Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Shaoyuan Tan, Weixin Wu, Xinna Ge et al. · 2023 · One Health Advances
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Although modified live virus (MLV) vaccines are commonly used for PRRSV prevention and control, they still carry a risk of infecting the host and replicating in target cells, thereby increasing the likehood of virus recombination and reversion to virulence. In this study, we inserted the target sequence of miR-142 into the nsp2 hypervariable region of PRRSV to inhibit viral replication in its host cells of pigs, with the aim of achieving virus attenuation. The chimeri
View details →DOI: 10.1186/s44280-023-00002-2Cited by 10 Negative / Null Result ReportPsychology
Jeannette Fuller, James Tapp, Simon Draycott · 2019 · Criminal Behaviour and Mental Health
BACKGROUND: Motivation and readiness to change are important drives for forensic patients accessing interventions. It is thought that guilt and shame influence these drives, but to date, their relationship has not been empirically tested.…
View details →DOI: 10.1002/cbm.2105Cited by 10 Negative / Null Result ReportOpen accessMedicine
Michael Benatar, Christopher McDermott, Martin R. Turner et al. · 2024 · Brain
There is a long history in amyotrophic lateral sclerosis (ALS) of promoting therapies based on phase 2 data, which then fail in phase 3 trials. Experience suggests that studies of 6 months in duration are too short, especially with…
View details →DOI: 10.1093/brain/awae396Cited by 10 Negative / Null Result Report
Yusuke Okada · 2010 · JALT Journal
While the pedagogical value of teachers’ questioning in classrooms has been well studied, what exactly teachers do if a question fails to obtain an adequate response has not yet been sufficiently addressed from an interactional…
View details →DOI: 10.37546/jaltjj32.1-3Cited by 10 Negative / Null Result Report
N. Naef, T. Steiner, J. Wehrlin · 2015 · International Journal of Sports Medicine
Abstract Duplicate haemoglobin mass (Hbmass) measurements are recommended before and after altitude training sojourns to identify individual adaptations in athletes with a high level of certainty. Duplicate measurements reduce typical…
View details →DOI: 10.1055/s-0034-1398583Cited by 10 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Peipei Ma, Mogens Sandø Lund, Xiangdong Ding et al. · 2014 · Journal of Animal Breeding and Genetics
This study investigated the effect of including Nordic Holsteins in the reference population on the imputation accuracy and prediction accuracy for Chinese Holsteins. The data used in this study include 85 Chinese Holstein bulls genotyped…
View details →DOI: 10.1111/jbg.12111Cited by 10 Negative / Null Result ReportOpen accessMedicine
Eun-Ju Kim, Chan Kyo Kim, Hyun Soo Kim et al. · 2020 · British Journal of Radiology
Objective: To evaluate the usefulness of histogram analysis of stretched exponential model (SEM) on diffusion-weighted imaging in evaluating clinically significant prostate cancer (CSC). Methods: A total of 85 patients with prostate cancer…
View details →DOI: 10.1259/bjr.20190757Cited by 10 Negative / Null Result Report
C Länger, P Ernst, M Bender et al. · 2021 · New Journal of Physics
Abstract Hydrogen-covered Si(001) surfaces were exposed to swift heavy ions (SHI) and slow highly charged ions (HCI). Using scanning tunneling microscopy as analysis tool, the ion-induced modifications on the surface were resolved on the…
View details →DOI: 10.1088/1367-2630/ac254dCited by 10 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Cedric Popa, Karel Holvoet, Tessa Van Montfort et al. · 2018 · Frontiers in Pharmacology
Background: Profits in the biopharmaceutical industry have been scrutinized in social debate. However, drawing conclusions based on industry profitability only is inappropriate as such an analysis does not account for risks faced by investors. This study aims to measure risks and returns in the biopharmaceutical industry and investigates whether risk-adjusted return on investment in the biopharmaceutical industry is higher than that in other industries. Methods: To enable appropriate comparison, we identified six benchmark industries with characteristics that match those of the biopharmaceutic
View details →DOI: 10.3389/fphar.2018.01108Cited by 10 Negative / Null Result ReportOpen accessMedicine
Jacobien H. F. Oosterhoff, Anne de Hond, Rinne M Peters et al. · 2024 · Clinical Orthopaedics and Related Research
BACKGROUND: Estimating the risk of revision after arthroplasty could inform patient and surgeon decision-making. However, there is a lack of well-performing prediction models assisting in this task, which may be due to current conventional…
View details →DOI: 10.1097/corr.0000000000003018Cited by 10 Negative / Null Result Report
