Negative / Null Result ReportOpen accessEngineering
Kaituo Li, Lin Zhu, Fei Xiong et al. · 2026 · Processes
Enhanced geothermal systems (EGS) are a key technology for developing deep geothermal resources, yet they face significant challenges in constructing efficient thermal reservoirs within high-stress, high-strength, and low-permeability crystalline rock formations. Traditional hydraulic fracturing (HF) techniques encounter deep challenges in these environments, including excessively high fracturing pressures, limited fracture network patterns, and the risk of induced seismicity. This paper reviews the multi-scale thermal-mechanical mechanisms, fracture evolution patterns, and control strategies
View details →DOI: 10.3390/pr14081199Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Dawn Finzi, Eshed Margalit, Kendrick Kay et al. · 2026 · Nature Communications
Human visual cortex is organized into dorsal, lateral, and ventral streams. A long-standing hypothesis is that the functional organization into streams emerged to support distinct visual behaviors. Here, we compare neural network-based…
View details →DOI: 10.1038/s41467-026-76098-yCited by 9 Negative / Null Result ReportOpen accessComputer Science
Alex Cloud, Minh Le, James Chua et al. · 2026 · Nature
. Here we show that distillation can lead to subliminal learning-the transmission of behavioural traits through semantically unrelated data. In our main experiments, a 'teacher' model with some trait T (such as disproportionately generating responses favouring owls or showing broad misaligned behaviour) generates datasets consisting solely of number sequences. Remarkably, a 'student' model trained on these data learns T, even when references to T are rigorously removed. More realistically, we observe the same effect when the teacher generates math reasoning traces or code. The effect occurs on
View details →DOI: 10.1038/s41586-026-10319-8Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alessandro Magini, Alessandro Datti · 2026 · International Journal of Molecular Sciences
Curcumin is widely recognized for its anti-inflammatory and antioxidant properties; however, this conventional framing obscures a broader, complex, and mechanistically diverse pharmacology. Here, we advance a refined perspective that situates curcumin within a hierarchical and multilayered architecture shaped by the dynamic interplay of intrinsic chemical reactivity, metabolic transformation and exposure, and microbial modulation. From this standpoint, curcumin functions as a network-level modulator, producing context-dependent outcomes rather than uniform or linear responses. Consequently, it
View details →DOI: 10.3390/ijms27052212Cited by 9 Negative / Null Result ReportOpen accessHealth Professions
Basit Ali Chaudhry, Christopher Louis Robinson, Edoardo Caronna et al. · 2026 · Toxins
Temporomandibular disorders (TMDs) are common musculoskeletal chronic orofacial pain conditions involving peripheral and central sensitization within trigeminal nociceptive pathways, manifesting as mechanical allodynia and functional impairment. Botulinum toxin type A (BoNT-A) has been explored as a treatment targeting both muscle hyperactivity and nociceptive modulation. Preclinical and clinical evidence demonstrate that BoNT-A reduces peripheral neurotransmitter release, neurogenic inflammation, and central neuronal excitability, leading to attenuation of mechanical allodynia in TMD models a
View details →DOI: 10.3390/toxins18010028Cited by 9 Negative / Null Result ReportOpen accessPsychology
Steph F Suddell, Lili Zhang, Chi Tak Lee et al. · 2026 · Psychological Medicine
Abstract Background Prior research shows that humans adjust their learning rate based on environmental volatility. This adaptation has been shown to be reduced in individuals with high levels of anxious-depression, but past studies have been cross-sectional, making it unclear whether this adaptation is trait-like or responsive to treatment. There are also questions about the basic replicability of this effect with recent studies failing to find robust associations. Method In the Precision in Psychiatry study, we examined changes in learning rate adaptation in a points-loss task, following four
View details →DOI: 10.1017/s0033291726105698Cited by 9 Negative / Null Result ReportOpen accessEngineering
Mingqi Wang, Yulin Ye, Ruqiang Yuan et al. · 2025 · Cancer Cell International
The limited clinical translation of preclinical anticancer drug efficacy underscores the urgent need for advanced models that faithfully replicate tumor pathophysiology. While three-dimensional (3D) tumor cultures improve the fidelity of…
View details →DOI: 10.1186/s12935-025-04064-7Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Jamie Lars Hanson, Dorthea J Adkins, Brendon M. Nacewicz et al. · 2026 · Brain and Environment
