Negative / Null Result ReportOpen accessPhysics and Astronomy
Xiangdong Ji, Yang Chen · 2026 · Nuclear Physics B
Momentum current density (MCD) $T^{ij}$ is a general physics concept describing the momentum conservation through momentum flow generated from both the kinetic motion of particles and the interacting forces among them. It has been suggested by M. Polyakov et al. that the MCD in the nucleon, characterized by the form factor $C/D$ of the QCD energy-momentum tensor, can be interpreted as the pressure and shear forces between adjacent parts of the system because the nucleon interior approximates a continuous medium. While intuitively appealing, we find that the interpretation is hard to justify fr
View details →DOI: 10.1016/j.nuclphysb.2026.117342Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Adriano Gravina, P. Gargiulo, Michelino De Laurentiis et al. · 2025 · ESMO Open
BACKGROUND: The Hormonal Bone Effects (HOBOE) study tested whether adjuvant triptorelin plus either letrozole (L) or zoledronic acid (Z) plus L (ZL) was more effective than tamoxifen (T) in premenopausal patients with hormone…
View details →DOI: 10.1016/j.esmoop.2024.104085Cited by 9 Negative / Null Result ReportOpen accessMedicine
Shun He, Tianchang Xia, Zhihou Guo et al. · 2025 · Nature Communications
Kidney fibrosis is a key pathological feature of chronic kidney disease (CKD), characterized by the activation and accumulation of αSMA-positive myofibroblasts. The cellular origin of myofibroblasts in kidney fibrosis has been a subject of…
View details →DOI: 10.1038/s41467-025-67373-5Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Tamara Evstafyeva, Nils Peter Siemonsen, William E. East · 2026 · Physical review. D/Physical review. D.
We reinvestigate the stability properties of ultracompact spinning boson stars with a stable light ring using fully nonlinear 3+1 and 2+1 numerical relativity simulations and two different formulations of the Einstein equations. We find no…
View details →DOI: 10.1103/2vz3-s39rCited by 9 Negative / Null Result ReportOpen accessMedicine
Lion Stammen, Eva J I Hoeijmakers, Thomas G. Flohr et al. · 2025 · European Radiology
OBJECTIVES: To evaluate diagnostic image quality (IQ) for pulmonary embolism detection in photon-counting detector CT (PCD-CT) with significantly reduced contrast media (CM) dose vs conventional energy-integrating detector CT (EID-CT), using optimized and individualized CM protocols. MATERIALS AND METHODS: Consecutive CT pulmonary angiography (CTPA) scans performed on the EID-CT (Jan 2024-Mar 2024) with an individualized kilovoltage (kV) and total body weight (TBW) adapted CM protocol, and on the PCD-CT (Aug 2023-Feb 2024) with a TBW adapted CM protocol matching the 70 kV EID-CT protocol, were
View details →DOI: 10.1007/s00330-025-12054-6Cited by 9 Negative / Null Result ReportOpen accessMedicine
Jijuan Zhang, Hancheng Yu, Tingting Geng et al. · 2025 · BMC Medicine
BACKGROUND: Accelerated aging is a dynamic process, yet few studies examined the association of changes in accelerated aging with cardiovascular disease (CVD) and mortality. This study aims to evaluate this association in three prospective…
View details →DOI: 10.1186/s12916-025-04365-8Cited by 9 Methods Dead-EndOpen accessEnvironmental Science
Reo Van Eynde, Kevin J. Dillman, Jefim Vogel et al. · 2026 · Ecological Economics
Post-growth has emerged as an umbrella concept for various sustainability visions that prioritise the pursuit of environmental sustainability, social equity, and human wellbeing, while questioning the pursuit of economic growth. Although there are increasing calls to include post-growth scenarios in high-level assessments, there is no coherent framework that specifies what is required to model post-growth. This article addresses this gap by: (1) identifying the minimum requirements for post-growth models, and (2) establishing a set of model elements for representing post-growth policy themes.
