A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21257 results · page 198 of 709
· 2019 · Journal of Gynecology & Reproductive Medicine
Karyotyping is a technique to examine the chromosomes-abnormality or structural defects. Karyotyping can be used to detect a variety of genetic disorders. For example, a woman who has premature ovarian failure may have a chromosomal defect…
Dalia M. Kamel, Nashwa S. Hamed, Neveen A. Abdel Raoof et al. · 2017 · Journal of Advanced Research
The aim of this study was to compare the effects of pulsed electromagnetic field versus pulsed ultrasound in treating patients with postnatal carpal tunnel syndrome. The study was a randomized, double-blinded trial. Forty postnatal female patients with idiopathic carpal tunnel syndrome were divided randomly into two equal groups. One group received pulsed electromagnetic field, with nerve and tendon gliding exercises for the wrist, three times per week for four weeks. The other group received pulsed ultrasound and the same wrist exercises. Pain level, sensory and motor distal latencies and con
Stefan J. Jodl, Margitta Worm, Frauke Friedrichs et al. · 2025 · Dermatology and Therapy
Abstract Introduction Interleukin-1 receptor-associated kinase 4 (IRAK4) is expressed in various immune cells and regulates proinflammatory cytokine production. Its inhibition represents a novel, promising therapeutic option in the treatment of atopic dermatitis (AD). Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor that suppresses markers of local and systemic immune responses. This study aimed to evaluate the efficacy and safety of zabedosertib in adults with moderate-to-severe AD. Methods DAMASK was a randomized, double-blind, 12-week, placebo-controlled, phase 2a, proof-of-
Girish Parthan, Shobhit Bhansali, Anura V. Kurpad et al. · 2018 · BMC Pharmacology and Toxicology
Abstract Background Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control by promoting GLP1-mediated glucose-dependent insulin secretion and suppression of glucagon. Sitagliptin and vildagliptin have been shown to improve insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). However, these patients had uncontrolled blood glucose at inclusion; therefore, the improvement in insulin sensitivity observed in these studies could be attributed to the drug per se and/or reduction in glucotoxicity. This study examines the effect of linagliptin on insulin sensitivity and β-ce
Christine Annaheim, Kerstin Hug, Caroline Stumm et al. · 2022 · Frontiers in Human Neuroscience
BackgroundFrontal brain dysfunction is a major challenge in neurorehabilitation. Neurofeedback (NF), as an EEG-based brain training method, is currently applied in a wide spectrum of mental health conditions, including traumatic brain injury.ObjectiveThis study aimed to explore the capacity of Infra-Low Frequency Neurofeedback (ILF-NF) to promote the recovery of brain function in patients with frontal brain injury.Materials and methodsTwenty patients hospitalized at a neurorehabilitation clinic in Switzerland with recently acquired, frontal and optionally other brain lesions were randomized to
Weichuan Zhang, Mingxian Zhao, Zhongyan Yang et al. · 2024 · Developments in the Built Environment
A significant amount of waste is generated during the sandstone mining process. This study explores the use of red sandstone waste as a supplementary cementitious material to address environmental concerns in cement production. The experimental methods include isothermal calorimetry, compressive strength testing, thermogravimetric analysis, X-ray diffraction, infrared spectroscopy, scanning electron microscopy, high-temperature damage testing (200, 600, and 900 °C), and mesoscopic image analysis. The experimental findings reveal the following: (1) Red sandstone powder enhanced cement hydration
Almira Ada Diken Türksayar, Simge Baytur · 2023 · Sabiad
Objective: The aim of this in vitro study was to compare the biaxial flexural strengths of permanent restorative materials produced by additive manufacturing and milling after thermal aging. Material and methods: For this study, three study groups were formed by producing disc-shaped specimens with a 3D printer (Form3, Formlabs) using permanent crown material (Permanent Crown, Somerville, MA) and two different resin-containing materials (Brilliant Crios,Coltene/ Whaledent; Cerasmart, GC Europe) by the milling method (n=10). The entire production process was carried out in accordance with the m
D O Geavlete, C Beladan, D Deleanu et al. · 2019 · European Heart Journal
Abstract Introduction Different consequences concerning the cardiac function and structure in patients with renal artery stenosis (RAS) and completely different patterns of activation of the renin-angiotensin-aldosteron system were…
