Negative / Null Result ReportOpen accessEngineering
Rui Zhao, Qiushi Feng, Yangyang Xia et al. · 2025 · Pharmaceuticals
The inherent complexity and heterogeneity of tumors pose substantial challenges for the development of effective oncology therapeutics. Organoids, three-dimensional (3D) in vitro models, have become essential tools for predicting therapeutic responses and advancing precision oncology, with established correlations to clinical outcomes in patient-derived models. These systems have transformed preclinical drug screening by bridging the gap between conventional two-dimensional (2D) cultures and in vivo models, preserving tumor histopathology, cellular heterogeneity, and patient-specific molecular
View details →DOI: 10.3390/ph18101540Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Zahra Ghorbanzadeh, Bahman Panahi, Leila Purhang et al. · 2025 · Agronomy
Developing climate-resilient and high-quality cotton cultivars remains an urgent challenge, as the key target traits yield, fibre properties, and stress tolerance are highly polygenic and strongly influenced by genotype–environment interactions. Recent advances in chromosome-scale genome assemblies, pan-genomics, and haplotype-resolved resequencing have greatly enhanced the capacity to identify causal variants and recover non-reference alleles linked to fibre development and environmental adaptation. Parallel progress in functional genomics and precision genome editing, particularly CRISPR/Cas
View details →DOI: 10.3390/agronomy15102393Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Jacob A. Westerberg, Pieter R. Roelfsema · 2025 · Trends in Cognitive Sciences
Perceptual experience depends on recurrent interactions between lower and higher cortices. One theory, predictive coding, posits that feedback from higher to lower brain regions decreases neuronal activity predicted by higher-level representations. Despite the widespread adoption of predictive coding in neuroscience, the correspondence to neurophysiological findings in sensory cortices remains elusive. Here, we review how the canonical patterns of intra- and inter-cortical interactions that occur during perception and shifts of attention deviate from those predicted by predictive coding. We ar
View details →DOI: 10.1016/j.tics.2025.09.018Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Anna Carolina Bruno Ferreira, Ygor Velloso Tavares, Nina Rezende Fontana et al. · 2026 · Molecules
The widespread utilization of synthetic dyes within the textile industry, driven by their chemical recalcitrance and diverse chromatic spectra, constitutes a significant global environmental challenge. Improper discharge of these highly stable effluents into natural water bodies leads to severe ecological imbalances, affecting aquatic life and soil integrity while posing indirect risks to human health due to their mutagenic potential. Conventional physicochemical treatment methods are often hindered by prohibitive operational costs and the frequent generation of hazardous secondary pollutants.
View details →DOI: 10.3390/molecules31071085Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Shaofeng Wang, Hao Zhang · 2026 · International Journal of Educational Technology in Higher Education
Abstract The rapid integration of generative artificial intelligence (GenAI) into higher education has precipitated a critical tension between the pursuit of efficiency and the imperative for deep, transformative learning. While GenAI offers unprecedented speed in knowledge processing, it raises concerns that efficiency-driven motivations may erode the cognitive struggle essential for intellectual growth. This study investigates how Human-GenAI pedagogical partnerships influence transformative learning through the dual cognitive pathways of vigilance and offloading, moderated by efficiency ori
View details →DOI: 10.1186/s41239-026-00585-xCited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Zhendong Zhao, Huiwang Dai, Tiantian Nie et al. · 2025 · Nature Communications
High-valent iron-oxo species (FeIV=O) have garnered increasing attention for water purification, while the selective generation of FeIV = O in Fenton-like reactions still lacks an effective control protocol at the atomic level. Here, we…
View details →DOI: 10.1038/s41467-025-66177-xCited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Sofience · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This record provides SΔϕ-65 — Slop as Externalized Restabilization Cost: AI Slop, Human Slop, Authority Pollution, and the Cost of Re-entry (v1.0). SΔϕ-65 defines Slop not by whether it is produced by AI or humans, but by whether low execution or production cost externalizes high verification, rebuttal, correction, interpretation, cleanup, and restabilization cost onto others. The central proposition of this document is: Slop is not defined by the producer. Slop is defined by a cost asymmetry: low execution TCC on the producer side, high restabilization TCC on the receiver, platform, expert, p
