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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21247 results · page 145 of 709

Negative / Null Result ReportOpen accessMedicine

Results of the Kigali Imbereheza Project: A 2-Arm Individually Randomized Trial of TI-CBT Enhanced to Address ART Adherence and Mental Health for Rwandan Youth Living With HIV.

Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · PubMed

BACKGROUND: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. SETTING: Two urban clinics in Kigali, Rwanda. METHODS: A 2-arm individual randomized controlled trial compared…

View details →DOI: 10.1097/qai.0000000000002911Cited by 10
Negative / Null Result Report

Development of a ground-based sensorimotor disorientation analog to replicate astronaut postflight experience

Sarah C. Moudy, Brian T. Peters, Torin K. Clark et al. · 2024 · Frontiers in Physiology

The perceptual and motor coordination problems experienced following return from spaceflight reflect the sensory adaptation to altered gravity. The purpose of this study was to develop a ground-based analog that replicates similar…

View details →DOI: 10.3389/fphys.2024.1369788Cited by 10
Negative / Null Result ReportSocial Sciences

Effects of Information Veracity and Message Frames on Information Dissemination: A Case Study of 2016 Zika Epidemic Discussion on Twitter

Qian Xu, Shi Chen, Lida Safarnejad · 2020 · Health Communication

By taking the 2016 Zika outbreak as a case study, this research examines how information veracity (true information vs. misinformation) interacted with message frames to influence the dissemination of information about Zika through retweet…

View details →DOI: 10.1080/10410236.2020.1773705Cited by 10
Negative / Null Result ReportOpen accessEnvironmental Science

Both species richness and growth forms affect nutrient removal in constructed wetlands: A mesocosm experiment

Yumei Luo, Quan Chen, Fan Liu et al. · 2023 · Frontiers in Ecology and Evolution

Introduction Plant richness is thought to improve the function of constructed wetlands (CWs), but most CWs are planted with monocultures, with only a few employed polycultures, which have drawn contradictory conclusions. We suppose functional diversity is the key to better performance of plant communities and hypothesize that CWs planted with diverse growth forms are superior in plant growth and nutrient removal. Methods In this study, six emergent plant species categorized into slender type ( Schoenoplectus tabernaemontani, Typha orientalis ), fan type ( Iris sibirica, Acorus calamus ) and la

View details →DOI: 10.3389/fevo.2023.1139053Cited by 10
Negative / Null Result Report

HEATING EFFECT OF THERMALLY SIGNIFICANT BLOOD VESSELS IN PERFUSED TUMOR TISSUE DURING CRYOSURGERY

Z. F. LIU, G. ZHAO, Y. H. CHENG et al. · 2012 · Journal of Mechanics in Medicine and Biology

The purpose of this work is to evaluate the heating effect of thermally significant blood vessels (TSBVs) during cryosurgery process. A theoretical model is developed to describe the heat transfer of perfused tissue containing a 6…

View details →DOI: 10.1142/s0219519411004575Cited by 10
Negative / Null Result ReportOpen accessEngineering

The relevance of preferential flow in catchment scale simulations: Calibrating a 3D dual‐permeability model using DREAM

Luisa Hopp, Barbara Glaser, Julian Klaus et al. · 2019 · Hydrological Processes

Abstract The occurrence of preferential flow in the subsurface has often been shown in field experiments. However, preferential flow is rarely included in models simulating the hydrological response at the catchment scale. If it is…

View details →DOI: 10.1002/hyp.13672Cited by 10
Negative / Null Result ReportOpen accessChemistry

Net Analyte Signal-based Quantitative Determination of Fusel Oil in Korean Alcoholic Beverage Using FT-NIR Spectroscopy

Santosh Lohumi, Lalit Mohan Kandpal, Young Wook Seo et al. · 2016 · Journal of Biosystems Engineering

Purpose: Fusel oil is a potent volatile aroma compound found in many alcoholic beverages. At low concentrations, it makes an essential contribution to the flavor and aroma of fermented alcoholic beverages, while at high concentrations, it…

View details →DOI: 10.5307/jbe.2016.41.3.208Cited by 10
Negative / Null Result ReportOpen accessMedicine

Discordant Biological and Chronological Age: Implications for Cognitive Decline and Frailty

