Gut‒heart axis: emerging therapies targeting trimethylamine N-oxide production
Efrain Ricardo Torres; Jennifer Wilcox; W. H. Wilson Tang · 2025 · Gut Microbes
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Trimethylamine N-oxide (TMAO) has garnered considerable attention because of its role in the pathophysiology and pathogenesis of various disorders, particularly heart and kidney disease. Gut microbes produce trimethylamine (TMA) moieties from common dietary precursors, such as choline or carnitine, which are subsequently metabolized by the liver into TMAO. Circulating TMAO then exerts various effects, influencing dyslipidemia, metabolic syndrome, endothelial dysfunction, and inflammation, as well as other detrimental processes. Many existing medications have been shown to decrease TMAO levels
Abstract by Efrain Ricardo Torres; Jennifer Wilcox; W. H. Wilson Tang, Gut Microbes (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1080/19490976.2025.2604868