including 134 general dentists and dental specialists. A self-administered questionnaire was used to assess their level of knowledge in various sections pertaining to prescription of radiographs. Their level of knowledge was com

Negative / Null Result ReportOpen accessSports medicine

Is the Lind or LaPrade Technique Able to Control Anterior and Rotational Laxity in Medial-Side Knee Injuries? A Controlled Laboratory Study of 18 Knees

Michel Drouineau MD, Baptiste Guegan MD, Harold Common MD et al. · 2025 · Orthopaedic Journal of Sports Medicine

Background: Reconstruction of the medial collateral ligament (MCL) and posterior oblique ligament (POL) is necessary to restore stability in chronic lesions on the medial side of the knee. The Lind technique uses a single-strand, pedicled semitendinosus tendon autograft to perform continuous reconstruction of the MCL and POL. The LaPrade technique uses 2 free grafts: 1 graft for the MCL (double-strand semitendinosus tendon graft) and 1 graft for the POL (double-strand gracilis tendon graft). Purpose: To investigate the LaPrade and Lind techniques in restraining tibial translation and rotation

View details →DOI: 10.1177/23259671251389124
Negative / Null Result ReportOpen accessMedicine

The Timing of the Melatonin Onset and Phase Angle to Sleep Onset in Older Adults after Uncontrolled vs. Controlled Lighting Conditions

Arturo Arrona-Palacios, Jung-Hie Lee, Charles A. Czeisler et al. · 2023 · Clocks & Sleep

The main aim of this study was to explore how melatonin onset timing and phase angle to bedtime in healthy older adults are impacted by prior light exposure. A total of 13 healthy older (ages 56–74) individuals were studied on two successive evenings. Prior to the first evening, the participants were in self-selected lighting conditions for the first 4–6 h of the day and then were in dim light (3 lux) until their scheduled bedtime. On the second day, individuals from Project A remained in the dim lighting conditions throughout the entire day but those in Project B were in more typical indoor l

View details →DOI: 10.3390/clockssleep5030026
Negative / Null Result ReportOpen accessAgriculture (General)

Índíces de conforto térmico e concentração de gases em galpões avícolas no semiárido Paraibano Indices of thermal comfort and gases concentration in broilers houses in the semiarid region, Brazil

Dermeval A. Furtado, Herlucio P. Rocha, José W. B. Nascimento et al. · 2010 · Engenharia Agrícola

Esta pesquisa teve o objetivo de determinar os índices de conforto térmico e a concentração de gases no interior de galpões avícolas e suas influencias sobre o desempenho de frangos de corte comercias, em condições de verão, na região semiárida paraibana. Utilizaram-se dois aviários, um coberto com telha de cerâmica e outro coberto com telha de fibrocimento. Observou-se que não houve diferença significativa (p > 0,05) entre a temperatura ambiente (TA), umidade relativa do ar (UR), temperatura da água de bebida (Tágua) e da cama entre os galpões, sendo que os valores médios de TA (das 8h às 17h

View details →DOI: 10.1590/s0100-69162010000600001
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

The Mechanism of Gefitinib Resistance Induced by Hepatocyte Growth Factor in Sensitive Non-small Cell Lung Cancer Cells in Vitro

Xianglan XUAN, Changshan AN, Caicun ZHOU · 2013 · Chinese Journal of Lung Cancer

Background and objective Previous studies have reported that Met might be related to gefitinib resistance in non-small cell lung cancer (NSCLC). The present study aims to explore the mechanism of hepatocyte growth factor (HGF)-induced gefitinib resistance in different gene types of sensitive NSCLC in vitro. Methods The PC-9 and H292 cell lines were chosen and induced by HGF. The cell survival was measured using MTT assay, the cell cycle distribution was measured using PI assay, and cell apoptosis with an Annexin V-PE assay, respectively. The c-Met and p-Met protein expression was determined vi

View details →DOI: 10.3779/j.issn.1009-3419.2013.01.01
Negative / Null Result ReportOpen accessDentistry

