Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Atif Mahmood, Asad Mehmood, Simone Terzani et al. · 2025 · Management Decision
Purpose The environmental, social and governance (ESG) topic has recently received increasing attention from scholars due to increasing regulations for firms’ non-financial disclosure with respect to environmental and social issues. For instance, the European Union (EU) recently issued the Corporate Sustainability Reporting Directive (CSRD) in December 2022 and implemented it starting in 2024 in member states. Non-financial disclosure is relevant for various stakeholders and could affect firm value. Therefore, this study aims to examine the effect of ESG disclosure on firm value in the EU cont
View details →DOI: 10.1108/md-10-2024-2480Cited by 17 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michael Rabbia, Maitea Guridi Ormazabal, Hannah Staunton et al. · 2024 · Journal of Neuromuscular Diseases
Background: Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne muscular dystrophy (DMD) aged ≥4 years. Objective: To compare SV95C-in its first-ever clinical trial application as a secondary endpoint-with established motor function COAs used in the trial (Four-Stair Climb [4SC] velocity, North Star Ambulatory Assessment [NSAA], and Six-Minute Walk Distance [6MWD]). Methods: SV95C was a secondary endpoint in a subset (n = 47)
View details →DOI: 10.3233/jnd-230188Cited by 17 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Onur Karakuş, Cara Nissen, Christoph Voelker et al. · 2025 · Global Biogeochemical Cycles
Abstract The particulate organic carbon (POC) flux from the euphotic zone to the deep ocean is central to the biological carbon pump. It is typically evaluated using “export efficiency” and “transfer efficiency,” which reflect POC formation and sinking and carbon sequestration efficiency in the ocean's interior, respectively. Since observations of these metrics are limited, biogeochemical models can elucidate the controls of large‐scale patterns. This study uses the global ocean‐biogeochemical model FESOM‐REcoM, with a new sinking routine that accounts for ballast minerals, seawater viscosity,
View details →DOI: 10.1029/2024gb008403Cited by 17 Negative / Null Result Report
Xiaoxiao Ma · 2023 · Green and Low-Carbon Economy
Facing severe air pollution, the Chinese government has introduced bottom-up public participation in environmental policy. The increase in public environmental attention can promote the participation of all people in environmental…
View details →DOI: 10.47852/bonviewglce3202868Cited by 17 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Sadek Ahmed, Osama Saher, Heba Attia et al. · 2026 · Frontiers in Pharmacology
Introduction: Vaginal candidiasis remains a recurrent fungal infection affecting millions of women worldwide, necessitating innovative local delivery systems to overcome poor drug solubility and mucosal barriers. This study introduces Dual-Functional Hybrid Cationic PEGylated Proniosomes (DHCPP) as a smart nano-platform designed to boost the vaginal delivery of Fenticonazole Nitrate (FTN). Methods: DHCPP systems were fabricated via the coacervation phase separation method and optimized using a full 2 3 factorial design, achieving a high desirability value of 0.931. The optimized DHCPP exhibite
View details →DOI: 10.3389/fphar.2025.1746918Cited by 17 Negative / Null Result ReportOpen accessMedicine
Soichiro Sasaki, Takayuki Matsuura, Rei Takahashi et al. · 2026 · PubMed
Regular exercise has recognized health benefits, partly because it reportedly lowers the levels of the oxidation products of proteins and DNA at rest, in contrast with the effect of acute exercise. However, when we compared oxidative…
View details →DOI: 10.22029/eir.2013.1678Cited by 16 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kevin J. Mitchell, Darren Dahly, Dorothy Bishop · 2025 · Neuron
The idea that the gut microbiome causally contributes to autism has gained currency in the scientific literature and popular press. Support for this hypothesis comes from three lines of evidence: human observational studies, preclinical experiments in mice, and human clinical trials. We critically assessed this literature and found that it is beset by conceptual and methodological flaws and limitations that undermine claims that the gut microbiome is causally involved in the etiology or pathophysiology of autism.
