A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Luca Testa, J M De La Torre Hernandez, Giovanni Luigi De Maria et al. · 2026 · New England Journal of Medicine
BACKGROUND: Percutaneous coronary intervention (PCI) is increasingly used for revascularization of unprotected left main coronary artery disease. Whether intravascular ultrasonographic (IVUS) guidance during PCI results in better clinical…
Jiacheng Ma, Shengrui Liu, Yuting Pei · 2025 · Scientific Reports
Sports injury prediction is crucial for university football player health, yet existing research predominantly focuses on professional athletes and lacks interpretability. Using the Kaggle "University Football Injury Prediction Dataset"…
Shujun Hu, Xiaopeng Yin, Wen Liu et al. · 2025 · Structures
In prefabricated concrete structures, interfacial slip induced by shear at connection zones can critically undermine structural integrity, particularly when load transfer relies on reinforcing bar lap splices. To address this issue, this…
Luísa Sório Flor, Cory N Spencer, Jack Cagney et al. · 2025 · The Lancet
BACKGROUND: Violence against women and against children are human rights violations with lasting harms to survivors and societies at large. Intimate partner violence (IPV) and sexual violence against children (SVAC) are two major forms of such abuse. Despite their wide-reaching effects on individual and community health, these risk factors have not been adequately prioritised as key drivers of global health burden. Comprehensive x§and reliable estimates of the comparative health burden of IPV and SVAC are urgently needed to inform investments in prevention and support for survivors at both nat
Sanaa R. Elsegeny, Fatima S. Radwan, Yomna M. Elshamy et al. · 2025 · Annals of Microbiology
Abstract Background Aquaculture is an essential sector for global food security, providing protein-rich food, reducing pressure on wild stocks, creating jobs, and contributing to national economies. However, it faces major sustainability challenges, including disease outbreaks, inefficient feed utilization, and environmental impact. Main body The significance of probiotics in mitigating these issues is highlighted in this review. The current review underscores and highlights important considerations while developing or using probiotics in the aquaculture field: how strains are selected as cand
Roberta Ottria, Susan Mirmajidi, Pierangela Ciuffreda · 2026 · International Journal of Molecular Sciences
This review delves into the complex relationship between short-chain fatty acids (SCFAs) produced by the gut microbiota and inflammatory bowel disease (IBD). IBD, which includes Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal disorders with an increasing global incidence. Despite extensive research, the exact etiopathogenesis remains elusive, although a complex interplay involving genetic predisposition, environmental influences, and abnormal immune responses against commensal gut microbes is widely recognized. SCFAs, primarily acetate and butyrate, emerge as key
Aliasghar Azma, Yakun Liu, Eden Tatek Alemu · 2026 · Scientific Reports
The aim of this study was to evaluate groundwater quality the Marvdasht aquifer using the Groundwater Quality Index (GWQI), which was determined using a conventional method and also predicted using three machine learning algorithms:…
Zhiyu Yang, Fanny‐Dhelia Pajuste, Kristina Zguro et al. · 2025 · Nature Genetics
Abstract Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with disease susceptibility. Considering nine common diseases ( n cases ranging from 11,980 to 124,682) across seven biobanks, we systematically compared genetic architectures of susceptibility and progression, defined as disease-specific mortality. We identified only one locus substantially associated with disease-specific mortality and showed that, at a si
Amélie Cabirol, Andrew Quinn, Julie Schafer et al. · 2026 · Proceedings of the National Academy of Sciences
Abstract The composition of the gut microbiota has recently been identified as a cause of cognitive variability in humans and animals. Germ-free individuals and individuals exposed to an antibiotic treatment show severe alteration of their learning and memory performance measured in various cognitive tasks. While different species of bacteria are known to interact in the gut, their cumulative or synergistic effects on cognitive performance remain elusive. Here we established a defined bacterial community - composed of core members of the corbiculate bee microbiota - which enhances honey bees’
Harkeran K. Jandu, Colin Veal, Laura Fachal et al. · 2023 · Radiotherapy and Oncology
Background and purpose Up to a quarter of breast cancer patients treated by surgery and radiotherapy experience clinically significant toxicity. If patients at high risk of adverse effects could be identified at diagnosis, their treatment could be tailored accordingly. This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity two years following whole breast radiotherapy. Materials and Methods A genome-wide association study (GWAS) was performed in 1,640 breast cancer patients with complete SNP, clinical, treatment and toxicity data, recruited a
Jesús Giménez, Julen Castellano, Patrycja Lipińska et al. · 2020 · International Journal of Environmental Research and Public Health
The aim of this study was to investigate the relationships among physical demands of two friendly matches (FMs) and three task training sessions (TS1,2,3) combining in a different way: a Small-Sided Game (SSG), Mini-Goals (MG), a ball Circuit Training (CT) and a Large-Sided Game (LSG): SSG+MG+LSG (TS1), SSG+CT+LSG (TS2) and MG+CT+LSG (TS3). The TS and match demands in running intensities were monitored in fourteen professional soccer players (age = 23.2 ± 2.7 years, height = 178 ± 6 cm, body mass = 73.2 ± 6.9 kg, mean and SD, respectively) using 10-Hz global positioning system devices, and pla
Sulggi A. Lee, Joel Mefford, Yong Huang et al. · 2016 · AIDS
OBJECTIVE: Plasma kynurenine/tryptophan ratio, a biomarker of indoleamine 2,3-dioxygenase-1 (IDO) activity, is a strong independent predictor of mortality in HIV-infected Ugandans initiating antiretroviral therapy (ART) and may play a key…