Effects of Ozone and Prophylactic Antimicrobial Applications on Shear Bond Strength of Orthodontic Brackets

Özer Alkan, Burcu Oktay Çöven, Betül Özçopur et al. · 2017 · Turkish Journal of Orthodontics

Objective:The present study aimed to evaluate the effects of ozone and prophylactic antimicrobial applications on the shear bond strengths and bond failure interfaces of orthodontic brackets.Methods:Sixty human canine teeth were randomly divided into three groups (n=20), receiving the following treatments: Group I-pumice prophylaxis (Isler Dental, Ankara, Turkey)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+Transbond XT primer and adhesive (3M Unitek, Monrovia, USA); Group II-prophylaxis paste (Topex, NJ, USA)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+ Transbon

View details →DOI: 10.5152/turkjorthod.2017.17032
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy

Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang et al. · 2020 · BMC Cancer

Abstract Background The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margin status and locoregional recurrence (LRR). Methods Our institutional prospectively maintained database was reviewed to identify patients who were treated with NACT between January 2008 and April 2018. Results Among the main partial mastectomy specimens available for analysis (n = 161), 28 had margins 2 mm. LRR occurred in 16 patients (9.9%) and distant metastases were

View details →DOI: 10.1186/s12885-020-06955-6
Negative / Null Result ReportOpen accessMicrobiology

Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns

Yuhan Xie, Gang Peng, Hongyu Zhao et al. · 2023 · Metabolites

Pregnancy at an advanced maternal age is considered a risk factor for adverse maternal, fetal, and neonatal outcomes. Here we investigated whether maternal age could be associated with differences in the blood levels of newborn screening (NBS) markers for inborn metabolic disorders on the Recommended Universal Screening Panel (RUSP). Population-level NBS data from screen-negative singleton infants were examined, which included blood metabolic markers and covariates such as age at blood collection, birth weight, gestational age, infant sex, parent-reported ethnicity, and maternal age at deliver

View details →DOI: 10.3390/metabo14010005
Negative / Null Result ReportOpen accessAgriculture

Investigating Carbonate Distribution in Particle Size Components of Some Soils of Khuzestan Province

S. Jafari, M. Karimzadeh, A. Abdeshahi · 2021 · علوم آب و خاک

Characteristics of most soils in arid and semi-arid regions affected by carbonates. The study aimed to determine the distribution of carbonates in the size components of some soils in Khuzestan province. Upward to the bottom of Karun, Karkheh, and Jarahi rivers were studied at depths of 0-50, 50-100, and 150-100 cm. The results showed that the average amount of carbonates in the soils of the Jarahi river basin (37%) was significantly different from the amount in the soils of the other two rivers (33%). Carbonates were observed in all soil size components but the maximum was present in the clay

Negative / Null Result ReportOpen accessDentistry

Comparison Of Transfer Accuracy Among Hexed Implant Mounts, Clips Impression Copings, And Open-Tray Impression Copings at Different Implant Angulations: An In Vitro Study

Merna M. Seif, Ahmed A. Abdel Hakim, Hassan M. Abouelkheir et al. · 2025 · BMC Oral Health

Abstract Background Accurate impression registration is essential for transferring the three-dimensional (3D) implant position to the definitive cast, ensuring passivity of the final prosthesis. Various impression techniques have been developed to optimize accuracy, particularly for angulated implants. This study aimed to evaluate and compare the accuracy of open-tray impression copings, clips impression copings, and hexed implant mounts in transferring implant positions for both straight and angulated implants. Methods Five implants with different angulations (three at 0°, one at 15°, and one

View details →DOI: 10.1186/s12903-025-06304-8
Negative / Null Result ReportOpen accessMedicine

Precipitating factors of diabetic ketoacidosis in type 1 diabetes patients at a tertiary hospital: a cross-sectional study with a two-time-period comparison

Laura Emanuelle da Rosa Carlos Monteiro, Sheila Piccoli Garcia, Leonardo Grabinski Bottino et al. · 2022 · Archives of Endocrinology and Metabolism

