Negative / Null Result ReportOpen accessMedicine
Ramasindrazana B, Rahalison ZA, Gauthier P et al. · 2025 · PLoS neglected tropical diseases
Background The plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and…
View details →DOI: 10.1371/journal.pntd.0013278 Negative / Null Result ReportMedicine
Espada-Musitu D, Manero-Azua Á, Vado Y et al. · 2025 · Anales de pediatria
Advances in next-generation sequencing (NGS) technologies have made the detection of the molecular causes of paediatric diseases increasingly affordable, accessible and rapid. While exome sequencing and genome sequencing were until…
View details →DOI: 10.1016/j.anpede.2024.503712 Negative / Null Result ReportOpen accessMedicine
Paracino R, De Domenico P, Ricciuti RA et al. · 2025 · Surgical neurology international
Background Idiopathic normal pressure hydrocephalus (iNPH) is a benign neurologic condition with treatment response rates ranging only between 30 and 50%. Several studies have attempted to identify clinical or radiological predictive…
View details →DOI: 10.25259/sni_975_2024 Negative / Null Result ReportMedicine
Pelegrín-Mateo FJ, Zambrano CB, Vázquez EB et al. · 2025 · European journal of internal medicine
Cancer-associated thrombosis (CAT) remains a leading cause of morbidity and mortality among oncology patients, with an incidence influenced by tumor type, stage, treatment, and molecular characteristics. This review explores the molecular…
View details →DOI: 10.1016/j.ejim.2025.04.004 Negative / Null Result ReportMedicine
Datta A, Katyayan I, Das KK et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Parent Artery Occlusion (PAO) is a valid treatment choice in giant internal carotid artery (ICA) aneurysms of the cavernous segment when the preoperative balloon test occlusion (BTO) demonstrates an adequate cross circulation from the…
View details →DOI: 10.1016/j.jocn.2025.111044 Negative / Null Result ReportOpen accessMedicine
Stahlmann K, Reitsma JB, Zapf A · 2023 · Statistical methods in medical research
Most diagnostic studies exclude missing values and inconclusive results from the analysis or apply simple methods resulting in biased accuracy estimates. This may be due to the lack of availability or awareness of appropriate methods. This…
View details →DOI: 10.1177/09622802231192954 Negative / Null Result ReportMedicine
Saber Tanha A, Hosseini S, Soltani E et al. · 2025 · Clinical nuclear medicine
Abstract A 47-year-old woman, recently diagnosed with breast cancer, underwent staging. A whole-body bone scan revealed an unexpected focal 99m Tc-MDP uptake in her right ovary. Extensive literature review suggested various malignant…
View details →DOI: 10.1097/rlu.0000000000005606 Negative / Null Result Report
Vezirian K, Beffara B, begue l · 2024 · Preprint
To develop pharmaceutical drugs, people experiment on lab-animals, and a wide variety of factors might predict the involvement into this situation. Using an ultra-realistic protocol mimicking animal research (n = 145), we examined…
View details →DOI: 10.31234/osf.io/ft7xe Negative / Null Result ReportOpen accessMedicine
Dudnyk A, Tytarenko N, Lytvyniuk O et al. · 2026 · Therapeutic advances in infectious disease
Background Patients with multidrug-resistant tuberculosis (MDR-TB) receive treatment that is at least 20% less effective than drug-susceptible cases globally. Objectives The study evaluated the diagnostic accuracy of mfloDx MDR-TB assay…
View details →DOI: 10.1177/20499361261436542 Negative / Null Result ReportMedicine
Mieites V, Fernández-Manteca MG, Santiuste Torcida I et al. · 2025 · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
This study explores the potential of conventional Raman spectroscopy and commonly used spectral analysis pipelines for rapid and straightforward assessment of degradation in serum samples resulting from storage delays. Serum samples from…