View details →DOI: 10.5281/zenodo.20127428Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Xinyi Zhang, Liangjie Wang, Jian Wei et al. · 2026 · Nature Communications
Oxygen vacancies (Ov) on metal oxide surfaces exhibit high catalytic activity for activating peroxymonosulfate (PMS) in wastewater decontamination, yet their in-situ regeneration remains a significant challenge. This study successfully…
View details →DOI: 10.1038/s41467-025-68180-8Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Sieun Kim · 2025 · Scientific Reports
This study investigated the neurophysiological and affective responses elicited by nature-inspired indoor design elements, including curvilinear forms (CL), nature views (N), and wooden interiors (W), in a virtual environment, and their…
View details →DOI: 10.1038/s41598-025-18629-zCited by 10 Negative / Null Result ReportOpen accessMedicine
Tara L. Alvarez, Mitchell Scheiman, Farzin Hajebrahimi et al. · 2025 · British Journal of Sports Medicine
OBJECTIVE: The CONCUSS randomised clinical trial compared the effectiveness of immediate office-based vergence/accommodative therapy with movement (OBVAM) to delayed therapy for the treatment of concussion-related convergence insufficiency…
View details →DOI: 10.1136/bjsports-2025-109807Cited by 10 Negative / Null Result ReportOpen accessMedicine
Yu Jun Wong, Laurent Lam, Pierre‐Antoine Soret et al. · 2025 · Journal of Hepatology
BACKGROUND & AIMS: Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis (PBC). However, the frequency and clinical relevance of discordant biochemical and LSM changes remain unclear. We aim to determine the performance of the most recent or current LSM (LSMc) in predicting first hepatic decompensation (HD) in the setting of discordant biochemical and LSM responses. METHODS: In this international, multicenter study, we included patients with at least two reliable LSM performed at least 6 months apart. Patients
View details →DOI: 10.1016/j.jhep.2025.09.024Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sami Alobaidi · 2025 · Frontiers in Medicine
Chronic kidney disease (CKD) remains a major global health issue, affecting millions and presenting persistent diagnostic and therapeutic challenges. Conventional biomarkers such as serum creatinine and estimated glomerular filtration rate have well-recognized limitations, underscoring the need for novel diagnostic tools and interventions. Emerging evidence highlights the gut-kidney axis as a central contributor to CKD pathogenesis, shaped by microbial dysbiosis and altered metabolite production. Harmful metabolites such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide promote
View details →DOI: 10.3389/fmed.2025.1675458Cited by 10 Negative / Null Result ReportOpen accessDentistry
Gilliana Rozenblum, Karima Ait‐Aissa, G. E. D. Zahran et al. · 2025 · Alzheimer s & Dementia
Oral dysbiosis contributes to Alzheimer's disease (AD) by promoting neuroinflammation. Pathobionts such as Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum release virulence factors that induce amyloid beta aggregation and tau hyperphosphorylation, while the loss of commensals like Streptococcus salivarius and Neisseria spp. impairs anti-inflammatory protection, worsening neuronal damage. P. gingivalis is strongly linked to an increased risk of AD, especially in individuals with systemic conditions like diabetes, hypertension, and chronic kidney disease. Its presence
View details →DOI: 10.1002/alz.71011Cited by 10 Negative / Null Result ReportOpen accessMedicine
Fanjing Kong, Yanru Zhao, Weiming Zhang et al. · 2026 · Nature Communications
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were initially approved for type 2 diabetes mellitus. Recent evidence suggests their therapeutic potential in various diseases, though their efficacy and safety remain incompletely…
View details →DOI: 10.1038/s41467-025-67701-9Cited by 10 Negative / Null Result ReportOpen accessMedicine
Jörg Matthes, Anne Reinhardt, Selma Hodzic et al. · 2026 · Journal of Medical Internet Research
Background: The rise of generative artificial intelligence (AI) tools such as ChatGPT is rapidly transforming how people access information online. In the health context, generative AI is seen as a potentially disruptive information source due to its low entry barriers, conversational style, and ability to tailor content to users' needs. However, little is known about whether and how individuals use generative AI for health purposes, and which groups may benefit or be left behind, raising important questions of digital health equity. Objective: This study aimed to assess the current relevance
View details →DOI: 10.2196/75648Cited by 10 Negative / Null Result ReportOpen accessMedicine
Sherry S. Y. Nyeo, Erin M. Cumming, Oliver S. Burren et al. · 2026 · Nature