Marian Dovgialo, Anna Chabuda, Anna Duszyk et al. · 2019 · International Journal of Neural Systems
Disorders of consciousness (DOC) are among the major challenges of contemporary medicine, mostly due to the high rates of misdiagnoses in clinical assessment, based on behavioral scales. This turns our attention to potentially objective…
Caroline K. Kramer, Bernard Zinman, Haysook Choi et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Glucagon-like peptide-1 agonists acutely lower serum glucagon. However, in the Liraglutide and β-Cell Repair (LIBRA) Trial, 48-week treatment with liraglutide yielded lower/unchanged fasting glucagon but, surprisingly, enhanced…
N. C. Hunt, K. M. Ghosh, A. P. Blain et al. · 2015 · The Bone & Joint Journal
The aim of this study was to compare the maximum laxity conferred by the cruciate-retaining (CR) and posterior-stabilised (PS) Triathlon single-radius total knee arthroplasty (TKA) for anterior drawer, varus–valgus opening and rotation in…
Nawhath Thanvisitthpon · 2021 · Sustainability
This research proposes an updated version of homestay indicators for 10 existing component-level homestay requirements. The updated indicators were aimed to replace the decade-old original indicators for Thai homestay businesses. Besides,…
Marja-Liisa Nuotio, Heini Sánez Tähtisalo, Alexandra Lahtinen et al. · 2022 · Epigenetics
Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related ACY3 gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the ACY3 TSS with BP
Olayemi O. Adeoye, Vincent Bouthors, Margaret C. Hubbell et al. · 2014 · Journal of Applied Physiology
Recent studies suggest that VEGF contributes to hypoxic remodeling of arterial smooth muscle, although hypoxia produces only transient increases in VEGF that return to normoxic levels despite sustained changes in arterial structure and…
Onno Kruse, S. Klein, Isabell Tapia León et al. · 2020 · Human Brain Mapping
Extinction of appetitive conditioning is regarded as an important model for the treatment of psychiatric disorders like addiction. However, very few studies have investigated its neural correlates. Therefore, we investigated neural…
S.J.H. Bredie, Miek C. Jong · 2011 · Journal of Cardiovascular Pharmacology
BACKGROUND: Medicinal treatment of vasospastic Raynaud phenomenon is limited to primarily vasodilator medicines. OBJECTIVE: To explore the possible beneficial effects and tolerability of 120 mg two times a day of Ginkgo Biloba special…
Bożena Nejman-Faleńczyk, Beata Nadratowska-Wesołowska, Agnieszka Szalewska-Pałasz et al. · 2010 · Microbiology
The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that…
Zouhaier Aloui, Mekki Hamdaoui, Samir Maktouf · 2024 · Transnational Corporation Review
This paper examines the moderating role of governance in the effect of Foreign Direct Investment (FDI) on poverty using simultaneous equations models for sub-Saharan African, Asian, Latin American and Eastern European countries over the…
Kam Ng, Todd Sullivan · 2017 · Geotechnical Research
In Wyoming, pile foundations for bridges are often driven on rock materials because of the state’s shallow bedrock stratigraphy. Unfortunately, no static analysis methods are currently available for estimating the resistance of these…
Anthony N. Reffi, Caitlin M. Pinciotti, Holly K. Orcutt · 2018 · Journal of Interpersonal Violence
Institutional betrayal reflects the failings of a trusted institution to prevent or respond appropriately to negative experiences. Following sexual assault, survivors who encounter institutional betrayal may experience greater distress and…
Alexander D. Stajković, Jessica M. Greenwald, Kayla Stajkovic · 2022 · Journal of Organizational Behavior
Summary The effects of primed money have received widespread attention in social psychology but not in the organizational literature. This research examines whether priming money causes people to think and behave in ways consistent with…
Guangsheng Song, Zhihui Qian, Xiangyu Liu et al. · 2023 · Advanced Functional Materials
Abstract Degenerative disc disease (DDD) has become a significant public health issue worldwide. This can result in loss of spinal function affecting patient health and quality of life. Artificial total disc replacement (A‐TDR) is an…
Esra Yiğit, Fikri Gökpınar · 2010 · Communications Faculty Of Science University of Ankara Series A1Mathematics and Statistics
The classical F-test to compare several population means depends on the assumption of homogeneity of variance of the population and the normality. When these assumptions especially the equality of variance is dropped, the classical F-test fails to reject the null hypothesis even if the data actually provide strong evidence for it. This can be considered a serious problem in some applications, especially when the sample size is not large. To deal with this problem, a number of tests are available in the literature. In this study, the Brown-Forsythe, Weerahandiís Generalized F, Parametric Bootst
Damian J. Ruck, R. Alexander Bentley, Alberto Acerbi et al. · 2017 · Advances in Complex Systems
Here, we test Neutral models against the evolution of English word frequency and vocabulary at the corpus scale, as recorded in annual word frequencies from three centuries of English language books. Against these data, we test both static…
Joshua K. Hartshorne, Lauren Skorb, Sven L. Dietz et al. · 2019 · Collabra Psychology
We report the first set of results in a multi-year project to assess the robustness – and the factors promoting robustness – of the adult statistical word segmentation literature. This includes eight total experiments replicating six different experiments. The purpose of these replications is to assess the reproducibility of reported experiments, examine the replicability of their results, and provide more accurate effect size estimates. Reproducibility was mixed, with several papers either lacking crucial details or containing errors in the description of method, making it difficult to ascert
Dominic Guitard, Leonie M. Miller, Ian Neath et al. · 2019 · Journal of Cognitive Psychology
People are better at recalling lists of high- than low-frequency words but as Parmentier, Comesãna, and Soares [(2017). Disentangling the effects of word frequency and contextual diversity on serial recall performance. Quarterly Journal of…