Negative / Null Result ReportOpen accessPhysics and Astronomy
K. D. Alexander, R. Margutti, Sebastian Gomez et al. · 2026 · The Astrophysical Journal
Abstract Recent observations presented in Y. Cendes et al. show that optically selected tidal disruption events (TDEs) commonly produce delayed radio emission that can peak years after disruption. Here, we explore the multiwavelength properties of a sample of radio-observed optically selected TDEs, to shed light on the physical process(es) responsible for the late-rising radio emission. We combine new late-time X-ray observations with archival optical, UV, X-ray, and radio data to conclude that a diversity of accretion-driven outflows may power the delayed radio emission in TDEs. Our analysis
View details →DOI: 10.3847/1538-4357/ae40abCited by 9 Negative / Null Result ReportOpen accessMedicine
F Visalli, Matteo Capobianco, F. Cappellani et al. · 2026 · International Journal of Molecular Sciences
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
View details →DOI: 10.3390/ijms27010485Cited by 9 Negative / Null Result ReportOpen accessPsychology
Chantal A. Miller, Keshun Zhang, Ronald Hübner · 2025 · Humanities and Social Sciences Communications
Abstract Aesthetic preferences vary widely among individuals and across cultures. These culture-specific aesthetic preferences are reflected in the environment, artistic behaviour, and consumer choices. People have the ability to infer the aesthetic preferences of others within their own culture through their Theory of Aesthetic Preferences , which is a subcategory of the Theory of Mind. An important question is whether people can also infer aesthetic preferences across different cultures. This study aimed to investigate aesthetic preference and aesthetic inference, as well as the underlying m
View details →DOI: 10.1057/s41599-025-04806-yCited by 9 Negative / Null Result ReportOpen accessMedicine
Fedir Hladkykh, Tetiana Liadova, Mariia Matvieienko et al. · 2026 · Journal of Pain Research
Introduction: Central sensitization explains the mismatch between structural damage or inflammation and pain intensity in chronic musculoskeletal diseases. It defines the phenotype of fibromyalgia and contributes to persistent pain in…
View details →DOI: 10.2147/jpr.s571311Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Yashvee Dunneram, Jia Yi Lee, Cody Z. Watling et al. · 2026 · British Journal of Cancer
BACKGROUND: Vegetarian diets might influence cancer risk. METHODS: We studied 1,645,555 meat eaters, 57,016 poultry eaters, 42,910 pescatarians, 63,147 vegetarians and 8849 vegans in 9 cohorts (UK, US, Taiwan, India). After a median 16 years follow-up, incident cancers were: 4504 mouth and pharynx, 1308 oesophagus (squamous cell), 2105 oesophagus (adenocarcinoma), 3578 stomach, 30,528 colorectum, 2970 liver, 8030 pancreas, 3077 lung (never smokers), 61,368 breast, 11,220 endometrium, 8076 ovary, 45,946 prostate, 7193 kidney, 6869 bladder, 11,651 non-Hodgkin lymphoma, 4658 multiple myeloma and
View details →DOI: 10.1038/s41416-025-03327-4Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mohammad Fayyad‐Kazan, Sarah Ayad Al-Tameemi, Allal Ouhtit · 2026 · Cells
Cancer immunotherapy has transformed modern oncology, yet durable responses remain limited for many patients due to immune exclusion, adaptive resistance, and tumor heterogeneity. Oncolytic viruses (OVs) have emerged as a novel class of immunotherapeutics that unify direct tumor cytolysis with stimulation of antitumor immunity. By inducing immunogenic cell death (ICD) and releasing tumor-associated antigens (TAAs), OVs remodel the tumor microenvironment (TME) into an inflamed and immune-permissive niche capable of enabling systemic immune activation. Rapid advances in viral engineering have st
View details →DOI: 10.3390/cells15050393Cited by 9 Negative / Null Result ReportOpen accessMedicine
T. Nguyen, Tam Dao, Ha Thu Nguyen et al. · 2026 · Endocrinology and Metabolism
Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function, which increases the risk of falls, frailty, and loss of independence. Despite growing recognition and its…
