Negative / Null Result ReportOpen accessSocial Sciences
Briony D. Pulford, Poonam Gill · 2014 · Judgment and Decision Making
We report a series of experiments investigating the influence of feeling lucky or unlucky on people’s choice of known-risk or ambiguous options using the traditional Ellsberg Urns decision-making task. We induced a state of feeling lucky or unlucky in subjects by using a rigged wheel-of-fortune game, which just missed either the bankrupt or the jackpot outcome. In the first experiment a large reversal of the usual ambiguity aversion effect was shown, indicating that feeling lucky made subjects significantly more ambiguity seeking than usual. However, this effect failed to replicate in five ref
View details →DOI: 10.1017/s1930297500005520 Negative / Null Result ReportOpen accessMedicine
Abraham D. Flaxman, Riley Hazard, Ian Riley et al. · 2020 · BMC Medicine
Abstract We recently published in BMC Medicine an evaluation of the comparative diagnostic performance of InSilicoVA, a software to map the underlying causes of death from verbal autopsy interviews. The developers of this software claim to have failed to replicate our results and appear to have also failed to locate our replication archive for this work. In this Correspondence, we provide feedback on how this might have been done more usefully and offer some suggestions to improve future attempts at reproducible research. We also offer an alternative interpretation of the results presented by
View details →DOI: 10.1186/s12916-020-01517-w Negative / Null Result ReportOpen accessComputer Science
Robert McCarthy, Daniel C. H. Tan, Dominik Schmidt et al. · 2024 · arXiv
Scaling deep learning to massive and diverse internet data has driven remarkable breakthroughs in domains such as video generation and natural language processing. Robot learning, however, has thus far failed to replicate this success and remains constrained by a scarcity of available data. Learning from videos (LfV) methods aim to address this data bottleneck by augmenting traditional robot data with large-scale internet video. This video data provides foundational information regarding physical dynamics, behaviours, and tasks, and can be highly informative for general-purpose robots. This su
Negative / Null Result ReportOpen accessPhysics
Pedro Augusto, Peter N. Wilkinson · 2000 · arXiv
A radio-based search for strong gravitational lensing, with image separations in the range 160-300 milliarcsec (mas), has yielded a null result for a sample of 1665 sources (Augusto, Wilkinson & Browne 1998) whose mean redshift is estimated to be ~1.3. The lensing rate for this previously-unexplored separation range, <1:555 at the 95% confidence level, is less than on arcsecond-scales - as expected from models of lensing galaxy populations. Lensing on 160-300 mas scales is expected to arise predominantly from spiral galaxies at a rate dependent on the disk-halo mass ratio and the evolving numb
Negative / Null Result ReportOpen accessSocial Sciences
Mark Nieuwenstein, Hedderik van Rijn · 2012 · Judgment and Decision Making
According to the deliberation without attention (DWA) hypothesis, people facing a difficult choice will make a better decision after a period of distraction than after an equally long period of conscious deliberation, an effect referred to as the unconscious thought advantage (UTA). The status of the DWA hypothesis is controversial, as many studies have tried but failed to replicate the UTA. Here, we report a series of experiments that sought to identify the conditions under which the UTA can be replicated. Our starting point was a recent meta-analysis that identified the conditions under whic
Negative / Null Result ReportOpen accessMedicine
Haley Appel, Rogger P Carmen-Orozco, Clayton P Santiago et al. · 2025 · eLife
The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes neurogenesis, recent genetic studies have failed to replicate glia-to-neuron conversion following Ptbp1 loss of function. To evaluate the role of Ptbp1 in developmental neurogenesis in vivo, we conditionally disrupted Ptbp1 in mouse retinal progenitors. Ptbp1 was robustly expressed in both retinal progenitors and Müller glia but absent from p
View details →DOI: 10.7554/elife.108331 Negative / Null Result ReportOpen accessScience
Veronica Boyce, Maya Mathur, Michael C. Frank · 2023 · Royal Society Open Science
Cumulative scientific progress requires empirical results that are robust enough to support theory construction and extension. Yet in psychology, some prominent findings have failed to replicate, and large-scale studies suggest replicability issues are widespread. The identification of predictors of replication success is limited by the difficulty of conducting large samples of independent replication experiments, however: most investigations reanalyse the same set of [Formula: see text]. We introduce a new dataset of 176 replications from students in a graduate-level methods course. Replicati
View details →DOI: 10.1098/rsos.231240 Negative / Null Result ReportOpen accessSocial Sciences
Christine M. Smith, Paulina Dzik, Errin Fornicola · 2019 · Social Influence