Abstract Epstein–Barr virus (EBV) is an endemic herpesvirus implicated in autoimmunity, cancer and neurological disorders. Although primary infection is often subclinical, persistent EBV infection can drive immune dysregulation and long-term complications. Despite the ubiquity of infection, the determinants of EBV persistence following primary exposure remain poorly understood, although human genetic variation partially contributes to this phenotypic spectrum 1–3 . Here we demonstrate that existing whole genome sequencing (WGS) data of human populations can be used to quantify persistent EBV D
View details →DOI: 10.1038/s41586-025-10020-2Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras et al. · 2026 · Nature Medicine
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome. In multivariable confounder-adjusted regression models, antibiotic use <1 year before fecal sampling was associated with the greatest reduction in species diversity, but significant asso
View details →DOI: 10.1038/s41591-026-04284-yCited by 10 Negative / Null Result ReportOpen accessMedicine
Anna Morena D’Alise, Jason Willis, Fahriye Duzagac et al. · 2026 · Nature Medicine
Cancer interception is a preventative approach aiming to reduce cancer incidence by targeting precancers and early-stage cancers. Lynch syndrome (LS) is a prevalent hereditary cancer syndrome affecting ~1 in 300 individuals, with an…
View details →DOI: 10.1038/s41591-025-04182-9Cited by 10 Negative / Null Result ReportOpen accessMedicine
Mengting Zhu, Jonathan Lee · 2025 · Nutraceuticals
Short-chain fatty acids (SCFAs) are metabolites derived from the fermentation of dietary fibre by gut bacteria. SCFAs function as essential regulators of host-microbiome interactions by participating in numerous physiological and pathological processes within the gastrointestinal (GI) tract. In recent years, the depletion of SCFAs has been increasingly linked to the pathogenesis of GI diseases. In this review, we summarize the current understanding of the therapeutic mechanisms of SCFAs in GI diseases, including inflammatory bowel disease, irritable bowel syndrome, metabolic dysfunction-associ
View details →DOI: 10.3390/nutraceuticals5030019Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Xinyue Huang, Bowen Yang, Nating Liu et al. · 2026 · Journal of the American Heart Association
BACKGROUND: The synergistic effects of multiple environmental factors on stroke remain unknown. The aim of this study was to explore the relationship between multiple living environment factors and stroke in middle-aged and older Chinese…
View details →DOI: 10.1161/jaha.125.043867Cited by 10 Negative / Null Result ReportOpen accessPsychology
Anatolia Batruch, Nicolas Sommet, Frédérique Autin · 2025 · Nature Human Behaviour
Abstract Theoretical models have been developed to understand how social class influences individual thoughts, feelings and behaviours. However, the validity of these models is threatened by the prevailing use of small, non-diverse samples and flexible measurement practices. We preregistered replications of 35 key hypotheses from 17 correlational and 5 experimental studies, and collected large, quota-based or probability samples from the USA, France, Switzerland and India ( N total = 33,536). Our analysis yielded three central findings: (1) ~50% of the effects were successfully replicated; (2)
View details →DOI: 10.1038/s41562-025-02234-1Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Muhammad Haziq Saharuddin, M. Khalid M. Nasir, Muhammad Sofwan Mahmud · 2025 · International Journal of Learning Teaching and Educational Research
Technological pedagogical content knowledge (TPACK) is a theory that describes the knowledge and skills required by a teacher to integrate technology into their teaching. This study aimed to identify the level of TPACK among primary school…
View details →DOI: 10.26803/ijlter.24.1.7Cited by 10 Negative / Null Result ReportOpen accessPsychology
Hae Won Kim, Jee In Kang, Eunhee Hwang et al. · 2018 · PLoS ONE
Accumulating evidence suggests that the glutamatergic system plays a major role in the pathophysiology of obsessive compulsive disorder (OCD) and empathic processing. Particularly, genetic influence of glutamate transporter gene (SLC1A1) on OCD has been frequently replicated in previous studies, but several studies did not replicate the result. Therefore, we aimed to replicate the associations between the SLC1A1 and OCD in a Korean population. In addition, we investigated the influence of SLC1A1 on trait empathy, impairments in which are characteristic of OCD. Six single-nucleotide polymorphis
View details →DOI: 10.1371/journal.pone.0190593Cited by 10 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Faisal AlReshaid, Alper Ertürk, Razan Alkhayyat et al. · 2025 · Frontiers in Psychology