Vincent Reynaert, Vincent Reynaert, Jalal Possik et al. · 2024 · Frontiers in Education
IntroductionThe field of poetry learning is currently facing significant challenges, primarily due to a lack of motivation and interest among students. This has resulted in educators encountering difficulties in identifying suitable educational alternatives. To address the latter issue, immersive learning has emerged as a potential solution, as it has been demonstrated to enhance motivation and learning outcomes in a multitude of fields.MethodsIn light of the aforementioned considerations, this field study seeks to examine the potential of virtual reality (VR) tools in enhancing the memorizati
AHMAD ZAAZA, Nevien Mohamed, Gaffar El Halawani · 2025 · Alexandria Dental Journal
Introduction: Osseo-integrated dental implants were traditionally load-free for up to six months while they healed. Patients usually feel dissatisfied with the long loading times. Several studies have been conducted to improve osseointegration, decrease loading time, and increase patient satisfaction.Objectives: This study aimed to evaluate and compare both clinically and radiographically the effect of hyaluronic acid (HA) versus Titanium-Platelet Rich Fibrin (T-PRF) in enhancing osseointegration around anterior maxillary dental implants. Materials and Methods: Twelve patients with extracted m
Elif Özdemir, Şeyda Türkölmez · 2020 · Ankara Medical Journal
INTRODUCTION: This study aims to disclose the frequency and clinical significance of incidental prostatic uptake during FDG PET imaging. METHODS: FDG PET images of 1839 male patients undergoing imaging for non-prostate and non-urinary bladder malignancy indications were retrospectively reviewed for the presence of incidental prostatic FDG uptake. Prostatic volume, calcification and the presence and pattern of FDG uptake were evaluated. Further follow-up prostatic evaluation results were comparatively assessed. RESULTS: Incidental prostatic FDG uptake was detected in 41 out of 1839 patients(2.2
DUAN Peng, LIU Zong-de, TAO Xiang-qian, GU Shu-chao · 2021 · Cailiao Baohu
At present, the changes of microstructure and mechanical properties of T23 steel after served for more than 50 000 h have been less studied.In this work, with using the heat-delivery surface tubes of a 600 MW super-critical boiler as research object, the T23 steel final reheater tubes at various positions after about 80 000 h of service time were tested by microstructure analysis, tensile properties tests at room temperature and 525 ℃ temperature, and the deterioration degree and difference in mechanical properties between back and meet smoke side of tubes after long-term service were investig
Eric V. Li, Sai K. Kumar, Jonathan A. Aguiar et al. · 2024 · BJUI Compass
Abstract Objective This study aimed to evaluate the association of dynamic contrast enhancement (DCE) with clinically significant prostate cancer (csPCa, Gleason Grade Group ≥2) and compare biparametric magnetic resonance imaging (bpMRI) and multiparametric MRI (mpMRI) nomograms. Subjects/patients and methods We identified a retrospective cohort of biopsy naïve patients who underwent pre‐biopsy MRI separated by individual MRI series from 2018 to 2022. csPCa detection rates were calculated for patients with peripheral zone (PZ) lesions scored 3–5 on diffusion weighted imaging (DWI) with availab
Takuji Yokoe, Takuya Tajima, Shuichi Kawagoe et al. · 2022 · BMC Musculoskeletal Disorders
Abstract Background A number of studies have evaluated risk factors for lateral ankle sprain (LAS) or chronic lateral ankle instability (CLAI). However, the definitive risk factors for LAS or CLAI remain controversial. The purpose of this study was to evaluate whether the contralateral healthy ankles of subjects with ipsilateral mechanical lateral ankle laxity (group I) show greater lateral ankle laxity in comparison to the healthy ankles of bilateral healthy controls (group B). Methods From March 2020, anterior talofibular ligament (ATFL) lengths of young adult volunteers were cross-sectional
Mahmoodzadeh Hossein, Movafegh Ali, Beigi Noshin · 2009 · Saudi Journal of Anaesthesia
Background: Dextromethorphan, the D-isomer of the codeine analog levorphanol, is a weak, noncompetitive N-Methyl-D-Aspartate (NMDA) receptor antagonist. It has been suggested that NMDA receptor antagonists induce preemptive analgesia when administered before tissue injury occurs, thus decreasing the subsequent sensation of pain. Materials and Methods: The study was conducted in the Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran, between February 2005 and December 2006. In this study, 72 patients scheduled for elective cholesyctectomy were randomized into three g
YAN Rui, TANG Min, CHEN Dongfang, HUANG Shirong, MEI Xin · 2023 · Shipin Kexue