View details →DOI: 10.1016/j.saa.2025.126297 Negative / Null Result ReportOpen accessMedicine
de Oliveira Castro Marques TR, Vidal SA, da Costa HA et al. · 2026 · Hematology, transfusion and cell therapy
Background Stroke, the most severe neurological complication of sickle cell disease, can result in irreversible sequelae and death. Transcranial Doppler combined with periodic blood transfusions reduces the chances of stroke by 90 %. In…
View details →DOI: 10.1016/j.htct.2026.106458 Negative / Null Result ReportMedicine
Tu Y, Miao J, Wu Q et al. · 2025 · Respiratory medicine
Background Previous epidemiological studies have explored the association between obstructive sleep apnea (OSA) and osteoporosis (OP), with inconclusive results due to various biases. Herein, we sought to determine the causal association…
View details →DOI: 10.1016/j.rmed.2025.108090 Negative / Null Result ReportMedicine
Guarneri C, Reschini M, Pinna M et al. · 2024 · Journal of assisted reproduction and genetics
Purpose To evaluate whether a second biopsy, following a first diagnostic failure on blastocysts tested for preimplantation genetic testing for monogenic diseases (PGT-M), allows to obtain genetic diagnosis and to what extent this…
View details →DOI: 10.1007/s10815-024-03078-w Negative / Null Result Report
Mehta SP, Antonio Aguirre B, See WYN et al. · 2025 · Preprint
Purpose Whole exome or genome sequencing (WES and WGS, respectively) can be valuable in identifying the molecular basis of inherited retinal disorders (IRD), particularly when panel-based testing yields negative or inconclusive results.…
View details →DOI: 10.1101/2025.03.03.25322102 Negative / Null Result ReportOpen accessMedicine
Su XY, Schroder A, Tse LA et al. · 2025 · BMC research notes
Background Sex hormones may play a role in the development of nasopharyngeal carcinoma (NPC), but the evidence is limited. Methods This case-control study collected information on sex hormonal and reproductive factors of 99 female incident…
View details →DOI: 10.1186/s13104-025-07471-1 Failed Experiment ReportOpen accessMedicine
Jiménez-Martínez J, Alarcón-López F, Chirosa-Ríos LJ et al. · 2025 · Frontiers in sports and active living
Background Rehabilitation programs following an anterior cruciate ligament (ACL) injury tend to focus on improving conditional aspects such as biomechanics. Recently, some studies have analyzed the relationship between cognition and ACL…
View details →DOI: 10.3389/fspor.2025.1601744 Negative / Null Result Report
Khorram A · 2024 · Preprint
Abstract Introduction: To date, studies exploring shockwave-assisted orthodontic tooth movement and tooth mobility have produced inconclusive results, largely attributable to varying methodologies and a lack of standardized reporting. This…
View details →DOI: 10.21203/rs.3.rs-5280491/v1 Negative / Null Result ReportOpen accessMedicine
Rosa ML, Bordignon C, Schuch JB et al. · 2026 · Diagnostics (Basel, Switzerland)
Background/Objectives : Formalin-fixed paraffin-embedded tissue is widely used in pathology and molecular diagnostics, yet its variable quality can critically influence the accuracy of sequencing-based analyses. This study investigated…
View details →DOI: 10.3390/diagnostics16111595 Negative / Null Result ReportOpen accessMedicine
Gopalaswamy R, Kumar N, Vashistha H et al. · 2023 · Frontiers in public health
Introduction Truenat MTB-RIF assay (Truenat), a nucleic acid amplification test (NAAT), is a real-time polymerase chain reaction (RT-PCR) chip-based assay that can detect Mycobacterium tuberculosis ( Mtb ) and rifampicin (RIF) drug…
View details →DOI: 10.3389/fpubh.2023.1255756 Negative / Null Result ReportMedicine
Tavelli R, Callens M, Grootaert C et al. · 2024 · Trends in Food Science & Technology.