View details →DOI: 10.3803/enm.2025.2656Cited by 9 Negative / Null Result ReportOpen accessMedicine
Eleanor Quek, Neve Horn, Salman Siddiqui · 2025 · ImmunoTargets and Therapy
Asthma represents a profoundly heterogeneous syndrome underpinned by multiple, distinct and overlapping immunopathological mechanisms. Nevertheless, prevailing management algorithms continue to adopt a largely uniform, stepwise approach in…
View details →DOI: 10.2147/itt.s532291Cited by 9 Negative / Null Result ReportOpen accessMedicine
Dinh Van Trung, Bui Thi Huong Giang, Đang Quoc Tuan et al. · 2025 · Scientific Reports
Electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP…
View details →DOI: 10.1038/s41598-025-29787-5Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Mohammadreza Kamsari, Soroush Sadeghi, Gabriel Gomes de Oliveira et al. · 2025 · Scientific Reports
This study conducts a comprehensive analysis of various configurations of the UNet + ConvNeXt Tiny architecture for breast tumor segmentation. We assess the influence of data augmentation, skip connections, attention mechanisms, and…
View details →DOI: 10.1038/s41598-025-29841-2Cited by 9 Negative / Null Result ReportOpen accessMedicine
Pia De Stefano, Sira M. Baumann, Urs Fisch et al. · 2026 · Neurology
BACKGROUND AND OBJECTIVES: Although etiology is considered central to outcomes in status epilepticus (SE), previous studies often lacked standardized classification and adjustment for confounders, particularly withdrawal of life-sustaining treatment (WLST). This study examined the association between SE etiology, mortality, and neurologic recovery using the International League Against Epilepsy (ILAE) classification while accounting for confounders and WLST. METHODS: This 2-center observational study included adults (≥18 years) with SE treated at the University Hospitals of Basel and Geneva fr
View details →DOI: 10.1212/wnl.0000000000214624Cited by 9 Negative / Null Result ReportOpen accessMedicine
Sofia Asioli, Lidia Gatto, Uri Vardy et al. · 2024 · Cancers
Background: Glioblastoma IDH-wildtype (GBM IDH-wt) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping its tumor microenvironment (TME) regulate tumor progression and treatment response. The aim of this study was to characterize the main immunosuppressive elements of the GBM IDH-wt TME. Methods: Immunohistochemistry for CD3, CD4, CD8, CD163, programmed death ligand 1 (PD-L1) and programmed death 1 (PD1) was performed on surgical tumor specimens from patients diagnosed with GBM IDH-wt, according to the CNS WHO 202
View details →DOI: 10.3390/cancers16223859Cited by 9 Negative / Null Result ReportOpen accessMedicine
Corey A. Lester, Brigid Rowell, Yifan Zheng et al. · 2025 · JMIR Medical Informatics
Background: Artificial intelligence (AI)-based clinical decision support systems are increasingly used in health care. Uncertainty-aware AI presents the model's confidence in its decision alongside its prediction, whereas black-box AI only provides a prediction. Little is known about how this type of AI affects health care providers' work performance and reaction time. Objective: This study aimed to determine the effects of black-box and uncertainty-aware AI advice on pharmacist decision-making and reaction time. Methods: Recruitment emails were sent to pharmacists through professional listser
View details →DOI: 10.2196/64902Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Tim Linden, Thong T. Q. Nguyen, Tim M. P. Tait · 2026 · Journal of Cosmology and Astroparticle Physics
Abstract We model and constrain the unique indirect detection signature produced by dark matter particles that annihilate through a U(1) gauge symmetry into dark photons that subsequently decay into three-photon final states. We focus on scenarios where the dark photon is long-lived, and show that γ-ray probes of celestial objects can set strong constraints on the dark matter/baryon scattering cross section that in many cases surpass the power of current direct detection constraints, and in some cases even peer into the neutrino fog.