ABSTRACT Objective: To evaluate the precipitating factors of diabetic ketoacidosis (DKA) in patients with type 1 diabetes hospitalized through the emergency department of a tertiary hospital. Materials and methods: Individuals with type 1 diabetes hospitalized for DKA from January 2005 to March 2010 (first period [P1], n = 75) and from April 2010 to January 2017 (second period [P2], n = 97) were identified through a query of electronic medical records. Data were collected by reviewing medical records. Only the first hospitalization of each participant in each period was included. Results: In P

View details →DOI: 10.20945/2359-3997000000480
Negative / Null Result Report

Absence of significant effect of nitrogen addition on soil respiration in a subtropical Chinese fir plantation

Xiang Zheng, Yingying He, Minmin Cao et al. · 2025 · Canadian Journal of Forest Research

Chinese fir ( Cunninghamia lanceolata (Lamb.) Hook) is one of the most dominant tree species in southern China. However, the effect of different nitrogen (N) levels on soil respiration in subtropical Chinese fir plantations remains…

View details →DOI: 10.1139/cjfr-2025-0011
Negative / Null Result ReportOpen accessNursing

Effect of Wearing a Face Mask on Oxygen Saturation among Hemodialysis Patients Versus Healthy Staff Members

Tarek Mahmoud Shaker Mohamed, Hala Mohamed Abdelhamed Ali, Asmaa Sayed Abd-Almageed et al. · 2022 · International Egyptian Journal of Nursing Sciences and Research

Background: COVID-19 represents a major threat to hemodialysis health life, due to their low immunity, it is essential to wear a face mask to protect them against the outbreak of the COVID-19 pandemic. Aim: To evaluate the effect of wearing a face mask on oxygen saturation among hemodialysis patients versus healthy staff members.Methods: Research design: a quasi-experimental research design Setting: dialysis units at Mansoura University and New General Mansoura hospital. Subjects: A purposive sample with a total of 190 patients was classified into two equal groups, entitled hemodialysis patien

View details →DOI: 10.21608/ejnsr.2022.247067
Negative / Null Result ReportOpen accessSports medicine

The Effect of Warming on Visual Response Time in Dominant and Non-Dominant Lower and Upper Extremities

Nurtekin Erkmen, Yağmur Kocaoğlu, Ahmet Kaan Aslan et al. · 2023 · Türk Spor ve Egzersiz Dergisi

The aim of this study was to investigate the effect of warm-up activity on the visual response time of the dominant and non-dominant hand and foot in basketball players. A total of 13 male basketball athletes with an age of 14.38 ± .506 years, height 180.15 ± 8.07 cm, body weight 66.54 ± 13.73 and sports experience 4.69 ± 13.73 years were voluntarily included in the study. Visual response time of the dominant and non-dominant hand and foot were measured before and after the warm-up protocol. The warm-up protocol consisted of a 20-minute warm-up activity including basketball-specific movements

View details →DOI: 10.15314/tsed.1380623
Negative / Null Result ReportOpen accessOphthalmology

Comparison of surgical outcomes between initial trabeculectomy and Ex-PRESS in terms of achieving an intraocular pressure below 15 and 18 mmHg: a retrospective comparative study

Shunsuke Nakakura, Ryo Asaoka · 2022 · Eye and Vision

Abstract Background To evaluate the postoperative outcomes of initial trabeculectomy (Trab) and Ex-PRESS (EX) in terms of achieving an intraocular pressure (IOP) below 15 and 18 mmHg. Methods This study retrospectively analyzed 64 and 54 cases of Trab and EX, respectively, performed by the same surgeon with uniform management from April 2018 to March 2019. Surgical success was defined as 5 < IOP < 15 mmHg (criterion 1) and 5 < IOP < 18 mmHg (criterion 2) without additional glaucoma medication, needling, and bleb reconstruction 2 months after surgery. Survival analysis with Cox regression was p

View details →DOI: 10.1186/s40662-022-00279-1
Negative / Null Result ReportOpen accessMedicine (General)