Using the lens of Deindividuation Theory, Leon Mann explored the formation of baiting crowds in a small sample of public suicides/suicide attempts. Instead of attempting to prevent the suicide, baiting crowds encourage the victim to jump. Our aim was to replicate Mann's study with a larger more diverse sample of suicide attempts and a broadened theoretical lens (Frustration-Aggression). Using ProQuest, we identified 152 public suicide attempts reported in English language newspapers and failed to replicate Mann’s findings. Rather, baiting crowd formation was associated with variables that incr
View details →DOI: 10.1080/15534510.2019.1669488 Negative / Null Result ReportOpen accessBiology (General)
Sancar Aziz, Mankinen Richard W, Lee Daekee et al. · 2006 · Journal of Circadian Rhythms
Abstract Background Recent studies have implicated the epidermal growth factor receptor (EGFR) within the subparaventricular zone as being a major mediator of locomotor and masking behaviors in mice. The results were based on small cohorts of mice homozygous for the hypomorphic Egfr wa 2 allele on a mixed, genetically uncontrolled background, and on intraventricular infusion of exogenous EGFR ligands. Subsequenlty, a larger study using the same genetically mixed background failed to replicate the original findings. Since both previous approaches were susceptible to experimental artifacts relat
View details →DOI: 10.1186/1740-3391-4-15 Negative / Null Result ReportOpen accessMicrobiology
Miao Jiang, Pekka Kolehmainen, Laura Kakkola et al. · 2021 · Microbiology Spectrum
ABSTRACT The primary target organ of coronavirus disease 2019 (COVID-19) infection is the respiratory tract. Currently, there is limited information on the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect and regulate innate immunity in human immune cells and lung epithelial cells. Here, we compared the ability of four Finnish isolates of SARS-CoV-2 from COVID-19 patients to replicate and induce interferons (IFNs) and other cytokines in different human cells. All isolates failed to replicate in dendritic cells, macrophages, monocytes, and lymphocytes, and no in
View details →DOI: 10.1128/spectrum.00774-21 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Stella Aslibekyan, Marguerite R. Irvin, Bertha A. Hidalgo et al. · 2017 · Journal of Nutrition & Intermediary Metabolism
Background: Trimethylamine-N-oxide (TMAO), an atherogenic metabolite species, has emerged as a possible new risk factor for cardiovascular disease. Animal studies have shown that circulating TMAO levels are regulated by genetic and environmental factors. However, large-scale human studies have failed to replicate the observed genetic associations, and epigenetic factors such as DNA methylation have never been examined in relation to TMAO levels. Methods and results: We used data from the family-based Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) to investigate the heritable determi
View details →DOI: 10.1016/j.jnim.2017.03.002 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Sung Hye Kong · 2026 · Endocrinology and Metabolism
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations. Moreover, growing evidence suggesting an increased fall risk associated with high-dose bolus administration has necessitated a re-evaluation of safety assumptions. This review synthesizes these discordant findings to propose a framework grounded in precision medicine. We explore the ‘dive
View details →DOI: 10.3803/enm.2026.2938 Failed Experiment Report
Moreno-Sanchez PM, Oudin A, Kisakol B et al. · 2025 · Preprint
ABSTRACT Immune-based strategies have so far failed to demonstrate clinical benefit in glioblastoma (GBM), largely due to the profound immunosuppressive tumor microenvironment (TME). To achieve more predictive preclinical insights,…
View details →DOI: 10.1101/2025.11.20.689484 Negative / Null Result ReportOpen accessSocial Sciences
Briony D.
Pulford, Poonam
Gill · 2014 · Judgment and Decision Making
We report a series of experiments investigating the influence of feeling lucky or unlucky on people's choice of known-risk or ambiguous options using the traditional Ellsberg Urns decision-making task. We induced a state of feeling lucky or unlucky in subjects by using a rigged wheel-of-fortune game, which just missed either the bankrupt or the jackpot outcome. In the first experiment a large reversal of the usual ambiguity aversion effect was shown, indicating that feeling lucky made subjects significantly more ambiguity seeking than usual. However, this effect failed to replicate in five ref
Negative / Null Result ReportOpen accessPsychology
Singh, Anjali, Durand, Guillaume · 2022 · Tutorials in Quantitative Methods for Psychology
This study is a replication of Andreassen and colleagues (2013) [The relationships between behavioral addictions and the five-factor model of personality. Journal of Behavioral Addictions, 2(2), 90-99]. We partially replicated the findings of the original study. Our results support the role of personality, particularly conscientiousness, in predicting behavioral addictions, such as video game, Internet, and mobile phone addiction. However, we failed to replicate the same pattern of personality traits for each behavioral addiction.