Jan Reinhard, Melanie Schindler, Franziska Leiss et al. · 2023 · Archives of Orthopaedic and Trauma Surgery
Abstract Introduction Enhanced recovery after surgery (ERAS) leads to less morbidity, faster recovery, and, therefore, shorter hospital stays. The expected increment of primary total hip arthroplasty (THA) in the U.S. highlights the need…
View details →DOI: 10.1007/s00402-023-04858-2Cited by 10 Negative / Null Result Report
Amanda Sundberg, Anna Carin Wahlberg, Niklas Zethraeus et al. · 2021 · BMJ Open
Objectives Telephone advice nursing is introduced in many countries with one key aim being a reduction of avoidable healthcare visits. The aim of this study was to explore whether callers to a telephone advice nursing service followed the…
View details →DOI: 10.1136/bmjopen-2021-051233Cited by 10 Negative / Null Result ReportOpen accessComputer Science
Conor Hanrahan · 2019 · ARROW@Dublin Institute of Technology (Dublin Institute of Technology)
The presence of noise in electroencephalography (EEG) signals can significantly reduce the accuracy of the analysis of the signal. This study assesses to what extent stacked autoencoders designed using one-dimensional convolutional neural…
Negative / Null Result Report
Youn-Goo Kang, Taeyoung Lee, Jaeyoung Ro et al. · 2023 · Nutrients
Obesity is a major global health problem which is associated with various diseases and psychological conditions. Increasing understanding of the relationship between obesity and gut microbiota has led to a worldwide effort to use…
View details →DOI: 10.3390/nu15081859Cited by 10 Negative / Null Result Report
Rae Morris, Fiona Lewis, Nancy Baker et al. · 2021 · Health & Social Work
Abstract Homelessness is a long-standing issue at the forefront of healthcare globally, and discharge of homeless patients from hospital settings can exacerbate gaps and burdens in healthcare systems. In hospitals, social workers often…
View details →DOI: 10.1093/hsw/hlab039Cited by 10 Negative / Null Result Report
Kaoru Ochi, Tamaki Mizuno, Prosenjit Samanta et al. · 2021 · mSphere
Cholera is an acute diarrheal disease caused by pathogenic strains of V. cholerae generated by lysogenization of the filamentous cholera toxin phage CTXΦ. The analysis revealed that recent isolates possessed altered CTXΦ prophage array of…
View details →DOI: 10.1128/msphere.00337-21Cited by 10 Negative / Null Result ReportComputer Science
Pertti Vakkari · 2011 · Online Information Review
Purpose This paper seeks to evaluate to what extent Google retrieved correct answers to queries inferred from factual and topical requests in a digital Ask‐a‐Librarian service. Design/methodology/approach In total, 100 factual and 100…
View details →DOI: 10.1108/14684521111193201Cited by 10 Replication FailureOpen accessMedicine
Daniela Achkova, Richard Beatson, John Maher · 2022 · Cells
Macrophage colony-stimulating factor receptor (M-CSFR) is found in cells of the mononuclear phagocyte lineage and is aberrantly expressed in a range of tumours, in addition to tumour-associated macrophages. Consequently, a variety of cancer therapies directed against M-CSFR are under development. We set out to engineer chimeric antigen receptors (CARs) that employ the natural ligands of this receptor, namely M-CSF or interleukin (IL)-34, to achieve specificity for M-CSFR-expressing target cells. Both M-CSF and IL-34 bind to overlapping regions of M-CSFR, although affinity of IL-34 is significa
View details →DOI: 10.3390/cells11142190Cited by 10 Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology
Dennis Poel, Elske C. Gootjes, Lotte Bakkerus et al. · 2020 · Cancer Medicine
BACKGROUND: Palliative systemic therapy is currently standard of care for patients with extensive metastatic colorectal cancer (mCRC). A biomarker predicting chemotherapy benefit which prevents toxicity from ineffective treatment is urgently needed. Therefore, a previously developed tissue-derived microRNA profile to predict clinical benefit from chemotherapy was evaluated in tissue biopsies and serum from patients with mCRC. METHODS: Samples were prospectively collected from patients (N = 132) who were treated with capecitabine or 5-FU/LV with oxaliplatin ± bevacizumab. Response evaluation wa
View details →DOI: 10.1002/cam4.3371Cited by 10 Negative / Null Result ReportOpen accessMedicine
Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · PubMed
BACKGROUND: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. SETTING: Two urban clinics in Kigali, Rwanda. METHODS: A 2-arm individual randomized controlled trial compared…
View details →DOI: 10.1097/qai.0000000000002911Cited by 10 Negative / Null Result Report
Sarah C. Moudy, Brian T. Peters, Torin K. Clark et al. · 2024 · Frontiers in Physiology