Introduction: Leaders' self-awareness is essential to leadership effectiveness. Cognitive styles-how individuals perceive and process information-are key factors in fostering self-awareness. Drawing on Social Identity Theory (SIT), this study explores whether cognitive style congruence between supervisors and subordinates enhances supervisors' self-awareness, and whether Leader-Member Exchange (LMX) mediates this relationship. Methods: We used a time-lagged dyadic design and multilevel polynomial regression to analyze data from 189 subordinates and 36 supervisors. Cognitive styles were measure
View details →DOI: 10.3389/fpsyg.2025.1583837Cited by 10 Negative / Null Result ReportOpen accessMedicine
I Gede Nyoman Mindra Jaya, Yudhie Andriyana, Bertho Tantular et al. · 2025 · Sustainability
Accurate dengue forecasting is essential for sustainable public health planning, especially in tropical regions where the disease remains a persistent threat. This study evaluates the predictive performance of seven modeling approaches—Seasonal Autoregressive Integrated Moving Average (SARIMA), Extreme Gradient Boosting (XGBoost), Recurrent Neural Network (RNN), Long Short-Term Memory (LSTM), Bidirectional LSTM (BiLSTM), Convolutional LSTM (CNN–LSTM), and a Bayesian spatiotemporal model—using monthly dengue incidence data from 2009 to 2023 in Bandung City, Indonesia. Model performance was asse
View details →DOI: 10.3390/su17156777Cited by 10 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jing Zeng, Ali Punjwani · 2025 · Sustainability
Achieving environmental sustainability remains a critical challenge for governments worldwide, particularly within the G20 bloc, due to rapid urbanization, resource-intensive industrial activities, and the environmental pressures associated with globalization. Despite various efforts, ecological degradation continues to escalate, necessitating a deeper understanding of the factors influencing environmental sustainability. This study investigates the role of technological innovation (TLI), education (EDU), human capital (HMC), and natural resources (NTS) in shaping ecological sustainability, wh
View details →DOI: 10.3390/su17073130Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jong Won Shin, Minh Nguyen Thien, Sun Ha Jee · 2025 · Healthcare
Background: Bilirubin is a potent endogenous antioxidant that plays a key role in regulating oxidative stress and inflammation, both closely linked to lung carcinogenesis. This study reinterprets the ALBI (Albumin–Bilirubin) and PALBI (Platelet–Albumin–Bilirubin) indices as composite markers of antioxidant and inflammatory status and evaluates their associations with lung cancer risk by sex, including stratified analyses by major lifestyle factors such as smoking and alcohol use. Methods: This study utilized data from the Korean Cancer Prevention Study-II (KCPS-II) cohort, which included 133,6
View details →DOI: 10.3390/healthcare13111321Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jiahui Lin, Zhongping Mao, Fei Yan · 2026 · Biosensors
Developing an ultrasensitive electrochemiluminescence (ECL) detection platform remains challenging due to the limited enrichment efficiency of ECL emitters and co-reactants at the electrode interface, as well as the insufficient catalytic enhancement of co-reactant conversion. Moreover, simultaneous in situ analyte enrichment and efficient anti-interference capability are often difficult to achieve in a single sensing interface. Herein, a new ECL platform was developed based on nanocatalyst-supported nanochannel-confined surfactant micelle (SM) system, which integrates an enhanced luminol-diss
View details →DOI: 10.3390/bios16050236Cited by 10 Negative / Null Result ReportOpen accessPhysics and Astronomy
Asifa Ashraf, M. Yousaf, Chengxun Yuan et al. · 2026 · The European Physical Journal C
Abstract In this draft, we investigate constant redshift function Morris–Thorne-like traversable wormhole (WH) models which described as a relativistic static fluid distribution in Schwarzschild-type coordinates with a topological global monopole charge under the influence of D -dimensional Einstein gravity. In this scenario we consider three distinct shape functions, while matter sector is supported by anisotropic fluid configuration. We show some basic criteria for the viability of all three shape function models, the radial null energy condition is generally violated while tangential compon
View details →DOI: 10.1140/epjc/s10052-026-15351-6Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Ke Shi, Qing Zheng, Baorong Wang et al. · 2026 · Nature Communications
Abstract Extracellular polymeric substances (EPS) are key microbial residues that contribute to soil organic carbon (SOC) and promote soil aggregation. Yet, their abundance and large-scale controls have only begun to be investigated. We conduct extensive soil sampling across a European transect spanning diverse climates, bedrocks, and land uses. Average soil EPS content is 956 ± 55 µg g -1 soil ( n = 92 sites), with EPS-carbon (EPS-C) contributing 1.6 ± 0.1% to SOC. Bedrock influences EPS content, EPS-C contribution to SOC, and the EPS-C/microbial biomass carbon (MBC) ratio, whereas land use m
View details →DOI: 10.1038/s41467-026-70068-0Cited by 10 