View details →DOI: 10.1016/j.neuron.2025.10.006Cited by 16 Negative / Null Result ReportOpen accessMedicine
Yu Zhang, Yuxi Liu, Yanping Li et al. · 2026 · JAMA
Importance: Evidence linking coffee and tea to cognitive health remains inconclusive, and most studies fail to differentiate caffeinated from decaffeinated coffee. Objective: To investigate associations of coffee and tea intake with…
View details →DOI: 10.1001/jama.2025.27259Cited by 16 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhiyu Yang, Fanny‐Dhelia Pajuste, Kristina Zguro et al. · 2025 · Nature Genetics
Abstract Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with disease susceptibility. Considering nine common diseases ( n cases ranging from 11,980 to 124,682) across seven biobanks, we systematically compared genetic architectures of susceptibility and progression, defined as disease-specific mortality. We identified only one locus substantially associated with disease-specific mortality and showed that, at a si
View details →DOI: 10.1038/s41588-025-02342-8Cited by 16 Negative / Null Result ReportOpen accessEnergy
Yuqi Ren, Miao Cheng, Hongbin He et al. · 2025 · Nature Communications
CO2-to-hydrocarbon fuel conversion via artificial photosynthesis is limited by catalyst poisoning under high O2 partial pressures and sluggish C2-product formation. Herein, Ru0.6Cu1(Cu0–Cu1+)/CeO2 catalysts with adaptive O2 tolerance are…
View details →DOI: 10.1038/s41467-025-67844-9Cited by 16 Negative / Null Result ReportOpen accessNeuroscience
Yi-Ting Chiu, Ariel Y. Deutch, Wei Wang et al. · 2026 · Nature Neuroscience
ABSTRACT Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder,…
View details →DOI: 10.1038/s41593-026-02375-0Cited by 16 Negative / Null Result ReportOpen accessMedicine
Xinchi Luan, Xuezhe Wang, Ying Shi et al. · 2025 · Frontiers in Psychiatry
Depression represents a global health challenge with complex etiology and significant societal impact. Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression). On this basis, we have summarized that abnormal lipid metabolism may serve as a diagnostic and therapeu
View details →DOI: 10.3389/fpsyt.2025.1589663Cited by 16 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Amélie Cabirol, Andrew Quinn, Julie Schafer et al. · 2026 · Proceedings of the National Academy of Sciences
Abstract The composition of the gut microbiota has recently been identified as a cause of cognitive variability in humans and animals. Germ-free individuals and individuals exposed to an antibiotic treatment show severe alteration of their learning and memory performance measured in various cognitive tasks. While different species of bacteria are known to interact in the gut, their cumulative or synergistic effects on cognitive performance remain elusive. Here we established a defined bacterial community - composed of core members of the corbiculate bee microbiota - which enhances honey bees’
View details →DOI: 10.1073/pnas.2608600123Cited by 16 Negative / Null Result ReportOpen accessEnvironmental Science
Jonne Kotta, Helen Orav‐Kotta, Kristjan Herkül et al. · 2024 · Työväentutkimus Vuosikirja
Following the establishment of the invasive gammarid amphipod Gammarus tigrinus the native gammarids almost disappeared from some habitats of the northeastern Baltic Sea.The aims of the current work were to experimentally study whether the habitat choice of G. tigrinus and G. salinus was similar and whether G. tigrinus modified the habitat selection of G. salinus, providing thus evidence that competition for space between the two species might explain the disappearance of the native gammarids from the study area.In general, the gammarid amphipods had a significant overlap in habitat selection.
View details →DOI: 10.60910/ccar-5vq8Cited by 16 Negative / Null Result ReportOpen accessNeuroscience
Nicholas Forelli, Trace Thome, Deborah Eaton et al. · 2026 · Science
Abstract Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i…
View details →DOI: 10.1126/science.aeh4856Cited by 16 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Aliasghar Azma, Yakun Liu, Eden Tatek Alemu · 2026 · Scientific Reports
The aim of this study was to evaluate groundwater quality the Marvdasht aquifer using the Groundwater Quality Index (GWQI), which was determined using a conventional method and also predicted using three machine learning algorithms:…
View details →DOI: 10.1038/s41598-026-44906-6Cited by 16 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roohi Chaudhary, Ralf Weiskirchen, Marcelo Ehrlich et al. · 2025 · Frontiers in Pharmacology
The transforming growth factor-β (TGF-β) superfamily (TGF-β-SF) comprises over 30 cytokines, including TGF-β, activins/inhibins, bone morphogenetic proteins (BMPs), and growth differentiation factors (GDFs). These cytokines play critical roles in liver function and disease progression. Here, we discuss Smad-dependent (canonical) and non-Smad pathways activated by these cytokines in a hepatocellular context. We highlight the connection between the deregulation of these pathways or the balance between them and key hepatocellular processes (e.g., proliferation, apoptosis, and epithelial-mesenchym
View details →DOI: 10.3389/fphar.2025.1580500Cited by 16 Negative / Null Result ReportOpen accessMedicine
Federica Canfora · 2025 · Journal of Oral & Facial Pain and Headache
Burning Mouth Syndrome (BMS) is a complex, chronic neuropathic orofacial pain disorder characterized by a persistent burning or dysesthetic sensation in the oral cavity without an identifiable organic cause. Accurate diagnosis and…
View details →DOI: 10.22514/jofph.2025.064Cited by 16 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Ashish Sriram Mishra, Bhavna Ghosh, Sivakumar Ponnurengam Malliappan et al. · 2026 · RSC Advances