The Analgesic Effectiveness Test of Cocoa Husk (Theobroma cacao L.) Extract to Licking Time of Mice Induced by Formalin

Yuli Lusiana Sari, Desi Dwi Wisudanti, Muhammad Ali Shodikin · 2018 · Journal of Agromedicine and Medical Sciences (AMS)

Cocoa (Theobroma cacao L) is an industrial material that often used in chocolates production, but the part that used is cocoa bean, so that cocoa husk accumulate as waste. This study aimed to determine effectiveness of cocoa husk extracts to first and second phase of licking time of mice induced formalin. This study used 28 mices that divided into seven groups. NaCMC 1% to group K(-), 0.0048 mg/gBW sodium diclofenac to K(+), extracts dose variations, ie 0.25 mg/gBW, 0.5 mg/gBW, 1 mg/gBW, 2mg/gBW and 4 mg/gBW to group K1, K2, K3, K4, and K5 administered orally 30 minutes before subcutaneous inj

View details →DOI: 10.19184/ams.v4i2.6328
Negative / Null Result ReportOpen accessOrthopedic surgery

A comparison of healing and complication rates between common flaps utilized in total knee arthroplasty: a review of the literature

Akhil A. Chandra, Filippo Romanelli, Alex Tang et al. · 2022 · Knee Surgery & Related Research

Abstract Background Flap reconstruction with perforator, fasciocutaneous, muscular, and/or free microvascular flaps is utilized to cover wound defects and improve vascularization and antibiotic/nutrient delivery. Flap use in revision procedures for total knee arthroplasty has been explored previously; however, current data are limited and studies comparing healing and complication rates between different flap types are lacking. Methods A literature review was performed using PubMed on 13 January 2022. Studies were included if they reported healing and complication rates for either gastrocnemiu

View details →DOI: 10.1186/s43019-022-00145-3
Negative / Null Result ReportOpen accessAgriculture

The cross-sectional area of the superficial digital flexor tendon of trained and untrained Thoroughbred racehorses Área transversal do tendão flexor digital superficial de cavalos Puro Sangue Inglês de corrida em treinamento e sem treinamento

Ana Guiomar Matos Santiago Reis, Raquel Yvonne Arantes Baccarin · 2010 · Ciência Rural

Twenty Thoroughbred racehorses were ultrasonographically evaluated to determine the relation between normal values of the cross-sectional area (CSA) of the right and left forelimbs superficial digital flexor tendons (SDFT) in the metacarpal region for trained and untrained Thoroughbreds racehorses. Ultrasonography revealed that CSA at 26cm distal to the accessory carpal bone is larger than other proximal levels, for either left or right forelimbs. In addition, the CSA at 2, 4, 6, 8, 10, 12 and 14cm distal to the accessory carpal bone of the left forelimb are larger (P 0.05) between left and ri

View details →DOI: 10.1590/s0103-84782010000800018
Negative / Null Result ReportOpen accessSurgery

Safety and Efficacy of Pelvic Reinforcement Procedure for Preventing Postoperative Perineal Hernia After Robotic Abdominoperineal Resection: A Single‐Center, Retrospective Cohort Study

Yoshihiro Sakai, Shunsuke Kasai, Akio Shiomi et al. · 2026 · Annals of Gastroenterological Surgery

ABSTRACT Aim Few reports have described pelvic reinforcement procedure (PRP) to prevent perineal hernia (PH) in robotic abdominoperineal resection (Ro‐APR) for rectal cancer. This study aimed to investigate the safety and efficacy of PRP in Ro‐APR. Methods Patients who underwent Ro‐APR for rectal cancer between January 2020 and June 2023 were retrospectively examined. PRP was performed as a prophylactic procedure for PH. Four types of PRP were performed depending on the case (closure of the levator ani muscles, the pelvic peritoneum with the uterus, the pelvic peritoneum, and the pelvic perito

View details →DOI: 10.1002/ags3.70066
Negative / Null Result ReportOpen accessMedicine (General)