View details →DOI: 10.1088/1475-7516/2026/08/056Cited by 9 Negative / Null Result ReportOpen accessPsychology
Ryan K. McBain, Jonathan Cantor, J. Breslau et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: The rapid expansion of artificial intelligence (AI) chatbots has coincided with a persistent youth mental health crisis in the US, raising a question about the extent to which young people are turning to this technology for…
View details →DOI: 10.1001/jamapediatrics.2026.2015Cited by 9 Replication FailureOpen accessMedicine
Tijmen A. van Zadelhoff, Rianne A. van der Heijden, Sita M. A. Bierma-Zeinstra et al. · 2026 · European Radiology
OBJECTIVES: To determine if genicular artery embolization (GAE) is more effective in relieving pain symptoms after 12 months compared to a sham procedure in patients with mild to moderate knee osteoarthritis. A secondary aim was to investigate changes in synovitis observed at 4 months and the correlation with other clinical outcomes. MATERIALS AND METHODS: A randomized controlled trial included patients with mild to moderate knee osteoarthritis unresponsive to conservative treatment, who were randomly assigned to receive either GAE or sham treatment. Follow-up was at 1, 4, 8, and 12 months. Pa
View details →DOI: 10.1007/s00330-026-12505-8Cited by 9 Negative / Null Result ReportOpen accessMedicine
Akhilesh Mishra, Ajay Sharma, Kuldeep Gupta et al. · 2026 · Science Advances
Optimizing dosing strategies is critical to balance effectiveness and toxicity, especially for drugs with narrow therapeutic windows such as antibody-drug conjugates (ADCs). This study evaluates whether positron emission tomography (PET) imaging targeting Nectin-4 can noninvasively quantify the real-time interaction of the ADC enfortumab vedotin (EV) with tumors in urothelial carcinoma. Using the imaging agent [ 68 Ga]AJ647, dynamic changes in the interaction of EV with Nectin-4 were measured across preclinical models and correlated with therapeutic responses. PET imaging identified dose-depen
View details →DOI: 10.1126/sciadv.ady1111Cited by 9 Negative / Null Result ReportOpen accessMathematics
Freya Pollington, Spiros Denaxas, Kezhi Li et al. · 2025 · Journal of the American Medical Informatics Association
OBJECTIVES: Increasingly, structured longitudinal electronic health records (EHRs) are being harnessed to predict risk of having present but as yet undetected disease by analyzing "patient trajectories." Trajectory studies explore clinical event associations, characterize disease trajectories, and enhance risk prediction. This scoping review assesses study characteristics and objectives, identifies model types, and appraises model performance and reporting. MATERIALS AND METHODS: We conducted a scoping review, focused on a PubMed and Web of Science search for studies using temporal EHR sequenc
View details →DOI: 10.1093/jamia/ocaf208Cited by 9 Negative / Null Result ReportOpen accessMedicine
Ruxandra Oiegar, Dana Pop · 2025 · Journal of Clinical Medicine
Background/Objectives: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovium. The inflammation accelerates the development and progression of atherosclerosis, a key phenomenon in the onset of cardiovascular diseases. The aim of this review was to synthetize the traditional and RA-specific cardiovascular risk (CVR) factors and the CVR assessment guidelines in RA patients. Methods: We performed a PubMed search using specific keywords. We synthetized the main findings. Results: Although the risk factors are the traditional ones, with certain par
View details →DOI: 10.3390/jcm14186461Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Assaf Shmuel, Teddy Lazebnik, Eyal Heifetz et al. · 2025 · npj natural hazards.
Fire weather indices (FWIs) are widely used to assess wildfire risk, but are typically designed for specific regions and not adapted globally. Here, we present a systematic effort to generate country-specific FWIs that capture regional…
View details →DOI: 10.1038/s44304-025-00126-yCited by 9 Negative / Null Result ReportOpen accessMedicine
Maria Dalamaga, Rodopi Emfietzoglou, Dimitra Petropoulou et al. · 2026 · Current Nutrition Reports
PURPOSE OF REVIEW: Vitamin D is a pleiotropic hormone with an established role in skeletal integrity and broader actions in immune regulation, inflammation, cellular proliferation, and energy homeostasis. Despite decades of research, its extra-skeletal effects remain controversial, largely due to discordant findings across observational studies, Mendelian randomization studies (MRS), and randomized controlled trials (RCTs). Unlike many prior reviews, this state-of-the-art review synthesizes triangulated evidence across these study designs to clarify outcome-specific causal relationships and on
View details →DOI: 10.1007/s13668-026-00748-2Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Gonzalo Olmedo‐Saura, E Bernardi, Lidia Bojtos et al. · 2025 · International Journal of Molecular Sciences
Huntington's disease (HD) is the most common autosomal dominant neurodegenerative disorder, characterized by a triad of motor dysfunction, cognitive decline, and psychiatric disturbances. While recent efforts have focused on developing disease-modifying therapies, no treatment has yet demonstrated clinical efficacy. As a result, symptomatic treatment remains the cornerstone of care. However, high-quality evidence from large randomized trials is limited, and therapeutic decisions must rely on clinical expertise and extrapolation from other neurological or psychiatric conditions. This narrative
