Kinetics of the West Nile virus induced transcripts of selected cytokines and Toll-like receptors in equine peripheral blood mononuclear cells
Muhammad Jasim Uddin; Willy W. Suen; Angela M. Bosco‐Lauth; Airn-Elizabeth Hartwig; Roy A. Hall; Richard A. Bowen; Helle Bielefeldt‐Ohmann · 2016 · Veterinary Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
West Nile virus (WNV) is one of the most common causes of epidemic viral encephalitis in horses worldwide. Peripheral blood mononuclear cells (PBMCs) are amongst the first to encounter the virus following a mosquito bite. This study aimed to elucidate the transcription kinetics of cytokine, Toll-like receptor (TLRs) and TLRs-associated genes following WNV challenge of equine PBMCs. PBMCs were challenged with an Australian strain of WNV (WNVNSW2011) and transcriptomes were quantified at 2, 6, 12 and 24 h post-infection (pi) using qRT-PCR. Type I and II interferons (IFNα, β and γ) mRNA transcrip
Abstract by Muhammad Jasim Uddin; Willy W. Suen; Angela M. Bosco‐Lauth; Airn-Elizabeth Hartwig; Roy A. Hall; Richard A. Bowen; Helle Bielefeldt‐Ohmann, Veterinary Research (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13567-016-0347-8