View details →DOI: 10.1016/j.ecolecon.2026.108928Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
George Yumnam, Parul R. Raghuvanshi, J. D. Budai et al. · 2025 · Cell Reports Physical Science
We provide experimental evidence for the absence of a magnetic moment in bulk RuO 2 , a candidate altermagnetic material, by using a combination of Mössbauer spectroscopy, nuclear forward scattering, inelastic X-ray and neutron scattering,…
View details →DOI: 10.1016/j.xcrp.2025.102852Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
M. Rossi, Stefania Salvadori, Á. Skúladóttir et al. · 2025 · The Astrophysical Journal
Abstract The elusive properties of the first (Population III or Pop III) stars can be indirectly unveiled by uncovering their true descendants. To this end, we exploit our data-calibrated model for the best-studied ultrafaint dwarf galaxy (UFD), Boötes I, which tracks the chemical evolution (from carbon to zinc) of individual stars from their formation to the present day. We explore the chemical imprint of Pop III supernovae (SNe), with different explosion energies and masses, showing that they leave distinct chemical signatures in their descendants. We find that UFDs are strongly affected by
View details →DOI: 10.3847/1538-4357/add5e9Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chan Seok Lim, Jisun Lee, Jisun Lee et al. · 2025 · Nature Communications
SUMMARY We report the cryo-EM structures of clusters of TNF receptor family proteins, TNFR1 and BAFFR. The receptor-ligand complexes were anchored to a flat lipid layer to mimic the membrane-bound state. We observed that the TNFα-TNFR1…
View details →DOI: 10.1038/s41467-025-61271-6Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nevin Sanlier, Elif Yildiz Kaya, Ikbal Irem Yucel · 2026 · Food Science & Nutrition
Honey, bee pollen, propolis, bee bread, royal jelly, bee venom, beeswax, and apilarnil are among the bee-derived products that may serve health-related purposes, as they exhibit various biological activities such as antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, antitumor, vasodilatory, and blood pressure-lowering effects. In this review, the possible health effects and action mechanisms of bee products frequently used in apitherapy were examined. The therapeutic potential of bee-derived products is attributed to their content of amino acids, fatty acids, carbohydrates,
View details →DOI: 10.1002/fsn3.71165Cited by 9 Negative / Null Result ReportOpen accessMedicine
Alexander N. Klishko, Jonathan Harnie, Claire E. Hanson et al. · 2025 · The Journal of Physiology
It has been suggested that during locomotion, the nervous system controls movement by activating groups of muscles, or muscle synergies. Analysis of muscle synergies can reveal the organization of spinal locomotor networks and how it…
View details →DOI: 10.1113/jp288089Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Nurcan Kilinc‐Ata, Alia Al-Fori · 2026 · Journal of risk and financial management
The intersection of financial innovation and environmental sustainability offers important opportunities for low- and middle-income (LMI) countries. This study examines the association between FinTech investment, geopolitical-economic uncertainty, urbanization, economic development, and carbon dioxide (CO2) emissions in LMI countries. CO2 emissions per capita are used as an environmental outcome indicator rather than as a direct measure of green finance. Using a panel dataset covering 2010–2021, the study applies fixed-effects panel regressions as the main empirical approach and reports one-st
View details →DOI: 10.3390/jrfm19050362Cited by 9 Negative / Null Result ReportOpen accessMedicine
Ismail Gögenür, Tobias Freyberg Justesen, Line Schmidt Tarpgaard et al. · 2026 · Journal of Clinical Oncology
PURPOSE: Neoadjuvant immune checkpoint inhibition has shown promise in localized deficient mismatch repair (dMMR) colorectal cancer, yet the optimal treatment duration, regimen, and methods for response evaluation remain undefined. This trial aimed to investigate the efficacy and safety of neoadjuvant pembrolizumab for patients with localized dMMR colon cancer. METHODS: Participants received a single cycle of pembrolizumab (4 mg/kg, max 400 mg, every-6-weeks dosing regimen), followed by a preoperative endoscopy with biopsies and surgery 3-5 weeks later. The primary end point was pathologic com
View details →DOI: 10.1200/jco-25-02274Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sourav Goswami, Alisha Ansari, Chetan Saraf et al. · 2026 · Nature Communications
Bifidobacteria are key health-associated members of the human gut microbiome and are widely used as probiotics, but their colonization success varies substantially between individuals, partly due to baseline microbiome composition. We…
View details →DOI: 10.1038/s41467-026-72289-9Cited by 9 Negative / Null Result ReportOpen accessMedicine
Emanuel J. Novais, Olivia K. Ottone, Sanjana Jagannath et al. · 2026 · Bone Research
Genetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeutic strategies to mitigate it: Navitoclax (Nav.) and a cocktail of Dasatinib and Quercetin (DQ). While Nav. treatment did not improve severe degeneration in SM/J mice or senescence status, DQ-treated mice showed lower grades of degeneration and a decreased abundance of senescence markers, including p19ARF, p21, and the senescence-assoc
View details →DOI: 10.1038/s41413-026-00526-4Cited by 9 Negative / Null Result ReportOpen accessMedicine
Danielle J Sisnett, Katherine B Zutautas, Dan Hoang Nguyet Vo et al. · 2026 · Frontiers in Immunology
Endometriosis is a chronic inflammatory, hormone dependent disorder that affects more than 200 million women worldwide. Immune dysfunction has emerged as one of the predominant mechanisms facilitating endometriosis lesion growth and survival. In particular, T cell subsets are predominant effector immune cells within the complex endometriosis lesion microenvironment. T cell biology encompasses a highly regulated and diverse network of cellular differentiation, antigen recognition, and immune regulation, all of which play critical roles in immune homeostasis. This complexity becomes particularly
View details →DOI: 10.3389/fimmu.2026.1712360Cited by 9 Negative / Null Result ReportOpen accessMedicine
Cristina Gonzalez‐Robles, Oliver Bandmann, Anthony H.V. Schapira · 2025 · Neurology and Therapy
Parkinson disease (PD) is a progressive neurodegenerative condition characterised by tremor, bradykinesia and rigidity, as well as other motor and non-motor symptoms, for which no effective disease-modifying treatments have been…
View details →DOI: 10.1007/s40120-025-00793-zCited by 9 Negative / Null Result ReportOpen accessMaterials Science
Jingyi Xu, Zhanming Wu, Yunan Tan et al. · 2026 · Journal of Advanced Ceramics
Abstract The escalating complexity of the electromagnetic environment calls for advanced electromagnetic wave (EMW) absorption materials capable of efficient multi-frequency attenuation. Silicon carbide (SiC) is a promising dielectric candidate but is hindered by intrinsic impedance mismatch and limited polarization loss. Herein, we report a novel ternary heterostructure absorber consisting of SiC nanowires synergistically coupled with dual rare-earth silicides (Ce5Si4 and Pr5Si4) fabricated via a combined magnesiothermic and carbothermal reduction process using an MFI-type zeolite precursor.
View details →DOI: 10.26599/jac.2026.9221325Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Niti Sureka, Rashi Maheshwari, Amit H Agravat et al. · 2026 · Frontiers in Oncology
Hypoxia, a defining hallmark of solid tumors, arises from structurally and functionally abnormal vasculature, rapid cellular proliferation, and impaired perfusion, resulting in chronic and cycling oxygen deprivation within the tumor massThe hypoxic tumor microenvironment orchestrates extensive molecular reprogramming primarily through stabilization and activation of hypoxia-inducible factors (HIF-1α and HIF-2α), which regulate broad transcriptional networks governing metabolism, angiogenesis, stemness, invasion, and immune modulation. Under low oxygen tension, tumor cells shift toward aerobic
View details →DOI: 10.3389/fonc.2026.1771365Cited by 9 Replication FailureOpen accessMedicine
Nick Woznitza, Lesley Smith, Janette Rawlinson et al. · 2026 · Nature Medicine
Prioritizing artificial intelligence (AI)-detected imaging findings may reduce the time to diagnosis of lung cancer. This prospective, multicentre, randomized controlled trial tested whether immediate AI prioritization of primary care-requested chest X-rays (CXR) influenced time to computed tomography (CT) and lung cancer diagnosis, the primary outcomes. Secondary outcomes included the number of urgent suspected lung cancer referrals, incidence and stage of lung cancer, times to urgent referral and treatment, concordance between AI and radiology reports, and algorithm accuracy. AI was availabl
View details →DOI: 10.1038/s41591-026-04253-5Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Canan Doğanlı, Oskar Kaaber Thomsen, Daniel A. Baird et al. · 2026 · PLoS Biology
Pathogenic variants in the genes encoding the non-canonical TGFB signaling components TAK1 (MAP3K7 ) , TAB2 and PKA-Cα (PRKACA) cause rare multisystem disorders, which may include congenital heart disease (CHD). To investigate the role of TAK1 signaling in CHD, we performed genetic analysis of CHD patients and discovered an increased burden of rare TAB2 and TAK1 variants in patients with extracardiac abnormalities. To address the mechanism of TAK1 in heart development, we performed experiments in cell and animal models. Zebrafish tak1 and tab2 mutants presented with cardiac and extracardiac de
View details →DOI: 10.1371/journal.pbio.3003902Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh et al. · 2026 · Nature