The feasibility of using white radish powder as a nitrite substitute in dry fermented pork sausages was evaluated. Four groups of sausage were prepared by using a multi-strain starter culture (VBM-60, Sacco): negative control (NC, without nitrate or nitrite), positive control (PC, with 150 mg/kg sodium nitrite), 0.5% white radish powder (R0.5), and 1% white radish powder (R1). The effects of nitrite substitution by white radish powder on the physicochemical, microbiological and sensory characteristics of dry fermented sausage during production and storage were investigated. The results showed
Jinli Guo, Chaona Gao, Haifeng Xin et al. · 2019 · Journal of Orthopaedic Surgery and Research
Abstract Purposes Hip fracture leads to decreased activity and an increased risk of pulmonary complications. The main purpose of this study was to observe the lung capacity, cough capacity of the elderly patient with acute hip fracture, and assess the effects and the feasibility of using a special-designed “upper-body yoga” training to treat elderly patients with hip fracture. Methods This was a prospective, randomized, and single-blind study. Eighty-four subjects aged over 65 years were randomly divided into either a control group or a yoga group to undergo an abdominal breathing program or a
Jing Zhang, Chengcheng Shao, Jiajia Zhu et al. · 2025 · Frontiers in Cardiovascular Medicine
BackgroundThis study investigated the clinical characteristics of in-hospital cardiac arrest (IHCA) in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock and assessed the related in-hospital and post-discharge mortality.MethodsThis study included 148 patients with AMI complicated by cardiogenic shock who were admitted to the Cardiac Critical Care Center, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University between September 1, 2021 and July 31, 2024. Study participants were divided into two groups according to the occurrence of IHCA (IHCA
Shenghong Ye, Haoyun Yan, Zhengyu Lin et al. · 2022 · Frontiers in Psychology
Consumers often feel embarrassed when buying products like condoms, hemorrhoid cream, and beriberi cream in crowded pharmacies. There is an interesting phenomenon in life: Some beriberi creams use the images of a “real foot”, while others use the images of a “cartoon foot.” Imagine if a young woman needed to go to a retail store for beriberi cream that would embarrass her, she would choose a “real foot image” or a “cartoon foot image” beriberi cream? It has been shown that the embarrassment of these products has a strong negative impact on consumer buying behavior. Previous researches have exp
Hamide Abbaspour kasgari, Maria Tavakoli Ardakani, Abdollah Farhadinasab · 2019 · Journal of Mazandaran University of Medical Sciences
Background and purpose: Memantine is a medication used to treat moderate to severe Alzheimer’s disease. Memantine targeting the glutamatergic system specifically N-Methyl-D-Aspartate offer a novel approach in treatment of psychiatric disorders such as schizophrenia and schizoaffective disorder. The purpose of this study was to evaluate the efficacy and safety of memantine in combination with antipsychotics in patients with schizophrenia and schizoaffective disorder. Materials and methods: A double-blind, placebo-controlled trial was performed in patients aged 18-65 years old with confirmed dia
Christian Rothe, Jørgen Lund, Morten Troels Jenstrup et al. · 2020 · BMC Anesthesiology
Abstract Background The sensory innervation of the shoulder is complex and there are variations in the branching patterns of the sensory fibres. Articular branches from the axillary nerve to the subacromial bursa are described in more than 50% of investigated shoulders but the isolated contribution of sensory input from the axillary nerve has never been investigated clinically. We hypothesized that a selective block of the axillary nerve would reduce morphine consumption and pain after arthroscopic subacromial decompression. Methods We included 60 patients in a randomized, blinded, placebo-con
Ya-qian LIANG, Yong-lei YANG, Lei XU et al. · 2022 · Siliao yanjiu
The experiment was to investigate the effect of adding different levels of vitamin C (VC) to parent pigeons' diets on body weight, slaughter performance, meat quality, serum biochemical indexes and blood routine of squabs. 90 pairs of parent pigeons and 270 squabs with similar body weight at one-day-old were selected, and the parent pigeons and squabs were randomly divided into five groups, with six repelicates in each group. There were three cages in each cage with one pair of baby pigeons and three squabs. Group A, group B, group C, group D and group E were supplemented with 0, 200, 400, 800
Hasan M. Al-Dorzi, Abdulaziz Al-Dawood, Fahad M. Al-Hameed et al. · 2022 · Scientific Reports
Abstract There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in c
