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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21266 results · page 217 of 709

Negative / Null Result ReportOpen accessMedicine

The value of transpulmonary thermodilution parameters in predicting hemodynamic instability in intensive care patients undergoing continuous renal replacement therapy.

Keser CS, Erdemir M, Yilmaz M et al. · 2025 · BMC nephrology

Background Hemodynamic instability related to renal replacement therapy (HIRRT) is a serious complication of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), significantly increasing…

View details →DOI: 10.1186/s12882-025-04712-0
Negative / Null Result ReportOpen accessMedicine

Neighborhood Physical Disinvestment and Incident Diabetes between visits 1 and 2 of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Smith CM, Spalt EW, Gallo LC et al. · 2026 · Journal of urban health : bulletin of the New York Academy of Medicine

Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and…

View details →DOI: 10.1007/s11524-026-01061-7
Negative / Null Result ReportOpen accessMedicine

Burden of atherosclerosis, cardiovascular risk factors and atrial fibrillation in individuals with covert brain infarcts in late midlife: the Akershus Cardiac Examination 1950 Study.

Ihle-Hansen H, Walle-Hansen MM, Berge T et al. · 2026 · BMJ open

Background Current expert consensus statements generally suggest cardiovascular risk assessment, including atrial fibrillation (AF) screening, on detection of covert brain infarctions (CBIs). However, evidence to guide management of CBI…

View details →DOI: 10.1136/bmjopen-2025-114232
Negative / Null Result ReportOpen accessMedicine

Histological signatures of hormone replacement therapy in the endometrium.

Abdalla M · 2026 · Frontiers in medicine

Background Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases…

View details →DOI: 10.3389/fmed.2026.1718508
Negative / Null Result ReportMedicine

Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.

O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…

View details →DOI: 10.1038/s41372-026-02601-4
Negative / Null Result ReportOpen accessMedicine

Stable bloodstream infection rates despite rising colonization: insights from a hospital system using in-house polymerase chain reaction screening for <i>Candidozyma auris</i>.

Rosa R, Rosello G, Manzanillo K et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE

Following the implementation of in-house Candidozyma auris ( C. auris ) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C. auris already present at hospital…

View details →DOI: 10.1017/ash.2025.10076
Negative / Null Result ReportOpen accessMedicine

Ki67 and Lymphovascular Invasion as Histopathological Predictors of Residual Cancer Burden After Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Study.

Carabas BA, Țǎpoi DA, Costache M · 2026 · Diagnostics (Basel, Switzerland)

Background: Neoadjuvant chemotherapy (NAC) is widely used in the management of stage I-III breast cancer, with tumor regression serving as an important surrogate for long-term outcome. Identifying reliable pathological biomarkers…

View details →DOI: 10.3390/diagnostics16081213
Negative / Null Result ReportOpen accessMedicine

Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation.

Lee CC, Miller AA, Tallman PS et al. · 2025 · American journal of human biology : the official journal of the Human Biology Council

Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological…

View details →DOI: 10.1002/ajhb.70069
Negative / Null Result ReportOpen accessMedicine

Circulating Levels of Soluble α-Klotho and FGF23 in Childhood Cancer Survivors: Lack of Association with Nephro- and Cardiotoxicity-A Preliminary Study.

Kozłowski K, Konończuk K, Muszyńska-Rosłan K et al. · 2024 · Journal of clinical medicine

Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood cancer survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and…

View details →DOI: 10.3390/jcm13102968
Negative / Null Result ReportOpen accessMedicine

Correlation of Mean Platelet Volume With Angiographic Severity in Diabetic Coronary Artery Disease: A Cross-Sectional Study.

Agarwal Y, Metgudmath A, Metgudmath V · 2026 · Cureus

Aim To evaluate the association of mean platelet volume (MPV) and immature platelet fraction (IPF) with coronary angiographic severity, categorised by the number of significantly diseased epicardial vessels (single, double or triple vessel…

View details →DOI: 10.7759/cureus.102326
Negative / Null Result ReportOpen accessMedicine

Dietary Fiber Intake Was Inversely Associated with All-Cause Mortality but Not with Cancer and Cardiovascular Disease Mortalities in the US.

Akbar Z, Fituri S, Shi Z et al. · 2025 · Diseases (Basel, Switzerland)

Background Evidence linking dietary fiber intake with cancer risk and mortality is equivocal. Objective We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US…

View details →DOI: 10.3390/diseases13080272
Negative / Null Result ReportMedicine

PICU Admission of Children for Status Epilepticus: Is There a Different Approach Between Referral and Second-Level Hospitals in an Italian Region?

Bonardi CM, Nosadini M, Lorenzoni G et al. · 2024 · Clinical pediatrics

Appropriate status epilepticus (SE) management is key to minimize admission to the pediatric intensive care unit (PICU). We retrospectively describe 115 children admitted to the PICU of the tertiary-care referral hospital of Padova for…

View details →DOI: 10.1177/00099228231220174
Negative / Null Result ReportOpen accessMedicine

Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.

Errigo A, Dore MP, Mocci G et al. · 2024 · Scientific reports

More than two decades ago, in the central-eastern region of the Mediterranean island of Sardinia, a mountain area was identified where the population displays exceptional longevity, especially among men (the Longevity Blue Zone, LBZ). This…

View details →DOI: 10.1038/s41598-024-80497-w
Negative / Null Result ReportOpen accessMedicine

Effect of Supplementation with Red Rooibos Tea on Body Composition, Metabolic Outcomes, and Movement in Ovariectomized Sprague-Dawley Rats.

