Negative / Null Result ReportOpen accessMedicine
Sofia Asioli, Lidia Gatto, Uri Vardy et al. · 2024 · Cancers
Background: Glioblastoma IDH-wildtype (GBM IDH-wt) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping its tumor microenvironment (TME) regulate tumor progression and treatment response. The aim of this study was to characterize the main immunosuppressive elements of the GBM IDH-wt TME. Methods: Immunohistochemistry for CD3, CD4, CD8, CD163, programmed death ligand 1 (PD-L1) and programmed death 1 (PD1) was performed on surgical tumor specimens from patients diagnosed with GBM IDH-wt, according to the CNS WHO 202
View details →DOI: 10.3390/cancers16223859Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Jo Pearson, Itiel E. Dror, Emma Jayes et al. · 2026 · Scientific Reports
The use of Artificial Intelligence (AI) to effectively support human decision making depends on whether humans are willing to trust in, and thus rely on, AI. Understanding human reliance on AI is critical given controversial reports of AI inaccuracy and bias. Furthermore, the erroneous belief that using technology removes biases may lead to overreliance on AI. To examine humans’ reliance on AI, human participants (N = 295, Mage = 33.79) judged the authenticity of 80 faces (40 real, 40 AI-synthesized) presented alongside guidance supposedly from humans or from AI. This guidance was correct only
View details →DOI: 10.1038/s41598-026-34983-yCited by 9 Negative / Null Result ReportOpen accessMedicine
Fedir Hladkykh, Tetiana Liadova, Mariia Matvieienko et al. · 2026 · Journal of Pain Research
Introduction: Central sensitization explains the mismatch between structural damage or inflammation and pain intensity in chronic musculoskeletal diseases. It defines the phenotype of fibromyalgia and contributes to persistent pain in…
View details →DOI: 10.2147/jpr.s571311Cited by 9 Replication FailureOpen accessMedicine
Tijmen A. van Zadelhoff, Rianne A. van der Heijden, Sita M. A. Bierma-Zeinstra et al. · 2026 · European Radiology
OBJECTIVES: To determine if genicular artery embolization (GAE) is more effective in relieving pain symptoms after 12 months compared to a sham procedure in patients with mild to moderate knee osteoarthritis. A secondary aim was to investigate changes in synovitis observed at 4 months and the correlation with other clinical outcomes. MATERIALS AND METHODS: A randomized controlled trial included patients with mild to moderate knee osteoarthritis unresponsive to conservative treatment, who were randomly assigned to receive either GAE or sham treatment. Follow-up was at 1, 4, 8, and 12 months. Pa
View details →DOI: 10.1007/s00330-026-12505-8Cited by 9 Negative / Null Result ReportOpen accessNursing
Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer et al. · 2025 · Pharmaceutics
Selenium nanoparticles (SeNPs) have emerged as promising metal-based nanoparticles for drug delivery due to their unique physicochemical properties, intrinsic bioactivity, and biocompatibility. SeNPs offer a lower toxicity, higher bioavailability, and flexibility to be customized for surface chemistry compared to traditional selenium compounds. Advances in synthetic strategies, including chemical reduction, green biosynthesis, and surface functionalization with polymers, peptides, or ligands, have improved their stability, targeting capability, and circulation time. SeNP-based systems have dem
View details →DOI: 10.3390/pharmaceutics17121556Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hasan Demirci, Jessica Paola Bahena-López, Смородченко Алина Тихоновна et al. · 2025 · JCI Insight
Kidney thick ascending limb cells reabsorb sodium, potassium, calcium, and magnesium and contribute to urinary concentration. These cells are typically viewed as of a single type that recycles potassium across the apical membrane and generates a lumen-positive transepithelial voltage driving calcium and magnesium reabsorption, although variability in potassium channel expression has been reported. Additionally, recent transcriptomic analyses suggest that different cell types exist along this segment, but classifications have varied and have not led to a new consensus model. We used immunolocal
View details →DOI: 10.1172/jci.insight.190992Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ariadna Tibau, Edward R. Scheffer Cliff, Alejandra Romano et al. · 2025 · EClinicalMedicine
Background: The accelerated approval pathway allows the FDA to approve drugs for serious conditions based on promising surrogate measures, with confirmatory studies required later. If subsequent testing shows an unfavorable benefit-risk profile, the indication may be withdrawn. This study aimed to identify factors associated with the withdrawal of drug indications following accelerated approval. Methods: In this retrospective cohort study, we identified FDA-approved drugs for solid and hematologic cancers from 1992 to 2022 and extracted factors present at the time of accelerated approval, incl
View details →DOI: 10.1016/j.eclinm.2025.103088Cited by 9 Negative / Null Result ReportOpen accessMedicine
Akhilesh Mishra, Ajay Sharma, Kuldeep Gupta et al. · 2026 · Science Advances