C. Elizabeth Shaaban, Caterina Rosano, Xiaonan Zhu et al. · 2023 · The Journals of Gerontology Series A

BACKGROUND: Older adults with discordant biological and chronological ages (BA and CA) may vary in cognitive and physical function from those with concordant BA and CA. METHODS: To make our approach clinically accessible, we created…

View details →DOI: 10.1093/gerona/glad174Cited by 10
Negative / Null Result ReportEarth and Planetary Sciences

Dissipative models of swell propagation across the Pacific

Camille Zaug, John D. Carter · 2021 · Studies in Applied Mathematics

Abstract Ocean swell plays an important role in the transport of energy across the ocean, yet its evolution is not well understood. In the late 1960s, the nonlinear Schrödinger (NLS) equation was derived as a simplified model for the…

View details →DOI: 10.1111/sapm.12423Cited by 10
Negative / Null Result ReportOpen accessNeuroscience

Majority language skill, not measures of bilingualism, predicts executive attention in bilingual children

David Giguere, Daniel J. Dickson, Michelle K. Tulloch et al. · 2021 · Journal of Experimental Child Psychology

Evidence is mixed regarding whether and why bilingual children might be advantaged in the development of executive functions. Five preregistered hypotheses regarding sources of a bilingual advantage were tested with data from 102 Spanish-English bilingual children and 25 English monolingual children who were administered a test of executive attention, the flanker task, at 7, 8, and 9 years of age. Measures of the children's early and concurrent bilingual exposure and their concurrent English and Spanish skill were available from a larger longitudinal study in which these children participated.

View details →DOI: 10.1016/j.jecp.2021.105256Cited by 10
Negative / Null Result ReportMedicine

Estimated glomerular filtration rate by formulas in patients with cirrhosis: An unreliable procedure

Carlos González‐Alayón, Esteban Porrini, Sergio Luis‐Lima et al. · 2021 · Liver International

BACKGROUND & AIMS: In cirrhosis, the reliability of formulas that estimate renal function, either those specifically developed in this population or the classic equations, has not been properly quantified. We studied the agreement between…

View details →DOI: 10.1111/liv.15134Cited by 10
Negative / Null Result Report

Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis

Li Wang, Jiting Zhang, Li Zhang et al. · 2022 · Frontiers in Cellular and Infection Microbiology

Background Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing…

View details →DOI: 10.3389/fcimb.2022.1005392Cited by 10
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Genomic and phenomic prediction for soybean seed yield, protein, and oil

Liza Van der Laan, Kyle Parmley, Mojdeh Saadati et al. · 2025 · The Plant Genome

Developments in genomics and phenomics have provided valuable tools for use in cultivar development. Genomic prediction (GP) has been used in commercial soybean [Glycine max L. (Merr.)] breeding programs to predict grain yield and seed…

View details →DOI: 10.1002/tpg2.70002Cited by 10
Negative / Null Result ReportOpen accessMedicine

“Fast track” rehabilitation after gastric cancer resection: experience with 80 consecutive cases

Jingxiang Song, Xiaohuang Tu, Bing Wang et al. · 2014 · BMC Gastroenterology

BACKGROUND: To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS: Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic and operative data, gastrointestinal function, postoperative hospital stays, surgical and general complications and mortality were assessed prospectively. RESULTS: Of the 80 patients (mean age 56.3 years), 10 (12.5%) received proximal subtotal gastrectomy (Billroth I), 38 (47.5%)

View details →DOI: 10.1186/1471-230x-14-147Cited by 10
Negative / Null Result ReportOpen accessMedicine

Aspirin With or Without Statin in Individuals Without Atherosclerotic Cardiovascular Disease Across Risk Categories

Safi U. Khan, Ahmad Naeem Lone, Neal S. Kleiman et al. · 2023 · JACC Advances

The effects of aspirin in adults without atherosclerotic cardiovascular disease (ASCVD), stratified by statin use across different ASCVD risks, remain uncertain. The purpose of this study was to examine the effects of aspirin in adults…

View details →DOI: 10.1016/j.jacadv.2022.100197Cited by 10
Negative / Null Result ReportHealth Professions

Parallel Exploratory RCT of Polyethylene Wrap for Heat Loss Prevention in Infants Born at Less than 24 Weeks’ Gestation

Maureen Reilly, Sunita Vohra, Valeria E. Rac et al. · 2019 · Neonatology

<b><i>Background:</i></b> The treatment effect of occlusive wrap applied immediately after delivery in infants born 24–28 weeks’ gestation has been studied, but the effect is not known in infants born at less than…