Feld RS, Ianiero MA, Goncharow MK et al. · 2026 · Current developments in nutrition

Background Menopause is associated with increases in visceral adipose tissue, reductions in lean mass, and a reduced energy expenditure. The ovariectomized (OVX) rat model can be used to model these changes and to test potential…

View details →DOI: 10.1016/j.cdnut.2026.107656
Negative / Null Result ReportOpen accessMedicine

Effects of a Moisturizer and Emollient on the Stratum Corneum Assessed by Confocal Raman Spectroscopy in Patients With and Without Atopic Dermatitis: An Assessor-Blinded Prospective Cohort Study.

Fukuda R, Hashimoto R, Pak K et al. · 2026 · Health science reports

Background and aims Atopic dermatitis (AD) is characterized by impaired skin barrier function and reduced moisturizing factors. Moisturizers and emollients restore the barrier through distinct mechanisms, but their longitudinal molecular…

View details →DOI: 10.1002/hsr2.72671
Negative / Null Result ReportMedicine

Melatonin Prevents Thymic Atrophy but Does Not Protect Against Disruption of T Cell Maturation Related to Cyclophosphamide Exposure.

Pimenta GF, Dourado TMH, de Souza KDB et al. · 2025 · Cell biochemistry and function

Increased oxidative stress and apoptosis are key mechanisms of thymic atrophy induced by cyclophosphamide (CYP). Atrophy leads to changes in the thymic microenvironment and disrupts T cell maturation. The hormone melatonin displays…

View details →DOI: 10.1002/cbf.70052
Negative / Null Result Report

Bioassays with Allium cepa for the Monitoring of Toxicity in the Groundwater of Yucatan, Mexico

Cauich-Suárez LY, Sánchez-Sánchez VE, Moreno-Ortiz GE et al. · 2024 · Preprint

This study employed the Allium cepa bioassay to evaluate the toxic effects of contaminants in the Yucatan aquifer. Seven monitoring wells were studied during September and October 2021. Nutrient concentrations showed significant variation…

View details →DOI: 10.20944/preprints202409.0818.v1
Negative / Null Result ReportOpen accessMedicine

Ligandrol lowers endurance and negatively affects lipid and hormonal profile of male rats.

Vasilev V, Georgieva K, Arabadzhiyska D et al. · 2025 · Naunyn-Schmiedeberg's archives of pharmacology

Selective androgen receptor modulators are currently not approved but are widely used in gyms. In the present study, the effects of ligandrol and its combination with endurance training on functional and clinically important parameters…

View details →DOI: 10.1007/s00210-025-04028-8
Negative / Null Result ReportMedicine

Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial.

Makhlin I, Demissei BG, D'Agostino R et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Preventing Anthracycline Cardiovascular Toxicity with Statins (PREVENT; NCT01988571) randomized patients with breast cancer or lymphoma receiving anthracyclines to atorvastatin 40 mg daily or placebo. We evaluated the effects of…

View details →DOI: 10.1158/1078-0432.ccr-23-3952
Negative / Null Result ReportOpen accessMedicine

Clinical efficacy of anti-amyloid antibodies in apolipoprotein E ε4 homozygotes: A Bayesian reanalysis of lecanemab and donanemab phase 3 results.

Teipel S, Tang Y, Khachaturian A · 2025 · Alzheimer's & dementia (New York, N. Y.)

Introduction We aimed to determine the clinical efficacy of treating apolipoprotein E (ApoE) ε4 homozygotes with recently approved anti-amyloid antibodies. Methods Data were derived from supplementary analyses in the regulatory studies…

View details →DOI: 10.1002/trc2.70083
Negative / Null Result ReportOpen accessMedicine

Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?

Girişgen İ, Altıncık SA, Avcı E et al. · 2025 · Journal of clinical research in pediatric endocrinology

Objective To compare serum mitochondrial open reading frame of 12S rRNA-c (MOTS-c) levels, a new potential biomarker for oxidative stress, in children with type 1 diabetes mellitus (T1DM) and healthy children. A further aim was to…

View details →DOI: 10.4274/jcrpe.galenos.2024.2024-5-6
Negative / Null Result ReportOpen accessMedicine

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study.

Tristani-Firouzi B, Pappas L, Joseph M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight…

View details →DOI: 10.1111/1471-0528.70088
Negative / Null Result ReportMedicine

Lack of association between periodontitis and rheumatoid arthritis.

Posada-López A, Duque JD, Pineda-Tamayo RA et al. · 2023 · Reumatologia clinica

Background and objective Periodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials…

View details →DOI: 10.1016/j.reumae.2022.03.006
Negative / Null Result ReportMedicine

Association of machine-learning-rated supportive counseling skills with psychotherapy outcome.

Zhang X, Goldberg SB, Baldwin SA et al. · 2025 · Journal of consulting and clinical psychology

Objective This study applied a machine-learning-based skill assessment system to investigate the association between supportive counseling skills (empathy, open questions, and reflections) and treatment outcomes. We hypothesized that…

View details →DOI: 10.1037/ccp0000935
Negative / Null Result ReportMedicine

Opioid and healthcare service use in medical cannabis patients with chronic pain: a prospective study.

Sznitman S, Mabouk C, Said Z et al. · 2023 · BMJ supportive & palliative care

Background Various jurisdictions have legalised medical cannabis (MC) for use in chronic pain treatment. The objective of this study was to determine if the use of MC is related to a reduction in the use of prescription opioids and other…

View details →DOI: 10.1136/bmjspcare-2020-002661