A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21697 results · page 130 of 724
Erik Hansen, Gerda Vaitkunaite, Johannes Schneider et al. · 2023 · Lubricants
While the modification of surface contacts offers significant potential for friction reduction, obtaining an underlying consistent friction behaviour of real-life experiments and virtual simulations is still an ongoing challenge. In…
Vaiva Petrylė · 2017 · Ekonomika
The concept of a country’s competitiveness still does not have a clear and straightforward meaning and remains ambiguous. Different economists stress various aspects of the concept and use a number of different methods to evaluate how…
A. S. Santoro, M. G. Cooper, A. Cheng · 2012 · Anaesthesia and Intensive Care
A ‘can't intubate, can't oxygenate’ scenario in a child is fortunately extremely rare. We report a case of this life-threatening event in a four-year-old boy suffering from a rare genetic disorder, fibrodysplasia ossificans progressiva. He…
Mollie E. Herget, Kristina M. Hufford, Daniel L. Mummey et al. · 2015 · Restoration Ecology
When landscapes are heavily impacted by biological invasion, local populations of native plant species may no longer be adapted to altered environmental conditions. In these cases, it is useful to investigate alternative sources of…
Wil Biddle, David G. Schwark, Margaret A. Schmitt et al. · 2022 · Frontiers in Chemistry
The expansion of the genetic code beyond a single type of noncanonical amino acid (ncAA) is hindered by inefficient machinery for reassigning the meaning of sense codons. A major obstacle to using directed evolution to improve the efficiency of sense codon reassignment is that fractional sense codon reassignments lead to heterogeneous mixtures of full-length proteins with either a ncAA or a natural amino acid incorporated in response to the targeted codon. In stop codon suppression systems, missed incorporations lead to truncated proteins; improvements in activity may be inferred from increase
Janine Stein, Melanie Luppa, Hanna Kaduszkiewicz et al. · 2015 · Psychological Assessment
The aim of the study was to investigate the psychometric properties of a Short Form of the Mini-Mental State Examination (SMMSE) for the screening of dementia in older primary care patients. Data were obtained from a large longitudinal…
Yvonne Stikkelbroek, Gerko Vink, Maaike H. Nauta et al. · 2020 · Scientific Reports
We examined if manualized cognitive behavioral therapy (CBT) was more effective than Treatment As Usual (TAU) for clinically depressed adolescents within routine care. This multisite Randomized controlled trail included 88 clinically depressed adolescents (aged 12-21 years) randomly assigned to CBT or TAU. Multiple assessments (pre-, post treatment and six-month follow-up) were done using semi-structured interviews, questionnaires and ratings and multiple informants. The primary outcome was depressive or dysthymic disorder based on the KSADS. Completers, CBT (n = 19) and TAU (n = 26), showed a
Xiao Hui Gu, Hao Lin, Jun Hong Xia · 2018 · Aquaculture Research
Identifying candidate genes involved into osmoregulation provides a basis for developing molecular markers for breeding of saline tilapia. In this study, we characterized and conducted a functional analysis of the Enhancer of Polycomb…
Arvinder Kaur, Kamaldeep Kaur, Shilpi Jain · 2016
The objective of this paper is to study the relationship between different types of object-oriented software metrics, code smells and actual changes in software code that occur during maintenance period. It is hypothesized that code smells…
Jeong‐Mi Do, Ji Won Hong, Ho‐Sung Yoon · 2025 · Frontiers in Microbiology
Traditional nanoparticle synthesis relies on chemical and physical methods that often involve hazardous reagents, high energy consumption, and environmental toxicity. As a sustainable alternative, biological synthesis utilizes biomolecules in an eco-friendly manner to form nanoparticles. This study explores the green synthesis of silver nanoparticles (AgNPs) using extracellular polymeric substances (EPS) secreted by the microalga Graesiella emersonii KNUA204, highlighting the potential of microalgal biomolecules in nanotechnology. EPS-rich supernatant from G. emersonii enabled AgNP formation u