View details →DOI: 10.1159/000497253Cited by 10
Negative / Null Result Report

Did the UN convention on the rights of the child reduce child mortality around the world? An interrupted time series analysis

Christopher A. Tait, Abtin Parnia, Nishan Zewge-Abubaker et al. · 2020 · BMC Public Health

Abstract Background Child mortality has been reduced by more than 50 % over the past 30 years. A range of secular economic and social developments have been considered to explain this phenomenon. In this paper, we examine the association…

View details →DOI: 10.1186/s12889-020-08720-7Cited by 10
Negative / Null Result Report

Hatchery propagation did not reduce natural steelhead productivity relative to habitat conditions and predation in a mid-Columbia River subbasin

Ian I. Courter, Tom Chance, Ryan Gerstenberger et al. · 2022 · Canadian Journal of Fisheries and Aquatic Sciences

For over 150 years, hatchery-origin anadromous salmon and trout have been reared and released throughout the Pacific Northwest to mitigate for lost habitat and sustain harvest opportunity. Some studies demonstrate that introgression of…

View details →DOI: 10.1139/cjfas-2021-0351Cited by 10
Negative / Null Result ReportOpen accessMedicine

Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection

Chandran Ramakrishna, Mari S. Golub, Abby J. Chiang et al. · 2017 · Behavioural Neurology

Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. Anxiety level

View details →DOI: 10.1155/2017/5238402Cited by 10
Negative / Null Result ReportOpen accessMedicine

Balancing Potential Benefits and Risks of Bruton Tyrosine Kinase Inhibitor Therapies in Multiple Sclerosis During the COVID-19 Pandemic

Martin S. Weber, Jacqueline Nicholas, Michael R. Yeaman · 2021 · Neurology Neuroimmunology & Neuroinflammation

Bruton tyrosine kinase inhibitors (BTKis) encompass a new class of therapeutics currently being evaluated for the treatment of multiple sclerosis (MS). Whether BTKis affect COVID-19 risk or severity or reduce vaccine efficacy are important…

View details →DOI: 10.1212/nxi.0000000000001067Cited by 10
Negative / Null Result ReportOpen accessMedicine

Use of Automated Insulin Delivery in Pregnancies Complicated by Type 1 Diabetes

Mahima Chillakanti, Elaine Young, April Hopcroft et al. · 2024 · touchREVIEWS in Endocrinology

AID systems can achieve near-desired glycaemic targets with minimal hypoglycaemia in pregnant women with T1D. Randomized controlled trials are needed to confirm these findings and to win FDA indications in pregnancy.

View details →DOI: 10.17925/ee.2024.20.2.14Cited by 10
Negative / Null Result ReportOpen accessMedicine

Low EGFR/MET ratio is associated with resistance to EGFR inhibitors in non-small cell lung cancer

Silvia Park, Emma Langley, Jong‐Mu Sun et al. · 2015 · Oncotarget

// Silvia Park 1, * , Emma Langley 2, * , Jong-Mu Sun 1 , Steve Lockton 2 , Jin Seok Ahn 1 , Anjali Jain 2 , Keunchil Park 1 , Sharat Singh 2 , Phillip Kim 2 , Myung-Ju Ahn 1 1 Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Prometheus Laboratories Inc, A Nestlé Health Science Company, Department of Research and Development, San Diego, CA, USA * These authors have contributed equally to this work Correspondence to: Myung-Ju Ahn, e-mail: silkahn@skku.edu Phillip Kim, e-mail: pkim@prometheuslabs.co

View details →DOI: 10.18632/oncotarget.5131Cited by 10
Negative / Null Result ReportOpen accessMedicine

A phase II trial of nivolumab followed by ipilimumab and nivolumab in advanced non‐clear‐cell renal cell carcinoma

Ciara Conduit, Ian D. Davis, Jeffrey C. Goh et al. · 2023 · British Journal of Urology

OBJECTIVE: To evaluate the efficacy of sequential treatment with ipilimumab and nivolumab following progression on nivolumab monotherapy in individuals with advanced, non-clear-cell renal cell carcinoma (nccRCC). MATERIALS AND METHODS:…

View details →DOI: 10.1111/bju.16190Cited by 10
Replication FailureOpen accessImmunology and Microbiology