Microplastics (MPs) contaminate the global marine and terrestrial ecosystems. This environmental contamination can enter the food chain, with MPs found in drinking water, fishery products and other food categories. Consequently, ingestion…
View details →DOI: 10.1016/j.tifs.2022.08.021 Negative / Null Result Report
Mwakibete L, Hoarau AOG, Ahyong V et al. · 2024 · Preprint
Investigations of wildlife diseases and mortality events can sometimes lead to inconclusive results due to limitations in diagnostics combined with an ever-increasing number of emerging viruses. The use of tools such as unbiased…
View details →DOI: 10.1101/2024.12.21.629921 Negative / Null Result ReportMedicine
Juutilainen J, Khan MW, Naarala J et al. · 2024 · Occupational and environmental medicine
Objectives Studies assessing the association of adult cancers with extremely low frequency (ELF) magnetic fields (MF) have provided inconclusive results, probably affected by limitations such as low exposure levels, confounding and various…
View details →DOI: 10.1136/oemed-2024-109466 Negative / Null Result Report
Jäggi T, Sato S, Gygax P · 2024 · Preprint
Recently, researchers have started to experimentally investigate the claim that the grammaticalization of the future may impact our mental representations of future events. Yet, this research has mainly focused on the perceived distance of…
View details →DOI: 10.31234/osf.io/4h8gs Failed Experiment ReportOpen accessMedicine
Graziani L, Genovese S, Genovesi ML et al. · 2025 · Molecular cytogenetics
Background Monosomy 18p (MIM: 146390) is a well-known chromosomal disorder associated with intellectual disability, short stature, and non-specific craniofacial features resulting from partial or total deletion of the short arm of…
View details →DOI: 10.1186/s13039-025-00732-5 Negative / Null Result ReportOpen accessMedicine
Hernández-Cuellar E, Tsuchiya K, Medina-Contreras O et al. · 2025 · Journal of clinical medicine
Background/Objectives : Sepsis is a life-threatening condition characterized by an uncontrolled immune response due to systemic infections. It is responsible for millions of deaths worldwide. Although inflammasomes play an important role…
View details →DOI: 10.3390/jcm14197102 Negative / Null Result Report
Teuwen CJ, Vorstermans K, Kusurkar RA et al. · 2024 · Preprint
Interprofessional education is one of the interventions used to increase health care students’ motivation for working with older patients. Previous research about such interventions has been conducted without the use of control groups and…
View details →DOI: 10.12688/mep.19773.2 Negative / Null Result ReportMedicine
Nielsen MK, Bartholdy ID, Kristensen KS et al. · 2025 · Veterinary parasitology
Equine strongylids are ubiquitous and can cause severe health issues. Anthelmintic resistance is widely common in cyathostomin parasites, and recent studies have documented increasing incidence of resistance to the macrocyclic lactone drug…
View details →DOI: 10.1016/j.vetpar.2025.110465 Negative / Null Result ReportMedicine
MacCarrick G, Aradhya S, Bailey M et al. · 2024 · American journal of medical genetics. Part A
Molecular genetics enables more precise diagnoses of skeletal dysplasia and other skeletal disorders (SDs). We investigated the clinical utility of multigene panel testing for 5011 unrelated individuals with SD in the United States…
View details →DOI: 10.1002/ajmg.a.63646 Negative / Null Result ReportOpen accessMedicine
Karvasarski E, Park J, Savaris S et al. · 2026 · CJC open
Background Resting hemodynamic assessment of suspected pulmonary hypertension (PH) in older adults with cardiovascular risk factors may not effectively discriminate pre-capillary from post-capillary disease. Exercise right-heart…
View details →DOI: 10.1016/j.cjco.2026.02.005 Negative / Null Result ReportMedicine
Crabtree D, Seidler K, Barrow M · 2025 · Clinical nutrition ESPEN
Background and aims Epidemiological studies have associated reduced bacterial diversity and abundance and food allergy. This mechanistic review investigated the link between gut dysbiosis and food allergy with a focus on the role of…
View details →DOI: 10.1016/j.clnesp.2024.11.019 