A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Per M. Kristoffersen, Nils Vetti, Lars Grøvle et al. · 2022 · Spine
Study Design. Exploratory subgroup analyses of a randomised trial [Antibiotics in Modic changes (AIM) study]. Objective. The aim was to assess the effect of amoxicillin versus placebo in reducing Modic change (MC) edema in patients with…
Li Cao, Younes Hmimsa, Salama El fatehi et al. · 2023 · Scientific Reports
Abstract For thousands of years, humans have domesticated different plants by selecting for particular characters, often affecting less-known traits, including the volatile organic compounds (VOCs) emitted by these plants for defense or…
Andrew E Jaffe, John D Storey, Hongkai Ji et al. · 2013 · BMC Bioinformatics
Abstract Background Significance analysis plays a major role in identifying and ranking genes, transcription factor binding sites, DNA methylation regions, and other high-throughput features associated with illness. We propose a new…
Giselle Owens, Robert Heinsohn, Sam Eyles et al. · 2020 · Ecological Management & Restoration
Summary Fear may elicit behavioural and physiological responses in animals. We conducted a pilot study aiming to reduce bird nest predation in Tasmania by the introduced Sugar Glider ( Petaurus breviceps ) by broadcasting calls of…
Francesca Borgonovi, Gabriele Marconi · 2020 · Open Education Studies
Abstract Lack of comparable cross-country data on access to and participation into higher education (HE) among disadvantaged and marginalised communities prevents a comprehensive examination of the role of education in shaping social…
Vinnycius de Oliveira, Ricardo Viana, Naiane Morais et al. · 2021 · International Journal of Environmental Research and Public Health
This study compared the exergame beach volleyball’s acute effects on state anxiety level in single vs. multiplayer mode in adult men. Sixty adult men (age: 21.98 [4.58] years, body mass: 75.40 [15.70] kg, height: 1.77 [0.09] m, and body…
Pan Jiang, Junyi Jiang, Cong Yang et al. · 2023 · Atmosphere
Panicum milliaceum is a specialty crop that maintains the economic stability of agriculture in arid and barren regions of the world. Predicting the potential geographic distribution of Panicum milliaceum globally and clarifying the…
Marian Schini, Richard Jacques, Eleanor Oakes et al. · 2021 · European Journal of Endocrinology
Introduction The least significant change (LSC) is a term used in individuals in order to evaluate whether one measurement has changed significantly from the previous one. It is widely used when assessing bone mineral density (BMD) scans.…
Rebecca Cutts, Steve Turner · 2013 · Pediatric Allergy and Immunology
Abstract Background The principle aim of this study was to describe the variability of exhaled nitric oxide ( FE NO ) concentrations over 10 months in children with and without asthma. Methods FE NO was measured on six occasions at 2‐month…
Remco van Egmond, Murray L Barclay, Paul KL Chin et al. · 2013 · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
Background Thiopurine methyltransferase (TPMT) enzyme activity is measured before initiating thiopurine therapy to reduce the risk of severe drug-associated myelotoxicity in patients with low enzyme activity. TPMT activity may vary over…
Jingwen Yang, Xue Wu, Kyoshiro Sasaki et al. · 2021 · PeerJ
When people are confronted with health proposals during the coronavirus disease 2019 (COVID-19) pandemic, it has been suggested that fear of COVID-19 can serve protective functions and ensure public health compliance. However, health…
Matthew J Orringer, Nirav K Pandya · 2021 · International Journal of Sports Science & Coaching
Background Particularly at the level of professional athletics, injury prevention is of critical importance. We hypothesized that elevated in-game statistics over a period of 3-10 games places increased cumulative stress on players’ joints…
Chengcheng Huang, Tadashi Suzuki · 2020 · FEBS Letters
N‐ Glycosylated substrates that undergo ER‐associated degradation (ERAD) are often deglycosylated by the cytosolic peptide: N ‐glycanase (Ngly1) during their proteasomal degradation in the cytosol. Consequently, the presence of non‐ or…
Kim K. Johnson, Carole Bennett, Haresh Rochani · 2020 · Journal of the American Psychiatric Nurses Association
Objective: Patients with somatic symptom disorders (SSD) are prevalent in primary care, urgent care, and emergency rooms and present with reduced quality of life, increased disability, and suicidality . Criteria for SSD include (1) somatic…
Roberta De Bei, Lukas Papagiannis, Sigfredo Fuentes et al. · 2020 · OENO One
Aim: Shoot thinning is a common canopy management practice used to obtain a desired shoot density and to improve canopy microclimate. Since thinning is often carried out manually, the cost can be high. In this study the effect of severe…