The development of colon-targeted drug delivery systems (CDDS) has gained increasing attention due to their potential to improve therapeutic outcomes for diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, and other colonic disorders. Targeted delivery to the colon offers the advantages of site-specific action, reduced systemic side effects, and improved patient compliance. However, several physiological barriers, such as variable pH, microbial metabolism, enzymatic degradation, and transit time, pose significant formulation challenges. This re
View details →DOI: 10.1039/d5ra05194kCited by 16 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Harkeran K. Jandu, Colin Veal, Laura Fachal et al. · 2023 · Radiotherapy and Oncology
Background and purpose Up to a quarter of breast cancer patients treated by surgery and radiotherapy experience clinically significant toxicity. If patients at high risk of adverse effects could be identified at diagnosis, their treatment could be tailored accordingly. This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity two years following whole breast radiotherapy. Materials and Methods A genome-wide association study (GWAS) was performed in 1,640 breast cancer patients with complete SNP, clinical, treatment and toxicity data, recruited a
View details →DOI: 10.1016/j.radonc.2023.109806Cited by 16 Negative / Null Result ReportOpen accessMedicine
Jesús Giménez, Julen Castellano, Patrycja Lipińska et al. · 2020 · International Journal of Environmental Research and Public Health
The aim of this study was to investigate the relationships among physical demands of two friendly matches (FMs) and three task training sessions (TS1,2,3) combining in a different way: a Small-Sided Game (SSG), Mini-Goals (MG), a ball Circuit Training (CT) and a Large-Sided Game (LSG): SSG+MG+LSG (TS1), SSG+CT+LSG (TS2) and MG+CT+LSG (TS3). The TS and match demands in running intensities were monitored in fourteen professional soccer players (age = 23.2 ± 2.7 years, height = 178 ± 6 cm, body mass = 73.2 ± 6.9 kg, mean and SD, respectively) using 10-Hz global positioning system devices, and pla
View details →DOI: 10.3390/ijerph17082904Cited by 16 Negative / Null Result ReportOpen accessNeuroscience
Sulggi A. Lee, Joel Mefford, Yong Huang et al. · 2016 · AIDS
OBJECTIVE: Plasma kynurenine/tryptophan ratio, a biomarker of indoleamine 2,3-dioxygenase-1 (IDO) activity, is a strong independent predictor of mortality in HIV-infected Ugandans initiating antiretroviral therapy (ART) and may play a key…
View details →DOI: 10.1097/qad.0000000000001124Cited by 16 Negative / Null Result Report
Marian Dovgialo, Anna Chabuda, Anna Duszyk et al. · 2019 · International Journal of Neural Systems
Disorders of consciousness (DOC) are among the major challenges of contemporary medicine, mostly due to the high rates of misdiagnoses in clinical assessment, based on behavioral scales. This turns our attention to potentially objective…
View details →DOI: 10.1142/s012906571850048xCited by 16 Negative / Null Result ReportOpen accessMedicine
Caroline K. Kramer, Bernard Zinman, Haysook Choi et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Glucagon-like peptide-1 agonists acutely lower serum glucagon. However, in the Liraglutide and β-Cell Repair (LIBRA) Trial, 48-week treatment with liraglutide yielded lower/unchanged fasting glucagon but, surprisingly, enhanced…
View details →DOI: 10.1210/jc.2017-00928Cited by 16 Negative / Null Result Report
N. C. Hunt, K. M. Ghosh, A. P. Blain et al. · 2015 · The Bone & Joint Journal
The aim of this study was to compare the maximum laxity conferred by the cruciate-retaining (CR) and posterior-stabilised (PS) Triathlon single-radius total knee arthroplasty (TKA) for anterior drawer, varus–valgus opening and rotation in…
View details →DOI: 10.1302/0301-620x.97b5.34999Cited by 16 Negative / Null Result Report
Nawhath Thanvisitthpon · 2021 · Sustainability
This research proposes an updated version of homestay indicators for 10 existing component-level homestay requirements. The updated indicators were aimed to replace the decade-old original indicators for Thai homestay businesses. Besides,…
View details →DOI: 10.3390/su13020936Cited by 16 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marja-Liisa Nuotio, Heini Sánez Tähtisalo, Alexandra Lahtinen et al. · 2022 · Epigenetics
Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related ACY3 gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the ACY3 TSS with BP
View details →DOI: 10.1080/15592294.2022.2038418Cited by 16 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Olayemi O. Adeoye, Vincent Bouthors, Margaret C. Hubbell et al. · 2014 · Journal of Applied Physiology
Recent studies suggest that VEGF contributes to hypoxic remodeling of arterial smooth muscle, although hypoxia produces only transient increases in VEGF that return to normoxic levels despite sustained changes in arterial structure and…
View details →DOI: 10.1152/japplphysiol.00012.2014Cited by 16 Negative / Null Result ReportOpen accessNeuroscience
Onno Kruse, S. Klein, Isabell Tapia León et al. · 2020 · Human Brain Mapping
Extinction of appetitive conditioning is regarded as an important model for the treatment of psychiatric disorders like addiction. However, very few studies have investigated its neural correlates. Therefore, we investigated neural…
View details →DOI: 10.1002/hbm.24915Cited by 16 Negative / Null Result ReportMedicine
S.J.H. Bredie, Miek C. Jong · 2011 · Journal of Cardiovascular Pharmacology
BACKGROUND: Medicinal treatment of vasospastic Raynaud phenomenon is limited to primarily vasodilator medicines. OBJECTIVE: To explore the possible beneficial effects and tolerability of 120 mg two times a day of Ginkgo Biloba special…
View details →DOI: 10.1097/fjc.0b013e31823c0bedCited by 16 