Optimizing dosing strategies is critical to balance effectiveness and toxicity, especially for drugs with narrow therapeutic windows such as antibody-drug conjugates (ADCs). This study evaluates whether positron emission tomography (PET) imaging targeting Nectin-4 can noninvasively quantify the real-time interaction of the ADC enfortumab vedotin (EV) with tumors in urothelial carcinoma. Using the imaging agent [ 68 Ga]AJ647, dynamic changes in the interaction of EV with Nectin-4 were measured across preclinical models and correlated with therapeutic responses. PET imaging identified dose-depen
View details →DOI: 10.1126/sciadv.ady1111Cited by 9 Negative / Null Result ReportOpen accessMathematics
Freya Pollington, Spiros Denaxas, Kezhi Li et al. · 2025 · Journal of the American Medical Informatics Association
OBJECTIVES: Increasingly, structured longitudinal electronic health records (EHRs) are being harnessed to predict risk of having present but as yet undetected disease by analyzing "patient trajectories." Trajectory studies explore clinical event associations, characterize disease trajectories, and enhance risk prediction. This scoping review assesses study characteristics and objectives, identifies model types, and appraises model performance and reporting. MATERIALS AND METHODS: We conducted a scoping review, focused on a PubMed and Web of Science search for studies using temporal EHR sequenc
View details →DOI: 10.1093/jamia/ocaf208Cited by 9 Negative / Null Result ReportOpen accessMedicine
Qun Xiao, WeiCheng Huang, Yuheng Zhuang et al. · 2025 · Aging Clinical and Experimental Research
BACKGROUND: Stroke is a significant public health issue, with its risk influenced by various metabolic factors. The Cholesterol, High-Density Lipoprotein, Glucose (CHG) index has been identified as a valid stroke predictor. However, the…
View details →DOI: 10.1007/s40520-025-03243-wCited by 9 Negative / Null Result ReportOpen accessMedicine
Ruxandra Oiegar, Dana Pop · 2025 · Journal of Clinical Medicine
Background/Objectives: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovium. The inflammation accelerates the development and progression of atherosclerosis, a key phenomenon in the onset of cardiovascular diseases. The aim of this review was to synthetize the traditional and RA-specific cardiovascular risk (CVR) factors and the CVR assessment guidelines in RA patients. Methods: We performed a PubMed search using specific keywords. We synthetized the main findings. Results: Although the risk factors are the traditional ones, with certain par
View details →DOI: 10.3390/jcm14186461Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Assaf Shmuel, Teddy Lazebnik, Eyal Heifetz et al. · 2025 · npj natural hazards.
Fire weather indices (FWIs) are widely used to assess wildfire risk, but are typically designed for specific regions and not adapted globally. Here, we present a systematic effort to generate country-specific FWIs that capture regional…
View details →DOI: 10.1038/s44304-025-00126-yCited by 9 Negative / Null Result ReportOpen accessMedicine
Maria Dalamaga, Rodopi Emfietzoglou, Dimitra Petropoulou et al. · 2026 · Current Nutrition Reports
PURPOSE OF REVIEW: Vitamin D is a pleiotropic hormone with an established role in skeletal integrity and broader actions in immune regulation, inflammation, cellular proliferation, and energy homeostasis. Despite decades of research, its extra-skeletal effects remain controversial, largely due to discordant findings across observational studies, Mendelian randomization studies (MRS), and randomized controlled trials (RCTs). Unlike many prior reviews, this state-of-the-art review synthesizes triangulated evidence across these study designs to clarify outcome-specific causal relationships and on
View details →DOI: 10.1007/s13668-026-00748-2Cited by 9 Negative / Null Result ReportOpen accessPsychology
Chantal A. Miller, Keshun Zhang, Ronald Hübner · 2025 · Humanities and Social Sciences Communications
Abstract Aesthetic preferences vary widely among individuals and across cultures. These culture-specific aesthetic preferences are reflected in the environment, artistic behaviour, and consumer choices. People have the ability to infer the aesthetic preferences of others within their own culture through their Theory of Aesthetic Preferences , which is a subcategory of the Theory of Mind. An important question is whether people can also infer aesthetic preferences across different cultures. This study aimed to investigate aesthetic preference and aesthetic inference, as well as the underlying m
View details →DOI: 10.1057/s41599-025-04806-yCited by 9 Negative / Null Result ReportOpen accessArts and Humanities
Guangxiang Liu, Md Kamal Hossain · 2026 · Journal of Computer Assisted Learning
ABSTRACT Background Amid Bangladesh's national efforts to enhance digital inclusion, rural university students continue to face persistent infrastructural and educational inequalities that limit their access to quality English learning…
View details →DOI: 10.1002/jcal.70196Cited by 9 Negative / Null Result ReportOpen accessMedicine
Dayoung Seo, Yangsean Choi, Eunseon Jeong et al. · 2025 · Nature Communications