Xiaohui Sun, Jie Ping, Xingyi Guo et al. · 2024 · Molecular Carcinogenesis
Abstract The association between metformin use and risk of prostate cancer remains controversial, while data from randomized trials is lacking. We aim to evaluate the association of genetically proxied metformin effects with prostate…
Pedro Perim, Nathan Gobbi, Breno Duarte et al. · 2021 · European Journal of Sport Science
ABSTRACT This study investigated the effect of beta‐alanine supplementation on short‐duration sprints and final 4‐km simulated uphill cycling time‐trial performance during a comprehensive and novel exercise protocol representative of the…
David Jarrett, Stephen G. Willis · 2024 · Ibis
Passive acoustic devices are increasingly being used to monitor biodiversity. However, few studies have compared the accuracy of acoustic surveys and traditional surveys against ground‐truthed data. Here, we assess whether acoustic…
Richard Lu, Vu Tran Hoang, Wing-Keung Wong · 2020 · Studies in Economics and Finance
Purpose The literature has demonstrated that lump-sum (LS) outperforms dollar-cost averaging (DCA) in uptrend markets while DCA outperforms LS only when the asset price is mean-reverted or downtrend. To bridge the gap in the literature,…
Helen E Tilbrook, Taeko Becque, Hannah Buckley et al. · 2014 · Journal of Evaluation in Clinical Practice
Abstract Rationale Attrition is a threat to the validity of randomized trials. Few randomized studies have been conducted within randomized trials to test methods of reducing attrition. Aim To test whether using yellow post‐it notes on…
N. Vargas Jurado, A. E. Tanner, S. R. Blevins et al. · 2014 · Grass and Forage Science
Abstract Feed intake and diet choice affect production efficiency in livestock. Plant waxes, in particular n ‐alkanes, have been used as markers to predict intake and diet preferences. Still, when n ‐alkane profiles of plants within mixed…
Xiao-Li Dong, Si-Si Cao, Li-Ping Zhou et al. · 2016 · The American Journal of Chinese Medicine
Our previous studies found that different extracts or fractions of Fructus ligustri lucidi (FLL) played different roles in altering the regulation of bone and mineral metabolism in different animal models. The present study was designed to…
Fan Liu, Jordon Hogg, Susie Kracht et al. · 2019 · Animal Production Science
Context Lactoferrin is a non-haem binding protein that possesses antimicrobial, antioxidant and anti-inflammatory properties. A previous study showed lactoferrin supplementation from early gestation to weaning improved lactation…
Vladimira Vroblova, Filip Vrbacky, Monika Hrudkova et al. · 2010 · European Journal of Haematology
Abstract Introduction: It is widely accepted that expression of ZAP‐70 in chronic lymphocytic leukemia (CLL) remains stable in time. However, data supporting this notion are surprisingly scarce. Therefore, we assessed expression of ZAP‐70…
Sara Redenšek Trampuž, David Vogrinc, Katja Goričar et al. · 2023 · Frontiers in Molecular Neuroscience
Introduction Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, have been associated with COVID-19 However, the mechanisms associated with…
Caio SM Motoyama, Mônica JS Pinto, Fabio S Lira et al. · 2010 · Diabetology & Metabolic Syndrome
Abstract Introduction The increased intake of dietary fructose can be associated with alterations on energy homeostasis and lipid/carbohydrate metabolism, such as insulin resistance and dislipidemia. On the other hand, the ingestion of…
Tzuan A. Chen, Lorraine R. Reitzel, Ezemenari M. Obasi et al. · 2021 · Nutrients
Nutrition assistance programs such as school meals and the Supplemental Nutrition Assistance Program (SNAP) are designed to provide a safety net for the dietary intake of children from low-income families. However, compared with eligible…
Yibin Xu, Yangyu Huang · 2019 · Security and Communication Networks
Blockchain mining should not be a game among power oligarchs. In this paper, we present the Multiple Winners Proof of Work Protocol (MWPoW), a mining-pool-like decentralised blockchain consensus protocol. MWPoW enables disadvantaged nodes…
Susan M. Robertson, Shawn R. McGrath, Samuel Scarlett et al. · 2022 · Animal Production Science
Context Clinical deficiencies of calcium and magnesium may result in the metabolic disorders hypocalcaemia and hypomagnesaemia, resulting in ewe and lamb mortality. However, the contribution of subclinical deficiencies to perinatal lamb…
Marlene M. Moretti, Sebastian P. Dys, Stephanie G. Craig et al. · 2024 · JCPP Advances
Abstract Background Given the prevalence and recent increases in youth mental health problems, there is a pressing need for interventions that target transdiagnostic protective factors that could be targeted as mechanisms of change in…