Evaluating the effectiveness and adverse effects of oral versus transdermal estradiol for endometrial preparation in frozen-thawed embryo transfer: a randomized controlled trial

Thuy Thi-Thanh Tran, Huy Phuong Tran, Loc Thai Ly et al. · 2024 · Middle East Fertility Society Journal

Abstract Background Endometrial preparation significantly influences the success of embryo transfer procedures. Although both oral and transdermal estradiol are common methods for endometrial priming, their efficacy and potential side effects remain uncertain. This randomized controlled trial aims to compare the effectiveness of oral and transdermal estradiol in endometrial preparation, while also evaluating their respective side effects in patients undergoing assisted reproduction treatments. Method This randomized clinical trial (ISRCTN15301227) was conducted at Hung Vuong Hospital between J

View details →DOI: 10.1186/s43043-024-00204-7
Negative / Null Result ReportOpen accessMedicine

Hormone therapy with or without platelet-rich plasma (PRP) for treatment Asherman syndrome; A randomized clinical trial

Elham Naghshineh, Safoura Rouholamin, Zahra Derakhshandeh · 2023 · Advanced Biomedical Research

Background: Asherman syndrome is a controversial issue in obstetrics and gynecology without any consensus on its management and treatment. It is characterized by variable lesions inside the uterine cavity and also causes menstrual irregularities, infertility, and placental abnormalities. The study aimed to assess the platelet-rich plasma (PRP) effect in women with intrauterine adhesions by evaluating the improvement of the menstrual cycle and intrauterine adhesion (IUA) stage. Materials and Methods: This clinical trial study was performed on 60 women with Asherman syndrome in two groups of 30.

View details →DOI: 10.4103/abr.abr_411_21
Negative / Null Result Report

P5264There is no significant effect of ischemic time and elapse time since cardiac allograft transplant on myocardial T1 relaxation time

J Vietheer, C Unbehaun, K Classen et al. · 2019 · European Heart Journal

Abstract Background Graft failure caused by allograft rejection and vasculopathy is the most common cause of mortality after heart transplantation. To detect an early allograft rejection, endomyocardial biopsy is still needed. Tissue…

View details →DOI: 10.1093/eurheartj/ehz746.0235
Negative / Null Result Report

The Pandemic Effect: Secondary Impact on the Diagnosis of Clinically Significant Congenital Heart Disease and Role of Deprivation Index

Cassandra Campbell, Kristin Wyckoff, Ronak Naik et al. · 2025 · Pediatric Cardiology

Abstract We sought to determine the impact of the COVID-19 on prenatal diagnosis (PND) of clinically significant congenital heart disease (CHD) and the role of socioeconomic status (SES), complexity of diagnosis, and proximity to advance…

View details →DOI: 10.1007/s00246-025-03844-2
Negative / Null Result Report

Non-significant Effect of El Niño on the Nest Occupancy and Breeding Success of Markham’s Storm Petrel <i>Hydrobates markhami</i>

Fernando Medrano, Benjamín Gallardo, Pablo Gutiérrez et al. · 2024 · Marine Ornithology

The impact of the El Niño varies across seabirds, usually altering the distribution and causing population declines. Understanding El Niño’s effects is thus critical for conservation. We monitored 296 nests of the little-known Hydrobates…

View details →DOI: 10.5038/2074-1235.52.2.1603
Negative / Null Result ReportOpen access

Correlation of c-erbb2 Expression in Undifferentiated Nasopharyngeal Carcinoma and Tumor Size (T-Stage) (Dyah Fauziah et al.) 290 CORRELATION OF C-ERBB2 EXPRESSION IN UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA AND TUMOR SIZE (T-STAGE), REGIONAL LYMPHNODES

Willy Sandhika, Faroek Hoesin, Dyah Fauziah · 2020

No significant correlation was found between c-erbB2 expression and tumor size (T-stage). c-erbB2 expression in various N-stages were as follows: N0 (80%), N1 (33,3%), N2 (50%), N3 (42,9%). No significant correlation was found between…