Socioeconomic status (SES) in childhood can impact behavioral and brain development. Past work has consistently focused on the amygdala and hippocampus, two brain areas critical for emotion and behavioral responding. While there are SES differences in amygdala and hippocampal volumes, there are many unanswered questions in this domain connected to neurobiological specificity, and for whom these effects may be more pronounced. We may be able to investigate some anatomical subdivisions of these brain areas, as well as if relations with SES vary by participant age and sex. No work to date has how
View details →DOI: 10.1016/j.braen.2026.100022Cited by 9 Negative / Null Result ReportOpen accessHealth Professions
Shukun Luo, Joshua Bulos, Ricky Uroza et al. · 2025 · Pharmaceutics
Background: Photostability assessment is a critical component in the development of drug products, particularly for antibody–drug conjugates (ADCs) containing light-sensitive small molecules such as camptothecin (CPT) and its derivatives. ADCs conjugated with CPT derivative payloads often require extensive formulation and drug product development to ensure product stability due to their unique light-induced degradation pathways. In this study, we assessed the photostability of two ADC molecules with a CPT derivative payload (deruxtecan, DXd). Methods: Following light exposure, the stability of
View details →DOI: 10.3390/pharmaceutics17111397Cited by 9 Negative / Null Result ReportOpen accessMaterials Science
Abhilash Purohit, S. Sathees Kumar, Pravat Ranjan Pati et al. · 2026 · Scientific Reports
Abstract The growing demand for sustainable materials has stimulated the development of bio-based composites, yet the combination of natural fibers and industrial waste fillers in polymer matrices has not been exploited synergistically. In line with Sustainable Development Goal 12 (SDG-12), the paper focuses on reusing the steel industry by-product Linz–Donawitz (LD) sludge to enhance the mechanical properties of epoxy composites when used with the jute fiber. Six composite specimens with constant jute fiber loading (20 wt%) and a range of LD sludge content (0–25 wt%) were prepared using hand
View details →DOI: 10.1038/s41598-026-53330-9Cited by 9 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Bálint Soczó, Ildikó Pethes · 2025 · Journal of Molecular Liquids
Describing the interactions of water molecules is one of the most common, yet critical, tasks in molecular dynamics simulations . Because of its unique properties, hundreds of attempts have been made to construct an ideal interaction potential model for water. In various studies, the models have been evaluated based on their ability to reproduce different properties of water. This work focuses on the atomic-scale structure in the liquid phase of water. Forty-four classical water potential models are compared to identify those that can accurately describe the structure in alignment with experim
View details →DOI: 10.1016/j.molliq.2025.127975Cited by 9 Negative / Null Result ReportOpen accessEngineering
Tuğba Özer, Sakda Jampasa, Atchara Lomae et al. · 2026 · Analytical Chemistry
High Resolution Image Download MS PowerPoint Slide Herein, we present a potentiometric biosensor based on amine magnetic beads functionalized with electrostatically neutral peptide nucleic acids (PNA) for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A screen-printed carbon electrode was modified with a plasticized polymeric membrane. A SARS-CoV-2 specific peptide nucleic acid probe was designed and synthesized. We exploited the advantage of neutral PNAs to remove the negatively charged DNA probes that cause fouling due to the attraction of positively charged b
View details →DOI: 10.1021/acs.analchem.6c00766Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
António Afonso, José Alves, João Jalles et al. · 2026 · Scottish Journal of Political Economy
ABSTRACT We examine how geopolitical risks (GPR) affect fiscal (FS) and external sustainability (ES) across 27 European Union economies over 2001Q4–2022Q3. We apply a two‐step strategy: first, estimating time‐varying FS and ES coefficients…
View details →DOI: 10.1111/sjpe.70059Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Sebastian Schorcht, Fabian Anton Müller, Nils Frederik Buchholtz · 2026 · ZDM
Abstract Large Language Models (LLMs) are increasingly discussed as tools for supporting mathematical problem solving. However, existing research predominantly evaluates LLM performance in terms of correctness, while the mathematics educational quality of AI-generated worked-out solutions remains largely unexplored. This study investigates how the mathematics educational quality (a set of quality criteria relating to teaching and learning mathematics) of AI-generated problem solutions can be influenced by model choice and prompt engineering. Four LLMs (Gemini 1.5 Pro (Advanced), Claude 3.5 Son
View details →DOI: 10.1007/s11858-026-01784-6Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Elias Sabri, Agustín Mangiarotti, Rumiana Dimova · 2026 · Nature Communications