View details →DOI: 10.20982/tqmp.18.1.r001 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Adam J.O. Dede, Wenyi Xiao, Nemanja Vaci et al. · 2025 · Molecular Autism
Abstract Background Autism is a complex neurodevelopmental condition, the precise neurobiological underpinnings of which remain elusive. Here, we focus on group differences in resting state EEG (rsEEG). Although many previous reports have pointed to differences between autistic and neurotypical participants in rsEEG, results have failed to replicate, sample sizes have typically been small, and only a small number of variables are reported in each study. Methods Here, we combined five datasets to create a large sample of autistic and neurotypical individuals (n = 776) and extracted 726 variable
View details →DOI: 10.1186/s13229-025-00647-3 Negative / Null Result ReportOpen accessMedicine
Sabrina Lorenz, Birte Alex, Thomas Kammer · 2020 · PLoS ONE
Recently, modulatory effects of static magnetic field stimulation (tSMS) on excitability of the motor cortex have been reported. In our previous study we failed to replicate these results. It was suggested that the lack of modulatory effects was due to the use of an auditory oddball task in our study. Thus, we aimed to evaluate the role of an oddball task on the effects of tSMS on motor cortex excitability. In a within-subject-design we compared 10 minutes tSMS with and without oddball task. In one of the two sessions subjects had to solve an auditory oddball task during the exposure to the ma
View details →DOI: 10.1371/journal.pone.0233614 Negative / Null Result ReportOpen accessMedicine
Liu HZ, Khanna V, Ayeni OR et al. · 2025 · Cureus
Background Adipose-derived stem cells (ADSCs) hold therapeutic potential for the treatment of orthopedic conditions. However, no surveys to date have evaluated physicians' awareness and receptiveness toward these therapies - an essential…
View details →DOI: 10.7759/cureus.86456 Negative / Null Result ReportOpen accessEducation (General)
Maik Beege, Maik Beege, Christoph Mengelkamp et al. · 2026 · Frontiers in Education
IntroductionThe disfluency effect proposes that deliberately introducing challenges or difficulties into the learning process can be advantageous. Particularly, perceptual disfluency (e.g., harder to read fonts) might affect learning positively. However, an ongoing debate persists regardxing the robustness of this effect, as some studies have failed to replicate it or have uncovered opposing outcomes.MethodsTo investigate potential moderators of the disfluency effect, two experiments were conducted using different types of instructional materials (instructional texts: N1 = 76; concept maps: N2
View details →DOI: 10.3389/feduc.2025.1731080 Negative / Null Result ReportOpen accessPsychology
Caroline eBarras, Dirk eKerzel · 2016 · Frontiers in Psychology
It has been claimed that stimuli sharing the color of the nogo-target are suppressed because of the strong incentive to not process the nogo-target, but we failed to replicate this finding. Participants searched for a color singleton in the target display and indicated its shape when it was in the go color. If the color singleton in the target display was in the nogo color, they had to withhold the response. The target display was preceded by a cue display that also contained a color singleton (the cue). The cue was either in the color of the go or nogo target, or it was in an unrelated, neutr
View details →DOI: 10.3389/fpsyg.2016.00630 Negative / Null Result ReportOpen accessPhysics
Daniel Lima Nascimento · 2013 · arXiv
A reanalisis of the effect of a moving frame of reference is done, showing that the null result of the Michelson-Morley's experimente of 1887 on the possibility of detecting the variation of the velocity of light with respect to a moving observer, na observer at the Earth, was already implied in these equations; thereforewith no need of new ad hoc hypotheses to explain it in the classical framework. In fact, it will be shown that behind those equations is hidden the fascinating phenomenon of the absolute motion.
Negative / Null Result ReportOpen accessComputer Science
Jaron Maene, Mingxiao Li, Marie-Francine Moens · 2021 · arXiv
The lottery ticket hypothesis states that sparse subnetworks exist in randomly initialized dense networks that can be trained to the same accuracy as the dense network they reside in. However, the subsequent work has failed to replicate this on large-scale models and required rewinding to an early stable state instead of initialization. We show that by using a training method that is stable with respect to linear mode connectivity, large networks can also be entirely rewound to initialization. Our subsequent experiments on common vision tasks give strong credence to the hypothesis in Evci et a
Negative / Null Result ReportOpen accessElementary particle physics
John K. Webb, Chung-Chi Lee, Dinko Milaković · 2022 · Universe
Recent advances in spectroscopic instrumentation and calibration methods dramatically improve the quality of quasar spectra. Supercomputer calculations show that, at high spectral resolution, procedures used in some previous analyses of spacetime variations of fundamental constants are likely to generate spurious measurements, biased systematically towards a null result. Developments in analysis methods are also summarised and a prescription given for the analysis of new and forthcoming data.