Ghuzayyil Mohammed Al-Otaibi · 2019 · Journal of language and Education
English as a Foreign Language (EFL) learners find some phrasal verbs problematic because of their idiomatic and polysemous nature. They are frequently used in spoken English and textbooks suggest an arbitrary way in teaching them. Cognitive linguists proposed that the particle plays a major role in determining the meaning of such phrasal verbs. This study investigated the effectiveness of a cognitive approach (i.e., Rudzka-Ostyn’s Model) in teaching taught and new phrasal verbs including metaphorical ones. Using a list of frequent phrasal verbs, a quasi-experimental design was used in which an
Zifei Fay Chen, Weiting Tao · 2020 · International Journal of Strategic Communication
This study investigates whether hybrid strategy would be more effective than corporate social responsibility (CSR) strategy in boosting CSR information recall and company evaluation. Informed by the corporate ability (CA)-CSR-hybrid…
Laura O’Halloran, Brian Pennie, Lee Jollans et al. · 2018 · Alcoholism Clinical and Experimental Research
BACKGROUND: Impulsivity, broadly characterized as the tendency to act prematurely without foresight, is linked to alcohol misuse in college students. However, impulsivity is a multidimensional construct and different subdomains likely…
Nima Jamalian, Marco Gillies, Frédéric Fol Leymarie et al. · 2022
Until recently, Virtual Reality (VR) applications relied on controllers to enable user interaction in virtual environments. With advances in tracking technology, HMDs are now able to track the movements of users’ hands in real-time with…
Travis A. Smith, Eliza M. Mojduszka, Shun Chen · 2020 · Applied Economic Perspectives and Policy
Abstract School meal programs represent the second largest form of food assistance in the United States. Schools receive federal reimbursements, totaling $17 billion in 2018, provided they meet certain nutritional standards. The Healthy…
Robert Riener, Luca Rabezzana, Yves Zimmermann · 2023 · Frontiers in Robotics and AI
The incessant progress of robotic technology and rationalization of human manpower induces high expectations in society, but also resentment and even fear. In this paper, we present a quantitative normalized comparison of performance, to…
Goran Rondovic, Dragan Djordjevic, Ivo Udovicic et al. · 2022 · Biomedicines
Complex immune response to infection has been highlighted, more than ever, during the COVID-19 pandemic. This review explores the immunomodulatory treatment of moderate-to-severe forms of this viral sepsis in the context of specific…
Moran Plonsky-Toder, Daniella Magen, Shirley Pollack · 2023 · Cells
Chronic kidney disease (CKD) constitutes a worldwide epidemic, affecting approximately 10% of the global population, and imposes significant medical, psychological, and financial burdens on society. Individuals with CKD often face elevated…
Mark E. Olver, Sarah M. Beggs Christofferson, Stephen C. P. Wong · 2015 · Behavioral Sciences & the Law
We examined the use of the clinically significant change (CSC) method with the Violence Risk Scale‐Sexual Offender version (VRS‐SO), and its implications for risk communication, in a combined sample of 945 treated sexual offenders from…
Andrew Street, Laia Maynou, Simon Conroy · 2023 · BMJ Quality & Safety
Objectives To evaluate whether the Acute Frailty Network (AFN) was more effective than usual practice in supporting older people living with frailty to return home from hospital sooner and healthier. Design Staggered…
Brian P. Peppers, Anant Vatsayan, Jignesh Dalal et al. · 2018 · Immunity, Inflammation and Disease
Abstract Introduction Anaphylaxis is a life threatening systemic inflammatory process that share mediators involved in the coagulation cascade. Platelet activating factor, known to increase platelet aggregation, has also been implicated as…
Chad A. Baumwart, Tom J. Doherty, James Schumacher et al. · 2011 · American Journal of Veterinary Research