Although brain alterations have been reported in post-acute sequelae of SARS-CoV-2 (PASC), their prevalence and relationship to neurodegeneration remain unclear. We analyzed blood proteins and brain MRI from individuals approximately one…
View details →DOI: 10.1038/s41467-025-65597-zCited by 9 Negative / Null Result ReportOpen accessChemistry
Tongbo Zhu, Zhiying Wang, Lynn M. McMullen et al. · 2021 · Microorganisms
The locus of heat resistance (LHR) confers resistance to extreme heat, chlorine and oxidative stress in Escherichia coli. This study aimed to determine the function of the LHR in maintaining bacterial cell envelope homeostasis, the regulation of the genes comprising the LHR and the contribution of the LHR to alkaline pH response. The presence of the LHR did not affect the activity of the Cpx two-component regulatory system in E. coli, which was measured to quantify cell envelope stress. The LHR did not alter E. coli MG1655 growth rate in the range of pH 6.9 to 9.2. However, RT-qPCR results ind
View details →DOI: 10.3390/microorganisms9040701Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Gonzalo Olmedo‐Saura, E Bernardi, Lidia Bojtos et al. · 2025 · International Journal of Molecular Sciences
Huntington's disease (HD) is the most common autosomal dominant neurodegenerative disorder, characterized by a triad of motor dysfunction, cognitive decline, and psychiatric disturbances. While recent efforts have focused on developing disease-modifying therapies, no treatment has yet demonstrated clinical efficacy. As a result, symptomatic treatment remains the cornerstone of care. However, high-quality evidence from large randomized trials is limited, and therapeutic decisions must rely on clinical expertise and extrapolation from other neurological or psychiatric conditions. This narrative
View details →DOI: 10.3390/ijms26136220Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
K. D. Alexander, R. Margutti, Sebastian Gomez et al. · 2026 · The Astrophysical Journal
Abstract Recent observations presented in Y. Cendes et al. show that optically selected tidal disruption events (TDEs) commonly produce delayed radio emission that can peak years after disruption. Here, we explore the multiwavelength properties of a sample of radio-observed optically selected TDEs, to shed light on the physical process(es) responsible for the late-rising radio emission. We combine new late-time X-ray observations with archival optical, UV, X-ray, and radio data to conclude that a diversity of accretion-driven outflows may power the delayed radio emission in TDEs. Our analysis
View details →DOI: 10.3847/1538-4357/ae40abCited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nick Quinn-Bohmann, Alex V. Carr, Sean M. Gibbons · 2026 · PLoS Biology
Prebiotic, probiotic, and combined (synbiotic) interventions often show variable outcomes across individuals, driven by complex interactions between introduced biotics, the endogenous microbiota, and the host diet. Predicting individual-specific success or failure of probiotic and prebiotic therapies remains a major challenge. Here, we leverage microbial community-scale metabolic models (MCMMs) to predict probiotic engraftment and microbiota-mediated short-chain fatty acid (SCFA) production in response to probiotic and prebiotic interventions. Using data from two human clinical trial cohorts,
View details →DOI: 10.1371/journal.pbio.3003638Cited by 9 Negative / Null Result ReportOpen accessDentistry
Rafael Scaf de Molon, João Paulo Steffens, Érica Dorigatti de Ávila et al. · 2026 · Journal of Periodontal Research
Periodontitis is a chronic, host-mediated inflammatory disease in which microbial dysbiosis and dysregulated immune responses drive the destruction of tooth-supporting tissues. Although conventional therapy remains centered on mechanical biofilm control, persistent inflammation and alveolar bone loss in susceptible individuals underscore the need for adjunctive strategies. Translating preclinical discoveries into predictable clinical outcomes, however, remains a major challenge in periodontal research. This narrative review integrates two interrelated themes, translational research methodology
View details →DOI: 10.1111/jre.70060Cited by 9 Negative / Null Result ReportOpen accessMedicine
Sandra Heskamp, Otto C. Boerman, Janneke D.M. Molkenboer‐Kuenen et al. · 2014 · Molecular Pharmaceutics
Bevacizumab and cetuximab are approved for the treatment of cancer. However, in advanced colorectal cancer, addition of cetuximab to chemotherapy with bevacizumab did not improve survival. The reason for the lack of activity remains…
View details →DOI: 10.1021/mp500460gCited by 9 Negative / Null Result ReportOpen accessMedicine
Solveigh C. Koeberle, Maria Thürmer, Fengting Su et al. · 2025 · Theranostics
: Our study deciphers the structural features of silybin contributing to hepatic lipid remodeling and suggests that silymarin/silybin protects the liver in individuals with mild metabolic dysregulation, involving a lipid class switch from triglycerides to phospholipids, whereas it may be less effective in disease states associated with severe metabolic dysregulation.
