e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21266 results · page 216 of 709

Negative / Null Result ReportMedicine

Efficacy of a digitally designed anatomical repositioning splint for adolescent temporomandibular joint anterior disc displacement with reduction: a randomized controlled trial.

Wang, Wang, Wu et al. · 2026 · BMC oral health

Anterior disc displacement with reduction (ADDwR) is a common temporomandibular joint disorder in adolescents. Conventional anterior repositioning splints (ARS) often lack anatomical adaptation, which may limit their therapeutic precision…

View details →DOI: 10.1186/s12903-026-08753-1
Negative / Null Result ReportMedicine

Urologic outcomes in children with closed spinal dysraphism with and without untethering of the spinal cord.

Avellan, Pakkasjärvi, Palomäki et al. · 2026 · Journal of pediatric surgery

Closed spinal dysraphism (CSD) comprises a heterogeneous group of congenital anomalies that may remain asymptomatic or present with neurological and urological dysfunction. This study aimed to evaluate long-term urological outcomes in…

View details →DOI: 10.1016/j.jpedsurg.2026.163235
Negative / Null Result ReportMedicine

A TriNetX global collaborative network retrospective cohort study on the impact of COVID-19 vaccination on juvenile idiopathic arthritis.

Yong, Chiang, Yang et al. · 2026 · Scientific reports

The objective is to determine the Impact of COVID-19 Vaccination and Medical Utilization in Juvenile Idiopathic Arthritis (JIA) patients. Our study retrieved data from the US Collaborative Network in TriNetX between January 1st, 2020, and…

View details →DOI: 10.1038/s41598-026-52548-x
Negative / Null Result ReportMedicine

Does Tibial Tunnel Placement Affect Postoperative Function and Isokinetic Outcomes in Patients Undergoing Anatomical Single-Bundle Anterior Cruciate Ligament Reconstruction with Hamstring Autograft?

Arslantaş, Deveci, Ozdemir et al. · 2026 · The journal of knee surgery

Tunnel malposition is a frequent complication of anterior cruciate ligament (ACL) reconstruction. We evaluated whether the tibial tunnel location of patients who underwent anatomical single-bundle ACL reconstruction with hamstring tendons…

View details →DOI: 10.1055/a-2886-7914
Negative / Null Result ReportMedicine

Comparison of early-onset and average-onset colorectal cancer in Saudi Arabia: A multicenter retrospective cohort study.

Alessy, Al-Bawardy, Alabdullah et al. · 2026 · Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Although overall colorectal cancer (CRC) incidence has stabilized or declined in some regions, early-onset CRC (EO-CRC) is increasing in many countries. We aimed to compare EO-CRC with average-onset CRC (AO-CRC) to inform screening and…

View details →DOI: 10.4103/sjg.sjg_51_26
Negative / Null Result ReportMedicine

Thermal ablation versus hepatectomy in patients with liver metastases from RAS-mutated colorectal cancer.

Wen, Zhou, Chen et al. · 2026 · Journal of cancer research and therapeutics

To compare the efficacy and safety of thermal ablation therapy and hepatectomy in patients with RAS-mutated colorectal liver metastases (CRLMs). A 1:1 propensity score matching (PSM) analysis was conducted to categorize patients into…

View details →DOI: 10.4103/jcrt.jcrt_1515_25
Negative / Null Result ReportMedicine

Large Language Models and Metabolic Bariatric Surgery: A Pilot Concordance Study Between ChatGPT and Multidisciplinary Team Recommendations.

Ahmed, Bhanderi, Westerman et al. · 2026 · Obesity surgery

Operation selection in metabolic surgery is a complex decision making process led by a multidisciplinary team that integrates multiple anatomical, clinical, metabolic and psychosocial aspects. The ability of large language models (LLMs)…

View details →DOI: 10.1007/s11695-026-08777-0
Negative / Null Result ReportMedicine

Impact of Renal Artery Diameter and Bridging Stent Length on Renal Outcomes of Patients Treated by Multi-Branch Endovascular Aortic Repair.

Nunes, Theis, Gomes et al. · 2026 · Journal of vascular surgery

Branched endovascular aortic repair (BEVAR) has been increasingly utilized as a treatment option for thoracoabdominal aortic aneurysms (TAAAs), but risk of renal artery (RA) branch occlusion remains a concern. The aim of this study was to…

View details →DOI: 10.1016/j.jvs.2026.05.035
Negative / Null Result ReportMedicine

Masticatory Muscle Activity in a Group of Thai Children with Skeletal and Dental Malocclusions: A Pilot Study Using Surface Electromyography.

Saleechan, Pumklin, Puapichartdumrong et al. · 2026 · European journal of dentistry

This pilot study aimed to investigate masseter muscle (MM) and anterior temporal muscle activity, symmetry, synergy, and effort in Thai children with skeletal and dental malocclusions. Children aged 9 to 12 years were recruited ( N…

View details →DOI: 10.1055/s-0046-1820500
Negative / Null Result ReportMedicine

Contemporary management of paediatric acute mastoiditis in Aotearoa New Zealand.

Noakes, Stevenson, Bird et al. · 2026 · International journal of pediatric otorhinolaryngology

There has been a recent increase in the incidence of paediatric acute mastoiditis (AM) with a global trend towards more conservative management strategies. Our aim was to evaluate the contemporary management of paediatric AM in Aotearoa…

View details →DOI: 10.1016/j.ijporl.2026.112882
Negative / Null Result ReportMedicine

Extracorporeal Membrane Oxygenation Support Before Pediatric Heart Transplantation: A Comparison of Two Eras.