View details →DOI: 10.3390/ijms26136220Cited by 9 Negative / Null Result ReportOpen accessHealth Professions
Rachel O’Neill · 2025 · International Journal of Cultural Studies
Medical doctors are central to existing networks for wellness content on Instagram in and beyond the UK, yet remain overlooked within scholarship concerned with this terrain. Taking a case study approach, this article examines three such figures prominent in the UK context. In doing so, it challenges existing conceptualisations of the 'wellness influencer' and argues for an expanded understanding of the category, one that does not assume its representatives are 'lay' persons without recognised expertise in health and well-being. The analysis developed demonstrates that credentials cannot resol
View details →DOI: 10.1177/13678779241307032Cited by 9 Negative / Null Result ReportOpen accessMedicine
Brenda M O'Neill, Judy Martina Bradley, Bronwen A. Connolly et al. · 2026 · JAMA
Importance: Evidence for remote multicomponent rehabilitation among critical care survivors is sparse. Objective: To investigate the effects of a 6-week, remote, multicomponent rehabilitation intervention in survivors of critical illness following discharge from the hospital after an intensive care unit (ICU) admission compared with standard care on health-related quality of life at 8 weeks. Design, Setting, and Participants: Pragmatic, multicenter, assessor-blinded, randomized clinical trial conducted from December 2022 to November 2025 at 52 National Health Service hospitals in the UK. Parti
View details →DOI: 10.1001/jama.2026.7401Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anagha Krishna, Alison Meynert, Karamjit Singh Dolt et al. · 2026 · Nature Genetics
CTNNB1, the gene encoding β-catenin, is a frequent target for oncogenic mutations activating the canonical Wnt signaling pathway, typically through missense mutations within a degron hotspot motif in exon 3. Here, we combine saturation genome editing with a fluorescent reporter assay to quantify signaling phenotypes for all 342 possible missense mutations in the mutation hotspot. Our data define the genetic requirements for β-catenin degron function, refine the consensus motif for substrate recognition by β-TRCP and reveal diverse levels of signal activation among known driver mutations. Tumor
View details →DOI: 10.1038/s41588-025-02496-5Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Forest ISBELL, A. Mori, Michel Loreau et al. · 2026 · Nature
Stability can be desirable for many natural and social systems. Temporal stability, the invariability of a system over time, can be enhanced by resisting displacement during perturbations, accelerating recovery after them, or both1–4.…
View details →DOI: 10.1038/s41586-026-10498-4Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Louis Roberts, Juho Äijälä, Florian Bürger et al. · 2026 · Nature Communications
The cortex generates diverse neural dynamics, ranging from broadband fluctuations to narrowband oscillations at specific frequencies. Here, we investigated whether broadband and oscillatory dynamics play different roles in the encoding and transmission of visual information. We used information-theoretical measures to dissociate neural signals sharing common information (i.e., redundancy) from signals encoding complementary information (i.e., synergy). We analyzed electrocorticography (ECoG) and local field potentials (LFP) in the visual cortex of human and non-human primates (macaque) to inve
View details →DOI: 10.1038/s41467-026-72444-2Cited by 9 Replication FailureOpen accessMedicine
Sara A. Hurvitz, Rachel M. Layman, Giuseppe Curigliano et al. · 2026 · Journal of Clinical Oncology
PURPOSE Gedatolisib potently targets all four class I PI3K isoforms and mTORC1 and mTORC2 to comprehensively block the PI3K/AKT/mTOR pathway and has shown compelling activity in early clinical trials with palbociclib and fulvestrant.…
View details →DOI: 10.1200/jco-25-02643Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lucia Scisciola, Manuela Giovanna Basilicata, Marta Belmonte et al. · 2026 · Nutrients
BACKGROUND: The heart depends on a continuous and flexible energy supply from fatty acids, glucose, and other substrates. Emerging evidence shows that gut microbiota-derived metabolites-such as trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), secondary bile acids, indoles, phenylacetylglutamine (PAGln), and branched-chain amino acids-modulate cardiac metabolism and function. Although clinical evidence linking these metabolites to cardiovascular outcomes is expanding, most data remain associative, with limited causal or interventional proof. METHODS: A comprehensive narrative rev
View details →DOI: 10.3390/nu18030467Cited by 9 Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology
Yin Liu, Y Gong, X. Zhu et al. · 2025 · BMJ
Abstract Objective To evaluate the efficacy and safety of epirubicin and cyclophosphamide followed by weekly paclitaxel with or without carboplatin as adjuvant therapy for patients with high risk, early stage, triple negative breast…
View details →DOI: 10.1136/bmj-2025-085457Cited by 9 