View details →DOI: 10.7150/thno.99562Cited by 9 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Özgür Atılgan, Franz W. Kellermanns · 2025 · Family Business Review
We investigate how negative types of intra-family conflicts (i.e., status conflict and relationship conflict) influence the family firm leader’s socioemotional wealth importance (SEWi). Based on 159 matched responses from family firm…
View details →DOI: 10.1177/08944865251315791Cited by 9 Replication FailureOpen accessMedicine
Christopher C. Butler, Andrew Pinto, Victoria Harris et al. · 2026 · New England Journal of Medicine
BACKGROUND: Nirmatrelvir-ritonavir has been shown to reduce progression to severe illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in unvaccinated high-risk outpatients. The effectiveness of nirmatrelvir-ritonavir in persons who have been vaccinated, infected naturally, or both is unclear. METHODS: In two open-label platform trials (PANORAMIC in the United Kingdom and CanTreatCOVID in Canada), we enrolled higher-risk adults (≥50 years of age or ≥18 years of age with coexisting conditions) in the community who tested positive for SARS-CoV-2 and had been unwell for 5 day
View details →DOI: 10.1056/nejmoa2502457Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Stacey Hynd · 2026 · Open Research Exeter (University of Exeter)
The position of women and the operation of justice were both contentious issues in colonial Africa. However, when combined in the discussion and sentencing of African women charged with murder and facing the death penalty for their crimes,…
View details →DOI: 10.25365/phaidra.1061_02Cited by 9 Negative / Null Result ReportOpen accessDecision Sciences
Mark Ramos · 2025 · Accountability in Research
BACKGROUND: Positive publication bias is the tendency to favor studies that reject null hypotheses for publication and is widely regarded as detrimental to research enterprise quality. However, this view oversimplifies the interplay between selection biases and the statistical properties of hypothesis testing. METHODS: Using theoretical models under varying assumptions about the research landscape in terms of the truth values of hypotheses investigated, we examine how increasing bias towards publishing studies with statistically significant results over those without inflates false positive ra
View details →DOI: 10.1080/08989621.2025.2538066Cited by 9 Negative / Null Result ReportOpen accessMedicine
F Visalli, Matteo Capobianco, F. Cappellani et al. · 2026 · International Journal of Molecular Sciences
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
View details →DOI: 10.3390/ijms27010485Cited by 9 Negative / Null Result ReportOpen accessEngineering
Yufan Zhu, Huifan Liu, Zhiqiang Yang et al. · 2026 · Theranostics
Background: Excessive inflammation and exacerbated oxidative stress are significant hallmarks of the diabetic bone microenvironment, which give rise to dysregulated immune reactions and impaired bone homeostasis, thereby hindering bone defect healing and increasing the incidence of bone nonunion.Methods: A biodegradable photothermal hybrid (SC/MTZ) was developed through the in situ self-assembly of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles on tannic acid (TA)-functionalized Ti3C2Tx MXene nanosheets, which were then integrated into a methacrylated silk fibroin/carboxymethyl chitosa
View details →DOI: 10.7150/thno.130240Cited by 9 Negative / Null Result Report
P. Sumithran, K. Purcell, S. Kuyruk et al. · 2017 · Clinical Obesity
Summary Consistent, strong predictors of obesity treatment outcomes have not been identified. It has been suggested that broadening the range of predictor variables examined may be valuable. We explored methods to predict outcomes of a…
View details →DOI: 10.1111/cob.12229Cited by 9 