Biomolecular condensates, essential for cellular organization, possess mesoscale properties largely governed by hydrophobicity, influencing molecule partitioning and material characteristics like viscosity, surface tension, and hydration. While hydrophobicity's role is increasingly recognized, its impact on membrane-condensate interactions remains unexplored. Here, we combine hyperspectral imaging of an environment-sensitive dye and phasor analysis, to quantitatively map the local dielectric permittivity of both condensates and their environment with pixel resolution. This robust method senses
View details →DOI: 10.1038/s41467-026-71273-7Cited by 9 Negative / Null Result ReportOpen accessMedicine
Patrick Highton, Mark P. Funnell, Pankaj Gupta et al. · 2025 · Diabetologia
Abstract Medication adherence is critical for optimal glycaemic management and the prevention of complications in type 2 diabetes mellitus. Despite its importance, non-adherence remains a prevalent issue, with global estimates suggesting that approximately 38% of people with type 2 diabetes do not take their medications as prescribed, although estimates vary widely due to a range of patient-related, socioeconomic, condition-related (e.g. chronicity, severity of comorbidities) and healthcare system factors. This review synthesises the current evidence on the prevalence of non-adherence in type
View details →DOI: 10.1007/s00125-025-06617-xCited by 9 Negative / Null Result ReportOpen accessMedicine
Aris Liakos, Thomas Karagiannis, Ioannis Avgerinos et al. · 2026 · Current Diabetes Reports
PURPOSE OF REVIEW: The pharmacologic management of type 2 diabetes prioritises sodium-glucose cotransporter 2 (SGLT-2) inhibitors or glucagon-like peptide 1 (GLP-1) receptor agonists for their demonstrated cardiovascular benefits in individuals with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors, chronic kidney disease, and heart failure. However, while current guidelines recommend these drug classes alone, combination therapy is not explicitly advocated. Herein we summarise the rationale and available evidence in support for combination therapy. RECENT FINDINGS
View details →DOI: 10.1007/s11892-025-01616-zCited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ruiyi Tian, Xiaoyu Zong, Duo Ren et al. · 2026 · Nature Medicine
Abstract Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk. Here among 154,169 young adults from the United Kingdom Biobank, systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965–1974 versus 1950–1954, and was associated with early-onset solid cancer r
View details →DOI: 10.1038/s41591-026-04448-wCited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Luyanda Majenge, Sakhile Mpungose, Simiso Msomi · 2025 · Energies
The transition of South Africa from coal-dependent energy systems to renewable energy alternatives presents economic and environmental trade-off complexities that require empirical investigation. This study employed threshold-switching dynamic models, NARDL analysis, and threshold Granger causality tests to investigate nonlinear relationships between renewable energy generation, economic growth, and carbon dioxide emissions in South Africa from 1980 to 2023. The threshold-switching dynamic models revealed critical structural breakpoints: a 56.4% renewable energy threshold for carbon dioxide em
View details →DOI: 10.3390/en18174642Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yuko Shimizu‐Motohashi · 2025 · Brain and Development
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder caused by variants of the DMD that leads to progressive muscle degeneration. Recent advances in gene therapy have opened new therapeutic avenues, particularly through the use of adeno-associated virus (AAV)-mediated micro-dystrophin delivery. Delandistrogene moxeparvovec, the first FDA-approved gene therapy for DMD, has demonstrated transgene expression and potential functional improvement in early phase trials, although its long-term efficacy, durability, and safety remain unconfirmed. Immune-mediated toxicities including
View details →DOI: 10.1016/j.braindev.2025.104424Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Xiangdong Ji, Yang Chen · 2026 · Nuclear Physics B
Momentum current density (MCD) $T^{ij}$ is a general physics concept describing the momentum conservation through momentum flow generated from both the kinetic motion of particles and the interacting forces among them. It has been suggested by M. Polyakov et al. that the MCD in the nucleon, characterized by the form factor $C/D$ of the QCD energy-momentum tensor, can be interpreted as the pressure and shear forces between adjacent parts of the system because the nucleon interior approximates a continuous medium. While intuitively appealing, we find that the interpretation is hard to justify fr
View details →DOI: 10.1016/j.nuclphysb.2026.117342Cited by 9 Negative / Null Result ReportOpen accessMedicine
Agamemnon Bakakos, Zoi Sotiropoulou, Nektarios Anagnostopoulos et al. · 2025 · Respiratory Medicine
Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality around the globe. Its main characteristics are persistent respiratory symptoms and progressive airflow limitation, both of which are driven by chronic inflammation. Despite the use of maximum bronchodilation and in selected patients inhaled corticosteroids (ICS), current therapies neither halt disease progression nor prevent exacerbations and loss of lung function. Recent research has focused on developing novel anti-inflammatory agents targeting specific pathways implicated in COPD pathogenesis, ai
View details →DOI: 10.1016/j.rmed.2025.108396Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Efrain Ricardo Torres, Jennifer Wilcox, W. H. Wilson Tang · 2025 · Gut Microbes
Trimethylamine N-oxide (TMAO) has garnered considerable attention because of its role in the pathophysiology and pathogenesis of various disorders, particularly heart and kidney disease. Gut microbes produce trimethylamine (TMA) moieties from common dietary precursors, such as choline or carnitine, which are subsequently metabolized by the liver into TMAO. Circulating TMAO then exerts various effects, influencing dyslipidemia, metabolic syndrome, endothelial dysfunction, and inflammation, as well as other detrimental processes. Many existing medications have been shown to decrease TMAO levels
View details →DOI: 10.1080/19490976.2025.2604868Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chunmei Cai, Guohua Ni, Lei Chen et al. · 2026 · Signal Transduction and Targeted Therapy
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a cascade of physiological responses. However, inadequate or excessive responses can lead to malacclimatization, resulting in hypoxemia and various high-altitude illnesses, including acute mountain sickness (AMS), high-altitude cerebral edema (HACE), high-altitude pulmonary edema (HAPE), chronic mountain sickness (CMS), and high-altitude pulmonary hy
View details →DOI: 10.1038/s41392-025-02531-1Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Tamara Evstafyeva, Nils Peter Siemonsen, William E. East · 2026 · Physical review. D/Physical review. D.
We reinvestigate the stability properties of ultracompact spinning boson stars with a stable light ring using fully nonlinear 3+1 and 2+1 numerical relativity simulations and two different formulations of the Einstein equations. We find no…
View details →DOI: 10.1103/2vz3-s39rCited by 9 Negative / Null Result ReportOpen accessMedicine
Lion Stammen, Eva J I Hoeijmakers, Thomas G. Flohr et al. · 2025 · European Radiology
OBJECTIVES: To evaluate diagnostic image quality (IQ) for pulmonary embolism detection in photon-counting detector CT (PCD-CT) with significantly reduced contrast media (CM) dose vs conventional energy-integrating detector CT (EID-CT), using optimized and individualized CM protocols. MATERIALS AND METHODS: Consecutive CT pulmonary angiography (CTPA) scans performed on the EID-CT (Jan 2024-Mar 2024) with an individualized kilovoltage (kV) and total body weight (TBW) adapted CM protocol, and on the PCD-CT (Aug 2023-Feb 2024) with a TBW adapted CM protocol matching the 70 kV EID-CT protocol, were
View details →DOI: 10.1007/s00330-025-12054-6Cited by 9 Negative / Null Result ReportOpen accessMedicine
Jijuan Zhang, Hancheng Yu, Tingting Geng et al. · 2025 · BMC Medicine
BACKGROUND: Accelerated aging is a dynamic process, yet few studies examined the association of changes in accelerated aging with cardiovascular disease (CVD) and mortality. This study aims to evaluate this association in three prospective…
View details →DOI: 10.1186/s12916-025-04365-8Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Matt Lowe, Madeline McKelway · 2026 · Journal of the European Economic Association
Abstract Joint household decision-making becomes more common as economies develop. Can external intervention advance this transition? We study this question in the context of female employment in India. We randomized which spouse was given…
View details →DOI: 10.1093/jeea/jvag046Cited by 9 Negative / Null Result ReportOpen accessPsychology
E. G. J. M. Arts, Bram Orobio de Castro, Ellen Luteijn et al. · 2024 · Social Development
Abstract This study investigated whether interactive virtual reality (VR) training of social and emotional abilities (InterAction) improves socio‐emotional functioning of youth with developmental language disorders (DLD). To this end we conducted a multiple baseline intervention study, comparing participants’ social abilities during a baseline phase with their changes in abilities during the intervention and posttest phase. The training group consisted of 29 adolescents ( 20 boys, 9 girls ) with DLD from the Netherlands. The training consisted of nine, weekly (45–50 min) individual sessions wi
View details →DOI: 10.1111/sode.12784Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michael Korenjak, Nuri A. Temiz, Stéphane Keïta et al. · 2026 · Genome Medicine
BACKGROUND: Tobacco use is linked to multiple cancer types and a quarter of cancer deaths. Tobacco smoke contains numerous mutagenic chemicals such as polycyclic aromatic hydrocarbons (PAH), however, the mutagenicity of many chemicals in…
View details →DOI: 10.1186/s13073-026-01685-zCited by 9 