OBJECTIVE: To determine the effectiveness of preinduction hyperbaric oxygen treatment (HBOT) in ameliorating signs of experimentally induced endotoxemia in horses. ANIMALS: 18 healthy adult horses. PROCEDURES: Horses were randomly assigned…
Hadgu Gerensea, Rajalakshmi Murugan · 2016 · Advances in Nursing
Background . Children’s decisions concerning investigation and treatment may be based on the results of temperature alone. Although the accuracy of axillary temperature measurement is affected by a number of factors, device dwell time and device type are common. Objective . Compare body temperature between glass mercury thermometer (GMT) and digital thermometer (DT). Method . Comparative descriptive study was used. A total of 101 samples were taken with convenient sampling technique, but 98 were analyzed. Statistical significance (p<0.01) and clinical significance (MD≥0.2°C) were used in th
Weidong Zhao, Gan Zhao, Shuren Zhang et al. · 2018 · Oncotarget
// Weidong Zhao 1 , Gan Zhao 1 , Shuren Zhang 1 , Xianzheng Wang 1 , Xueping Yu 2 and Bin Wang 1 1 Key Laboratory of Medical Molecular Virology of The Ministry of Health and Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China 2 Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China Correspondence to: Bin Wang, email: bwang3@fudan.edu.cn Keywords: GM-CSF; IFN-α; therapeutic vaccine; HBV; Ly6C hi monocyte Received: April 14, 2017 Accepted: October 30, 2017 Epub
Charlotte Seijger, Joost Raaphorst, Judith M. Vonk et al. · 2021 · Respiration
BACKGROUND: Non-invasive home mechanical ventilation (HMV) is a complex treatment in myotonic dystrophy type 1 (DM1) patients, due to a presumed poor adherence, variable symptom improvement, and uncertainty regarding survival benefits.…
Thomas Kubiszyn, Sarah S. Mire, Sonia Dutt et al. · 2012 · School Psychology Quarterly
Some side effects (SEs) of increasingly prescribed psychotropic medications can impact student performance in school. SE risk varies, even among drugs from the same class (e.g., antidepressants). Knowing which SEs occur significantly more…
Dejan Georgiev, Harith Akram, Marjan Jahanshahi · 2021 · Psychoradiology
Following the established application of deep brain stimulation (DBS) in the treatment of movement disorders, new non-neurological indications have emerged, such as for obsessive-compulsive disorders, major depressive disorder, dementia, Gilles de la Tourette Syndrome, anorexia nervosa, and addictions. As DBS is a network modulation surgical treatment, the development of DBS for both neurological and psychiatric disorders has been partly driven by advances in neuroimaging, which has helped explain the brain networks implicated. Advances in magnetic resonance imaging connectivity and electrophy
Aaron Simpson, Renata Krowka, Jennifer Kerrigan et al. · 2013 · BMJ Open
OBJECTIVE: To determine the potential of opportunistic glycated haemoglobin (HbA1c) testing of pathology samples to detect previously unknown diabetes. DESIGN: Pathology samples from participants collected for other reasons and suitable…
Jun Ueda, Norihito Uemura, Tomoyuki Ishimoto et al. · 2023 · Movement Disorders
Abstract Background The intercellular transmission of pathogenic proteins plays a crucial role in the progression of neurodegenerative diseases. Previous research has shown that the neuronal uptake of such proteins is activity‐dependent;…
Xiao Li, Maierhaba Maitiyaer, Qing Tan et al. · 2024 · Frontiers in Pharmacology
Primary Sjögren's Syndrome (pSS) is a complex autoimmune disorder characterized by exocrine gland dysfunction, leading to dry eyes and mouth. Despite growing interest in biologic therapies for pSS, FDA approval has proven challenging due to trial complications. This review addresses the absence of a molecular-target-based approach to biologic therapy development and highlights novel research on drug targets and clinical trials. A literature search identified potential pSS treatment targets and recent advances in molecular understanding. Overlooking extraglandular symptoms like fatigue and depr