Diego Zanolli de Solminihac MD, Emilio Wagner MD, Pablo Wagner MD et al. · 2017 · Foot & Ankle Orthopaedics
Category: Bunion Introduction/Purpose: Hallux Rigidus (HR) is characterized initially by a decrease in Hallux metatarsophalangeal joint (MTPJ) dorsiflexion, decreasing the total range of motion. To be able to study different surgical treatment options, a cadaveric model has to be developed that recreates the limited range of motion. Our objective was to develop an Hallux Rigidus cadaveric model by shortening the plantar fascia (PF). Hallux MTPJ range of motion and joint stiffness were evaluated. Methods: 8 cadaveric foot- ankle – distal tibia specimens were prepared, identifying all extensor a
Jae-Hong Kim, Chang-Su Na, Myoung-Rae Cho et al. · 2022 · PLoS ONE
This study aimed to provide preliminary evidence for the efficacy of invasive laser acupuncture (ILA) for chronic non-specific low back pain (CNLBP). This was a single-center, randomized, patient and assessor-blinded, placebo-controlled, parallel-arm, clinical trial with a 1:1:1 allocation ratio that included a full analysis set. Forty-five participants with CNLBP were randomly assigned to the control group (sham laser), 650 group (650 nm-wavelength ILA), or 830 group (830 nm-wavelength ILA) (n = 15/group). All participants received ILA for 10 min, followed by electroacupuncture for 10 min on
Ali Yakar, Bilal Duman · 2022 · International Journal of Contemporary Educational Research
The purpose of the present study is to determine the effects of two multi-modal representations, the use of text and graph for learning, on problem solving, academic achievement and retention when used in a process-based instruction (PBI). The study was designed as quasi-experimental study complying with pretest-posttest control group design. The study group consists of (N=30+34=64) students from the department of classroom teacher education in the Education Faculty of a university from west of Turkey in 2015-2016 academic year. The data in the study were collected through problem solving inve
Alper Kucukbasmaci, Ali Sabir · 2019 · Acta Scientiarum Polonorum: Hortorum Cultus
Testing the globally popular grapevine rootstocks for affinity with new grape cultivars or tolerance potential to stress factors like drought is essential for districts where supplemental irrigation is more frequently needed due to the pressures of a global climate change. In this study, a seasonal evaluation of leaf gas exchange, leaf temperature, leaf greenness (chlorophyll content prediction) and vegetative development of Vitis vinifera L. cv. ‘Prima’ grafted to different rootstock genotypes having great variability in drought tolerance, were investigated. The experiment was conducted in a
Rudhir Jaga, Dinell Behari, Anton P Doubell et al. · 2022 · African Journal of Emergency Medicine
Introduction: Intended for use by prehospital first responders, the Lubo TM cervical collar is an adjustable, radiolucent, single-use device that incorporates a mechanical jaw thrust mechanism. The combination enables non-invasive airway management in cases of trauma where cervical motion restriction is necessary. The potential benefits include use as an airway adjuvant maintaining upper airway patency, reducing provider task loading. The limited research on the device efficacy and safety requires further investigation.Methods: A randomized, crossover, interventional study was performed to com
Janace J. Gifford, Jenna R. Pluchino, Rebecca Della Valle et al. · 2021 · Frontiers in Global Women's Health
Purpose: The purpose of this study was to assess the association between various risk factors with postpartum depression severity using a large dataset that included variables such as previous mental health status, social factors, societal factors, health care access, and other state-wide or region-specific variables.Methods: We obtained the most recently available (2016–2017) dataset from the Pregnancy Risk Assessment Monitoring System (PRAMS), which is a dataset compiled by the Centers for Disease Control (CDC) that collects state-specific, population-based data on maternal attitudes and exp
Bejo Utomo Handayani, Luwih Bisono, Dadik Wahyu Wijaya et al. · 2025 · JAI (Jurnal Anestesiologi Indonesia)
Background: Antiseptics or germicides are chemical compounds used to kill or inhibit the growth of microorganisms on living tissue such as the surface of the skin and mucous membranes. Objective: To determine the comparative effectiveness of povidone iodine 10% antiseptic compared to octenidine hydrochloride 0.1% in neuraxial blockade in patients undergoing surgery at Haji Adam Malik General Hospital, Medan. Methods: This study is an experimental study of the two-group pre-test - post-test study type. This design is a design that groups patients into certain groups that receive different treat