A phase 3, randomized, double-blind, multicenter, placebo-controlled study of S-588410, a five-peptide cancer vaccine as an adjuvant therapy after curative resection in patients with esophageal squamous cell carcinoma

Tomoki Makino, Hiroshi Miyata, Takushi Yasuda et al. · 2024 · Esophagus

BACKGROUND: S-588410, a cancer peptide vaccine (CPV), comprises five HLA-A*24:02-restricted peptides from five cancer-testis antigens. In a phase 2 study, S-588410 was well-tolerated and exhibited antitumor efficacy in patients with urothelial cancer. Therefore, we aimed to evaluate the efficacy, immune response, and safety of S-588410 in patients with completely resected esophageal squamous cell carcinoma (ESCC). METHODS: This phase 3 study involved patients with HLA-A*24:02-positive and lymph node metastasis-positive ESCC who received neoadjuvant therapy followed by curative resection. After

View details →DOI: 10.1007/s10388-024-01072-wCited by 10
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The beneficial effect of probiotics in the prevention of irinotecan-induced diarrhea in colorectal cancer patients with colostomy: a pooled analysis of two probiotic trials (Probio-SK-003 and Probio-SK-005) led by Slovak Cooperative Oncology Group

Michal Mego, Barbora Judita Kasperová, Jozef Chovanec et al. · 2024 · Frontiers in Oncology

Background: Probiotics could decrease irinotecan-induced diarrhea due to the reduction of intestinal beta-d-glucuronidase activity. This study included a combined analysis of two clinical trials aimed to determine the effectiveness of the probiotics in the prophylaxis of irinotecan-induced diarrhea in metastatic colorectal cancer (CRC) patients. Methods: This combined analysis included 46 patients with CRC enrolled in the Probio-SK-003 (NCT01410955) and 233 patients from Probio-SK-005 (NCT02819960) starting a new line of irinotecan-based therapy with identical eligibility criteria. Patients we

View details →DOI: 10.3389/fonc.2024.1438657Cited by 10
Negative / Null Result ReportOpen accessMedicine

Can early measles vaccination control both measles and respiratory syncytial virus infections?

Lien Anh Ha Do, Zheng Quan Toh, Paul Vincent Licciardi et al. · 2021 · The Lancet Global Health

Measles virus and respiratory syncytial virus (RSV) are two important global health pathogens causing substantial morbidity and mortality worldwide. The current measles vaccination schedule has the first dose given at 9-12 months of age…

View details →DOI: 10.1016/s2214-109x(21)00464-2Cited by 10
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells

Zhongwei Liu, Shuang Shi, Haitao Zhu et al. · 2018 · International Heart Journal

The phenotype shifting of vascular smooth muscle cells (VSMCs) was indicated to play a role during the initial stage of atherosclerotic plaque formation by facilitating extracellular matrix deposition. This study was aimed at investigating…

View details →DOI: 10.1536/ihj.17-625Cited by 10
Negative / Null Result ReportOpen accessMedicine

Development of a measuring app for systemic sclerosis-related digital ulceration (SALVE: Scleroderma App for Lesion VErification)

Adrian K. Davison, Ashma Krishan, Robert P New et al. · 2024 · Lara D. Veeken

OBJECTIVES: To test the hypothesis that photographs (in addition to self-reported data) can be collected daily by patients with SSc using a smartphone app designed specifically for digital lesions, and could provide an objective outcome measure for use in clinical trials. METHODS: An app was developed to collect images and patient-reported outcome measures including Pain score and the Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU) questionnaire. Participants photographed their lesion(s) each day for 30 days and uploaded images to a secure repository. Lesions were analysed both

View details →DOI: 10.1093/rheumatology/keae371Cited by 10
Negative / Null Result ReportOpen accessMedicine

A Multicenter Phase II Study of Gemcitabine plus S-1 Chemotherapy for Advanced Biliary Tract Cancer

Shiho Arima, Kyoko Shimizu, Tomoyoshi Okamoto et al. · 2017 · Anticancer Research

BACKGROUND: Gemcitabine (GEM) plus cisplatin (CDDP) chemotherapy has been used worldwide as the standard first-line treatment for advanced biliary tract cancer (BTC). A phase II trial has also suggested promising activity of GEM plus S-1…

View details →DOI: 10.21873/anticanres.11398Cited by 10