Bilgili, Abu-Mowis, Jeng et al. · 2026 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

The United Network for Organ Sharing (UNOS) Database was studied to evaluate the state of extracorporeal membrane oxygenation (ECMO) utilization before pediatric heart transplantation and to compare outcomes over the last two decades. A…

View details →DOI: 10.1097/mat.0000000000002726
Negative / Null Result ReportMedicine

Effectiveness of Forum Play to promote respectful maternity care: A pilot intervention investigating self-reported perception and behaviour among care providers in urban Nepal.

Paudel Ghimire, Dahal, Joshi et al. · 2026 · PloS one

Ensuring respectful maternity care is crucial to promote positive childbirth experiences among women. Globally, 22-100% women report experiencing at least one form of disrespect and abuse during facility-based birth, with a study in Nepal…

View details →DOI: 10.1371/journal.pone.0349437
Negative / Null Result ReportMedicine

The Effect of Isotonic Versus Isometric Strength Exercise for Pain and Strength in Proximal Hamstring Tendinopathy: A Randomized Crossover Trial.

Rich, Ford, Cook et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

The effect of isometric exercise on pain and strength for various tendinopathies has been investigated but there are no published studies on proximal hamstring tendinopathy (PHT). The objective of this trial was to determine the…

View details →DOI: 10.1097/jsm.0000000000001478
Negative / Null Result ReportMedicine

Multiparametric MRI-Based Habitat Radiomics Combined with Deep Transfer Learning for Predicting Extrathyroidal Extension in Papillary Thyroid Carcinoma.

Li, Zeng, Wang et al. · 2026 · Journal of imaging informatics in medicine

The objective of the study is to develop and validate a multiparametric MRI (mpMRI)-based model that integrated with habitat-based radiomics, deep transfer learning (DTL), and quantitative parameters for the preoperative prediction of…

View details →DOI: 10.1007/s10278-026-02011-0
Negative / Null Result ReportMedicine

Early orthodontic traction does not compromise root development in inversely impacted maxillary central incisors: a three-year cone-beam computed tomography evaluation.

Yang, Dong, Cheng et al. · 2026 · Clinical oral investigations

To evaluate whether early orthodontic traction of inversely impacted maxillary central incisors with curved roots affects subsequent root development and labial/palatal alveolar bone support. A retrospective cone-beam computed tomography…

View details →DOI: 10.1007/s00784-026-06962-0
Negative / Null Result ReportMedicine

Venous thromboembolic events in traumatic brain injury. Does timing of prophylaxis matter? A single-center retrospective cohort study.

Hernandez, Christensen, Shumaker et al. · 2026 · Proceedings (Baylor University. Medical Center)

Patients with traumatic brain injury (TBI) are at increased risk for venous thromboembolism (VTE) due to immobilization and a hypercoagulable state. The administration and optimal timing for chemoprophylaxis remain unclear because of…

View details →DOI: 10.1080/08998280.2026.2677108
Negative / Null Result ReportMedicine

Endoscopic versus open flexor hallucis longus tendon transfer for reconstruction of chronic achilles tendon rupture: A prospective randomized pilot trial.

Afifi, Hewaidy, El Shazly et al. · 2026 · Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

Chronic Achilles tendon rupture often requires surgical reconstruction. Flexor hallucis longus (FHL) tendon transfer is widely used, and endoscopic techniques may reduce soft-tissue morbidity and facilitate early recovery. Thirty patients…

View details →DOI: 10.1016/j.fas.2026.05.015
Negative / Null Result ReportMedicine

Perception of the malar midface of patients with class III malocclusion after Le Fort I osteotomy.

Brochet, Cresseaux, Varazzani et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery

Maxillo-zygomatic hypoplasia is common in patients with a Class III malocclusion, resulting in a flat and concave appearance of the midface. Le Fort I osteotomy is considered to be an effective treatment for occlusal and facial aesthetic…

View details →DOI: 10.1016/j.jormas.2026.102866
Negative / Null Result ReportMedicine

The environmental cost of learning: CO 2 emission comparisons of virtual reality, online, and alternative distance education.

Istrate, Van Gelder, Szőllősi et al. · 2026 · Intensive care medicine

Environmental sustainability has become a critical concern across various sectors, including education and healthcare. Professional training programmes, particularly in intensive care medicine, are essential for maintaining competency but…

View details →DOI: 10.1007/s00134-026-08460-z
Negative / Null Result ReportMedicine

Lumbar Function and Muscle Preservation Following Hybrid Surgery Versus Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis: A Preliminary Comparative Study.

Tasdemir, Korkmaz, Durak et al. · 2026 · Turkish neurosurgery

To investigate lumbar motion and muscle change following hybrid surgery in adolescent idiopathic scoliosis (AIS). We conducted a prospective study design including 16 patients (14 female, 2 male) who underwent either hybrid surgery or…

View details →DOI: 10.5137/1019-5149.jtn.49086-25.3
Failed Experiment ReportMedicine

Evaluation of Neonatal Sprague-Dawley Rats as a Potential Animal Model for the Neurovirulence Test of an Iranian Mumps Vaccine Strain, RS-12.

Mohammad Kazem, Mohammad, Mohammad Hasan et al. · 2025 · Archives of Razi Institute

Mumps virus (MuV), a neurotropic member of paramyxoviridae, causes mumps disease. Since the 1960s, when the first live-attenuated vaccine against the MuV was developed, mumps outbreaks have dramatically decreased. A monkey-based…

View details →DOI: 10.32598/ari.80.5.3696