View details →DOI: 10.3390/universe8050266 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Albert Le Floch, Guy Ropars · 2023 · Brain Sciences
When reading, dyslexic readers exhibit more and longer fixations than normal readers. However, there is no significant difference when dyslexic and control readers perform only visual tasks on a string of letters, showing the importance of cognitive processes in reading. This linguistic and cognitive processing requirement in reading is often perturbed for dyslexic readers by perceived additional letters and word mirror images superposed on the primary images on the primary cortex, inducing internal visual crowding. Here, we show that while for a normal reader, the number and the duration of f
View details →DOI: 10.3390/brainsci13101478 Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Mohamed Wishahi, Ahmed El Feel, Amr Elkhouly et al. · 2023 · BMC Urology
Abstract Background To compare the efficacy and safety of standard percutaneous nephrolithotomy (PCNL) with mini- PCNL for kidney stones 2–4 cm. Methods Eighty patients were enrolled in a comparative study, they were randomly divided into mini-PCNL group (n = 40) and standard-PCNL (n = 40). Demographic characteristics, perioperative events, complications, stone free rate (SFR) were reported. Results Both groups showed no significant difference in clinical data about age, stone location, back pressure changes, and body mass index. The mean operative time was (95 ± 17.9 min) in mini-PCNL, and (7
View details →DOI: 10.1186/s12894-023-01270-1 Negative / Null Result ReportOpen accessHistory of scholarship and learning. The humanities
Keljanović Anđela D. · 2021 · Zbornik Radova Filozofskog Fakulteta u Prištini
At the time when social psychologists believed they could be proud of their discipline, there was the devastating news that Diederik Stapel had committed a major scientific fraud. This event coincided with the start of the discussion on trust in psychological findings. It was soon followed by the report of a series of nine studies that failed to replicate the 'professor's study'. These replication results were astounding due to earlier reports of successful replications. Due to the crisis of confidence in the results of field research, the Open Science Collaboration subsequently replicated 100
View details →DOI: 10.5937/zrffp51-24851 Negative / Null Result ReportOpen accessGeography. Anthropology. Recreation
Ratha Sor, Seanghun Meas, Ken K.Y. Wong et al. · 2014 · Journal of Limnology
The incidence and abundance of Monogononta rotifer species were recorded from lakes and reservoirs in the upper part of the Cambodian Mekong River basin in April and November 2010. One hundred and seven species are reported, 25 of which are new records to Cambodia and 8 taxa were unidentifiable to species level. Species richness at the regional and local scale was not significantly different between habitat types or between seasons, whether it was estimated using incidence or abundance data. Comparison of incidence data also revealed no significant difference from species richness of ponds con
View details →DOI: 10.4081/jlimnol.2014.995 Negative / Null Result ReportOpen accessPhysics
D. L. Khokhlov · 2008 · arXiv
It is revisited the Michelson-Morley experiment within the quantum mechanics framework. One can define the wave function of photon in the whole space at a given moment of time. The phase difference between the source and receiver is a distance between the source and receiver at the time of reception hence it does not depend on the velocity of the frame. Then one can explain the null result of the Michelson-Morley experiment within the quantum mechanics framework.
Negative / Null Result ReportOpen accessComputer Science
L. Cooper, G. E. Stedman · 1995 · arXiv
A ring-laser experiment, similar to the Canterbury ring laser, to detect axion- and {\sc qed}-induced vacuum birefringence is proposed. It uses a slowly modulated magnetic field and a novel polarization geometry. Both axion coupling and vacuum birefringence would modulate the Sagnac beat frequency. A null result could place sensitive bounds on the axion mass and on two-photon coupling.
Negative / Null Result ReportOpen accessTechnology
Laochareonsuk, T., Kaewtaro, S. · 2005 · Songklanakarin Journal of Science and Technology (SJST)
The optimal conditions of nata production from the fermentation of sugar palm syrup by Acetobacter xylinum TISTR 107 was studied. The results showed that optimized production for a litre of sugar palm syrup medium should compose 15 ºBrix concentration, 7.0 g NH4H2PO4 and 0.7 g MgSO4. 7 H2O at pH 4.25 and incubation at room temperature. The thickness of nata production reached 1.15 cm in 9 days. Sensory evaluation showed that there were no significant difference in odor and acceptability between the nata from sugar palm syrup and the traditional nata production from coconut juice whereas there