The perceptual and motor coordination problems experienced following return from spaceflight reflect the sensory adaptation to altered gravity. The purpose of this study was to develop a ground-based analog that replicates similar…
View details →DOI: 10.3389/fphys.2024.1369788Cited by 10 Negative / Null Result ReportSocial Sciences
Qian Xu, Shi Chen, Lida Safarnejad · 2020 · Health Communication
By taking the 2016 Zika outbreak as a case study, this research examines how information veracity (true information vs. misinformation) interacted with message frames to influence the dissemination of information about Zika through retweet…
View details →DOI: 10.1080/10410236.2020.1773705Cited by 10 Negative / Null Result ReportOpen accessEnvironmental Science
Yumei Luo, Quan Chen, Fan Liu et al. · 2023 · Frontiers in Ecology and Evolution
Introduction Plant richness is thought to improve the function of constructed wetlands (CWs), but most CWs are planted with monocultures, with only a few employed polycultures, which have drawn contradictory conclusions. We suppose functional diversity is the key to better performance of plant communities and hypothesize that CWs planted with diverse growth forms are superior in plant growth and nutrient removal. Methods In this study, six emergent plant species categorized into slender type ( Schoenoplectus tabernaemontani, Typha orientalis ), fan type ( Iris sibirica, Acorus calamus ) and la
View details →DOI: 10.3389/fevo.2023.1139053Cited by 10 Negative / Null Result Report
Z. F. LIU, G. ZHAO, Y. H. CHENG et al. · 2012 · Journal of Mechanics in Medicine and Biology
The purpose of this work is to evaluate the heating effect of thermally significant blood vessels (TSBVs) during cryosurgery process. A theoretical model is developed to describe the heat transfer of perfused tissue containing a 6…
View details →DOI: 10.1142/s0219519411004575Cited by 10 Negative / Null Result ReportOpen accessEngineering
Luisa Hopp, Barbara Glaser, Julian Klaus et al. · 2019 · Hydrological Processes
Abstract The occurrence of preferential flow in the subsurface has often been shown in field experiments. However, preferential flow is rarely included in models simulating the hydrological response at the catchment scale. If it is…
View details →DOI: 10.1002/hyp.13672Cited by 10 Negative / Null Result ReportOpen accessChemistry
Santosh Lohumi, Lalit Mohan Kandpal, Young Wook Seo et al. · 2016 · Journal of Biosystems Engineering
Purpose: Fusel oil is a potent volatile aroma compound found in many alcoholic beverages. At low concentrations, it makes an essential contribution to the flavor and aroma of fermented alcoholic beverages, while at high concentrations, it…
View details →DOI: 10.5307/jbe.2016.41.3.208Cited by 10 Negative / Null Result ReportOpen accessMedicine
C. Elizabeth Shaaban, Caterina Rosano, Xiaonan Zhu et al. · 2023 · The Journals of Gerontology Series A
BACKGROUND: Older adults with discordant biological and chronological ages (BA and CA) may vary in cognitive and physical function from those with concordant BA and CA. METHODS: To make our approach clinically accessible, we created…
View details →DOI: 10.1093/gerona/glad174Cited by 10 Negative / Null Result ReportEarth and Planetary Sciences
Camille Zaug, John D. Carter · 2021 · Studies in Applied Mathematics
Abstract Ocean swell plays an important role in the transport of energy across the ocean, yet its evolution is not well understood. In the late 1960s, the nonlinear Schrödinger (NLS) equation was derived as a simplified model for the…
View details →DOI: 10.1111/sapm.12423Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
David Giguere, Daniel J. Dickson, Michelle K. Tulloch et al. · 2021 · Journal of Experimental Child Psychology
Evidence is mixed regarding whether and why bilingual children might be advantaged in the development of executive functions. Five preregistered hypotheses regarding sources of a bilingual advantage were tested with data from 102 Spanish-English bilingual children and 25 English monolingual children who were administered a test of executive attention, the flanker task, at 7, 8, and 9 years of age. Measures of the children's early and concurrent bilingual exposure and their concurrent English and Spanish skill were available from a larger longitudinal study in which these children participated.
View details →DOI: 10.1016/j.jecp.2021.105256Cited by 10 Negative / Null Result ReportMedicine
Carlos González‐Alayón, Esteban Porrini, Sergio Luis‐Lima et al. · 2021 · Liver International
BACKGROUND & AIMS: In cirrhosis, the reliability of formulas that estimate renal function, either those specifically developed in this population or the classic equations, has not been properly quantified. We studied the agreement between…
View details →DOI: 10.1111/liv.15134Cited by 10 