Abstract Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation and the effect of human genetic variation on disease 1–6 . Here we create and evaluate a resource of more than 92 million enhancer–gene regulatory interactions across 1,458 biosamples covering 369 cell types and tissues, by integrating predictive models, chromatin states, three-dimensional contacts and large-scale genetic perturbations generated by the ENCODE Consortium 7 . We first create a systematic benchmarking pipeline to compare predictive models, assembling a dataset of 1
View details →DOI: 10.1038/s41586-026-10781-4Cited by 9 Negative / Null Result ReportOpen accessMedicine
Brenda M O'Neill, Judy Martina Bradley, Bronwen A. Connolly et al. · 2026 · JAMA
Importance: Evidence for remote multicomponent rehabilitation among critical care survivors is sparse. Objective: To investigate the effects of a 6-week, remote, multicomponent rehabilitation intervention in survivors of critical illness following discharge from the hospital after an intensive care unit (ICU) admission compared with standard care on health-related quality of life at 8 weeks. Design, Setting, and Participants: Pragmatic, multicenter, assessor-blinded, randomized clinical trial conducted from December 2022 to November 2025 at 52 National Health Service hospitals in the UK. Parti
View details →DOI: 10.1001/jama.2026.7401Cited by 9 Replication FailureOpen accessImmunology and Microbiology
Tine Wrønding, Kilian Vomstein, Agnete Troen Lundgaard et al. · 2026 · The Lancet Microbe
BACKGROUND: A vaginal microbiota dominated by Lactobacillus species is associated with reduced risk of infection and adverse reproductive outcomes. Effective interventions to restore healthy microbiota remain scarce. In this study, we…
View details →DOI: 10.1016/j.lanmic.2025.101294Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Devan Rawn, Cody Prouty, Asmita Gautam et al. · 2026 · Frontiers in Insect Science
Introduction Globally, beekeepers must manage the invasive mite pest Varroa destructor . The mite’s populations can grow quickly, overwhelming honey bee colonies through direct parasitism and the transmission of honey bee viruses. RNA interference is promising next-generation tool and has been demonstrated to control invertebrate pest populations. The novel product Norroa™ is the first of its kind marketed to beekeepers for the control of V. destructor . Field-level studies are critical to understanding the efficacy of the product and how to fit it into integrated pest management plans. Method
View details →DOI: 10.3389/finsc.2026.1751606Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Suresh Raja Neethirajan · 2026 · Agriculture
Digital twin technology is widely promoted as a transformative step for precision live-stock farming, yet no fully realized, engineering-grade digital twins are deployed in commercial dairy or poultry systems today. Existing platforms are better described as near-digital-twin systems with partial sensing and modelling, digital-twin-inspired prototypes, simulation frameworks or decision-support tools that are often labelled as twins despite lacking continuous synchronization and closed-loop control. This distinction matters because the empirical foundation supporting many claims remains limited
View details →DOI: 10.3390/agriculture16020166Cited by 9 Replication FailureOpen accessMedicine
Jeremy M. Shefner, Merit Cudkowicz, Angela L. Genge et al. · 2025 · JAMA Neurology
Importance: Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective: To assess the effect of reldesemtiv vs…
View details →DOI: 10.1001/jamaneurol.2025.0241Cited by 9 Negative / Null Result ReportOpen accessMedicine
Mathilde Duchon, Raj Naik, Fabrice R Lecuru et al. · 2025 · Cancers
Background: The surgical and medical management of recurrent ovarian cancer is complex and requires a personalized approach based on several factors, including the timing of recurrence, the patient’s performance status, previous treatment regimens, and the tumor’s histology and molecular characteristics. Objectives: Five randomized trials—GOG-0213, DESKTOP III, SOC 1, HORSE, and CHIPOR—have been conducted and shed light on our practice. Results: Both the DESKTOP III and the SOC 1 trials support the benefit of secondary surgery. The GOG-0213 trial, however, did not show an overall survival bene
View details →DOI: 10.3390/cancers17040646Cited by 9 Negative / Null Result ReportOpen accessPsychology
Joaquin A. Anguera, Aleem Choudhry, Michael Seaman et al. · 2025 · JMIR Formative Research
Background There is evidence that cognitive training interventions can positively impact executive functions, and that some studies have demonstrated that athletes typically exhibit greater accuracy and faster response times on select cognitive tasks. While the engagement of executive functions is suggested to be part of high-level sporting activities, it is unclear whether such training approaches could directly benefit athletic performance. Objective The objective of this study was to evaluate the impact of a combined virtual reality (VR)– and tablet-based cognitive training intervention on
View details →DOI: 10.2196/66979Cited by 9 